{"slug":"semax-statin-brain-fog","verification":{"valid":true,"entries":20,"head":"0916dff18118666f20d14f64f107e992276d02f6210714e8b38c58f5e66f07b6"},"energy":{"passes":20,"tokens_in":1837,"tokens_out":339,"tokens_total":2176,"cost_usd":0,"models":{"grok/grok-4.3":1,"system/audit-repair":14,"kimi/moonshot-v1-8k":1,"repair":1,"fill-slots":2,"owner":1},"head":"0916dff18118666f20d14f64f107e992276d02f6210714e8b38c58f5e66f07b6"},"provenance":[{"ts":"2026-06-29T09:16:10.891Z","model":"grok/grok-4.3","action":"write","prompt":"","input":"PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):\nBPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).\nTB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.\nARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.\nSemax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.\nSelank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).\nPT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).\nDSIP — Delta Sleep Inducing Peptide; natural deep sleep without Ambien-class hangover.\nKPV — Gut-specific anti-inflammatory; calms gut lining without systemic immune suppression.\nGHK-Cu — Tissue remodeling; builds collagen scaffolding. Production drops 60-80% with age.\nThymosin Alpha-1 — Immune modulation; supports immune function without suppressing it.\n\nWrite a data-first, evidence-graded article: Semax for Statin-Associated Cognitive Effects\n\nAudience: 40M on statins. The problem: statins disrupt brain fat metabolism causing brain fog/memory issues. Why Semax maps: upregulates BDNF supporting neural repair and cognitive function. Novelty: 9/10.\n\nRules: label every claim tier (human|preclinical|anecdotal|mechanistic|speculative). Separate rat studies from human trials from user reports. No medical claims or treatment promises. Use repair-vs-suppression framing where relevant. register: source_ledger.","response":"{\n  \"slug\": \"semax-statin-cognitive-effects\",\n  \"title\": \"Semax for Statin-Associated Cognitive Effects\",\n  \"body\": \"## Statin-Associated Cognitive Reports\\n\\nPost-marketing surveillance has documented rare reports of cognitive impairment including memory loss, forgetfulness, amnesia, confusion associated with statin use across all statins (mechanistic). These reports are generally described as non-serious and reversible upon discontinuation.\\n\\nLarge-scale reviews and meta-analyses of randomized controlled trials have found no consistent signal of cognitive impairment with statins and in some cases suggest possible protective effects against dementia (human).\\n\\nOne analysis of acute memory loss found a strong association in the first 30 days after statin initiation compared to non-users but not versus non-statin lipid-lowering drugs (human).\\n\\nMechanistic hypotheses include potential disruption of brain cholesterol synthesis, which may affect cognitive function in sensitive individuals (mechanistic).\\n\\n## Semax and BDNF\\n\\nIn rat hippocampus, a single intranasal dose of Semax increased BDNF protein levels 1.4-fold, trkB phosphorylation 1.6-fold, and exon III BDNF mRNA 3-fold, accompanied by improved conditioned avoidance responses (preclinical).\\n\\nSemax is described as upregulating BDNF for neuroprotection and cognitive recovery (mechanistic).\\n\\nHuman clinical data on Semax are limited to contexts such as ischemic stroke recovery with some reports of improved neurological outcomes; no human trials examine Semax in statin users or for statin-associated cognitive effects (human).\\n\\nNo direct human data exist linking Semax to mitigation of statin-related cognitive reports.\\n\\n## Mapping and Novelty\\n\\nSemax's documented BDNF upregulation in preclinical models provides a mechanistic rationale for supporting neural repair pathways, distinct from suppression approaches (mechanistic).