{"slug":"ss-31-diabetic-neuropathy","verification":{"valid":true,"entries":5,"head":"4c920711a3c36152692c0b5d978356fa1e24c45b013e1ab597d403e525e8f254"},"count":5,"sources":[{"id":"s1","type":"review","url":"https://www.mdpi.com/1422-0067/26/3/944","title":"Elamipretide: A Review of Its Structure, Mechanism of Action, and Clinical Applications","quote":"Elamipretide (SS-31, MTP-131, Bendavia) is a mitochondria-targeting tetrapeptide designed to treat mitochondrial dysfunction via binding to cardiolipin.","summary":"Details cardiolipin binding and ROS reduction mechanism.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:01.080Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"5834869991c1be9bd2abb8d04679af944106802b93dc875053ebbceeb23432a1"},{"id":"s2","type":"pubmed","url":"https://journals.physiology.org/doi/full/10.1152/ajprenal.00574.2014","title":"Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy","quote":"This study demonstrates a protective effect of SS-31 against HG-induced renal injury via an antioxidant mechanism in diabetic nephropathy.","summary":"Mouse diabetic nephropathy study with functional and histological improvements.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:01.080Z","link_status":"http_403","quote_status":"unverified","prev":"5834869991c1be9bd2abb8d04679af944106802b93dc875053ebbceeb23432a1","hash":"d975e06a21db61cf1b2ee49672ef849a9b82a56c208b352a1d4807f919efae92"},{"id":"s3","type":"review","url":"https://jppres.com/jppres/ss-31-for-diabetic-nephropathy/","title":"SS-31 for diabetic nephropathy","quote":"Further studies are required to confirm its findings.","summary":"Systematic review notes lack of human confirmation even for kidney.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:01.080Z","link_status":"ok","quote_status":"unverified","prev":"d975e06a21db61cf1b2ee49672ef849a9b82a56c208b352a1d4807f919efae92","hash":"a5d06b40b312b7d7a7b88a7e493e0472b3176c16720482359d131d111c6a59e2"},{"id":"s4","type":"pubmed","url":"https://www.nature.com/articles/s41598-018-34251-8","title":"The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes","quote":"Our results reveal that SS-31 exerts beneficial effects on the leukocytes of T2D patients by reducing oxidative stress...","summary":"Human cell data on ROS reduction.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:01.080Z","link_status":"ok","quote_status":"unverified","prev":"a5d06b40b312b7d7a7b88a7e493e0472b3176c16720482359d131d111c6a59e2","hash":"035bf4d85e05e2e97d76fa48d9385ffac21e9f0255105ec23a6c30a5da8196c5"},{"id":"s5","type":"clinical_trial","url":"https://www.neurology.org/doi/10.1212/WNL.0000000000207402","title":"Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy","quote":"This study provides Class I evidence that elamipretide does not improve the 6MWT or fatigue at 24 weeks compared with placebo...","summary":"Phase 3 trial results.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:01.080Z","link_status":"ok","quote_status":"unverified","prev":"035bf4d85e05e2e97d76fa48d9385ffac21e9f0255105ec23a6c30a5da8196c5","hash":"4c920711a3c36152692c0b5d978356fa1e24c45b013e1ab597d403e525e8f254"}]}