{"_self":{"principle":"Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.","widget":"article_voxels","feature":"voxels","name":"Voxel graph","what":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance.","contains":"claim voxels + source edges","slug":"ss-31-gabapentin","urls":{"read":"https://miscsubjects.com/api/articles/ss-31-gabapentin/voxels","write":"https://miscsubjects.com/api/protocol/claim"},"how_to_use":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance.","write":"https://miscsubjects.com/api/protocol/claim","imessage":null,"router_tag":null,"proof_chain":[{"step":1,"claim":"Articles are voxel graphs of tiered claims, not prose blobs.","verify":"https://miscsubjects.com/api/articles/constitution"},{"step":2,"claim":"Claims link to hash-chained sources via source_ids.","verify":"https://miscsubjects.com/api/articles/ss-31-gabapentin/sources"},{"step":3,"claim":"Ask reads topology; ingest/claim append to ledger.","verify":"https://miscsubjects.com/api/protocol"},{"step":4,"claim":"Models queue growth: populate → collaborate → repair → reflex.","verify":"https://miscsubjects.com/api/protocol/grow"},{"step":5,"claim":"Graph proves its own shape (reflex) and $/claim (yield).","verify":"https://miscsubjects.com/graph.html?layer=reflex"},{"step":6,"claim":"Full feature index + _explain on every API response.","verify":"https://miscsubjects.com/api/articles/system-map"}],"related_features":[{"id":"constitution","name":"Article constitution","what":"Binding rules: required article slots, claim/source rules, ontology anti-sprawl.","urls":{"read":"https://miscsubjects.com/api/articles/constitution","read_md":"https://miscsubjects.com/api/articles/constitution?format=markdown"}},{"id":"sources_ledger","name":"Source ledger","what":"Hash-chained cited sources; verify integrity at GET .../sources.","urls":{"read":"https://miscsubjects.com/api/articles/ss-31-gabapentin/sources","write":"https://miscsubjects.com/api/protocol/sources"}},{"id":"claim_post","name":"Claim post protocol","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by.","urls":{"read":"https://miscsubjects.com/api/articles/ss-31-gabapentin/voxels","write":"https://miscsubjects.com/api/protocol/claim"}}],"system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","not_medical_advice":true},"_explain":{"feature":"voxels","name":"Voxel graph","what":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance.","why":"Every feature is auditable collective intelligence","how":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance.","model":null,"verifies":null,"urls":{"read":"https://miscsubjects.com/api/articles/ss-31-gabapentin/voxels","write":"https://miscsubjects.com/api/protocol/claim"},"imessage":null,"router":null,"related":[{"id":"constitution","what":"Binding rules: required article slots, claim/source rules, ontology anti-sprawl."},{"id":"sources_ledger","what":"Hash-chained cited sources; verify integrity at GET .../sources."},{"id":"claim_post","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by."}],"not_medical_advice":true},"position":{"you_are_here":"https://miscsubjects.com/a/ss-31-gabapentin — SS-31 (Elamipretide) and Gabapentin / Pregabalin: Mitochondrial Repair vs Pain Signal Suppression","plane":"ss","master_entry":"https://miscsubjects.com/a/philosophy","siblings":[{"slug":"ss-31","title":"ss 31","url":"https://miscsubjects.com/a/ss-31"},{"slug":"ss-31-benzo-withdrawal","title":"SS-31 (Elamipretide) for Benzodiazepine Withdrawal: Mitochondrial Repair Pathways","url":"https://miscsubjects.com/a/ss-31-benzo-withdrawal"},{"slug":"ss-31-benzodiazepines","title":"SS-31 (Elamipretide) and Benzodiazepines: Mitochondrial Pathways in a Repair vs Suppression Frame","url":"https://miscsubjects.com/a/ss-31-benzodiazepines"},{"slug":"ss-31-brain-fog","title":"SS-31 (Elamipretide) and Statin-Associated Cognitive Effects: Evidence Review","url":"https://miscsubjects.com/a/ss-31-brain-fog"},{"slug":"ss-31-carpal-tunnel","title":"SS-31 (Elamipretide) for Carpal Tunnel Syndrome: Mitochondrial Evidence Review","url":"https://miscsubjects.com/a/ss-31-carpal-tunnel"},{"slug":"ss-31-chemo","title":"SS-31 (Elamipretide) for Chemotherapy Side Effects: Mitochondrial Evidence Review","url":"https://miscsubjects.com/a/ss-31-chemo"},{"slug":"ss-31-chemo-neuropathy","title":"SS-31 (Elamipretide) for Chemotherapy-Induced Neuropathy: Evidence Review","url":"https://miscsubjects.com/a/ss-31-chemo-neuropathy"},{"slug":"ss-31-cognition","title":"SS-31 (Elamipretide) for Cognition: Mitochondrial Evidence Graded","url":"https://miscsubjects.com/a/ss-31-cognition"},{"slug":"ss-31-corticosteroids","title":"SS-31 (Elamipretide) and Corticosteroid Injections: Mitochondrial Repair Context","url":"https://miscsubjects.com/a/ss-31-corticosteroids"},{"slug":"ss-31-diabetic-neuropathy","title":"SS-31 (Elamipretide) for Diabetic Neuropathy: Mitochondrial Evidence Review","url":"https://miscsubjects.com/a/ss-31-diabetic-neuropathy"},{"slug":"ss-31-frozen-shoulder","title":"SS-31 (Elamipretide) for Frozen Shoulder: Mitochondrial Evidence Review","url":"https://miscsubjects.com/a/ss-31-frozen-shoulder"},{"slug":"ss-31-glp-1","title":"SS-31 (Elamipretide) Mitochondrial Targeting with GLP-1 Agonists: Evidence Layers","url":"https://miscsubjects.com/a/ss-31-glp-1"},{"slug":"ss-31-glp1-agonists","title":"ss 31 glp1 agonists","url":"https://miscsubjects.com/a/ss-31-glp1-agonists"},{"slug":"ss-31-glp1-gut","title":"SS-31 (Elamipretide) for GLP-1 Agonist Gut Damage: Mitochondrial Evidence Review","url":"https://miscsubjects.com/a/ss-31-glp1-gut"},{"slug":"ss-31-gut","title":"SS-31 (Elamipretide) Mitochondrial Support for Gut: Evidence Review","url":"https://miscsubjects.com/a/ss-31-gut"},{"slug":"ss-31-herniated-disc","title":"SS-31 for Herniated Disc: Mitochondrial Targeting in Disc Repair Pathways","url":"https://miscsubjects.com/a/ss-31-herniated-disc"},{"slug":"ss-31-ibd","title":"SS-31 (Elamipretide) for IBD: Mitochondrial Repair Pathways in Crohn's and Colitis Research","url":"https://miscsubjects.com/a/ss-31-ibd"},{"slug":"ss-31-insomnia","title":"SS-31 (Elamipretide) for Insomnia: Evidence Review","url":"https://miscsubjects.com/a/ss-31-insomnia"},{"slug":"ss-31-metformin","title":"ss 31 metformin","url":"https://miscsubjects.com/a/ss-31-metformin"},{"slug":"ss-31-muscle-loss","title":"SS-31 (Elamipretide) for Muscle Loss: Mitochondrial Evidence Breakdown","url":"https://miscsubjects.com/a/ss-31-muscle-loss"},{"slug":"ss-31-nerve-damage","title":"SS-31 (Elamipretide) for Nerve Damage: Mitochondrial Repair Pathways","url":"https://miscsubjects.com/a/ss-31-nerve-damage"},{"slug":"ss-31-neuropathy","title":"SS-31 (Elamipretide) for Neuropathy: Mitochondrial Repair Evidence","url":"https://miscsubjects.com/a/ss-31-neuropathy"},{"slug":"ss-31-nsaids","title":"SS-31 for NSAIDs: Mitochondrial Repair vs Symptom Suppression","url":"https://miscsubjects.com/a/ss-31-nsaids"},{"slug":"ss-31-ozempic-face","title":"SS-31 (Elamipretide) for GLP-1 Facial Collagen Loss: Mitochondrial Repair Pathways and Evidence Review","url":"https://miscsubjects.com/a/ss-31-ozempic-face"},{"slug":"ss-31-plantar-fasciitis","title":"SS-31 (Elamipretide) for Plantar Fasciitis: Mitochondrial Evidence Review","url":"https://miscsubjects.com/a/ss-31-plantar-fasciitis"},{"slug":"ss-31-post-surgery","title":"SS-31 (Elamipretide) for Post-Surgery Recovery: Evidence-Graded Review","url":"https://miscsubjects.com/a/ss-31-post-surgery"},{"slug":"ss-31-postherpetic","title":"SS-31 (Elamipretide) and Postherpetic Neuralgia: Mitochondrial Repair in Damaged Nerves","url":"https://miscsubjects.com/a/ss-31-postherpetic"},{"slug":"ss-31-ppis","title":"SS-31 (Elamipretide) for PPI Users: Mitochondrial Pathways and Drug Context","url":"https://miscsubjects.com/a/ss-31-ppis"},{"slug":"ss-31-sciatica","title":"SS-31 for Sciatica: Mitochondrial Repair Evidence Graded Against Tissue and Nerve Layers","url":"https://miscsubjects.com/a/ss-31-sciatica"},{"slug":"ss-31-semaglutide","title":"SS-31 (Elamipretide) and Semaglutide: Mitochondrial Targeting and Metabolic Load Reduction Studied in Separate Contexts","url":"https://miscsubjects.com/a/ss-31-semaglutide"},{"slug":"ss-31-skin","title":"SS-31 (Elamipretide) for Skin: Mitochondrial Evidence Graded","url":"https://miscsubjects.com/a/ss-31-skin"},{"slug":"ss-31-statins","title":"ss 31 statins","url":"https://miscsubjects.com/a/ss-31-statins"},{"slug":"ss-31-stimulants","title":"SS-31 for Stimulant Load: Mitochondrial Support in a Multi-Peptide Stack","url":"https://miscsubjects.com/a/ss-31-stimulants"},{"slug":"ss-31-tendon","title":"SS-31 (Elamipretide) for Tendon Issues: Mitochondrial Repair Evidence","url":"https://miscsubjects.com/a/ss-31-tendon"},{"slug":"ss-31-tirzepatide","title":"SS-31 (Elamipretide) and Tirzepatide: Mitochondrial Targeting and Metabolic Load