{"slug":"ss-31-herniated-disc","verification":{"valid":true,"entries":5,"head":"1fa74a870b312ded4fbcbcea14b084e4858eee8643a86c333719b35a38780ccb"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://www.tandfonline.com/doi/abs/10.1080/10715762.2021.2018426","title":"The mitochondrial antioxidant SS-31 attenuated lipopolysaccharide-induced apoptosis and pyroptosis of nucleus pulposus cells","quote":"This study found that SS-31 ameliorated lipopolysaccharide (LPS)-induced loss of cell viability, ROS production, and apoptosis in NP cells... via scavenging ROS and maintaining the stability of mitochondrial dynamics","summary":"In vitro study on disc nucleus pulposus cells showing SS-31 mitochondrial protective effects.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:53:00.659Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"5db536b4bc294f704a065599d2b950e77f78d862cc19d8d1f63c81335442726b"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42082001/","title":"Elamipretide (SS-31) Promotes Recovery by Preserving Mitochondrial Bioenergetics and Neural Remodeling after Spinal Cord Injury","quote":"In a mouse thoracic contusion model, SS-31 treatment significantly enhanced locomotor recovery and gait performance... reduced lesion pathology and increased neuronal preservation","summary":"Mouse SCI model demonstrating SS-31 benefits via mitochondria.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:53:00.659Z","link_status":"ok","quote_status":"unverified","prev":"5db536b4bc294f704a065599d2b950e77f78d862cc19d8d1f63c81335442726b","hash":"2489d78c7f211fe1f6b9b0b860aebb191f097502202111ad35d21e094c0e00d8"},{"id":"s3","type":"news","url":"https://www.fightaging.org/archives/2025/10/fda-approval-for-mitochondrial-therapeutic-elamipretide-formerly-ss-31/","title":"FDA Approval for Mitochondrial Therapeutic Elamipretide, Formerly SS-31","quote":"The recent FDA approval of elamipretide is for the treatment of a rare disease","summary":"Reports 2025 FDA approval for Barth syndrome.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:53:00.659Z","link_status":"ok","quote_status":"unverified","prev":"2489d78c7f211fe1f6b9b0b860aebb191f097502202111ad35d21e094c0e00d8","hash":"abbdfe2a1d1cf3692c35682e92147ddae7b25ff5d42c4a34693c2e5e0c644584"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31266512/","title":"Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats","quote":"BPC 157 therapy was administered... Assessments were performed at 1, 4, 7, 15, 30, 90, 180, and 360 days after injury","summary":"Rat spinal cord injury study with BPC-157.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:53:00.659Z","link_status":"ok","quote_status":"unverified","prev":"abbdfe2a1d1cf3692c35682e92147ddae7b25ff5d42c4a34693c2e5e0c644584","hash":"9b29da5b8c0dfae031acca96f271aa5282fa722136044eeadb1f2e10b5bad22e"},{"id":"s5","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5741312/","title":"Targeting the innate repair receptor to treat neuropathy","quote":"These experimental and clinical studies show that ARA290 effectively reprograms a proinflammatory, tissue-damaging milieu into one of healing and tissue repair","summary":"Review of ARA-290 in neuropathy including clinical data.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:53:00.659Z","link_status":"ok","quote_status":"verified","prev":"9b29da5b8c0dfae031acca96f271aa5282fa722136044eeadb1f2e10b5bad22e","hash":"1fa74a870b312ded4fbcbcea14b084e4858eee8643a86c333719b35a38780ccb"}]}