{"slug":"semax-tbi-concussion","verification":{"valid":true,"entries":20,"head":"b12797b6d687006903f79914d1acd152f6ebaaaf1bc052e90b9e18f75683374d"},"energy":{"passes":20,"tokens_in":3095,"tokens_out":418,"tokens_total":3513,"cost_usd":0,"models":{"grok/grok-4.3":1,"grok-4.3":5,"system/audit-repair":9,"kimi/moonshot-v1-8k":1,"repair":1,"fill-slots":2,"owner":1},"head":"b12797b6d687006903f79914d1acd152f6ebaaaf1bc052e90b9e18f75683374d"},"provenance":[{"ts":"2026-06-29T09:17:07.833Z","model":"grok/grok-4.3","action":"write","prompt":"","input":"PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):\nBPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).\nTB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.\nARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.\nSemax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.\nSelank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).\nPT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).\nDSIP — Delta Sleep Inducing Peptide; natural deep sleep without Ambien-class hangover.\nKPV — Gut-specific anti-inflammatory; calms gut lining without systemic immune suppression.\nGHK-Cu — Tissue remodeling; builds collagen scaffolding. Production drops 60-80% with age.\nThymosin Alpha-1 — Immune modulation; supports immune function without suppressing it.\n\nWrite a data-first, evidence-graded article: Semax for TBI and Concussion\n\nAudience: 2.8M TBIs per year. The problem: concussion damages neurons; BDNF often insufficient for full recovery. Why Semax maps: increases BDNF, the brain's repair protein. Novelty: 8/10.\n\nRules: label every claim tier (human|preclinical|anecdotal|mechanistic|speculative). Separate rat studies from human trials from user reports. No medical claims or treatment promises. Use repair-vs-suppression framing where relevant. register: source_ledger.","response":"{\n  \"slug\": \"semax-tbi-concussion-evidence-review\",\n  \"title\": \"Semax for TBI and Concussion: Evidence Review\",\n  \"body\": \"## Background on TBI and BDNF\\n\\nConcussion and traumatic brain injury (TBI) involve neuronal damage where endogenous BDNF levels are frequently insufficient for complete recovery (mechanistic).\\n\\n## Semax Mechanism\\n\\nSemax is a synthetic heptapeptide analog of ACTH(4-10) that upregulates BDNF expression and signaling (mechanistic, supported by rat astrocyte and hippocampal studies).\\n\\n## Preclinical Evidence (Rat Studies)\\n\\nIn rat basal forebrain astrocyte cultures, Semax increased BDNF protein levels (preclinical). In rat hippocampus, a single dose elevated BDNF protein 1.4-fold, TrkB phosphorylation 1.6-fold, and related mRNA (preclinical). Additional rat ischemia and hypoxia models showed Semax-induced changes in BDNF and NGF gene expression in cortex and hippocampus (preclinical). No rat TBI-specific models identified in searches.\\n\\n## Human Data\\n\\nNo human clinical trials on Semax for TBI or concussion were identified. Human studies exist for ischemic stroke: one trial in 30 patients with acute hemispheric ischemic stroke and another reporting increased plasma BDNF in 110 post-stroke patients, with higher BDNF linked to improved rehabilitation timing (human). Semax is approved in Russia for certain neurological conditions including brain trauma, per secondary summaries.\\n\\n## User Reports and Anecdotal\\n\\nLimited anecdotal discussion on forums notes interest in peptides for brain repair post-TBI, but no verified Semax-specific TBI outcome reports tied to sources.\\n\\n## Evidence Summary\\n\\nAll direct BDNF upregulation data are preclinical (rat). Human data are limited to stroke contexts, not TBI. No human data exist for Semax in concussion or TBI recovery. Claims of support for repair pathways remain mechanistic or preclinical.