{"slug":"semax-trigeminal","verification":{"valid":true,"entries":5,"head":"848d8843c06bcb3cb70359b36b32cf30815e2262e73e3d32ab91ec1aa1998941"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/29798983/","title":"The efficacy of semax in the treatment of patients at different stages of ischemic stroke","quote":"Administration of semax, regardless of the timing of rehabilitation, increased BDNF plasma levels which remained high during the whole study period.","summary":"110-patient stroke cohort; semax raised BDNF and improved motor/Barthel scores.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:01:08.010Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"85ab861514ed31cc4f7ec006f2b15fb33c18e2b93904f86d63b1abbb0c484d23"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/30225715/","title":"Effects of Semax on the Default Mode Network of the Brain","quote":"A greater volume of the default mode network rostral (medial frontal cortex) subcomponent was detected in the Semax group in comparison with controls.","summary":"fMRI study in 24 healthy volunteers showing network changes post-intranasal semax.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:01:08.010Z","link_status":"ok","quote_status":"verified","prev":"85ab861514ed31cc4f7ec006f2b15fb33c18e2b93904f86d63b1abbb0c484d23","hash":"8df4bc6b96ae203d1f8cbdc36f0355afb000eafb9382f6b2adc4fc562ff04305"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/16996037/","title":"Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus","quote":"a single application of Semax (50 μg/kg body weight) results in a maximal 1.4-fold increase of BDNF protein levels... and a 3-fold... increase of exon III BDNF... mRNA levels","summary":"Rat study quantifying rapid BDNF/trkB upregulation and behavioral change.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:01:08.010Z","link_status":"ok","quote_status":"unverified","prev":"8df4bc6b96ae203d1f8cbdc36f0355afb000eafb9382f6b2adc4fc562ff04305","hash":"7ea34e9ba093fa14583918fb34dffddc2df9d532bed849dfaa81fcd95fe9138e"},{"id":"s4","type":"news","url":"https://healingmaps.com/semax-peptide-cerebral-ischemia-migraine-trigeminal-neuralgia/","title":"Semax: The Russian Nootropic Peptide Under FDA Review","quote":"Published evidence for this specific indication is thin but the clinical need is real, and PCAC will examine whether the available data supports compounding for this use.","summary":"Summarizes FDA compounding review context for trigeminal neuralgia.","claim_ids":["c4","c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:01:08.010Z","link_status":"ok","quote_status":"verified","prev":"7ea34e9ba093fa14583918fb34dffddc2df9d532bed849dfaa81fcd95fe9138e","hash":"d958c88611babbb719933348fee1862ae566fefda099401ea3c78be494fe181c"},{"id":"s5","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/5h3d77/giving_semax_to_my_elderly_father_hes_had_a/","title":"Giving Semax to my elderly father?","quote":"It helped pretty much immediately with my occipital neuralgia pain, but trigeminal neuralgia is a different beast.","summary":"Anecdotal user comment distinguishing neuralgia subtypes.","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:01:08.010Z","link_status":"ok","quote_status":"unverified","prev":"d958c88611babbb719933348fee1862ae566fefda099401ea3c78be494fe181c","hash":"848d8843c06bcb3cb70359b36b32cf30815e2262e73e3d32ab91ec1aa1998941"}]}