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Per-claim provenance.","urls":{"read":"https://miscsubjects.com/api/articles/semax-trigeminal/voxels","write":"https://miscsubjects.com/api/protocol/claim"}},{"id":"ask","name":"Ask protocol","what":"Answer only from topology; creates question_node with gaps and ingest_hint.","urls":{"read":"https://miscsubjects.com/api/articles/semax-trigeminal/prompts","write":"https://miscsubjects.com/api/protocol/ask"}},{"id":"ingest","name":"Ingest protocol","what":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","urls":{"write":"https://miscsubjects.com/api/protocol/ingest"}},{"id":"claim_post","name":"Claim post protocol","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by.","urls":{"read":"https://miscsubjects.com/api/articles/semax-trigeminal/voxels","write":"https://miscsubjects.com/api/protocol/claim"}},{"id":"llm_manifest","name":"LLM manifest","what":"Machine-readable read/write contract for external LLMs.","urls":{"read":"https://miscsubjects.com/api/articles/llm-manifest"}}],"system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","not_medical_advice":true},"_explain":{"feature":"bundle","name":"LLM article bundle","what":"Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution.","why":"Every feature is auditable collective intelligence","how":"Reference bundle for an LLM or reader. §SELF explains the surface; ingest and claim endpoints in llm_manifest are the write-back routes.","model":null,"verifies":null,"urls":{"read":"https://miscsubjects.com/api/articles/semax-trigeminal/bundle?format=markdown"},"imessage":null,"router":null,"related":[{"id":"topology","what":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER."},{"id":"voxels","what":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance."},{"id":"ask","what":"Answer only from topology; creates question_node with gaps and ingest_hint."},{"id":"ingest","what":"Parse pasted evidence → source ledger + claims + evidence_ingest node."},{"id":"claim_post","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by."},{"id":"llm_manifest","what":"Machine-readable read/write contract for external LLMs."}],"not_medical_advice":true},"MASTHEAD":{"sorry_status":"planes not merged yet — sorry-status activates after voxel-merge-planes","identity":{"slug":"semax-trigeminal","version":2,"content_hash":"004847fd4e788e6e8590b46ee52d21227138e1ae0d55780f801fc857ceb63bcd","thread_head":"genesis","divs":20},"thesis":{"root_claim":"c1","text":"Semax raised plasma BDNF levels in 110 post-ischemic stroke patients and correlated with faster functional recovery.","tier":"human"},"load_bearing":[{"id":"c2","tier":"human","status":"active","text":"Intranasal semax altered default-mode network volume on fMRI in healthy volunteers within 20 minutes."},{"id":"c4","tier":"human","status":"active","text":"No published human clinical trials test semax specifically for trigeminal neuralgia."},{"id":"c3","tier":"preclinical","status":"active","text":"In rats, semax increased hippocampal BDNF protein 1.4-fold and BDNF mRNA up to 3-fold within hours of dosing."},{"id":"c5","tier":"mechanistic","status":"active","text":"Semax is under FDA Pharmacy Compounding Advisory Committee review for possible inclusion on the 503A Bulks List for trigeminal neuralgia based on neuroprotectiv"},{"id":"c6","tier":"anecdotal","status":"active","text":"Reddit users report anecdotal observations of semax with occipital neuralgia but distinguish trigeminal neuralgia as potentially different."}],"standing_objections":{"open":0,"strongest_open":null,"link":"https://miscsubjects.com/api/articles/semax-trigeminal/discourse"},"verbs":{"read":"GET https://miscsubjects.com/api/articles/semax-trigeminal/voxels — DIVs + hashes + chains (free)","read_claims":"GET https://miscsubjects.com/api/articles/semax-trigeminal/claims — every formal claim as claim:<id> with current hash, thread, stable link, and exact contribution/edit bodies","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {slug, expected_thread_head, target_div?, expected_hash?, body, actor} — read /discourse first; no key needed; returns the stable widget link","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {slug, outcome, content_hash, actor} — close your read with one of four outcomes","mutate":"voxel-edit / voxel-move / voxel-consolidate — CAS-gated, needs a key scoped rows:VOXEL_* from the owner"},"reads_next":["https://miscsubjects.com/a/philosophy","https://miscsubjects.com/api/articles/semax-trigeminal/discourse","https://miscsubjects.com/api/protocol"]},"bundle_version":1,"generated_at":"2026-07-29T22:27:18.581Z","slug":"semax-trigeminal","title":"Semax for Trigeminal Neuralgia: Evidence-Graded Review","url":"https://miscsubjects.com/a/semax-trigeminal","register":"source_ledger","tags":["peptide","matrix"],"posted_at":"2026-06-29T21:33:19.934Z","updated_at":"2026-07-17T02:41:59.551Z","body":"## What's breaking down\nTrigeminal neuralgia involves irritation or damage along the trigeminal nerve pathways. This can include focal demyelination, vascular compression, or chronic low-grade inflammation that triggers ectopic nerve firing. The result is sudden, electric-shock-like facial pain. Over time the system tips toward degeneration when repair signals like neurotrophic factors fall short of the ongoing mechanical or inflammatory stress.