{"slug":"semax","verification":{"valid":true,"entries":36,"head":"48d1cb0b5d1d0a3866e7740528927f63b8fb78376e120064df604075dd734860"},"count":36,"models":["grok/grok-4.3","grok-4.3","system/audit-repair","kimi/moonshot-v1-8k","fill-slots"],"yield":{"passes":36,"energy_spent_rows":0,"total_cost_usd":0.000519,"waste_cost_usd":0,"total_tokens":3463,"material_outputs":2,"usd_per_output":0.00026,"models":[{"model":"kimi/moonshot-v1-8k","passes":1,"cost_usd":0.000519,"tokens_total":3463,"outputs":2,"waste_passes":0,"usd_per_output":0.00026},{"model":"grok/grok-4.3","passes":1,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"grok-4.3","passes":27,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"system/audit-repair","passes":5,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"fill-slots","passes":2,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST /api/protocol/collaborate","pricing_ppm":{"grok-4.3":[1.25,2.5],"grok/grok-4.3":[1.25,2.5],"grok-build-0.1":[1,2],"kimi/moonshot-v1-8k":[0.15,0.15],"gemini/gemini-2.5-flash":[0.075,0.3],"gemini/gemini-2.0-flash-lite":[0.075,0.3],"openai/gpt-4o":[2.5,10],"openai/gpt-4o-mini":[0.15,0.6],"system/reflex":[0,0],"ingest:deterministic":[0,0],"fill-slots":[0,0]}}},"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T08:32:19.974Z","model":"grok/grok-4.3","role":"writer","action":"redraft","payload":{"title":"Semax: BDNF Upregulation","register":"source_ledger","body":"## Overview\nSemax is described as a brain peptide that upregulates BDNF.\n\n## Preclinical Evidence (Rat Studies)\nIn rat hippocampus, a single intranasal dose of Semax (50 μg/kg) produced a maximal 1.4-fold increase in BDNF protein levels, accompanied by increased trkB phosphorylation and mRNA expression (preclinical tier). [Dolotov et al., 2006]\n\nSimilar increases in BDNF protein were observed in rat basal forebrain after intranasal administration (preclinical tier).\n\n## Human Data\nIn a study of 110 patients after ischemic stroke, Semax (two 10-day courses at 6000 μg/day) increased plasma BDNF levels regardless of rehabilitation timing (human tier). Higher BDNF levels correlated with improved motor performance and Barthel index scores.\n\nNo large-scale human trials on BDNF upregulation in healthy subjects or for cognitive enhancement in non-clinical populations were identified.\n\n## Mechanism Notes\nSemax effects on BDNF are reported via modulation of expression in specific brain regions; no systemic immune suppression or masking of symptoms is described in the reviewed sources (mechanistic tier).\n\nProduction or baseline changes with age are not addressed in the primary sources cited.","claims":[{"id":"c1","text":"In rat hippocampus, a single intranasal dose of Semax (50 μg/kg) produced a maximal 1.4-fold increase in BDNF protein levels, accompanied by increased trkB phosphorylation and mRNA expression.","section":"Preclinical Evidence (Rat Studies)","tier":"preclinical","source_ids":["s1"],"source_status":"sourced","why_material":"Core rat data establishing BDNF upregulation mechanism.","evidence_basis":"derived_inference","weight":0.5,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c2","text":"In a study of 110 patients after ischemic stroke, Semax increased plasma BDNF levels.","section":"Human Data","tier":"human","source_ids":["s2"],"source_status":"sourced","why_material":"Only identified human trial data on BDNF levels.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c3","text":"No large-scale human trials on BDNF upregulation in healthy subjects or for cognitive enhancement in non-clinical populations were identified.","section":"Human Data","tier":"human","source_ids":[],"source_status":"unsourced","why_material":"States absence of human data plainly.