{"_self":{"principle":"Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.","widget":"article_bundle","feature":"bundle","name":"LLM article bundle","what":"Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution.","contains":"body, claims, sources, voxels, provenance, question graph, constitution, llm_manifest","slug":"ss-31-neuropathy","urls":{"read":"https://miscsubjects.com/api/articles/ss-31-neuropathy/bundle?format=markdown"},"how_to_use":"Reference bundle for an LLM or reader. §SELF explains the surface; ingest and claim endpoints in llm_manifest are the write-back routes.","write":null,"imessage":null,"router_tag":null,"proof_chain":[{"step":1,"claim":"Articles are voxel graphs of tiered claims, not prose blobs.","verify":"https://miscsubjects.com/api/articles/constitution"},{"step":2,"claim":"Claims link to hash-chained sources via source_ids.","verify":"https://miscsubjects.com/api/articles/ss-31-neuropathy/sources"},{"step":3,"claim":"Ask reads topology; ingest/claim append to ledger.","verify":"https://miscsubjects.com/api/protocol"},{"step":4,"claim":"Models queue growth: populate → collaborate → repair → reflex.","verify":"https://miscsubjects.com/api/protocol/grow"},{"step":5,"claim":"Graph proves its own shape (reflex) and $/claim (yield).","verify":"https://miscsubjects.com/graph.html?layer=reflex"},{"step":6,"claim":"Full feature index + _explain on every API response.","verify":"https://miscsubjects.com/api/articles/system-map"}],"related_features":[{"id":"topology","name":"Article topology","what":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER.","urls":{"read":"https://miscsubjects.com/api/articles/ss-31-neuropathy/topology"}},{"id":"voxels","name":"Voxel graph","what":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance.","urls":{"read":"https://miscsubjects.com/api/articles/ss-31-neuropathy/voxels","write":"https://miscsubjects.com/api/protocol/claim"}},{"id":"ask","name":"Ask protocol","what":"Answer only from topology; creates question_node with gaps and ingest_hint.","urls":{"read":"https://miscsubjects.com/api/articles/ss-31-neuropathy/prompts","write":"https://miscsubjects.com/api/protocol/ask"}},{"id":"ingest","name":"Ingest protocol","what":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","urls":{"write":"https://miscsubjects.com/api/protocol/ingest"}},{"id":"claim_post","name":"Claim post protocol","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by.","urls":{"read":"https://miscsubjects.com/api/articles/ss-31-neuropathy/voxels","write":"https://miscsubjects.com/api/protocol/claim"}},{"id":"llm_manifest","name":"LLM manifest","what":"Machine-readable read/write contract for external LLMs.","urls":{"read":"https://miscsubjects.com/api/articles/llm-manifest"}}],"system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","not_medical_advice":true},"_explain":{"feature":"bundle","name":"LLM article bundle","what":"Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution.","why":"Every feature is auditable collective intelligence","how":"Reference bundle for an LLM or reader. §SELF explains the surface; ingest and claim endpoints in llm_manifest are the write-back routes.","model":null,"verifies":null,"urls":{"read":"https://miscsubjects.com/api/articles/ss-31-neuropathy/bundle?format=markdown"},"imessage":null,"router":null,"related":[{"id":"topology","what":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER."},{"id":"voxels","what":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance."},{"id":"ask","what":"Answer only from topology; creates question_node with gaps and ingest_hint."},{"id":"ingest","what":"Parse pasted evidence → source ledger + claims + evidence_ingest node."},{"id":"claim_post","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by."},{"id":"llm_manifest","what":"Machine-readable read/write contract for external LLMs."