\n\n## Why Semax might help you\n1. **What keeps failing:** Neural support pathways weaken under sustained trigeminal nerve stress, with reduced BDNF signaling that normally aids neuron survival and myelin maintenance.\n2. **What Semax is studied to do:** Semax is examined for raising BDNF protein and gene expression plus supporting neuronal resilience without directly blocking pain signals.\n3. **Therefore for you:** If the neural repair layer contributes to your trigeminal issue, Semax enters discussion because it targets building connections and resilience rather than suppressing symptoms.\n\n## How these fit together\nSingle-compound focus. Semax maps to the neural repair layer. If a broader stack appears later, other agents would address separate layers such as inflammation or mechanical load.\n\n## What the evidence actually shows\nHuman data: One study of 110 post-stroke patients found semax (two 10-day courses at 6000 mcg/day) raised plasma BDNF levels regardless of rehabilitation timing and correlated with faster motor recovery (Gusev et al., 2018, human|preclinical-adjacent). A separate resting-state fMRI trial in 24 healthy volunteers showed semax altered default-mode network volume after intranasal dosing (Lebedeva et al., 2018, human).\n\nPreclinical data: Rat hippocampal studies demonstrated single-dose semax increased BDNF protein 1.4-fold, trkB phosphorylation 1.6-fold, and exon III BDNF mRNA 3-fold, accompanied by more conditioned avoidance responses (Dolotov et al., 2006, preclinical). Another rat study linked semax to rapid induction of Bdnf and Ngf mRNAs (Dmitrieva et al., 2009, preclinical).\n\nTrigeminal-specific data: No published human trials exist. FDA Pharmacy Compounding Advisory Committee materials note ongoing review of semax for possible compounding use in trigeminal neuralgia based on general neuroprotective effects; published evidence for this exact indication remains thin (healingmaps.com summary, 2026, mechanistic).\n\n## What scientists say\nResearchers describe semax as an ACTH(4-10) analog that modulates neurotrophin expression and shows neuroprotective actions in hypoxia and glutamate toxicity models. Emphasis stays on BDNF/trkB pathway engagement and cognitive or recovery support rather than primary analgesia (multiple PubMed-linked abstracts, preclinical to early human).\n\n## What people say on Reddit\nUsers mention semax in passing for various nerve-related complaints. One thread notes possible benefit in occipital neuralgia but states trigeminal neuralgia behaves differently. Another speculates it could worsen certain nerve pain or questions its relevance. Anecdotal reports remain sparse and mixed (r/Nootropics threads, anecdotal).\n\n## What people say on X\nPublic posts referencing semax and trigeminal issues are rare. Discussions usually stay at the level of general nootropic interest or FDA compounding updates rather than personal outcome reports (anecdotal).\n\n## What we do not know\nNo randomized controlled trials exist for semax in trigeminal neuralgia. Long-term human safety data beyond short stroke-rehabilitation courses are limited. Whether BDNF changes translate to reduced trigeminal ectopic firing in humans is unknown. Dose-response, optimal route, and interaction with common trigeminal medications remain unstudied in this population.\n\n## Safety and limits\nReported human use in stroke studies showed no major adverse events during the described regimens. Individual responses vary. Semax remains unapproved by FDA for trigeminal neuralgia; any consideration occurs under compounding review scheduled for 2026. Always consult qualified clinicians for personal medical decisions.