\",\n  \"register\": \"source_ledger\",\n  \"claims\": [\n    {\n      \"id\": \"c1\",\n      \"text\": \"Concussion and TBI inv","tokens_in":0,"tokens_out":0,"cost":0,"prev":"genesis","hash":"7ccd402d3c010a1c70a5914a053144437360f002be4cf787584873b3d1f7a53c"},{"ts":"2026-06-29T11:12:14.488Z","model":"grok-4.3","action":"sources","prompt":"","input":"semax-tbi-concussion","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"7ccd402d3c010a1c70a5914a053144437360f002be4cf787584873b3d1f7a53c","hash":"d678dc9112313b89d039cd9e2168fa23ee14cd54db709daa43bdfa291b956b65"},{"ts":"2026-06-29T11:12:36.565Z","model":"grok-4.3","action":"sources","prompt":"","input":"semax-tbi-concussion","response":"7 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"d678dc9112313b89d039cd9e2168fa23ee14cd54db709daa43bdfa291b956b65","hash":"acecbbaecb80ca7b6f848e243f7ffb809e8350596cf31739fa8aad3faf64500b"},{"ts":"2026-06-29T11:12:56.972Z","model":"grok-4.3","action":"sources","prompt":"","input":"semax-tbi-concussion","response":"2 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"acecbbaecb80ca7b6f848e243f7ffb809e8350596cf31739fa8aad3faf64500b","hash":"9b4be2a03db16579093c42e356d463e9361ead076214a11a9d115842ce539744"},{"ts":"2026-06-29T11:13:22.695Z","model":"grok-4.3","action":"sources","prompt":"","input":"semax-tbi-concussion","response":"3 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"9b4be2a03db16579093c42e356d463e9361ead076214a11a9d115842ce539744","hash":"ea7a9133ecf8feab0d8c1ba18e143b9377c4b945df981c4d19d89e7882c011ca"},{"ts":"2026-06-29T12:49:08.535Z","model":"system/audit-repair","action":"repair","prompt":"","input":"semax-tbi-concussion","response":"{\"materialized\":0,\"before\":[\"missing constitution slots: what_it_is, what_is_known, what_is_unknown, limitations, disclaimer\"],\"after\":[\"missing constitution slots: what_it_is, what_is_known, what_is_unknown, limitations, disclaimer\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"ea7a9133ecf8feab0d8c1ba18e143b9377c4b945df981c4d19d89e7882c011ca","hash":"a449c8a35731fc54bb6458a507c6825c52a4d8e62ccc314b278665d55652b73b"},{"ts":"2026-06-29T12:49:09.136Z","model":"system/audit-repair","action":"claim","prompt":"","input":"semax-tbi-concussion c24","response":"Semax for TBI and Concussion: Evidence Review is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"a449c8a35731fc54bb6458a507c6825c52a4d8e62ccc314b278665d55652b73b","hash":"72f6edd75bb0765a3e76d0bbd292516091df29a7352b5834401050a12381c053"},{"ts":"2026-06-29T12:49:09.222Z","model":"system/audit-repair","action":"claim","prompt":"","input":"semax-tbi-concussion c25","response":"Per this ledger on Semax for TBI and Concussion: Evidence Review: 11 scientific and 8 anecdotal sources are catalogued; 7 preclinical claim(s) summarize animal/cell literature in-catalogue.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"72f6edd75bb0765a3e76d0bbd292516091df29a7352b5834401050a12381c053","hash":"72d7fb887f04b552f70a9b2d6cd5745338f5d4da20acefc2e199857e64ac55ff"},{"ts":"2026-06-29T12:49:09.307Z","model":"system/audit-repair","action":"claim","prompt":"","input":"semax-tbi-concussion c26","response":"Not established in this ledger: large randomized human trials for common marketed uses; long-term human safety beyond small pilots; condition-specific efficacy where only anecdotal or preclinical sources exist (explicit gaps remain in question graph).","tokens_in":0,"tokens_out":0,"cost":0,"prev":"72d7fb887f04b552f70a9b2d6cd5745338f5d4da20acefc2e199857e64ac55ff","hash":"4401922f03576477e2e3d55e1c6f740b4a6e0163cfa5f8fd25fb3592feaf1636"},{"ts":"2026-06-29T12:49:09.360Z","model":"system/audit-repair","action":"claim","prompt":"","input":"semax-tbi-concussion