{"slug":"semax-insomnia","verification":{"valid":false,"broken_at":2,"reason":"hash mismatch"},"count":5,"sources":[{"id":"s1","type":"review","url":"https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Semax-Cognitive-Vitality-For-Researchers.pdf","title":"Semax Cognitive Vitality For Researchers","quote":"Human research to suggest prevention of dementia and cognitive aging. In one pilot study in 24 healthy subjects...","summary":"Notes limited pilot studies and absence of large Western RCTs for most claims.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:09:03.485Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"fcc0928816c885fc0e7da3346063ce0cb9ffd46aab49cae8ffc37b48e5a50bb1"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/16635254/","title":"Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain","quote":"Semax stimulates the synthesis of brain-derived neurotrophic factor (BDNF)...","summary":"Rat study demonstrating BDNF increase after intranasal Semax.","claim_ids":["c2","c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:09:03.485Z","link_status":"ok","quote_status":"unverified","prev":"fcc0928816c885fc0e7da3346063ce0cb9ffd46aab49cae8ffc37b48e5a50bb1","hash":"93bb364c231fcdc75cab2fa544c0f949330c34a064e76166007060419b2c30ac"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/16996037/","title":"Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus","quote":"Semax affects cognitive brain functions by modulating the expression and the activation of the hippocampal BDNF/trkB system.","summary":"Additional rat data on BDNF and cognitive tasks.","claim_ids":["c2","c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:09:03.485Z","link_status":"ok","quote_status":"verified","prev":"93bb364c231fcdc75cab2fa544c0f949330c34a064e76166007060419b2c30ac","hash":"844fcdbd290d9c1fabfc24561227bc8482ab3b9d65fc6b6a1a15d17347456fd1"},{"id":"s4","type":"other","url":"https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Semax-Cognitive-Vitality-For-Researchers.pdf","title":"Semax Cognitive Vitality For Researchers","quote":"A study of 110 patients with stroke reported that treatment with semax increased plasma BDNF levels.","summary":"Human post-stroke BDNF observation.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:09:03.485Z","link_status":"ok","quote_status":"unverified","prev":"844fcdbd290d9c1fabfc24561227bc8482ab3b9d65fc6b6a1a15d17347456fd1","hash":"43e507096f4bbb420e5e848c3ba5cc0036e1eb384a77d98f5ce4fac1207de794"},{"id":"s5","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/lfsp8z/insomnia_after_semax/","title":"Insomnia after semax?","quote":"Now i go to bed at 10pm and wake up at 3am... Semax is an ACTH fragment... stress induced insomnia with Semax.","summary":"User reports linking Semax to sleep disruption.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:09:03.485Z","link_status":"ok","quote_status":"unverified","prev":"43e507096f4bbb420e5e848c3ba5cc0036e1eb384a77d98f5ce4fac1207de794","hash":"a2e6b63b7511735e700324dd38d21393bb50656440331759143bb1f6a745ecef"}]}