{"slug":"ss-31-cognition","verification":{"valid":true,"entries":6,"head":"5b07ccad97e9afca79cd397ff5e8e779d6697cf66e6f04e5c830c961f5638da9"},"count":6,"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31747905/","title":"Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice","quote":"Treatment with elamipretide significantly ameliorated LPS-induced learning and memory impairment during behavioral tests.","summary":"Mouse LPS model showing mitochondrial rescue and behavioral improvement.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:54.588Z","link_status":"timeout","quote_status":"unverified","prev":"genesis","hash":"3c6e7348eecf2b20b11d4d90f5b4648f33686d09a0083372f7cf5c7bde139365"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/28421000/","title":"Elamipretide (SS-31) Ameliorates Isoflurane-Induced Long-Term Impairments of Mitochondrial Morphogenesis and Cognition in Developing Rats","quote":"pretreatment with elamipretide not only provided protective effect against oxidative stress and mitochondrial damages, but also attenuated isoflurane-induced cognitive deficits.","summary":"Rat developmental anesthesia model with cognitive protection.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:54.588Z","link_status":"ok","quote_status":"unverified","prev":"3c6e7348eecf2b20b11d4d90f5b4648f33686d09a0083372f7cf5c7bde139365","hash":"557730601a9df23691a5d0c3f9161afddb78150ffe6be74af0fd975cb9027485"},{"id":"s3","type":"pubmed","url":"https://link.springer.com/article/10.1007/s11357-023-00845-y","title":"Targeting mitochondria in the aged cerebral vasculature with SS-31","quote":"We speculate that SS-31 mediated, enhanced mitochondrial function... may lead to improved... cognitive function during aging","summary":"Aged-mouse vascular and memory data referenced from prior work.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:54.588Z","link_status":"timeout","quote_status":"unverified","prev":"557730601a9df23691a5d0c3f9161afddb78150ffe6be74af0fd975cb9027485","hash":"c340e74ed3043ef4f9c48a7b7c7c6b00f012286794eceb566edd1bc1e512526a"},{"id":"s4","type":"pubmed","url":"https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.3508","title":"Mitochondrial antioxidant elamipretide improves learning and memory impairment induced by chronic sleep deprivation","quote":"SS-31 could improve the cognitive impairment induced by CSD.","summary":"Sleep-deprivation mouse model with cognitive rescue.","claim_ids":[],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:54.588Z","link_status":"timeout","quote_status":"unverified","prev":"c340e74ed3043ef4f9c48a7b7c7c6b00f012286794eceb566edd1bc1e512526a","hash":"e3e5699ed4ecfe981faa86ff9c1328e3d9659c71ebda7fd6d00cc7ea4a4e7ab3"},{"id":"s5","type":"review","url":"https://www.alzdiscovery.org/uploads/cognitive_vitality_media/SS-31-Cognitive-Vitality-For-Researchers.pdf","title":"SS-31 Cognitive Vitality For Researchers","quote":"But these effects have not been confirmed in humans. ... 0 clinical trials","summary":"Alzheimer's Drug Discovery Foundation summary noting zero human cognition trials.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:54.588Z","link_status":"ok","quote_status":"unverified","prev":"e3e5699ed4ecfe981faa86ff9c1328e3d9659c71ebda7fd6d00cc7ea4a4e7ab3","hash":"11890a9969dc903f6eba861b704e0c9f2ee4207a6037589aedad15cd25a3e298"},{"id":"s6","type":"reddit","url":"https://www.reddit.com/r/cfs/comments/1sawe29/is_ss31_a_good_peptide_to_take_for_mental/","title":"Is ss31 a good peptide to take for mental functioning?","quote":"It did not do anything for me... I think it is helping me with cognitive symptoms.","summary":"User reports on cognitive effects in CFS context.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:56:54.588Z","link_status":"ok","quote_status":"unverified","prev":"11890a9969dc903f6eba861b704e0c9f2ee4207a6037589aedad15cd25a3e298","hash":"5b07ccad97e9afca79cd397ff5e8e779d6697cf66e6f04e5c830c961f5638da9"}]}