\n","claims":[{"id":"c1","text":"Semax raised plasma BDNF levels in 110 post-ischemic stroke patients and correlated with faster functional recovery.","tier":"human","weight":0.8,"effective_weight":0.8,"slot":null,"source_ids":["s1"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c2","text":"Intranasal semax altered default-mode network volume on fMRI in healthy volunteers within 20 minutes.","tier":"human","weight":0.8,"effective_weight":0.8,"slot":null,"source_ids":["s2"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c4","text":"No published human clinical trials test semax specifically for trigeminal neuralgia.","tier":"human","weight":0.8,"effective_weight":0.8,"slot":null,"source_ids":["s4"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c5","text":"Semax is under FDA Pharmacy Compounding Advisory Committee review for possible inclusion on the 503A Bulks List for trigeminal neuralgia based on neuroprotective properties.","tier":"mechanistic","weight":0.3,"effective_weight":0.3,"slot":null,"source_ids":["s4"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c3","text":"In rats, semax increased hippocampal BDNF protein 1.4-fold and BDNF mRNA up to 3-fold within hours of dosing.","tier":"preclinical","weight":0.5,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s3"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c6","text":"Reddit users report anecdotal observations of semax with occipital neuralgia but distinguish trigeminal neuralgia as potentially different.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s5"],"who_claims":"grok/grok-4.3","status":"active"}],"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/29798983/","title":"The efficacy of semax in the treatment of patients at different stages of ischemic stroke","summary":"110-patient stroke cohort; semax raised BDNF and improved motor/Barthel scores.","quote":"Administration of semax, regardless of the timing of rehabilitation, increased BDNF plasma levels which remained high during the whole study period.","quote_status":"verified","link_status":"ok","claim_ids":["c1"],"hash":"85ab861514ed31cc"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/30225715/","title":"Effects of Semax on the Default Mode Network of the Brain","summary":"fMRI study in 24 healthy volunteers showing network changes post-intranasal semax.","quote":"A greater volume of the default mode network rostral (medial frontal cortex) subcomponent was detected in the Semax group in comparison with controls.","quote_status":"verified","link_status":"ok","claim_ids":["c2"],"hash":"8df4bc6b96ae203d"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/16996037/","title":"Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus","summary":"Rat study quantifying rapid BDNF/trkB upregulation and behavioral change.","quote":"a single application of Semax (50 μg/kg body weight) results in a maximal 1.4-fold increase of BDNF protein levels... and a 3-fold... increase of exon III BDNF... mRNA levels","quote_status":"unverified","link_status":"ok","claim_ids":["c3"],"hash":"7ea34e9ba093fa14"},{"id":"s4","type":"news","url":"https://healingmaps.com/semax-peptide-cerebral-ischemia-migraine-trigeminal-neuralgia/","title":"Semax: The Russian Nootropic Peptide Under FDA Review","summary":"Summarizes FDA compounding review context for trigeminal neuralgia.","quote":"Published evidence for this specific indication is thin but the clinical need is real, and PCAC will examine whether the available data supports compounding for this use.","quote_status":"verified","link_status":"ok","claim_ids":["c4","c5"],"hash":"d958c88611babbb7"},{"id":"s5","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/5h3d77/giving_semax_to_my_elderly_father_hes_had_a/","title":"Giving Semax to my elderly father?","summary":"Anecdotal user comment distinguishing neuralgia subtypes.","quote":"It helped pretty much immediately with my occipital neuralgia pain, but trigeminal neuralgia is a different beast.","quote_status":"unverified","link_status":"ok","claim_ids":["c6"],"hash":"848d8843c06bcb3c"}],"voxels":{"slug":"semax-trigeminal","counts":{"divs":20,"voxels":6,"sources":5,"edges":12},"note":"slim bundle — full voxels at /api/articles/semax-trigeminal/voxels"},"constitution":{"url":"https://miscsubjects.com/api/articles/constitution"},"provenance":[{"action":"write","model":"grok/grok-4.3","ts":"2026-06-30T00:01:13.598Z","hash":"73f1e7c50b6e774c","tokens_in":13792,"tokens_out":2902},{"action":"voxel_divide","model":"owner","ts":"2026-07-17T02:41:59.551Z","hash":"4267aedf7147add7","tokens_in":0,"tokens_out":0}],"contributions":[{"id":"k1","ts":"2026-06-30T00:01:13.598Z","model":"grok/grok-4.3","role":"writer","action":"redraft","rationale":"","hash":"b745ff26a1d500c4578773ffacf4f166a62a27059cacb07e7875494a359712b1"}],"topology":null,"slim":true,"ledger_totals":{"claims":6,"sources":5,"exported_claims":6,"exported_sources":5},"question_graph":{"slug":"semax-trigeminal","questions":[],"evidence":[],"edges":[],"counts":{"questions":0,"evidence":0,"edges":0}},"verification":{"provenance":{"valid":true,"entries":2,"head":"4267aedf7147add7c7ef7cb5e16ffc47a1415e07f8375bd487b6122e81c46a0f"},"sources":{"valid":true,"entries":5,"head":"848d8843c06bcb3cb70359b36b32cf30815e2262e73e3d32ab91ec1aa1998941"}},"counts":{"claims":6,"sources":5,"provenance":2,"contributions":1,"questions":0,"evidence_ingests":0,"voxel_edges":12},"transport":"Open