Reduction","url":"https://miscsubjects.com/a/ss-31-tirzepatide"},{"slug":"ss-31-trigeminal","title":"SS-31 (Elamipretide) for Trigeminal Issues: Mitochondrial Repair Evidence","url":"https://miscsubjects.com/a/ss-31-trigeminal"}],"machine_side":"https://miscsubjects.com/api/articles/ss-31-gabapentin/voxels","discourse":"https://miscsubjects.com/api/articles/ss-31-gabapentin/discourse","append_protocol":"https://miscsubjects.com/a/append-protocol","protocol_door":"https://miscsubjects.com/api/protocol"},"slug":"ss-31-gabapentin","div_mode":true,"voxel":{"mode":"div","divided_at":"2026-07-17T02:42:02.976Z","divided_by":"owner","original_body_sha":"c77e626d45d23dcc026bb4db20d96d5d28235db3af7c69375c31ed8217148b62","atoms":23,"version":1},"divs":[{"id":"d1","kind":"h","type":null,"order":1,"text":"## What's breaking down if you have Gabapentin / pregabalin","status":"active","vx_hash":"cf6f462a52986c66a2d2d67115f7ec49364d6003e58484118b3f228464095fba","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"612a87c95dea7c45f35d0319371f20f5dc9fcb16a5a9448659133e78aee1fcaf","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"728ed49a0856cb2b3b2319aeef7d3700256814a06228a43a8af11ea27b08e52e","detail":{"divided_from":"body","block":1,"kind":"h"},"prev":"genesis","hash":"612a87c95dea7c45f35d0319371f20f5dc9fcb16a5a9448659133e78aee1fcaf"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d1"},{"id":"d2","kind":"p","type":null,"order":2,"text":"If you take gabapentin or pregabalin for neuropathic pain, the underlying issue often involves nerve signaling problems. These drugs block calcium channels to reduce pain signals. They do not fix damaged nerves or mitochondria inside cells.","status":"active","vx_hash":"81209719f9b160ac20fc151824d28865dec74da9510a7d7d47fe133c8bc0bbf0","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"717cc1c7e898f312c3ebee05c8ab96061ab6d473ab00b6ef2a80e94df078c16a","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"b30242083b4f64cb104ca0c1dd02e54bb43572a22f095e23736dbf5c4b68645f","detail":{"divided_from":"body","block":2,"kind":"p"},"prev":"genesis","hash":"717cc1c7e898f312c3ebee05c8ab96061ab6d473ab00b6ef2a80e94df078c16a"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d2"},{"id":"d3","kind":"p","type":null,"order":3,"text":"Mitochondrial dysfunction can appear in nerve tissue during chronic pain states. Damaged mitochondria produce excess reactive oxygen species and lower ATP output. This can worsen nerve health over time. Gabapentin masks the symptom without addressing that layer.","status":"active","vx_hash":"a874488e67e08248f2018db13e9fee7416dc79a4c3fc898de312ff014ceefff6","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"4f305f01a5839960edb8b6cf664d1bc2bc5396aa0a542f0a6c1b8b0a097b3bc9","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"19416e593912263abdb244578a7ca543a78081dfd973e4185458d08fcfc3efea","detail":{"divided_from":"body","block":3,"kind":"p"},"prev":"genesis","hash":"4f305f01a5839960edb8b6cf664d1bc2bc5396aa0a542f0a6c1b8b0a097b3bc9"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d3"},{"id":"d4","kind":"h","type":null,"order":4,"text":"## Why SS-31 (Elamipretide) might help you","status":"active","vx_hash":"c39aeb4b67d86da613b9309a9eff257015a7a0297b0b2f1fd8fff4f607b4fddb","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"eae12c6b6936146f6fae583e90e5cb7e0725a364dd029312cf74229b87b8e301","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"7c3879b4bbf72978379a9eca09539b8ed98e02988cd3b0f996c11163dba1539a","detail":{"divided_from":"body","block":4,"kind":"h"},"prev":"genesis","hash":"eae12c6b6936146f6fae583e90e5cb7e0725a364dd029312cf74229b87b8e301"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d4"},{"id":"d5","kind":"list","type":null,"order":5,"text":"1. You are reading about Gabapentin / pregabalin — what breaks down matters before any compound name.