{"slug":"ss-31-muscle-loss","verification":{"valid":true,"entries":6,"head":"caa23887c3917662026358ae58e471450129d86a20376502c3959c8a812489a8"},"count":6,"sources":[{"id":"s1","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6588449/","title":"Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice","quote":"Treatment with SS-31 restores redox homeostasis, improves mitochondrial quality, and increases exercise tolerance without an increase in mitochondrial content.","summary":"Aged mice study showing mitochondrial and functional muscle benefits.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:51:52.225Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"8dee10a450c5984e52e5a1d663165c59104ca847cae033a249af83eadc8fcad1"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/34242343/","title":"In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial","quote":"In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial.","summary":"Human randomized trial on ATP in aging muscle.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:51:52.225Z","link_status":"ok","quote_status":"unverified","prev":"8dee10a450c5984e52e5a1d663165c59104ca847cae033a249af83eadc8fcad1","hash":"930ef738b977a9c93ffa162cc0a6650407b5c3f5786b3b8a700276bbbc58c3b2"},{"id":"s3","type":"pubmed","url":"https://www.neurology.org/doi/10.1212/WNL.0000000000005255","title":"Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy","quote":"Elamipretide increased exercise performance after 5 days of treatment in patients with PMM without increased safety concerns.","summary":"Phase 1/2 and later phase 3 context for PMM.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:51:52.225Z","link_status":"ok","quote_status":"unverified","prev":"930ef738b977a9c93ffa162cc0a6650407b5c3f5786b3b8a700276bbbc58c3b2","hash":"fefa0b9d9798a0af00ebe0cb2a691c5bf2be48ce5bad508dfdbfae9030636a66"},{"id":"s4","type":"pubmed","url":"https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.126.014397","title":"Targeting Mitochondrial Dysfunction With Elamipretide (SS-31) Improves Skeletal Muscle Performance in a HFpEF Rat Model","quote":"Elamipretide improved whole muscle contractile function and prevented atrophy development.","summary":"2026 rat study on muscle performance and atrophy prevention.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:51:52.225Z","link_status":"http_403","quote_status":"unverified","prev":"fefa0b9d9798a0af00ebe0cb2a691c5bf2be48ce5bad508dfdbfae9030636a66","hash":"607f72b27e049f45a23a396041ddc5e23ddc56c7c2c58ea9f7748f7d25ced0bb"},{"id":"s5","type":"pubmed","url":"https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.15266","title":"SS‐31 does not prevent or reduce muscle atrophy 7 days after a 65 kdyne contusion spinal cord injury in young male mice","quote":"SS-31 did not preserve body mass or hindlimb muscle mass 7 days post-SCI.","summary":"Negative finding in SCI atrophy model.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:51:52.225Z","link_status":"ok","quote_status":"unverified","prev":"607f72b27e049f45a23a396041ddc5e23ddc56c7c2c58ea9f7748f7d25ced0bb","hash":"24a9b4f86698e2eea2bccd6eea4de4ce2d1eb5ecab10d7f6d4db1f34de69c77b"},{"id":"s6","type":"reddit","url":"https://www.reddit.com/r/cfs/comments/1j2upcm/my_experience_treating_my_mecfs_with/","title":"My Experience Treating my ME/CFS with mitochondrial peptides","quote":"i notice very dramatic improvement to muscle strength on the ...","summary":"User reports of muscle strength changes with SS-31.","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:51:52.225Z","link_status":"ok","quote_status":"unverified","prev":"24a9b4f86698e2eea2bccd6eea4de4ce2d1eb5ecab10d7f6d4db1f34de69c77b","hash":"caa23887c3917662026358ae58e471450129d86a20376502c3959c8a812489a8"}]}