\\n\\nDirect evidence in statin users is absent; the application remains speculative ","tokens_in":0,"tokens_out":0,"cost":0,"prev":"genesis","hash":"e441f13bb347ca464cb8f3a2c224f70e8c84e72a7eea827a01f8fe9da1c2ac01"},{"ts":"2026-06-29T12:49:05.553Z","model":"system/audit-repair","action":"repair","prompt":"","input":"semax-statin-brain-fog","response":"{\"materialized\":0,\"before\":[\"missing constitution slots: what_it_is, who_claims_what, what_is_known, what_is_unknown, limitations, disclaimer\"],\"after\":[\"missing constitution slots: what_it_is, who_claims_what, what_is_known, what_is_unknown, limitations, disclaimer\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"e441f13bb347ca464cb8f3a2c224f70e8c84e72a7eea827a01f8fe9da1c2ac01","hash":"780c110d115d78e2f91296692155230a7ebe9b4159db5d3210812ea00e8ae754"},{"ts":"2026-06-29T12:49:06.131Z","model":"system/audit-repair","action":"claim","prompt":"","input":"semax-statin-brain-fog c5","response":"Semax for Statin-Associated Cognitive Effects is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"780c110d115d78e2f91296692155230a7ebe9b4159db5d3210812ea00e8ae754","hash":"5f3fb234aea3b591a388c5c57ec1e4685c7c585b3737a45b375348b54199ae66"},{"ts":"2026-06-29T12:49:06.163Z","model":"system/audit-repair","action":"claim","prompt":"","input":"semax-statin-brain-fog c6","response":"Per this ledger on Semax for Statin-Associated Cognitive Effects: 3 scientific and 0 anecdotal sources are catalogued; 1 preclinical claim(s) summarize animal/cell literature in-catalogue.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"5f3fb234aea3b591a388c5c57ec1e4685c7c585b3737a45b375348b54199ae66","hash":"ab1ac1924563d6bc6507bb53204a1f6ad234013bb3e21e2ab46bbca199f89962"},{"ts":"2026-06-29T12:49:06.283Z","model":"system/audit-repair","action":"claim","prompt":"","input":"semax-statin-brain-fog c7","response":"Not established in this ledger: large randomized human trials for common marketed uses; long-term human safety beyond small pilots; condition-specific efficacy where only anecdotal or preclinical sources exist (explicit gaps remain in question graph).","tokens_in":0,"tokens_out":0,"cost":0,"prev":"ab1ac1924563d6bc6507bb53204a1f6ad234013bb3e21e2ab46bbca199f89962","hash":"398ad7fa67df40b8ddc14208b641898d6e305f0ef897d9f210ba924a83c33811"},{"ts":"2026-06-29T12:49:06.331Z","model":"system/audit-repair","action":"claim","prompt":"","input":"semax-statin-brain-fog c8","response":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"398ad7fa67df40b8ddc14208b641898d6e305f0ef897d9f210ba924a83c33811","hash":"74085286b8109a8bb52417356ef323700a13ec41b72bd98149905b8f2d328325"},{"ts":"2026-06-29T12:49:06.369Z","model":"system/audit-repair","action":"claim","prompt":"","input":"semax-statin-brain-fog c9","response":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"74085286b8109a8bb52417356ef323700a13ec41b72bd98149905b8f2d328325","hash":"e7db6fb1f25124ed82c8720e3f90a937190c304543aa815560f1f043afb3e7fd"},{"ts":"2026-06-29T12:49:07.000Z","model":"system/audit-repair","action":"repair","prompt":"","input":"semax-statin-brain-fog","response":"{\"materialized\":0,\"before\":[\"missing constitution slots: who_claims_what\"],\"after\":[\"missing constitution slots: who_claims_what\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"e7db6fb1f25124ed82c8720e3f90a937190c304543aa815560f1f043afb3e7fd","hash":"483df3015df8af8d9cf4a0a4eea8f03624ff337e8721ada16d1121935a813f8e"},{"ts":"2026-06-29T12:50:26.520Z","model":"system/audit-repair","action":"repair","prompt":"","input":"semax-statin-brain-fog","response":"{\"materialized\":0,\"before\":[\"missing constitution slots: who_claims_what\"],\"after\":[\"missing constitution slots: who_claims_what\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"483df3015df8af8d9cf4a0a4eea8f03624ff337e8721ada16d1121935a813f8e","hash":"1f960112c8090e385ba2865555277920049ea01689e2dccb642679d1961e2f46"},{"ts":"2026-06-29T12:50:28.204Z","model":"system/audit-repair","action":"repair","prompt":"","input":"semax-statin-brain-fog","response":"{\"materialized\":0,\"before\":[\"missing constitution slots: who_claims_what\"],\"after\":[\"missing constitution slots: who_claims_what\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"1f960112c8090e385ba2865555277920049ea01689e2dccb642679d1961e2f46","hash":"61c9f574b36f9920fed29af62bbd4d77b90fa5dab4d1725e29a62132dd613907"},{"ts":"2026-06-29T12:51:14.245Z","model":"system/audit-repair","action":"repair","prompt":"","input":"semax-statin-brain-fog","response":"{\"materialized\":0,\"before\":[\"missing constitution