\n2. Therefore for you: If mitochondrial damage in nerves forms part of your situation, SS-31 is discussed because it targets repair at the mitochondrial membrane — not because it masks pain.","status":"active","vx_hash":"0736827dddcfaadd2612d8fcd564c95a73e93297435b102a4f0bdecc3011c081","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"474b96292527ae0dfac32e3f534976f1b9f71633e6a4c5809982ec57aeb5ea8f","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"2991f4701d8207d056f5e4aea7d0976781cee203fa1d875c787c6d35bf1ead53","detail":{"divided_from":"body","block":5,"kind":"list"},"prev":"genesis","hash":"474b96292527ae0dfac32e3f534976f1b9f71633e6a4c5809982ec57aeb5ea8f"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d5"},{"id":"d6","kind":"p","type":null,"order":6,"text":"SS-31 binds cardiolipin in the inner mitochondrial membrane. This stabilizes the electron transport chain and cuts electron leakage. Lower leakage means less oxidative stress and better ATP production. In models of nerve stress, that step can support nerve cell energy balance.","status":"active","vx_hash":"1322a63e918ff0319eb56b7e208520778a9189862bdd0f0cc3cfc8462538e170","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"11ebf58e0f0b80476c94989732b3393fd486979ca10960cfdba88b641c9b96d7","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"09a04db867a1d64bd4cd58bd4f41b2f5b6c2c1924706569a8e0c6931f902c938","detail":{"divided_from":"body","block":6,"kind":"p"},"prev":"genesis","hash":"11ebf58e0f0b80476c94989732b3393fd486979ca10960cfdba88b641c9b96d7"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d6"},{"id":"d7","kind":"p","type":null,"order":7,"text":"If your pain has a mitochondrial component, improved energy handling might allow natural repair processes to keep pace better with daily wear.","status":"active","vx_hash":"632c75f0ddb6906189bb4351b6f9d8aee1c75e6379105dd8766bac845f144e60","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"8e21bd2208317b23dbd2aec531f81a7bc1f8b5db8a3f68e0706ecf9d70c070bc","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"433bb995e9919ac8f2f8eb0e4b60ff32c4917389e58b716a0f18eb955cbac401","detail":{"divided_from":"body","block":7,"kind":"p"},"prev":"genesis","hash":"8e21bd2208317b23dbd2aec531f81a7bc1f8b5db8a3f68e0706ecf9d70c070bc"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d7"},{"id":"d8","kind":"h","type":null,"order":8,"text":"## Why Gabapentin / pregabalin matters for you","status":"active","vx_hash":"48c0e8e02e28693c74a724a68dadf5c17bf19e27a2d9f3d8855e0f3e05265ec4","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"0311f29668ad9eacff03e68e2cfb83ab2003640b2859e982dce778bbdcbab572","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"a89512f8aa2c485b62dd6e5ee18e36970e0a163bfab19607c1922ff06d26071b","detail":{"divided_from":"body","block":8,"kind":"h"},"prev":"genesis","hash":"0311f29668ad9eacff03e68e2cfb83ab2003640b2859e982dce778bbdcbab572"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d8"},{"id":"d9","kind":"p","type":null,"order":9,"text":"Drug: Gabapentin / pregabalin\nWhat it does: Masks neuropathic pain signal; does not repair nerve.\nTherefore for you: This drug suppresses a signal. Suppression can reduce immediate suffering and let you stay active. Activity itself supports tissue health. The trade-off is that it leaves the underlying mitochondrial or nerve stress unaddressed, so the root layer may continue.","status":"active","vx_hash":"f69a37db88c823f9d3ef3144219c7aaec375665f9c027b5915b12bebf9194acb","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"7d61b62e86fcba37f310f470b084c57c123bdf5ccab1802150ed0a221d17965e","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"febdecd6bb1f37ac2085060a191f4678a9f2c44e3dad20654418a8b00e666e6f","detail":{"divided_from":"body","block":9,"kind":"p"},"prev":"genesis","hash":"7d61b62e86fcba37f310f470b084c57c123bdf5ccab1802150ed0a221d17965e"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d9"},{"id":"d10","kind":"h","type":null,"order":10,"text":"## How these fit together","status":"active","vx_hash":"84230fc285227817c168666fa9db48e4b5e10f9582760304291d5722120209e6","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"ceb4392b09be7964793d87c779e51f13e7cadbd04bfc732a20b1b519a75c1a59","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"255677f13849515d0e42f067e34911236d8b3298d6c16100bfa19e68c3074d62","detail":{"divided_from":"body","block":10,"kind":"h"},"prev":"genesis","hash":"ceb4392b09be7964793d87c779e51f13e7cadbd04bfc732a20b1b519a75c1a59"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d10"},{"id":"d11","kind":"p","type":null,"order":11,"text":"SS-31 targets the mitochondrial layer. Gabapentin / pregabalin handles the symptom layer. The two address different parts of the same picture. One supports cellular energy machinery while the other quiets the alarm. No overlap in primary action, so they sit side by side rather than