{"slug":"ss-31-chemo-neuropathy","verification":{"valid":true,"entries":5,"head":"d554742bf8f2dd1e29259e9ac75a9bd29b17b5165a82d08bb2e9646ffd5b464c"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6051920/","title":"Protective Effect of a Mitochondria-Targeted Peptide against the Development of Chemotherapy-Induced Peripheral Neuropathy in Mice","quote":"Continuous administration of SS-20 protected against the development of oxaliplatin-induced neuropathic pain and mitigated the loss of intraepidermal nerve fibers to normal levels.","summary":"2018 mouse study showing SS-20 (related mitochondrial peptide) prevented CIPN behaviors and nerve fiber loss with oxaliplatin.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:58:02.111Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"28c00106f239bb377d341b396e11228bef83ea07eb009c68312c3cfe02a8d50c"},{"id":"s2","type":"review","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9260825/","title":"Mini-Review: Mitochondrial Dysfunction and Chemotherapy-Induced Peripheral Neuropathy","quote":"Chemotherapy-induced peripheral neuropathy that leads to a long-lasting bilateral neuropathic pain state (CIPN) is a common adverse side effect that develops in ... mitochondrial dysfunction caused by mitotoxic effects...","summary":"Review linking mitochondrial injury to CIPN mechanisms.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:58:02.111Z","link_status":"ok","quote_status":"unverified","prev":"28c00106f239bb377d341b396e11228bef83ea07eb009c68312c3cfe02a8d50c","hash":"e2cf28b5234055056803c3c7ac9c6ecddaaa5c653abcceb1cc456dcc2bc9adba"},{"id":"s3","type":"review","url":"https://journals.sagepub.com/doi/10.1177/17562864231163361","title":"Mitochondrial dysfunction: an emerging therapeutic target for chemotherapy-induced peripheral neuropathy","quote":"Elamipretide (SS-31), a mitochondria-targeted antioxidant, attenuated oxaliplatin-induced CIPN.","summary":"Review citing only preclinical attenuation; no human CIPN trials noted.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:58:02.111Z","link_status":"http_403","quote_status":"unverified","prev":"e2cf28b5234055056803c3c7ac9c6ecddaaa5c653abcceb1cc456dcc2bc9adba","hash":"7cace20ffe4336993a5a052b48b7b681579ecf7ed612a0e423bd33ba3a28c2d5"},{"id":"s4","type":"review","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3915349/","title":"Pregabalin in Neuropathic Pain: Evidences and Possible Mechanisms","quote":"Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-2-delta subunit to produce antiepileptic and analgesic actions.","summary":"Mechanism of gabapentinoids on calcium channels and neurotransmitter release.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:58:02.111Z","link_status":"ok","quote_status":"verified","prev":"7cace20ffe4336993a5a052b48b7b681579ecf7ed612a0e423bd33ba3a28c2d5","hash":"7dfdfa5f44d5e5ed43de0f2946bb60e6028e06718cb5991c97de79d7a1f6a8da"},{"id":"s5","type":"review","url":"https://spcare.bmj.com/content/14/3/269","title":"Gabapentinoids for chemotherapy-induced peripheral neuropathy","quote":"Based on the current limited evidence, gabapentinoids seem to be beneficial in the treatment of CIPN, but more evidence is required to substantiate this.","summary":"Assessment of limited and inconsistent evidence for gabapentinoids in CIPN.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:58:02.111Z","link_status":"http_403","quote_status":"unverified","prev":"7dfdfa5f44d5e5ed43de0f2946bb60e6028e06718cb5991c97de79d7a1f6a8da","hash":"d554742bf8f2dd1e29259e9ac75a9bd29b17b5165a82d08bb2e9646ffd5b464c"}]}