}],"not_medical_advice":true},"MASTHEAD":{"sorry_status":"planes not merged yet — sorry-status activates after voxel-merge-planes","identity":{"slug":"ss-31-neuropathy","version":2,"content_hash":"ea9df679c4131e4b161c99f831483b5b8239ac0701b7af4200a92a31c8bf5cee","thread_head":"genesis","divs":18},"thesis":{"root_claim":"c1","text":"SS-31 binds cardiolipin to stabilize inner mitochondrial membrane and reduce ROS.","tier":"mechanistic"},"load_bearing":[{"id":"c2","tier":"human","status":"active","text":"Phase II randomized trial of topical elamipretide in 12 LHON patients assessed safety and visual outcomes over 52 weeks."},{"id":"c5","tier":"human","status":"active","text":"No large human trials exist for common peripheral neuropathies such as diabetic neuropathy."},{"id":"c3","tier":"preclinical","status":"active","text":"In LPS mouse model, SS-31 reversed hippocampal mitochondrial dysfunction, lowered ROS and inflammation, preserved synapses, and improved memory tests."},{"id":"c4","tier":"anecdotal","status":"active","text":"Reddit users with CFS/long COVID report subjective energy, cognitive, and one case of sensory nerve improvement after SS-31."}],"standing_objections":{"open":0,"strongest_open":null,"link":"https://miscsubjects.com/api/articles/ss-31-neuropathy/discourse"},"verbs":{"read":"GET https://miscsubjects.com/api/articles/ss-31-neuropathy/voxels — DIVs + hashes + chains (free)","read_claims":"GET https://miscsubjects.com/api/articles/ss-31-neuropathy/claims — every formal claim as claim:<id> with current hash, thread, stable link, and exact contribution/edit bodies","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {slug, expected_thread_head, target_div?, expected_hash?, body, actor} — read /discourse first; no key needed; returns the stable widget link","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {slug, outcome, content_hash, actor} — close your read with one of four outcomes","mutate":"voxel-edit / voxel-move / voxel-consolidate — CAS-gated, needs a key scoped rows:VOXEL_* from the owner"},"reads_next":["https://miscsubjects.com/a/philosophy","https://miscsubjects.com/api/articles/ss-31-neuropathy/discourse","https://miscsubjects.com/api/protocol"]},"bundle_version":1,"generated_at":"2026-07-29T20:10:52.544Z","slug":"ss-31-neuropathy","title":"SS-31 (Elamipretide) for Neuropathy: Mitochondrial Repair Evidence","url":"https://miscsubjects.com/a/ss-31-neuropathy","register":"source_ledger","tags":["peptide","matrix"],"posted_at":"2026-06-29T21:33:23.792Z","updated_at":"2026-07-17T02:42:06.466Z","body":"## What's breaking down\n\nNeuropathy often stems from mitochondrial dysfunction inside neurons. Damaged mitochondria leak reactive oxygen species, impair ATP production, and trigger cell death or poor signaling along nerves. This creates a repair deficit where breakdown outruns regeneration. Oxidative stress and inflammation compound the issue in many cases, whether from metabolic stress, injury, or genetic mitochondrial defects. The result is persistent nerve signaling problems rather than simple symptom masking.\n\n## Why SS-31 (Elamipretide) might help you\n\nIf mitochondrial cardiolipin instability sits at the root of your nerve energy failure, SS-31 (Elamipretide) is discussed because it binds cardiolipin in the inner mitochondrial membrane. This stabilizes the membrane, supports electron transport chain efficiency, and lowers excess ROS production. Therefore for you: If that layer is part of your problem, SS-31 (Elamipretide) is discussed because it targets repair (tissue) — not because it masks pain. The logic chain runs: mitochondrial stabilization → better ATP output in neurons → reduced oxidative damage → support for nerve maintenance pathways.\n\n## How these fit together\n\nSingle-compound focus. SS-31 (Elamipretide) maps directly to the mitochondrial layer of degeneration. No sibling peptides in scope here.\n\n## What the evidence actually shows\n\nHuman data exist for one specific mitochondrial optic neuropathy. A phase II randomized, double-masked, vehicle-controlled trial tested topical elamipretide in 12 patients with Leber hereditary optic neuropathy (LHON, m.11778G>A mutation). The study ran 52 weeks double-masked followed by open-label extension. It assessed safety, tolerability, and potential efficacy on visual function (human tier). Preclinical mouse work showed clearer mitochondrial rescue: LPS-induced systemic inflammation caused hippocampal mitochondrial membrane potential drop, ATP loss, ROS rise, and memory deficits; SS-31 treatment reversed these markers, reduced apoptosis, preserved dendritic spines, and improved behavioral tests (preclinical tier). Rat spinal cord injury models have explored similar mitochondrial protection with behavioral readouts, but results vary across studies (preclinical tier). No large human trials address common peripheral neuropathy forms such as diabetic or idiopathic cases.