compete.","status":"active","vx_hash":"38a386d34d947e83dfff3916221803d205928017477c1ef1081fa95d3dde2276","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"20176502020a9f2c88d0decc145f7b28aa30c2e42642fbf8119181196f11e443","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"2c0b9cfb2a96aad24cb1c2f6d1a84cf878d70fb00644799ac30834c1ca5f118b","detail":{"divided_from":"body","block":11,"kind":"p"},"prev":"genesis","hash":"20176502020a9f2c88d0decc145f7b28aa30c2e42642fbf8119181196f11e443"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d11"},{"id":"d12","kind":"h","type":null,"order":12,"text":"## What the evidence actually shows","status":"active","vx_hash":"c508566aa7eded5cd76d3e0aa7b43f978b733accc127201e5dfd4caa8e9e6a5e","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"a270c8075b5d26e9c0111a1d235ddff494d9148e98a5ebeb18203a7300cc094f","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"a7a051e6a294dc45c15b7d4859b7020d561e719fe73844f03e3a8f9e7fed8de1","detail":{"divided_from":"body","block":12,"kind":"h"},"prev":"genesis","hash":"a270c8075b5d26e9c0111a1d235ddff494d9148e98a5ebeb18203a7300cc094f"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d12"},{"id":"d13","kind":"p","type":null,"order":13,"text":"No human trials test SS-31 together with gabapentin or pregabalin. Human data on SS-31 come from mitochondrial myopathy and Barth syndrome studies. Preclinical work shows SS-31 protects mitochondria in nerve and pain models.","status":"active","vx_hash":"0b5b541a6c5b913ab8a4cd233e9783302134cd1339ed5d4693804df18e3c9aaa","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"cabca22d4efb5bda6c97d416aa73552b6fcf6897a19eaf2aec3bba8739e6a7f3","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"e22bfa2f69d07b7e303f89fd603af0fc760f0f4021ec65d2d5f9ee0327e65c80","detail":{"divided_from":"body","block":13,"kind":"p"},"prev":"genesis","hash":"cabca22d4efb5bda6c97d416aa73552b6fcf6897a19eaf2aec3bba8739e6a7f3"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d13"},{"id":"d14","kind":"h","type":null,"order":14,"text":"## What scientists say","status":"active","vx_hash":"1904fa726d070ddad72e18ddfb8207e9c1d80e12a4e3ad022cf6d100ccd06281","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"fb273e2f489951c87caa05e173c2e1e7cada9b2615e0ec9bb7da9e9cc41e0c3d","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"2f1dd55083de1fa734f2f06a8337a050d5a0b3f635bfc8bb709abab75705a1ef","detail":{"divided_from":"body","block":14,"kind":"h"},"prev":"genesis","hash":"fb273e2f489951c87caa05e173c2e1e7cada9b2615e0ec9bb7da9e9cc41e0c3d"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d14"},{"id":"d15","kind":"p","type":null,"order":15,"text":"Researchers describe SS-31 as a cardiolipin stabilizer that improves mitochondrial respiration in stressed cells (source s1, s5). They note benefits in rodent models of inflammatory nerve damage and headache-related pain pathways (source s22). Human trials focus on rare mitochondrial diseases, not common neuropathic pain.","status":"active","vx_hash":"2a7f22669cb3980b087ec57e9114805671d7ee7117d8bff42200f07bffb0159a","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"f4a589eefe3624b98aaca54af4e6ded919ec20aa6aa19bbe8b82f7de603cb3c0","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"221c2d7a5c7dadd4cdcdcab1af50c3bd0d0fe1c1eb6aea7cf716e660f28a5b08","detail":{"divided_from":"body","block":15,"kind":"p"},"prev":"genesis","hash":"f4a589eefe3624b98aaca54af4e6ded919ec20aa6aa19bbe8b82f7de603cb3c0"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d15"},{"id":"d16","kind":"h","type":null,"order":16,"text":"## What people say on Reddit","status":"active","vx_hash":"c6c4d1f81f40d7838be41dbd685fa991f2530899b53c7820f020b07c2b9e1e5e","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"712c5fd4b1b3626fe5f7c8b5a9be9f50f135354af08cf854ae6ed3140fb7b12e","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"feb303756a303788527cf602bf2c3c6b00ab8c384fb9fff4baa9ffc53e0049c3","detail":{"divided_from":"body","block":16,"kind":"h"},"prev":"genesis","hash":"712c5fd4b1b3626fe5f7c8b5a9be9f50f135354af08cf854ae6ed3140fb7b12e"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d16"},{"id":"d17","kind":"p","type":null,"order":17,"text":"Anecdotal reports on peptide forums mention SS-31 for general energy or recovery but rarely link it directly to gabapentin use. Users discuss mitochondrial support separately from pain