{"slug":"ss-31-carpal-tunnel","verification":{"valid":true,"entries":5,"head":"221a87590549c4a32298d2cea3e0c203041a966254fcac500b48d4543800c4f1"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://www.neurology.org/doi/10.1212/WNL.0000000000005255","title":"Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy","quote":"Elamipretide increased exercise performance after 5 days of treatment in patients with PMM without increased safety concerns.","summary":"Phase 1/2 RCT showing dose-dependent exercise gains in PMM patients.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:59:02.340Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"3bf13bf6e7700f84b1c6d5e94e7034f5c640c15a43014b7f81047ea4028a2b81"},{"id":"s2","type":"pubmed","url":"https://www.mdpi.com/1422-0067/26/7/3327","title":"Mitochondrial Cardiolipin-Targeted Tetrapeptide, SS-31, Exerts Neuroprotective Effects Within In Vitro and In Vivo Models of Spinal Cord Injury","quote":"SS-31 not only mitigates acute mitochondrial dysfunction but also promotes long-term functional recovery, possibly by preserving neuronal...","summary":"Preclinical SCI study with neuroprotection and cardiolipin data.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:59:02.340Z","link_status":"http_403","quote_status":"unverified","prev":"3bf13bf6e7700f84b1c6d5e94e7034f5c640c15a43014b7f81047ea4028a2b81","hash":"8cef5c370f6c4d7a2456bb84c13ae9d1ee8c17c3d785af580767a6bc01d43559"},{"id":"s3","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11816484/","title":"Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential","quote":"Elamipretide (SS-31, MTP-131, Bendavia) is a mitochondria-targeting tetrapeptide designed to treat mitochondrial dysfunction via binding to cardiolipin (CL) on the inner mitochondrial membrane.","summary":"Mechanism review confirming cardiolipin binding and mitochondrial effects.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:59:02.340Z","link_status":"ok","quote_status":"verified","prev":"8cef5c370f6c4d7a2456bb84c13ae9d1ee8c17c3d785af580767a6bc01d43559","hash":"786a9f4495eed3a9414db134a4df72e9042ffb4df6dde8677a0f54e393341296"},{"id":"s4","type":"pubmed","url":"https://www.nature.com/articles/s41598-024-64368-y","title":"SS-31 treatment ameliorates cardiac mitochondrial dysfunction in a mouse model of Barth syndrome","quote":"The collected data showed that a long exposure to the peptide (48 weeks) resulted in a significant improvement in performance on the 6-Minute Walk Test...","summary":"Barth syndrome trial data on functional and cardiac improvements.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:59:02.340Z","link_status":"ok","quote_status":"unverified","prev":"786a9f4495eed3a9414db134a4df72e9042ffb4df6dde8677a0f54e393341296","hash":"aa0deaccbd0d54318b6da80b3e022a2309218ba4ac90640a13b4218b22010bfe"},{"id":"s5","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9192202/","title":"SS-31, a Mitochondria-Targeting Peptide, Ameliorates Kidney Injury","quote":"In an atherosclerotic renal artery stenosis phase IIa clinical trial... only patients in the SS-31 group showed increased renal blood flow... and renal cortical perfusion.","summary":"Renal stenosis trial showing perfusion benefits versus placebo.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:59:02.340Z","link_status":"ok","quote_status":"unverified","prev":"aa0deaccbd0d54318b6da80b3e022a2309218ba4ac90640a13b4218b22010bfe","hash":"221a87590549c4a32298d2cea3e0c203041a966254fcac500b48d4543800c4f1"}]}