every URL in this bundle with your browser or web / URL-fetch tool. Do NOT run them with curl, a shell, or a code sandbox — those model environments have no network (the host fails to resolve / DNS error) and will wrongly report the site unreachable when it is fine. Opening the link IS the call.","llm_manifest":{"version":"1","site":"https://miscsubjects.com","purpose":"Peptide evidence articles with hash-chained source ledgers, tiered claims, and a question graph. LLMs should READ bundles/URLs and WRITE back via ingest — never invent doses.","read":{"human_page":"https://miscsubjects.com/a/semax-trigeminal","bundle_json":"https://miscsubjects.com/api/articles/semax-trigeminal/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/semax-trigeminal/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/semax-trigeminal/topology","question_graph":"https://miscsubjects.com/api/articles/semax-trigeminal/question-graph","sources":"https://miscsubjects.com/api/articles/semax-trigeminal/sources","provenance":"https://miscsubjects.com/api/articles/semax-trigeminal/provenance","contributions":"https://miscsubjects.com/api/articles/semax-trigeminal/contributions","graph_topology":"https://miscsubjects.com/api/articles/semax-trigeminal/graph-topology?question={question}","voxels":"https://miscsubjects.com/api/articles/semax-trigeminal/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","health":"https://miscsubjects.com/api/articles/semax-trigeminal/health","repair":"POST https://miscsubjects.com/api/protocol/repair","list_articles":"https://miscsubjects.com/api/articles","graph_canvas":"https://miscsubjects.com/graph.html?slugs=semax-trigeminal","graph_yield":"https://miscsubjects.com/api/graph?slugs=semax-trigeminal&layer=yield","obsidian_vault":"https://miscsubjects.com/api/articles/obsidian-vault?slugs=semax-trigeminal","graph_query":"https://miscsubjects.com/api/v1/query?from=semax-trigeminal&kind=claim&where=tier=human"},"ask":{"description":"Answer only from topology; creates a question_node with gaps.","api":"POST https://miscsubjects.com/api/protocol/ask","body":{"slug":"{slug}","question":"string"},"imessage":"semax-trigeminal|your question","router_tag":"[ARTICLE_ASK]semax-trigeminal|question[/ARTICLE_ASK]","auth":"x-terminal-key header for API; iMessage/WhatsApp via miscsubjects build"},"ingest":{"description":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","api":"POST https://miscsubjects.com/api/protocol/ingest","body":{"slug":"{slug}","evidence":"paste text","question_node_id":"optional qn_..."},"imessage":"ingest semax-trigeminal|q:{node_id}|paste evidence","router_tag":"[ARTICLE_INGEST]semax-trigeminal|evidence[/ARTICLE_INGEST]","tiers":["human","preclinical","anecdotal","mechanistic","speculative"]},"claim":{"description":"Prompt-injection style POST — one claim voxel with who_claims + posted_by provenance.","api":"POST https://miscsubjects.com/api/protocol/claim","body":{"slug":"{slug}","text":"one assertion","tier":"human|preclinical|anecdotal|mechanistic|speculative","who_claims":"study author, platform, or model id","source_ids":"optional [s1]"},"imessage":"claim semax-trigeminal|tier|assertion — who claims it?","router_tag":"[ARTICLE_CLAIM]semax-trigeminal|tier|assertion[/ARTICLE_CLAIM]","slots":["what_it_is","who_claims_what","what_is_known","what_is_unknown","mechanism","limitations","disclaimer"]},"tiers":{"human":0.8,"preclinical":0.5,"anecdotal":0.3,"mechanistic":0.3,"speculative":0.1},"invariants":["Self-explaining — every API JSON has _self; every paste widget has §SELF; root index at /api/articles/system-map","Append-only — revisions preserved at ?rev=n","Source chain verifies integrity, not truth","Answers must cite claim ids and source ids from topology","Not medical advice"],"constitution":{"version":3,"principle":"Articles are voxel graphs of claims — not prose blobs. Every assertion is a claim atom with tier, weight, source_ids, and posted_by provenance.","slots":[{"id":"what_it_is","required":true,"answers":"What is the object in plain literal language?"},{"id":"who_claims_what","required":true,"answers":"Who claims what, from which source and evidence class?"