medications.","status":"active","vx_hash":"ac6453e6191abf4a7dfad14adb8af44f4fa7ef423a8d5555e5d844d76b75fe1f","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"af58e3fa071a10e275a6ecb0db537470306517f57fe3e9f45e51dc30a6a64113","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"16737ee33d52d81e682e21b4c37816b41df2138273e56330a3d172f3b1945c41","detail":{"divided_from":"body","block":17,"kind":"p"},"prev":"genesis","hash":"af58e3fa071a10e275a6ecb0db537470306517f57fe3e9f45e51dc30a6a64113"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d17"},{"id":"d18","kind":"h","type":null,"order":18,"text":"## What people say on X","status":"active","vx_hash":"6db637f649603f7c2de55c2aae62b9d2996d040b45ddca436894fa07c78bb4f9","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"0ec0b756dae1f645cc26387acd1bf7b74a932cc468f28a92600576fa60fd02c9","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"4dd8bbfdb0452cc6235c2300209b5132daba3913b8f54ab179b1a73109c298dd","detail":{"divided_from":"body","block":18,"kind":"h"},"prev":"genesis","hash":"0ec0b756dae1f645cc26387acd1bf7b74a932cc468f28a92600576fa60fd02c9"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d18"},{"id":"d19","kind":"p","type":null,"order":19,"text":"Posts on X about elamipretide center on its recent approval for Barth syndrome. Few mention gabapentin cross-use. Discussions stay at the level of mitochondrial health in rare conditions.","status":"active","vx_hash":"df4b2d21857d9aad2938bf116bb83610fcd0ad2957b485f8d9dd98b9069fca2e","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"4c725e564c89e36b34c98f63e63d2768e6c6e6ce8fe5f1a00d5536cc8c17ae5f","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"dc4f62dda12abe8324657512f67488d8540c12eafa23b51c2de72d4bac65aaa5","detail":{"divided_from":"body","block":19,"kind":"p"},"prev":"genesis","hash":"4c725e564c89e36b34c98f63e63d2768e6c6e6ce8fe5f1a00d5536cc8c17ae5f"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d19"},{"id":"d20","kind":"h","type":null,"order":20,"text":"## What we do not know","status":"active","vx_hash":"62beee20bbfe71d3999ce66fcf461f81fefda17d4a607ffa5e3567386b7ddec1","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"e538be1f950bbaf97afd49520dbfcefbf8e64442f3e5a708f7b232bf028b501a","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"7d96a49fba77f6a48c0321db2ae4180a902beae62e2aac0d23408fbf8333a177","detail":{"divided_from":"body","block":20,"kind":"h"},"prev":"genesis","hash":"e538be1f950bbaf97afd49520dbfcefbf8e64442f3e5a708f7b232bf028b501a"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d20"},{"id":"d21","kind":"p","type":null,"order":21,"text":"Direct interaction data between SS-31 and gabapentin is absent. Long-term effects on nerve repair in typical neuropathic pain patients remain untested in humans. Whether mitochondrial improvements translate to reduced pain medication needs is unknown.","status":"active","vx_hash":"ec1e5ea977b79f5cfec9ed0dddc3edeb770403a95db0f341663a8dd2116dc815","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"0d3844beffddac13a5744a7831e20cb37e13695e058e87eb5c446a423787e2ca","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"d47c463c19a48655e6f4b8e597bd317217deb5ee20884ae3a2f1e785704317eb","detail":{"divided_from":"body","block":21,"kind":"p"},"prev":"genesis","hash":"0d3844beffddac13a5744a7831e20cb37e13695e058e87eb5c446a423787e2ca"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d21"},{"id":"d22","kind":"h","type":null,"order":22,"text":"## Safety and limits","status":"active","vx_hash":"505791f8c0665537c4014b7c145404a8e3be8ee1aed941afc14b8e4c903fe304","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"f5a426326853402d785517b2f11e3adb58787cb1db4e11294d8d5338268de3fb","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"404f7427c043c6ec7a5cb4416bbec9ec336e19f8757fb217be5c5c2161ff8cb6","detail":{"divided_from":"body","block":22,"kind":"h"},"prev":"genesis","hash":"f5a426326853402d785517b2f11e3adb58787cb1db4e11294d8d5338268de3fb"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d22"},{"id":"d23","kind":"p","type":null,"order":23,"text":"SS-31 has shown good tolerability in completed human trials for mitochondrial disorders. Gabapentin carries its own side-effect profile including dizziness and sedation. Combining any compounds requires individual medical oversight. Evidence grading stays preclinical or mechanistic for this specific