{"slug":"ss-31-glp1-gut","verification":{"valid":true,"entries":6,"head":"9885394fe8e86157863020808ed7c0519f2e4cb0bcdb4982e7ac57f090bc91a5"},"count":6,"sources":[{"id":"s3","type":"pubmed","url":"https://jamanetwork.com/journals/jama/fullarticle/2810542","title":"GLP-1 Agonists and Gastrointestinal Adverse Events","quote":"Use of GLP-1 agonists compared with bupropion-naltrexone was associated with increased risk of ... gastroparesis (HR, 3.67 [95% CI, 1.15-11.90])","summary":"Observational study on GI risks including gastroparesis with GLP-1 agonists.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:54:05.405Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"bbdb283448a72ccc301e772a0ae07f03337793b162ee09d6f7a7d3bd5bb2ac8d"},{"id":"s9","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11816484/","title":"Elamipretide: A Review of Its Structure, Mechanism of Action ...","quote":"The stabilization of cardiolipin by Elamipretide results in improved mitochondrial function, reduced oxidative stress, and mitigated cell damage","summary":"Review of SS-31 mechanism via cardiolipin binding.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:54:05.405Z","link_status":"ok","quote_status":"verified","prev":"bbdb283448a72ccc301e772a0ae07f03337793b162ee09d6f7a7d3bd5bb2ac8d","hash":"48d133bdff37d87424017ac50b9633961ac4ca6a3c5dca131f175ef75bd80111"},{"id":"s10","type":"review","url":"https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/elamipretide","title":"Elamipretide - an overview","quote":"Elamipretide ... selectively binds cardiolipin ... leading to reduced mitochondrial reactive oxygen species (ROS) generation and improved ATP production.","summary":"Overview confirming mitochondrial targeting.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:54:05.405Z","link_status":"http_403","quote_status":"unverified","prev":"48d133bdff37d87424017ac50b9633961ac4ca6a3c5dca131f175ef75bd80111","hash":"2657acdc0fd2ee0d3c4bf6a216bace2e7a565ec16150b9b197f0c2956c409364"},{"id":"s12","type":"review","url":"https://www.alzdiscovery.org/uploads/cognitive_vitality_media/SS-31-Cognitive-Vitality-For-Researchers.pdf","title":"SS-31 (also known as Elamipretide®...) Cognitive Vitality For Researchers","quote":"In an ex vivo study of failing human hearts, SS-31 treatment improved mitochondrial function","summary":"Summary of human tissue and preclinical data.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:54:05.405Z","link_status":"ok","quote_status":"unverified","prev":"2657acdc0fd2ee0d3c4bf6a216bace2e7a565ec16150b9b197f0c2956c409364","hash":"9295f708b80697d18508908c59e36da569f1fd40152a93b74017707ee2145bf4"},{"id":"s16","type":"pubmed","url":"https://elifesciences.org/articles/55513","title":"Late-life restoration of mitochondrial function reverses ...","quote":"We show here that 8-week treatment of old mice with ... SS-31 ... can substantially reverse this deficit.","summary":"Rodent study on mitochondrial restoration in aging heart.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:54:05.405Z","link_status":"ok","quote_status":"unverified","prev":"9295f708b80697d18508908c59e36da569f1fd40152a93b74017707ee2145bf4","hash":"d37452a29a02b5859b2b3d6db8acd802e196ff1fad435a37dcae27994f92eb17"},{"id":"s28","type":"pubmed","url":"https://www.neurology.org/doi/10.1212/WNL.0000000000005255","title":"Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy","quote":"Participants who received the highest dose of elamipretide walked a mean of 64.5 m farther at day 5 compared to a change of 20.4 m in the placebo group","summary":"Human trial showing functional improvement in PMM.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:54:05.405Z","link_status":"ok","quote_status":"unverified","prev":"d37452a29a02b5859b2b3d6db8acd802e196ff1fad435a37dcae27994f92eb17","hash":"9885394fe8e86157863020808ed7c0519f2e4cb0bcdb4982e7ac57f090bc91a5"}]}