\n\n## What scientists say\n\nResearchers note SS-31's selective cardiolipin interaction improves bioenergetics and curbs apoptosis in mitochondrial disease models. They highlight its blood-brain barrier penetration in some contexts and call for more human neuropathy-specific work beyond rare optic forms. LHON trial authors emphasize safety in humans while noting efficacy signals remain preliminary (mechanistic and human tiers).\n\n## What people say on Reddit\n\nAnecdotal reports from users with chronic fatigue or long COVID describe subjective energy gains and cognitive clarity after SS-31 use. One user reported regained toe sensation after years of numbness and attributed it to nerve-level repair (anecdotal tier). Others note no benefit or stress that the compound remains investigational. These accounts come from self-experimentation threads and lack controlled verification.\n\n## What people say on X\n\nLimited public discussion appears on X. Mentions stay general, focusing on mitochondrial support in aging or rare disease contexts rather than neuropathy anecdotes. No high-visibility verified user reports surface in recent searches.\n\n## What we do not know\n\nDirect human evidence for common peripheral neuropathies is absent. Long-term nerve regeneration outcomes remain untested in controlled settings. Dose-response relationships, optimal duration, and combination effects with other interventions lack published data. Whether benefits persist after stopping treatment is unknown.\n\n## Safety and limits\n\nHuman trials report good tolerability in mitochondrial disease populations, including Barth syndrome and primary mitochondrial myopathy studies (human tier). Topical LHON use showed acceptable local safety. Animal work flags no major acute toxicity at tested doses. Because human neuropathy data are sparse outside rare optic cases, any application stays exploratory. Regulatory status remains investigational for most indications.","claims":[{"id":"c2","text":"Phase II randomized trial of topical elamipretide in 12 LHON patients assessed safety and visual outcomes over 52 weeks.","tier":"human","weight":0.8,"effective_weight":0.8,"slot":null,"source_ids":["s2"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c5","text":"No large human trials exist for common peripheral neuropathies such as diabetic neuropathy.","tier":"human","weight":0.8,"effective_weight":0.8,"slot":null,"source_ids":[],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c3","text":"In LPS mouse model, SS-31 reversed hippocampal mitochondrial dysfunction, lowered ROS and inflammation, preserved synapses, and improved memory tests.","tier":"preclinical","weight":0.5,"effective_weight":0.5,"slot":null,"source_ids":["s3"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c1","text":"SS-31 binds cardiolipin to stabilize inner mitochondrial membrane and reduce ROS.","tier":"mechanistic","weight":0.3,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s1"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c4","text":"Reddit users with CFS/long COVID report subjective energy, cognitive, and one case of sensory nerve improvement after SS-31.