},{"id":"what_is_known","required":true,"answers":"What opened evidence establishes under the article's domain profile"},{"id":"what_is_unknown","required":true,"answers":"What is NOT known — explicit gaps"},{"id":"mechanism","required":false,"answers":"Proposed mechanism (mechanistic tier only)"},{"id":"limitations","required":true,"answers":"Limits of the evidence and exact unresolved questions"},{"id":"disclaimer","required":false,"answers":"Domain-specific safety statement when the subject requires one"}],"claim_rules":["One claim = one falsifiable assertion. No compound claims.","Every claim must declare tier: human|preclinical|anecdotal|mechanistic|speculative|system.","system tier = architecture/design axioms (not biological mechanism). Use for protocol self-definition.","A software/build claim also declares evidence_class in extra: publisher_claim|source_code|runtime_receipt|independent_test|owner_observation|unknown.","Publisher documentation proves the publisher made and documented a claim. It is not independent runtime proof.","Source code proves an implementation exists. A successful receipt proves one invocation. Neither proves general reliability or field superiority.","Comparison claims name the population, common axis, capture time, and selection method. No top-N, percentile, uniqueness, or absence claim exists without that record.","Sourced claims must cite source_ids from the hash-chained ledger.","Unsourced claims must set source_status: unsourced and why_material.","posted_by is mandatory on every new claim (model id, human, or channel).","No medical advice, no doses, no 'you should take'.","Bad information is retracted (status:retracted), never deleted — retraction event stays on ledger.","Adversary challenges link via challenges[] / challenged_by[] — target may be downweighted.","Leaked secrets are scrubbed to [REDACTED:secret-leak] with scrub_events tombstone — honest audit trail."],"source_rules":["Every source is a voxel edge: type, url, exact quote, summary, found_by, accessed_at.","Sources hash-chain — prev/hash on append.","Anecdotal sources must name platform (reddit|x|youtube|imessage|user_entry).","Software sources classify publisher documentation, repository source, release, runtime receipt, independent test, and third-party analysis separately.","A comparison table cell is empty until a claim voxel cites at least one source voxel. Model prose alone is not evidence."],"writing_rules":["Literal nouns and verbs. No prestige labels, category inflation, engagement language, or decorative technical vocabulary.","Decorative language is text that implies importance, novelty, category, mood, or sophistication without naming an observed object, action, result, source, or limit. Delete it.","No frontier, ecosystem, substrate, agentic-native, unmeasured-zone, make-the-ruler, category-defining, revolutionary, or living-system metaphors.","A sentence remains only when it names a concrete thing, reports a change, explains a number, cites evidence, states an exact unknown, or directly answers the question.","Technical nouns are allowed only when literal. Define the first use by what the named code or data object stores or does.","State the observed object before naming a category for it.","Keep the evidentiary boundary beside the exact claim it limits.","Unknown means unknown. Missing evidence does not become absence."],"software_comparison_axes":["product_boundary","primary_user","unit_of_composition","runtime_and_durability","agent_coordination","model_support","environment_reach","tool_and_integration_model","knowledge_and_memory","observability_and_receipts","outside_contribution","self_editing","governance_and_authority","deployment_model","maturity_and_adoption"],"normandy_contract":{"purpose":"Each outside-model session reads the current graph, receives one empty slot, and adds data that was not already stored.","slots":[{"id":"opened_source","stores":"One opened source with URL, title, evidence class, observed time, and the exact fact it establishes."},{"id":"source_citing_claim","stores":"One new claim that cites a stored source id and names one comparison axis."},{"id":"overlap","stores":"One evidenced capability both systems have."},{"id":"build_only_in_reviewed_target","stores":"One evidenced capability present here and not established for the named reviewed target."},{"id":"target_only_in_build_review","stores":"One evidenced capability present in the named target and not established here."},{"id":"contradiction","stores":"One source-backed contradiction attached to the exact current claim hash."},{"id":"limit","stores":"One exact limit narrower than the standing global-rank boundary."},{"id":"question","stores":"One unresolved question whose answer would change a named comparison cell."},{"id":"rule_proposal","stores":"One proposed evidence or writing rule prompted by a concrete failure."