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}}],"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/16996037/","title":"Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus","quote":"Here, we found that a single application of Semax (50 microg/kg body weight) results in a maximal 1.4-fold increase of BDNF protein levels accompanying with 1.6-fold increase of trkB tyrosine phosporylation levels, and a 3-fold and a 2-fold increase of exon III BDNF and trkB mRNA levels, respectively, in the rat hippocampus.","link_status":"ok","quote_status":"verified"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/29798983/","title":"The efficacy of semax in the treatment of patients at the early and late stages of rehabilitation after ischemic stroke","quote":"Administration of semax, regardless of the timing of rehabilitation, increased BDNF plasma levels which remained high during the whole study period.","link_status":"ok","quote_status":"verified"}]},"rationale":"","tokens_in":0,"tokens_out":0,"prev_hash":"genesis","hash":"2cfb8ccf3ed6b0890d8a00f500402148988ebc45439f70058416c26d3d6711f0"},{"seq":1,"id":"k2","ts":"2026-06-29T09:40:06.590Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41479572/","title":"The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease","quote":"The open field, novel object recognition, and Barnes maze tests demonstrated that both Semax and its derivative improved cognitive functions in mice .","link_status":"ok","quote_status":"unverified"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40692165/","title":"Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice","quote":"Semax improved SCI functional recovery and inhibited LMP-related pyroptosis in SCI mice and neuroinflammation models, by decreasing ...","link_status":"ok","quote_status":"unverified"},{"id":"s5","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/41490200/","title":"Therapeutic Peptides in Orthopaedics: Applications, ...","quote":"Recovery-enhancing agents such as epithalon, delta sleep-inducing peptide, and pinealon target circadian and mitochondrial regulators, and neuroactive peptides like selank, semax, and dihexa enhance brain-derived neurotrophic factor and HGF/c-Met pathways critical to neuroplasticity.","link_status":"ok","quote_status":"verified"},{"id":"s6","type":"medical","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12755871/","title":"The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease","quote":"These findings demonstrate the high potential of Semax and its derivatives when used to develop therapeutic and corrective strategies for Alzheimer's disease.","link_status":"ok","quote_status":"unverified"},{"id":"s7","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1skhrm6/my_experience_with_semax_an_how_its_helped_me/","title":"My experience with semax an how it's helped me","quote":"I do cycles of 8 weeks on, 8 weeks off, and when I take it I feel like a fucking computer- I perform so much better at high level mental tasks at work, and in meetings my recall and articulation are noticeably improved to where I outperform everyone else in the room.","link_status":"ok","quote_status":"unverified"},{"id":"s8","type":"youtube","url":"https://www.youtube.com/watch?v=Ci-bsdaFL8U","title":"Why SEMAX Is the Peptide Everyone's Talking About for ...","quote":"Discover how SEMAX can boost your memory, learning capability, and mental agility in 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Resting state fMRI confirmed Semax effects on the neuronal network of the brain and demonstrated topography of these effects.","link_status":"ok","quote_status":"verified"},{"id":"s10","type":"review","url":"https://scholarworks.utrgv.edu/colloquium/2025/posters/50/","title":"Semax for Parkinson's Neuroprotection: A Qualitative Literature Review","quote":"While nearly all studies agree that Semax can improve anxiety, prior work on the effect of Semax with different types of PD-like rat models is inconsistent. ... low doses of Semax does not improve motor deficits in animal models and no clinical trials have tested its efficacy in human PD patients.","link_status":"ok","quote_status":"unverified"},{"id":"s11","type":"medical","url":"https://www.innerbody.com/semax-peptide","title":"Semax Peptide: Benefits, Safety & Buying Advice [2026]","quote":"In a paper for a 2017 study of Semax in rats, researchers claim that “the immune response is the process most markedly affected by the peptide”. ... A 2024 study of ACTH analogs in rodents showed that coadministration of Semax with another analog successfully reduced