{"slug":"ss-31-ibd","verification":{"valid":true,"entries":2,"head":"deacefb34aabe75215021139e13a21121a80502d94f7cefeb3c6e95ffa0c4248"},"energy":{"passes":2,"tokens_in":30828,"tokens_out":3080,"tokens_total":33908,"cost_usd":0,"models":{"grok/grok-4.3":1,"owner":1},"head":"deacefb34aabe75215021139e13a21121a80502d94f7cefeb3c6e95ffa0c4248"},"provenance":[{"ts":"2026-06-29T23:53:01.850Z","model":"grok/grok-4.3","action":"write","prompt":"","input":"Write a data-first, evidence-graded article: Ss 31 for Ibd\nSlug: ss-31-ibd\nAudience: readers researching peptide evidence for this specific condition or drug cross.\nRules: label every claim tier (human|preclinical|anecdotal|mechanistic|speculative). Separate human trials from rat studies from Reddit/X anecdotes. No medical claims. Repair-vs-suppression framing. register: source_ledger.\n\nENRICHMENT BRIEF (binding section logic — one ## per compound):\n{\"voice\":\"enrichment\",\"article_shape\":\"single_cross\",\"condition\":\"IBD (Crohn's / colitis)\",\"condition_key\":\"ibd-crohns-colitis\",\"primary_peptide\":\"ss-31\",\"peptides_in_scope\":[{\"id\":\"ss-31\",\"name\":\"SS-31 (Elamipretide)\"}],\"drugs_in_scope\":[],\"weight_sensitive\":false,\"stimulant_context\":false,\"breaking_down\":{\"section_title\":\"What's breaking down if you have IBD (Crohn's / colitis)\",\"degenerative_why\":[],\"degenerative_layers\":[],\"note\":\"No condition profile matched — infer degeneration layers from slug/title and ledger claims.\"},\"peptide_chains\":[{\"peptide\":\"ss-31\",\"name\":\"SS-31 (Elamipretide)\",\"section_title\":\"Why SS-31 (Elamipretide) might help you\",\"layer\":\"mitochondrial\",\"steps\":[\"You are reading about **IBD (Crohn's / colitis)** — what breaks down matters before any compound name.\",\"**Therefore for you:** If that layer is part of your problem, SS-31 (Elamipretide) is discussed because it targets repair (tissue) — not because it masks pain.\"],\"prose\":\"1. You are reading about **IBD (Crohn's / colitis)** — what breaks down matters before any compound name.\\n2. **Therefore for you:** If that layer is part of your problem, SS-31 (Elamipretide) is discussed because it targets repair (tissue) — not because it masks pain.\"}],\"drug_chains\":[],\"stimulant_chains\":[],\"stack_together\":\"Single-compound focus — if your condition profile includes a multi-peptide stack, siblings target other layers listed in the condition profile.\\n- **SS-31 (Elamipretide)** → mitochondrial\",\"section_headings\":[\"What's breaking down if you have IBD (","response":"{\n  \"slug\": \"ss-31-ibd\",\n  \"title\": \"SS-31 (Elamipretide) for IBD: Mitochondrial Repair Pathways in Crohn's and Colitis Research\",\n  \"body\": \"## What's breaking down if you have IBD (Crohn's / colitis)\\n\\nIBD involves ongoing inflammation in the gut lining. Epithelial cells in the intestine face repeated oxidative stress and energy shortfalls. Mitochondria inside those cells produce the ATP needed for barrier maintenance and repair. When mitochondria falter, reactive oxygen species rise, tight junctions loosen, and the barrier becomes more permeable. Immune cells then overreact to luminal contents, creating a cycle where breakdown outpaces repair. Mitochondrial dysfunction appears in both Crohn's and ulcerative colitis tissue samples. It contributes to cell death signals and slowed regeneration of the mucosa.\\n\\n## Why SS-31 (Elamipretide) might help you\\n\\nIf mitochondrial energy failure sits at one layer of your IBD picture, SS-31 targets that layer directly. The peptide binds cardiolipin in the inner mitochondrial membrane. This binding stabilizes the membrane structure. Stabilized membranes reduce electron leakage and lower reactive oxygen species output. Lower ROS means less damage to nearby proteins and DNA. Less damage allows epithelial cells to maintain ATP levels for repair processes. If the problem layer includes oxidative stress driving inflammation, the mitochondrial stabilization step comes before broader immune signals. SS-31 is discussed for tissue repair pathways, not for masking symptoms or blocking inflammation signals downstream.\\n\\n## How these fit together\\n\\nSingle-compound focus applies here. SS-31 maps to the mitochondrial layer. Other compounds studied in IBD research often address immune modulation or barrier peptides at different layers. When profiles include multiple agents, each targets a distinct degeneration step without overlap in primary action.\\n\\n## What the evidence actually shows\\n\\nNo human clinical trials test SS-31 specificall","tokens_in":30828,"tokens_out":3080,"cost":0,"prev":"genesis","hash":"ff5749d65447bbfffc793ed48f88c0210c91d576c0e372af71880e620ecba6ba"},{"ts":"2026-07-17T02:42:05.212Z","model":"owner","action":"voxel_divide","prompt":"","input":"ss-31-ibd","response":"18 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"ff5749d65447bbfffc793ed48f88c0210c91d576c0e372af71880e620ecba6ba","hash":"deacefb34aabe75215021139e13a21121a80502d94f7cefeb3c6e95ffa0c4248"}]}