{"slug":"ss-31-insomnia","verification":{"valid":true,"entries":4,"head":"b361921bdc9a671e0f23ec28139d457f424f5cc4a48182db41b5ad0d83f68a69"},"count":4,"sources":[{"id":"s1","type":"pubmed","url":"https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.3508","title":"Mitochondrial antioxidant elamipretide improves learning and memory impairment induced by chronic sleep deprivation in mice","quote":"This work suggests that SS-31 could be a novel agent for patients with chronic insomnia-associated cognitive impairment.","summary":"2024 mouse study on chronic sleep deprivation and elamipretide effects on cognition and mitochondria.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:51:52.226Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"739474ac3524fe772fb6183158848617ff59b7788a01e39aba34bb61579186f4"},{"id":"s2","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7573804/","title":"Adverse Neurological Effects of Short-Term Sleep Deprivation in Aging Mice Are Prevented by SS31 Peptide","quote":"The observations suggest possible therapeutic benefits of SS31 for alleviating adverse neurological effects of acute sleep loss.","summary":"2020 study showing SS-31 protection against sleep deprivation neurological effects in mice.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:51:52.226Z","link_status":"ok","quote_status":"unverified","prev":"739474ac3524fe772fb6183158848617ff59b7788a01e39aba34bb61579186f4","hash":"acb9248d1ee8ecdc39ed74810fc67c30656600496e4202e161b9c366e49d791a"},{"id":"s3","type":"review","url":"https://www.alzdiscovery.org/uploads/cognitive_vitality_media/SS-31-Cognitive-Vitality-For-Researchers.pdf","title":"SS-31 (also known as Elamipretide®, Bendavia®, and MTP-131)","quote":"Preclinical studies showed benefit in cognitive impairment... Clinical trials in heart failure and primary mitochondrial myopathy have failed.","summary":"Overview noting lack of insomnia-specific human data and mixed trial outcomes.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:51:52.226Z","link_status":"ok","quote_status":"unverified","prev":"acb9248d1ee8ecdc39ed74810fc67c30656600496e4202e161b9c366e49d791a","hash":"ad5f7428ddbff45b6da5d0b8fb27f6b328481286103a5eada4a93c3c58fb99c3"},{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/cfs/comments/1j2upcm/my_experience_treating_my_mecfs_with/","title":"My Experience Treating my ME/CFS with mitochondrial peptides (SS-31)","quote":"SS-31 has been the single most effective treatment I have tried for improving energy. It has improved my cognitive function by 50%.","summary":"User reports on SS-31 effects including energy and occasional sleep notes from multiple threads.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:51:52.226Z","link_status":"ok","quote_status":"unverified","prev":"ad5f7428ddbff45b6da5d0b8fb27f6b328481286103a5eada4a93c3c58fb99c3","hash":"b361921bdc9a671e0f23ec28139d457f424f5cc4a48182db41b5ad0d83f68a69"}]}