the severity of depressive symptoms and increased BDNF levels in the brain.","link_status":"ok","quote_status":"unverified"},{"id":"s12","type":"review","url":"https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Semax-Cognitive-Vitality-For-Researchers.pdf","title":"Semax Cognitive Vitality For Researchers","quote":"In one pilot study in 24 healthy subjects, intranasal 1% semax solution (total dose 1.2 mg) increased resting fMRI signal in the default mode network rostral subcomponent relative to placebo (Lebedeva et al, 2018). ... Another study in 110 patients with stroke reported that treatment with semax (2 courses 6000 µg/day for 10 days with 20-day interval) increased plasma BDNF levels.","link_status":"ok","quote_status":"unverified"},{"id":"s13","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1t4576f/my_semax_experience_injectable_vs_nasal/","title":"My Semax Experience: Injectable vs Nasal","quote":"TLDR: Both work really well for me, effects from nasal are more immediate but also more dampened. ... Injectable (later cycle): Took longer to “feel” (~30–60 min), but WAY more consistent ... increased my mental clarity, active recall, and reduced brain fog.","link_status":"ok","quote_status":"unverified"},{"id":"s14","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/14dhhr9/long_term_effects_of_semax_experiences/","title":"Long term effects of Semax? Experiences?","quote":"I've completed 1 bottle of 0.1% semac, and this thing works wonders. I used to have focus issues, memory issues... About 3-5 months later. I felt like I upgraded, not mentally but physically also. I felt like I got my mind back.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"prev_hash":"d28fd90aa4cc13d958348d982926d76c318c0972862cac03f2e2bebc85d25718","hash":"22fb6a92f63c39095cb05a350c5408304a835fefa7d4e01055ef29511066e37d"},{"seq":3,"id":"k4","ts":"2026-06-29T09:40:57.164Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s15","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/17prmbj/experience_with_semax/","title":"Experience with Semax : r/Nootropics","quote":"Short Story: I'm a 25-year-old male who has been grappling with severe brain fog, speech difficulties, and struggles ...","link_status":"ok","quote_status":"unverified"},{"id":"s16","type":"reddit","url":"https://www.reddit.com/r/TBI/comments/1t25t3z/semax_nasal_spray_life_changing_have_my_memory/","title":"Semax nasal spray life changing have my memory back","quote":"I started taking semax a couple weeks ago. I did get some memory back. ... I’m now on Semax Amidate it lasts longer in system.","link_status":"ok","quote_status":"unverified"},{"id":"s17","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1rohx2j/semax_side_effects_after_one_day/","title":"Semax side effects after one day : r/Nootropics","quote":"I took semax nasal spray for the first time ever yesterday. ... Today when I woke up I felt extremely groggy and tired. ... headache most of the day","link_status":"ok","quote_status":"unverified"},{"id":"s18","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1t5hr4v/has_anyone_tried_semax_and_selank_stack/","title":"Has anyone tried Semax and Selank Stack? : r/Biohackers","quote":"So just an update: Semax worked well for me but have now started on NA Semax and it is far longer lasting. ... I did a combo intra-nasally for one month. Subtle, yet not enough change to warrant a second purchase.","link_status":"ok","quote_status":"unverified"},{"id":"s19","type":"x","url":"https://x.com/BowTiedNeuron/status/1867370394078122275","title":"My first day using Semax","quote":"Within just a few minutes my visual acuity/sharpness increased and I felt a notable mental clarity set in ... This noticeable effect lasted from about 8:30am until around 2pm. There was no crash though","link_status":"ok","quote_status":"unverified"},{"id":"s20","type":"x","url":"https://x.com/morellifit/status/2064010445636448703","title":"Semax peptide experience","quote":"I've been using it for a few months and the cognitive benefits are insane. ... Within minutes, the room feels quieter, and there's less friction between my thoughts and my work. ... no spike and no