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s4"],"who_claims":"grok/grok-4.3","status":"active"}],"sources":[{"id":"s1","type":"review","url":"https://biomeme.com/applications/wellness/peptide-evidence/ss-31/","title":"SS-31 (Elamipretide) — Peptide Evidence Score","summary":"Mechanism summary from evidence framework page.","quote":"SS-31 selectively targets and stabilizes cardiolipin in the inner mitochondrial membrane... improves mitochondrial bioenergetics, reduces electron leak and ROS production","quote_status":"unverified","link_status":"ok","claim_ids":["c1"],"hash":"d42598e176ddffe3"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/37923251/","title":"Elamipretide Topical Ophthalmic Solution for the Treatment of Subjects with Leber Hereditary Optic Neuropathy: A Randomized Trial","summary":"Phase II human trial details for LHON.","quote":"This study aimed to assess the safety, tolerability, and potential efficacy of topical elamipretide in patients affected with Leber hereditary optic neuropathy (LHON).","quote_status":"verified","link_status":"ok","claim_ids":["c2"],"hash":"b689dbe517c13c8e"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31747905/","title":"Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice","summary":"Mouse study abstract detailing mitochondrial and behavioral outcomes.","quote":"These findings indicate that LPS-induced memory impairment can be attenuated by the mitochondrion-targeted antioxidant elamipretide.","quote_status":"verified","link_status":"ok","claim_ids":["c3"],"hash":"61137f50721f64d0"},{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/cfs/comments/1j2upcm/my_experience_treating_my_mecfs_with/","title":"My Experience Treating my ME/CFS with mitochondrial peptide SS-31","summary":"User anecdote on sensory recovery.","quote":"I can wiggle my toes in bed and feel them now. Ten years later! I 100% believe this is from the SS-31.","quote_status":"unverified","link_status":"ok","claim_ids":["c4"],"hash":"2cd73f80fe459e36"}],"voxels":{"slug":"ss-31-neuropathy","counts":{"divs":18,"voxels":5,"sources":4,"edges":9},"note":"slim bundle — full voxels at /api/articles/ss-31-neuropathy/voxels"},"constitution":{"url":"https://miscsubjects.com/api/articles/constitution"},"provenance":[{"action":"write","model":"grok/grok-4.3","ts":"2026-06-29T23:51:00.673Z","hash":"343e1b875b0d50c6","tokens_in":35870,"tokens_out":2690},{"action":"voxel_divide","model":"owner","ts":"2026-07-17T02:42:06.466Z","hash":"6c346e5bea7e9486","tokens_in":0,"tokens_out":0}],"contributions":[{"id":"k1","ts":"2026-06-29T23:51:00.673Z","model":"grok/grok-4.3","role":"writer","action":"redraft","rationale":"","hash":"177ad9f90adffa767bd76cfcc4fc8dde7fa72b6bece9d109402e2eab979d808a"}],"topology":null,"slim":true,"ledger_totals":{"claims":5,"sources":4,"exported_claims":5,"exported_sources":4},"question_graph":{"slug":"ss-31-neuropathy","questions":[],"evidence":[],"edges":[],"counts":{"questions":0,"evidence":0,"edges":0}},"verification":{"provenance":{"valid":true,"entries":2,"head":"6c346e5bea7e948684c6a982c32eca3939f01709dcb2cdd121a57acc6204a57b"},"sources":{"valid":true,"entries":4,"head":"2cd73f80fe459e362738ca06485252ae3525a1ba91fccf9f10f21c73b83d0f98"}},"counts":{"claims":5,"sources":4,"provenance":2,"contributions":1,"questions":0,"evidence_ingests":0,"voxel_edges":9},"transport":"Open every URL in this bundle with your browser or web / URL-fetch tool. Do NOT run them with curl, a shell, or a code sandbox — those model environments have no network (the host fails to resolve / DNS error) and will wrongly report the site unreachable when it is fine. Opening the link IS the call.","llm_manifest":{"version":"1","site":"https://miscsubjects.com","purpose":"Peptide evidence articles with hash-chained source ledgers, tiered claims, and a question graph. LLMs should READ bundles/URLs and WRITE back via ingest — never invent doses.","read":{"human_page":"https://miscsubjects.com/a/ss-31-neuropathy","bundle_json":"https://miscsubjects.com/api/articles/ss-31-neuropathy/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/ss-31-neuropathy/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/ss-31-neuropathy/topology","question_graph":"https://miscsubjects.com/api/articles/ss-31-neuropathy/question-graph","sources":"https://miscsubjects.com/api/articles/ss-31-neuropathy/sources","provenance":"https://miscsubjects.com/api/articles/ss-31-neuropathy/provenance","contributions":"https://miscsubjects.com/api/articles/ss-31-neuropathy/contributions","graph_topology":"https://miscsubjects.com/api/articles/ss-31-neuropathy/graph-topology?question={question}","voxels":"https://miscsubjects.com/api/articles/ss-31-neuropathy/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","health":"https://miscsubjects.com/api/articles/ss-31-neuropathy/health","repair":"POST