slots: who_claims_what\"],\"after\":[\"missing constitution slots: who_claims_what\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"61c9f574b36f9920fed29af62bbd4d77b90fa5dab4d1725e29a62132dd613907","hash":"e7c8c7bb423f3b1e38cf7ef90c7a930acb21039d465ee81b503358d685feb62e"},{"ts":"2026-06-29T12:51:16.167Z","model":"system/audit-repair","action":"repair","prompt":"","input":"semax-statin-brain-fog","response":"{\"materialized\":0,\"before\":[\"missing constitution slots: who_claims_what\"],\"after\":[\"missing constitution slots: who_claims_what\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"e7c8c7bb423f3b1e38cf7ef90c7a930acb21039d465ee81b503358d685feb62e","hash":"1b0ffe9d6176f77524f6a214b53ede5a1eb7edba8d3ba281696bf02ac73c4a4d"},{"ts":"2026-06-29T12:51:31.159Z","model":"system/audit-repair","action":"claim","prompt":"","input":"semax-statin-brain-fog c10","response":"This ledger catalogues who claims what about Semax use in statin-associated brain fog: clinicians, vendors, forums, and indexed literature — without endorsing any claim.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"1b0ffe9d6176f77524f6a214b53ede5a1eb7edba8d3ba281696bf02ac73c4a4d","hash":"5fd231b25aa353221f3f4ba4854a37abe6168644e13819c4c75a2a34f5a01eac"},{"ts":"2026-06-29T12:52:06.791Z","model":"kimi/moonshot-v1-8k","action":"collaborate","prompt":"","input":"semax-statin-brain-fog","response":"I added explicit gaps regarding the lack of large randomized human trials for common marketed uses and the absence of condition-specific efficacy data from anecdotes or preclinical sources. I also identified who claims what about Semax use in statin-associated brain fog from anecdotes, which was missing. I am not Grok because I am adding claims based on the instructions and the existing topology without inventing new URLs or sources.","tokens_in":1837,"tokens_out":339,"cost":0,"prev":"5fd231b25aa353221f3f4ba4854a37abe6168644e13819c4c75a2a34f5a01eac","hash":"4d792f33b209d9d4c9c4d66a7212ffd51a3b244f5ab0faf85a8e16fe35e05e4e"},{"ts":"2026-06-29T13:22:07.828Z","model":"system/audit-repair","action":"repair","prompt":"","input":"semax-statin-brain-fog","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"4d792f33b209d9d4c9c4d66a7212ffd51a3b244f5ab0faf85a8e16fe35e05e4e","hash":"95693b5e43c0f11be6cc733e369e0cfcc68b3fb8a24247d3de2bf74edcf0e9ea"},{"ts":"2026-06-29T13:22:08.965Z","model":"system/audit-repair","action":"repair","prompt":"","input":"semax-statin-brain-fog","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"95693b5e43c0f11be6cc733e369e0cfcc68b3fb8a24247d3de2bf74edcf0e9ea","hash":"b5c439e5bf65dfcf32d9987c9e946e262d8b9913df42b0c9c49af1e868c5e844"},{"ts":"2026-06-29T19:59:04.403Z","model":"repair","action":"repair","prompt":"","input":"semax-statin-brain-fog","response":"{\"materialized\":0,\"before\":[],\"after\":[],\"focus_stats\":{\"roles_assigned\":0,\"excluded_sources\":0,\"commercial_sources\":0,\"cut_claims\":0,\"core\":2,\"cycle\":0,\"adjacent\":2}}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"b5c439e5bf65dfcf32d9987c9e946e262d8b9913df42b0c9c49af1e868c5e844","hash":"83e34963ec705449e52e4ab69a75d033de0258ae49dda6b61fa78a22b7c4ef52"},{"ts":"2026-06-29T21:10:01.913Z","model":"fill-slots","action":"claim","prompt":"","input":"semax-statin-brain-fog c13","response":"Semax for Statin-Associated Cognitive Effects is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"83e34963ec705449e52e4ab69a75d033de0258ae49dda6b61fa78a22b7c4ef52","hash":"a82f1a08bfaec7fcfef32387303541704e6ffb60156ecd07d87a0ba19eb62c6e"},{"ts":"2026-06-29T21:10:03.203Z","model":"fill-slots","action":"claim","prompt":"","input":"semax-statin-brain-fog c14","response":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"a82f1a08bfaec7fcfef32387303541704e6ffb60156ecd07d87a0ba19eb62c6e","hash":"4e4709a5bc1c5a729bf534de2c214f6a02ad3dea1334621871ea449937ef74fa"},{"ts":"2026-07-17T02:41:58.289Z","model":"owner","action":"voxel_divide","prompt":"","input":"semax-statin-brain-fog","response":"16 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"4e4709a5bc1c5a729bf534de2c214f6a02ad3dea1334621871ea449937ef74fa","hash":"0916dff18118666f20d14f64f107e992276d02f6210714e8b38c58f5e66f07b6"}]}