crash","link_status":"ok","quote_status":"unverified"},{"id":"s21","type":"youtube","url":"https://www.youtube.com/watch?v=owegYxCpkrk","title":"I Tried Semax... Here's What Happened!","quote":"I'm excited to share my experience as you'll learn how Semax has helped me in the past, but also why I no longer use this cognitive supplement.","link_status":"http_429","quote_status":"unverified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"prev_hash":"22fb6a92f63c39095cb05a350c5408304a835fefa7d4e01055ef29511066e37d","hash":"1f47aed7b8ef4ea6f7c37496bfb0c1a567f1af88a328a8783fbbfc6354f8d874"},{"seq":4,"id":"k5","ts":"2026-06-29T09:41:19.154Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s22","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39442746/","title":"Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress","quote":"We found that chronic treatment with Semax and MTII reversed or substantially attenuated CUS-induced anhedonia, BW gain suppression, adrenal hypertrophy and a decrease in the hippocampal levels of BDNF.","link_status":"ok","quote_status":"verified"},{"id":"s23","type":"youtube","url":"https://www.youtube.com/watch?v=RcLPGVY6lc0","title":"Why SEMAX Is the Peptide Everyone's Talking About for Focus Without Stimulants","quote":"CAX is a regulatory peptide with neutropic effects... it actually can build and help you build new brain cells... particularly associated with some attention and focus enhancement, some mental stamina... works with what we call BDNF which is brain derived neurotrophic factor.","link_status":"http_429","quote_status":"unverified"},{"id":"s24","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1u3xk0b/semax_has_actual_human_clinical_data_but_its_all/","title":"Semax has actual human clinical data but it's all from ...","quote":"So Semax has a solid body of human observational studies covering stroke recovery, cognitive impairment, and neuroprotection.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 4","tokens_in":0,"tokens_out":0,"prev_hash":"1f47aed7b8ef4ea6f7c37496bfb0c1a567f1af88a328a8783fbbfc6354f8d874","hash":"a51968c9afa26b801301fc191a56aafdf61fe240dccaa30dca6bad2220a214ea"},{"seq":5,"id":"k6","ts":"2026-06-29T09:42:07.195Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s25","type":"medical","url":"https://riteaid.com/peptides/semax","title":"Semax Peptide: Benefits, Dosage & Nasal Spray | Rite Aid","quote":"It is one of the 12 peptides the FDA removed from its Section 503A Category 2 list in April 2026, and one of seven peptides under formal advisory review on July 23–24, 2026.","link_status":"http_403","quote_status":"unverified"},{"id":"s26","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/maswyn/semax_spray_01_or_1_and_which_dose/","title":"Semax spray - 0.1% or 1%? 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Pretty sure they suggest to take the 0.1% for \"normal\" situations and take another dose 15 minutes later if needed.","link_status":"ok","quote_status":"unverified"},{"id":"s27","type":"review","url":"https://link.springer.com/article/10.1007/s10517-025-06501-z","title":"The Effect of Peptide Semax, an ACTH(4-10) Analogue, on the Expression of Genes Encoding Neurotrophic Factors in the Rat Brain","quote":"Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"prev_hash":"a51968c9afa26b801301fc191a56aafdf61fe240dccaa30dca6bad2220a214ea","hash":"6e0faf0d3bf768c313754739435cb68cc7b16991de4bc8200cd6e99c35606a5c"},{"seq":6,"id":"k7","ts":"2026-06-29T09:42:27.758Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s28","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40496623/","title":"Semax, a Copper Chelator Peptide, Decreases the Cu(II) ...","quote":"This study provides valuable insights into the potential role of Semax in neurodegenerative disorders and into the design of new compounds with ...","link_status":"ok","quote_status":"unverified"},{"id":"s29","type":"medical","url":"https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.70122","title":"Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice","quote":"Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice - Liu - 2025 - British Journal of