https://miscsubjects.com/api/protocol/repair","list_articles":"https://miscsubjects.com/api/articles","graph_canvas":"https://miscsubjects.com/graph.html?slugs=ss-31-neuropathy","graph_yield":"https://miscsubjects.com/api/graph?slugs=ss-31-neuropathy&layer=yield","obsidian_vault":"https://miscsubjects.com/api/articles/obsidian-vault?slugs=ss-31-neuropathy","graph_query":"https://miscsubjects.com/api/v1/query?from=ss-31-neuropathy&kind=claim&where=tier=human"},"ask":{"description":"Answer only from topology; creates a question_node with gaps.","api":"POST https://miscsubjects.com/api/protocol/ask","body":{"slug":"{slug}","question":"string"},"imessage":"ss-31-neuropathy|your question","router_tag":"[ARTICLE_ASK]ss-31-neuropathy|question[/ARTICLE_ASK]","auth":"x-terminal-key header for API; iMessage/WhatsApp via miscsubjects build"},"ingest":{"description":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","api":"POST https://miscsubjects.com/api/protocol/ingest","body":{"slug":"{slug}","evidence":"paste text","question_node_id":"optional qn_..."},"imessage":"ingest ss-31-neuropathy|q:{node_id}|paste evidence","router_tag":"[ARTICLE_INGEST]ss-31-neuropathy|evidence[/ARTICLE_INGEST]","tiers":["human","preclinical","anecdotal","mechanistic","speculative"]},"claim":{"description":"Prompt-injection style POST — one claim voxel with who_claims + posted_by provenance.","api":"POST https://miscsubjects.com/api/protocol/claim","body":{"slug":"{slug}","text":"one assertion","tier":"human|preclinical|anecdotal|mechanistic|speculative","who_claims":"study author, platform, or model id","source_ids":"optional [s1]"},"imessage":"claim ss-31-neuropathy|tier|assertion — who claims it?","router_tag":"[ARTICLE_CLAIM]ss-31-neuropathy|tier|assertion[/ARTICLE_CLAIM]","slots":["what_it_is","who_claims_what","what_is_known","what_is_unknown","mechanism","limitations","disclaimer"]},"tiers":{"human":0.8,"preclinical":0.5,"anecdotal":0.3,"mechanistic":0.3,"speculative":0.1},"invariants":["Self-explaining — every API JSON has _self; every paste widget has §SELF; root index at /api/articles/system-map","Append-only — revisions preserved at ?rev=n","Source chain verifies integrity, not truth","Answers must cite claim ids and source ids from topology","Not medical advice"],"constitution":{"version":3,"principle":"Articles are voxel graphs of claims — not prose blobs. Every assertion is a claim atom with tier, weight, source_ids, and posted_by provenance.","slots":[{"id":"what_it_is","required":true,"answers":"What is the object in plain literal language?"},{"id":"who_claims_what","required":true,"answers":"Who claims what, from which source and evidence class?"},{"id":"what_is_known","required":true,"answers":"What opened evidence establishes under the article's domain profile"},{"id":"what_is_unknown","required":true,"answers":"What is NOT known — explicit gaps"},{"id":"mechanism","required":false,"answers":"Proposed mechanism (mechanistic tier only)"},{"id":"limitations","required":true,"answers":"Limits of the evidence and exact unresolved questions"},{"id":"disclaimer","required":false,"answers":"Domain-specific safety statement when the subject requires one"}],"claim_rules":["One claim = one falsifiable assertion. No compound claims.","Every claim must declare tier: human|preclinical|anecdotal|mechanistic|speculative|system.","system tier = architecture/design axioms (not biological mechanism). Use for protocol self-definition.","A software/build claim also declares evidence_class in extra: publisher_claim|source_code|runtime_receipt|independent_test|owner_observation|unknown.","Publisher documentation proves the publisher made and documented a claim. It is not independent runtime proof.","Source code proves an implementation exists. A successful receipt proves one invocation. Neither proves general reliability or field superiority.","Comparison claims name the population, common axis, capture