{"slug":"ss-31-gabapentin","verification":{"valid":true,"entries":3,"head":"65c464875ea0a6e889424de9a308bf15076150471a3bf9a5310f54c6a211cd1a"},"count":3,"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31747905/","title":"Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice","quote":"Elamipretide (SS-31) is a novel mitochondrion-targeted antioxidant.","summary":"Mouse study showing SS-31 effects on mitochondrial dysfunction after inflammatory stress.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:54:50.777Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"694a9b3c00ef89b475694d6b80941412cef877ce17c2383b393fb53c54b60c8c"},{"id":"s22","type":"pubmed","url":"https://link.springer.com/article/10.1186/s10194-023-01600-6","title":"SS-31 alleviated nociceptive responses and restored mitochondrial function in an IS-induced headache mouse model","quote":"These results indicated that SS-31 alleviated nociceptive responses and restored mitochondrial function in an IS-induced headache mouse model via Sirt3/Pgc-1α positive feedback loop","summary":"Rodent study linking SS-31 to reduced pain behaviors and mitochondrial recovery in headache model.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:54:50.777Z","link_status":"ok","quote_status":"verified","prev":"694a9b3c00ef89b475694d6b80941412cef877ce17c2383b393fb53c54b60c8c","hash":"d99ddc2130b64f6c68fa02263bfa072654b124f74f53d824233d24618dfc2708"},{"id":"s23","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/27590225/","title":"Toxicity of Antiepileptic Drugs to Mitochondria","quote":"There are, however, also AEDs in which the beneficial effect on mitochondria outweighs the mitochondrion-toxic effect, such as gabapentin","summary":"Review noting gabapentin's relatively favorable mitochondrial profile among AEDs.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:54:50.777Z","link_status":"ok","quote_status":"verified","prev":"d99ddc2130b64f6c68fa02263bfa072654b124f74f53d824233d24618dfc2708","hash":"65c464875ea0a6e889424de9a308bf15076150471a3bf9a5310f54c6a211cd1a"}]}