Pharmacology","link_status":"ok","quote_status":"unverified"},{"id":"s30","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41171324/","title":"The Effect of Peptide Semax, an ACTH(4-10) Analogue, on ...","quote":"We studied the effects of Semax on spontaneous fluctuations of intracellular calcium ion concentration [Ca 2+ ]i in pyramidal neurons ...","link_status":"ok","quote_status":"unverified"},{"id":"s31","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1u17hpb/what_semax_actually_is_and_what_the_research/","title":"What Semax actually is, and what the research really shows","quote":"Semax gets sold online as a clean cognitive upgrade: more focus, more BDNF, a sharper brain on demand. The real picture is more interesting and a ...","link_status":"ok","quote_status":"unverified"},{"id":"s32","type":"youtube","url":"https://www.youtube.com/watch?v=p3GOtQmPPFo","title":"Semax Results (No One Talks About These Benefits)","quote":"Semax is a peptide that can boost focus, memory and mental clarity . Semax works in the brain by adjusting dopamine and BDNF pathways ...","link_status":"http_429","quote_status":"unverified"},{"id":"s33","type":"medical","url":"https://www.helimeds.com/blog/semax-dosage","title":"Semax Peptide Dosage Guide: Benefits, Safety & Best Practices","quote":"Semax dosage protocols often yield sharper concentration, faster processing speed, and reduced mental fatigue within 30–60 minutes.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"prev_hash":"6e0faf0d3bf768c313754739435cb68cc7b16991de4bc8200cd6e99c35606a5c","hash":"a9610e6ea5504755dadfa58bd090a19d15b3f67ccef03f053af7e7a69a8ad8fc"},{"seq":7,"id":"k8","ts":"2026-06-29T09:42:44.833Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s34","type":"reddit","url":"https://www.reddit.com/r/USPeptides/comments/1uflo0m/has_anyone_tried_semax_nasal_spray_before_this/","title":"Has anyone tried Semax nasal spray before ? This was my ...","quote":"I've had a pretty good experience with Semax so far. I mainly noticed it seemed to help with mental clarity and focus without feeling ...","link_status":"ok","quote_status":"unverified"},{"id":"s35","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/3q9h7a/semax_effects_on_emotions/","title":"Semax effects on emotions : r/Nootropics","quote":"I experienced this to the point where it started to affect my relationship. I was taking 1mg sub-q for a few months with great effects: less ADD-related focus problems, more energy throughout the day, less fatigue-induced depression. After a while (not sure how long), I started to get emotionally blunted.","link_status":"ok","quote_status":"unverified"},{"id":"s36","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1rbq1zg/selank_semax_observed_effects_focus_anxiety_sleep/","title":"Selank + Semax – Observed Effects (Focus, Anxiety, Sleep, ...","quote":"Focus & Cognitive Performance: Sustained attention, Improved task persistence, Enhanced cognitive engagement. Observation: Clear increase in the ability to focus and almost have more mental energy than normal. Anxiety: Reduced baseline anxiety.","link_status":"ok","quote_status":"unverified"},{"id":"s37","type":"reddit","url":"https://www.reddit.com/r/Epilepsy/comments/1mjseg2/about_to_start_semax_peptide/","title":"About to start Semax peptide : r/Epilepsy","quote":"Update: it has helped immensely!!! I remember more from the days I take it, I’m focusing better, and I also noticed my speech improving!","link_status":"ok","quote_status":"unverified"},{"id":"s38","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/wswq8x/semax_giving_me_neutral_and_shortlived_symptoms/","title":"Semax giving me neutral and short-lived symptoms? What ...","quote":"For 15 minutes, I feel like my external senses are turned more 'on' and I pay attention more to my surroundings... Then after 15 minutes, I crash and become tired for a few mins.","link_status":"ok","quote_status":"unverified"},{"id":"s39","type":"x","url":"https://x.com/irvinnofficial/status/2070327711558750336","title":"My take on Semax","quote":"My take on Semax: great compound, nice smooth focus and reduced anxiety. 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