time, and selection method. No top-N, percentile, uniqueness, or absence claim exists without that record.","Sourced claims must cite source_ids from the hash-chained ledger.","Unsourced claims must set source_status: unsourced and why_material.","posted_by is mandatory on every new claim (model id, human, or channel).","No medical advice, no doses, no 'you should take'.","Bad information is retracted (status:retracted), never deleted — retraction event stays on ledger.","Adversary challenges link via challenges[] / challenged_by[] — target may be downweighted.","Leaked secrets are scrubbed to [REDACTED:secret-leak] with scrub_events tombstone — honest audit trail."],"source_rules":["Every source is a voxel edge: type, url, exact quote, summary, found_by, accessed_at.","Sources hash-chain — prev/hash on append.","Anecdotal sources must name platform (reddit|x|youtube|imessage|user_entry).","Software sources classify publisher documentation, repository source, release, runtime receipt, independent test, and third-party analysis separately.","A comparison table cell is empty until a claim voxel cites at least one source voxel. Model prose alone is not evidence."],"writing_rules":["Literal nouns and verbs. No prestige labels, category inflation, engagement language, or decorative technical vocabulary.","Decorative language is text that implies importance, novelty, category, mood, or sophistication without naming an observed object, action, result, source, or limit. Delete it.","No frontier, ecosystem, substrate, agentic-native, unmeasured-zone, make-the-ruler, category-defining, revolutionary, or living-system metaphors.","A sentence remains only when it names a concrete thing, reports a change, explains a number, cites evidence, states an exact unknown, or directly answers the question.","Technical nouns are allowed only when literal. Define the first use by what the named code or data object stores or does.","State the observed object before naming a category for it.","Keep the evidentiary boundary beside the exact claim it limits.","Unknown means unknown. Missing evidence does not become absence."],"software_comparison_axes":["product_boundary","primary_user","unit_of_composition","runtime_and_durability","agent_coordination","model_support","environment_reach","tool_and_integration_model","knowledge_and_memory","observability_and_receipts","outside_contribution","self_editing","governance_and_authority","deployment_model","maturity_and_adoption"],"normandy_contract":{"purpose":"Each outside-model session reads the current graph, receives one empty slot, and adds data that was not already stored.","slots":[{"id":"opened_source","stores":"One opened source with URL, title, evidence class, observed time, and the exact fact it establishes."},{"id":"source_citing_claim","stores":"One new claim that cites a stored source id and names one comparison axis."},{"id":"overlap","stores":"One evidenced capability both systems have."},{"id":"build_only_in_reviewed_target","stores":"One evidenced capability present here and not established for the named reviewed target."},{"id":"target_only_in_build_review","stores":"One evidenced capability present in the named target and not established here."},{"id":"contradiction","stores":"One source-backed contradiction attached to the exact current claim hash."},{"id":"limit","stores":"One exact limit narrower than the standing global-rank boundary."},{"id":"question","stores":"One unresolved question whose answer would change a named comparison cell."},{"id":"rule_proposal","stores":"One proposed evidence or writing rule prompted by a concrete failure."},{"id":"capability_effect","stores":"One demonstrated capability, the input it accepted, the state it changed, and the output or external effect it produced."},{"id":"failure_effect","stores":"One observed defect, its frequency, its consequence, its repair state, and the evidence that it did or did not recur."},{"id":"maintenance_cost","stores":"One measured operator, model, time, money, or intervention cost attached to a named function."