c27","response":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"4401922f03576477e2e3d55e1c6f740b4a6e0163cfa5f8fd25fb3592feaf1636","hash":"5e3985b47a14e2053baf500ed30c09363b828e7a0e7f2264b8cfa82e387fb7d9"},{"ts":"2026-06-29T12:49:09.408Z","model":"system/audit-repair","action":"claim","prompt":"","input":"semax-tbi-concussion c28","response":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"5e3985b47a14e2053baf500ed30c09363b828e7a0e7f2264b8cfa82e387fb7d9","hash":"47551001c2d50026921e55d7c31e1421b6d721e5614cb0f6f74d871f6f73d583"},{"ts":"2026-06-29T12:49:10.187Z","model":"system/audit-repair","action":"repair","prompt":"","input":"semax-tbi-concussion","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"47551001c2d50026921e55d7c31e1421b6d721e5614cb0f6f74d871f6f73d583","hash":"576bb2c0588512197dedeb7d30affbc7557367927d49d1d53f10c1f114533003"},{"ts":"2026-06-29T13:23:22.786Z","model":"system/audit-repair","action":"repair","prompt":"","input":"semax-tbi-concussion","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"576bb2c0588512197dedeb7d30affbc7557367927d49d1d53f10c1f114533003","hash":"e88893e26ef9bdf72cf26a22b853bd04bb8714286bbb95b52bf4ecd36f0924c3"},{"ts":"2026-06-29T13:23:23.948Z","model":"system/audit-repair","action":"repair","prompt":"","input":"semax-tbi-concussion","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"e88893e26ef9bdf72cf26a22b853bd04bb8714286bbb95b52bf4ecd36f0924c3","hash":"c14476711be57c167cd9e9860370de2503e02e8400d98a5c105ec183982f2424"},{"ts":"2026-06-29T14:06:52.231Z","model":"kimi/moonshot-v1-8k","action":"collaborate","prompt":"","input":"semax-tbi-concussion","response":"As collaborator #1 on the miscsubjects peptide evidence ledger, I am adding explicit claims about gaps in knowledge and naming sources of anecdotal claims where they are not explicitly stated. This is in line with the instructions to state explicit gaps and name who claims what from anecdotes if missing.","tokens_in":3095,"tokens_out":418,"cost":0,"prev":"c14476711be57c167cd9e9860370de2503e02e8400d98a5c105ec183982f2424","hash":"18115c360606f9ac42189e7657d3420e1e96559cc98a6ef081c53da22dc009d0"},{"ts":"2026-06-29T18:29:37.338Z","model":"grok-4.3","action":"sources","prompt":"","input":"semax-tbi-concussion","response":"6 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"18115c360606f9ac42189e7657d3420e1e96559cc98a6ef081c53da22dc009d0","hash":"6efc8a1b92629dbabda4d59be0967d6fc009d77fbae5b8499bd7d787f84264fb"},{"ts":"2026-06-29T20:00:06.906Z","model":"repair","action":"repair","prompt":"","input":"semax-tbi-concussion","response":"{\"materialized\":0,\"before\":[],\"after\":[],\"focus_stats\":{\"roles_assigned\":0,\"excluded_sources\":0,\"commercial_sources\":0,\"cut_claims\":0,\"core\":12,\"cycle\":0,\"adjacent\":0}}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"6efc8a1b92629dbabda4d59be0967d6fc009d77fbae5b8499bd7d787f84264fb","hash":"4994b6e8a68b51dabc25927da1743c945213894779c9b25b97b6454ae11a92c6"},{"ts":"2026-06-29T21:11:04.150Z","model":"fill-slots","action":"claim","prompt":"","input":"semax-tbi-concussion c38","response":"Semax for TBI and Concussion: Evidence Review is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"4994b6e8a68b51dabc25927da1743c945213894779c9b25b97b6454ae11a92c6","hash":"3f2d814af30c121b89ceb37d8fcb20873c89525af54b5cc9f58bcecee154d336"},{"ts":"2026-06-29T21:11:06.499Z","model":"fill-slots","action":"claim","prompt":"","input":"semax-tbi-concussion c39","response":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"3f2d814af30c121b89ceb37d8fcb20873c89525af54b5cc9f58bcecee154d336","hash":"d00985c7ea2528d85d63b6f9049ebc4c4672b25a63feba11dffc5fe319342a86"},{"ts":"2026-07-17T02:41:58.896Z","model":"owner","action":"voxel_divide","prompt":"","input":"semax-tbi-concussion","response":"15 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"d00985c7ea2528d85d63b6f9049ebc4c4672b25a63feba11dffc5fe319342a86","hash":"b12797b6d687006903f79914d1acd152f6ebaaaf1bc052e90b9e18f75683374d"}]}