pairing.","status":"active","vx_hash":"e4cd37e3209bb079a1a12ad4c95abfbbdd6e6c5ed425b00c38747721c6a52929","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"70bd68e7e9371aab3e9fd3ca76c37c09a5ea7a0604d7cc70db2bce4bee75449e","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:02.976Z","actor":"owner","text_sha":"b4f5503bfe859ee2236e5acb3eab818929d8956f3385a1dbf768d99c56ed82f0","detail":{"divided_from":"body","block":23,"kind":"p"},"prev":"genesis","hash":"70bd68e7e9371aab3e9fd3ca76c37c09a5ea7a0604d7cc70db2bce4bee75449e"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:02.976Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ss-31-gabapentin/d23"}],"voxels":[{"id":"c1","div_id":"claim:c1","kind":"claim","text":"SS-31 binds cardiolipin and stabilizes mitochondrial membranes in stressed cells.","tier":"mechanistic","standing":null,"weight":0.3,"section":"Why SS-31 (Elamipretide) might help you","status":"active","source_ids":["s1"],"source_status":"sourced","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:54:52.490Z","model":"grok/grok-4.3","rationale":""},"who_claims":"grok/grok-4.3","edges":[{"type":"supported_by","target":"s1","source_type":"pubmed","hash":"694a9b3c00ef89b4"},{"type":"posted_by","actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:54:52.490Z"}],"why_material":"Explains the core repair mechanism relevant to nerve energy layers.","content_hash":null,"stable_url":"https://miscsubjects.com/i/claim/ss-31-gabapentin/c1","machine_url":"https://miscsubjects.com/api/articles/ss-31-gabapentin/claims/c1"},{"id":"c2","div_id":"claim:c2","kind":"claim","text":"No human trials combine SS-31 with gabapentin or pregabalin.","tier":"human","standing":null,"weight":0.8,"section":"What the evidence actually shows","status":"active","source_ids":[],"source_status":"unsourced","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:54:52.490Z","model":"grok/grok-4.3","rationale":""},"who_claims":"grok/grok-4.3","edges":[{"type":"posted_by","actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:54:52.490Z"}],"why_material":"Sets accurate boundary on available data for this cross.","content_hash":null,"stable_url":"https://miscsubjects.com/i/claim/ss-31-gabapentin/c2","machine_url":"https://miscsubjects.com/api/articles/ss-31-gabapentin/claims/c2"},{"id":"c3","div_id":"claim:c3","kind":"claim","text":"Gabapentin suppresses pain signals without repairing nerves or mitochondria.","tier":"mechanistic","standing":null,"weight":0.3,"section":"Why Gabapentin / pregabalin matters for you","status":"active","source_ids":["s23"],"source_status":"sourced","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:54:52.490Z","model":"grok/grok-4.3","rationale":""},"who_claims":"grok/grok-4.3","edges":[{"type":"supported_by","target":"s23","source_type":"pubmed","hash":"65c464875ea0a6e8"},{"type":"posted_by","actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:54:52.490Z"}],"why_material":"Clarifies suppression vs repair framing for the reader.","content_hash":null,"stable_url":"https://miscsubjects.com/i/claim/ss-31-gabapentin/c3","machine_url":"https://miscsubjects.com/api/articles/ss-31-gabapentin/claims/c3"},{"id":"c4","div_id":"claim:c4","kind":"claim","text":"SS-31 improved mitochondrial function and reduced pain responses in a rodent headache model.","tier":"preclinical","standing":null,"weight":0.5,"section":"What scientists say","status":"active","source_ids":["s22"],"source_status":"sourced","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:54:52.490Z","model":"grok/grok-4.3","rationale":""},"who_claims":"grok/grok-4.3","edges":[{"type":"supported_by","target":"s22","source_type":"pubmed","hash":"d99ddc2130b64f6c"},{"type":"posted_by","actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:54:52.490Z"}],"why_material":"Provides concrete animal evidence for nerve pain context.","content_hash":null,"stable_url":"https://miscsubjects.com/i/claim/ss-31-gabapentin/c4","machine_url":"https://miscsubjects.com/api/articles/ss-31-gabapentin/claims/c4"}],"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31747905/","title":"Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice","quote":"Elamipretide (SS-31) is a novel mitochondrion-targeted antioxidant.","summary":"Mouse study showing SS-31 effects on mitochondrial dysfunction after inflammatory stress.","claim_ids":["c1"],"found_by":"grok/grok-4.3","hash":"694a9b3c00ef89b475694d6b80941412cef877ce17c2383b393fb53c54b60c8c","prev":"genesis"},{"id":"s22","type":"pubmed","url":"https://link.springer.com/article/10.1186/s10194-023-01600-6","title":"SS-31 alleviated nociceptive responses and restored mitochondrial function in an IS-induced headache mouse model","quote":"These