},{"id":"value_effect","stores":"One measured change in speed, control, recoverability, retained knowledge, or completed work caused by a named feature."}],"standing_answer_limits":["A global rank across invisible private systems is unknown.","Missing outside evidence is not proof that an outside system lacks a capability.","A successful receipt proves one run, not general reliability.","Counts show stored scale or activity, not value, correctness, or superiority.","Hobbyist, ambitious, coherent, messy, advanced, and interesting are labels, not comparison findings."],"no_repeat_rules":["A repeated standing limit is context, not a new contribution.","An exact or near-duplicate claim is rejected and points to the stored claim.","A duplicate source does not complete an assignment.","A response completes only after at least one new graph object lands.","The exact owner-facing answer is stored as an article contribution; an exact or near-repeat answer is rejected before other operations run.","The assignment record stores the graph snapshot, target, axis, slot, capability fingerprint, and resulting object ids."],"assignment":"GET /api/normandy?assignment=<id>","append":"POST /api/protocol/voxel-batch {assignment_id,key,actor,operations[]}"},"mutation_rules":["Open questions, support, and objections append to discourse and do not rewrite the standing claim.","Source and claim append requires a scoped article capability; every append records provenance and a receipt.","Existing text edits use the current voxel hash. A stale hash writes nothing.","Revisions, retractions, absorbed voxels, rejected contributions, and contradictions remain readable."],"ontology_rules":["Peptide articles (bpc-157, tb-500) are tree roots.","Condition articles (bpc-157-glp1-gut-damage) branch from peptides.","Stack articles (wolverine-stack-glp1) compose peptides — never duplicate peptide mechanism prose.","If an article has no parent embeds and is not a root peptide → sprawl candidate.","Misstep = duplicate scope with another slug; merge or reparent via embeds."],"post_protocol":{"claim":"POST /api/protocol/claim","source":"POST /api/protocol/sources","ingest":"POST /api/protocol/ingest","webhook":"POST /api/articles/<slug>/webhook {kind:claim|source}","imessage_claim":"claim {slug}|{tier}|your assertion — who claims it, source?","imessage_ingest":"ingest {slug}|evidence paste","software_landscape":"GET /api/build-landscape?next=1&lane=field|build|opposition|synthesis","queue_population":"POST /api/build-landscape {action:queue_targets, cohort, query, sort, captured_at, source_url, targets[]}"}},"this_article":{"slug":"ss-31-neuropathy","url":"https://miscsubjects.com/a/ss-31-neuropathy","bundle_url":"https://miscsubjects.com/api/articles/ss-31-neuropathy/bundle?format=markdown"},"voxel_procedure":{"what":"Every article has a human side (/a/ss-31-neuropathy) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"ss-31-neuropathy\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"ss-31-neuropathy\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"ss-31-neuropathy\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"ss-31-neuropathy\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"ss-31-neuropathy\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"ss-31-neuropathy\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/ss-31-neuropathy/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/ss-31-neuropathy/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/ss-31-neuropathy#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."}},"api_urls":{"bundle":"https://miscsubjects.com/api/articles/ss-31-neuropathy/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/ss-31-neuropathy/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/ss-31-neuropathy/topology","voxels":"https://miscsubjects.com/api/articles/ss-31-neuropathy/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","question_graph":"https://miscsubjects.com/api/articles/ss-31-neuropathy/question-graph","ask":"https://miscsubjects.com/api/protocol/ask","ingest":"https://miscsubjects.com/api/protocol/ingest","claim":"https://miscsubjects.com/api/protocol/claim","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown"}}