{"slug":"semaglutide-tirzepatide","verification":{"valid":true,"entries":5,"head":"756ec79fb1596f50599acead2dfb389356bfbd9e6f9018e0689dac5e72b9cdc8"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa2206038","title":"Tirzepatide Once Weekly for the Treatment of Obesity","quote":"The mean percentage change in weight at week 72 was −15.0% ... with 5-mg ... −19.5% ... 10-mg ... −20.9% ... 15-mg ... and −3.1% ... placebo","summary":"SURMOUNT-1 phase 3 trial results","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:18:00.520Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"d31047d1a7174db93b5273678e836aec9842fdbcabeaa281bd59d22fa7d3f3ad"},{"id":"s14","type":"pubmed","url":"https://www.nejm.org/doi/abs/10.1056/NEJMoa2416394","title":"Tirzepatide as Compared with Semaglutide for the Treatment of Obesity","quote":"least-squares mean percent change in weight at week 72 was −20.2% ... tirzepatide and −13.7% ... semaglutide","summary":"SURMOUNT-5 head-to-head trial","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:18:00.520Z","link_status":"http_403","quote_status":"unverified","prev":"d31047d1a7174db93b5273678e836aec9842fdbcabeaa281bd59d22fa7d3f3ad","hash":"71706a7448b3bbc7bc555745c26f84a04f23a53f2d3648775a8d9e93c405cc51"},{"id":"s10","type":"pubmed","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa2403664","title":"Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis","quote":"mean change in the WOMAC pain score at week 68 was −41.7 points with semaglutide and −27.5 points with placebo","summary":"Semaglutide OA pain trial","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:18:00.520Z","link_status":"http_403","quote_status":"unverified","prev":"71706a7448b3bbc7bc555745c26f84a04f23a53f2d3648775a8d9e93c405cc51","hash":"e071191a66eb994c784af7f9a4789409cd30d6635deb63d15e5098e4f31f793a"},{"id":"s12","type":"pubmed","url":"https://www.sciencedirect.com/science/article/abs/pii/S0003496725016292","title":"IMPACT OF TIRZEPATIDE ON MUSCULOSKELETAL PAIN","quote":"Initiation of tirzepatide was associated with overall lower risk of joint pain with HR 0.91 ... including low back pain (HR 0.89","summary":"Real-world tirzepatide joint pain study","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:18:00.520Z","link_status":"http_403","quote_status":"unverified","prev":"e071191a66eb994c784af7f9a4789409cd30d6635deb63d15e5098e4f31f793a","hash":"cb21b15912ce41cae423496d50296745380d059b293f12a1ba96962a751f4501"},{"id":"s4","type":"news","url":"https://www.pulmonologyadvisor.com/news/real-world-weight-loss-with-semaglutide-tirzepatide-less-than-that-seen-in-clinical-trials/","title":"Real-World Weight Loss With Semaglutide, Tirzepatide Less Than That Seen in Clinical Trials","quote":"weight loss at one year is 8.7 percent on average","summary":"Real-world cohort data","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:18:00.520Z","link_status":"dead","quote_status":"unverified","prev":"cb21b15912ce41cae423496d50296745380d059b293f12a1ba96962a751f4501","hash":"756ec79fb1596f50599acead2dfb389356bfbd9e6f9018e0689dac5e72b9cdc8"}]}