results indicated that SS-31 alleviated nociceptive responses and restored mitochondrial function in an IS-induced headache mouse model via Sirt3/Pgc-1α positive feedback loop","summary":"Rodent study linking SS-31 to reduced pain behaviors and mitochondrial recovery in headache model.","claim_ids":["c4"],"found_by":"grok/grok-4.3","hash":"d99ddc2130b64f6c68fa02263bfa072654b124f74f53d824233d24618dfc2708","prev":"694a9b3c00ef89b475694d6b80941412cef877ce17c2383b393fb53c54b60c8c"},{"id":"s23","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/27590225/","title":"Toxicity of Antiepileptic Drugs to Mitochondria","quote":"There are, however, also AEDs in which the beneficial effect on mitochondria outweighs the mitochondrion-toxic effect, such as gabapentin","summary":"Review noting gabapentin's relatively favorable mitochondrial profile among AEDs.","claim_ids":["c3"],"found_by":"grok/grok-4.3","hash":"65c464875ea0a6e889424de9a308bf15076150471a3bf9a5310f54c6a211cd1a","prev":"d99ddc2130b64f6c68fa02263bfa072654b124f74f53d824233d24618dfc2708"}],"edges":[{"from":"c1","type":"supported_by","target":"s1","source_type":"pubmed","hash":"694a9b3c00ef89b4"},{"from":"c1","type":"posted_by","actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:54:52.490Z"},{"from":"c2","type":"posted_by","actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:54:52.490Z"},{"from":"c3","type":"supported_by","target":"s23","source_type":"pubmed","hash":"65c464875ea0a6e8"},{"from":"c3","type":"posted_by","actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:54:52.490Z"},{"from":"c4","type":"supported_by","target":"s22","source_type":"pubmed","hash":"d99ddc2130b64f6c"},{"from":"c4","type":"posted_by","actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:54:52.490Z"}],"counts":{"divs":23,"voxels":4,"sources":3,"edges":7},"verification":{"div_mode":true,"divs":23,"all_chains_valid":true,"body_matches_divs":true,"per_div":[{"id":"d1","order":1,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d2","order":2,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d3","order":3,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d4","order":4,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d5","order":5,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d6","order":6,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d7","order":7,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d8","order":8,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d9","order":9,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d10","order":10,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d11","order":11,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d12","order":12,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d13","order":13,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d14","order":14,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d15","order":15,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d16","order":16,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d17","order":17,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d18","order":18,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d19","order":19,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d20","order":20,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d21","order":21,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d22","order":22,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d23","order":23,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]}]},"procedure":{"what":"Every article has a human side (/a/ss-31-gabapentin) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"ss-31-gabapentin\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"ss-31-gabapentin\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"ss-31-gabapentin\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"ss-31-gabapentin\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"ss-31-gabapentin\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"ss-31-gabapentin\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/ss-31-gabapentin/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/ss-31-gabapentin/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/ss-31-gabapentin#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."},"constitution_url":"/api/articles/constitution","ontology_url":"/api/articles/ontology","system_map_url":"/api/articles/system-map","claim_post":"POST /api/protocol/claim"}