},{"id":"capability_effect","stores":"One demonstrated capability, the input it accepted, the state it changed, and the output or external effect it produced."},{"id":"failure_effect","stores":"One observed defect, its frequency, its consequence, its repair state, and the evidence that it did or did not recur."},{"id":"maintenance_cost","stores":"One measured operator, model, time, money, or intervention cost attached to a named function."},{"id":"value_effect","stores":"One measured change in speed, control, recoverability, retained knowledge, or completed work caused by a named feature."}],"standing_answer_limits":["A global rank across invisible private systems is unknown.","Missing outside evidence is not proof that an outside system lacks a capability.","A successful receipt proves one run, not general reliability.","Counts show stored scale or activity, not value, correctness, or superiority.","Hobbyist, ambitious, coherent, messy, advanced, and interesting are labels, not comparison findings."],"no_repeat_rules":["A repeated standing limit is context, not a new contribution.","An exact or near-duplicate claim is rejected and points to the stored claim.","A duplicate source does not complete an assignment.","A response completes only after at least one new graph object lands.","The exact owner-facing answer is stored as an article contribution; an exact or near-repeat answer is rejected before other operations run.","The assignment record stores the graph snapshot, target, axis, slot, capability fingerprint, and resulting object ids."],"assignment":"GET /api/normandy?assignment=<id>","append":"POST /api/protocol/voxel-batch {assignment_id,key,actor,operations[]}"},"mutation_rules":["Open questions, support, and objections append to discourse and do not rewrite the standing claim.","Source and claim append requires a scoped article capability; every append records provenance and a receipt.","Existing text edits use the current voxel hash. A stale hash writes nothing.","Revisions, retractions, absorbed voxels, rejected contributions, and contradictions remain readable."],"ontology_rules":["Peptide articles (bpc-157, tb-500) are tree roots.","Condition articles (bpc-157-glp1-gut-damage) branch from peptides.","Stack articles (wolverine-stack-glp1) compose peptides — never duplicate peptide mechanism prose.","If an article has no parent embeds and is not a root peptide → sprawl candidate.","Misstep = duplicate scope with another slug; merge or reparent via embeds."],"post_protocol":{"claim":"POST /api/protocol/claim","source":"POST /api/protocol/sources","ingest":"POST /api/protocol/ingest","webhook":"POST /api/articles/<slug>/webhook {kind:claim|source}","imessage_claim":"claim {slug}|{tier}|your assertion — who claims it, source?","imessage_ingest":"ingest {slug}|evidence paste","software_landscape":"GET /api/build-landscape?next=1&lane=field|build|opposition|synthesis","queue_population":"POST /api/build-landscape {action:queue_targets, cohort, query, sort, captured_at, source_url, targets[]}"}},"this_article":{"slug":"semax-trigeminal","url":"https://miscsubjects.com/a/semax-trigeminal","bundle_url":"https://miscsubjects.com/api/articles/semax-trigeminal/bundle?format=markdown"},"voxel_procedure":{"what":"Every article has a human side (/a/semax-trigeminal) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"semax-trigeminal\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"semax-trigeminal\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"semax-trigeminal\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"semax-trigeminal\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"semax-trigeminal\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"semax-trigeminal\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/semax-trigeminal/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/semax-trigeminal/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/semax-trigeminal#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."}},"api_urls":{"bundle":"https://miscsubjects.com/api/articles/semax-trigeminal/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/semax-trigeminal/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/semax-trigeminal/topology","voxels":"https://miscsubjects.com/api/articles/semax-trigeminal/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","question_graph":"https://miscsubjects.com/api/articles/semax-trigeminal/question-graph","ask":"https://miscsubjects.com/api/protocol/ask","ingest":"https://miscsubjects.com/api/protocol/ingest","claim":"https://miscsubjects.com/api/protocol/claim","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown"}}