{"slug":"semaglutide-ppis","verification":{"valid":true,"entries":4,"head":"243b8de6337a3acad1633093790959b1960c7acf84f9dc2a630b76b0eb890b74"},"count":4,"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/29897249/","title":"A randomized study investigating the effect of omeprazole on the pharmacokinetics of oral semaglutide","quote":"There was a slight non-statistically significant increase in semaglutide exposure when oral semaglutide was administered with omeprazole","summary":"Human RCT on oral semaglutide + omeprazole PK interaction","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:20:59.394Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"920e00257e0871eecbc3fed9b1c1cb68df8930080c203aa7481d1d2c469f47df"},{"id":"s2","type":"news","url":"https://www.medscape.com/viewarticle/concurrent-proton-pump-inhibitor-glp-1-use-linked-increases-2026a1000f38","title":"Acid Blockers May Worsen Gastro Effects of Weight-Loss Drugs","quote":"Patients who took GLP-1s and PPIs concurrently were more than twice as likely to experience adverse effects of the upper GI (risk ratio [RR], 2.37","summary":"Large observational cohort on concurrent use risks","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:20:59.394Z","link_status":"ok","quote_status":"verified","prev":"920e00257e0871eecbc3fed9b1c1cb68df8930080c203aa7481d1d2c469f47df","hash":"90308884bb96cbb038bb45885e3bacb3fed8a204439ecd8f0a18b61f271e0c80"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/23532991/","title":"Weight loss can lead to resolution of gastroesophageal reflux disease symptoms","quote":"Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: a prospective intervention trial","summary":"Human intervention trial linking weight loss to GERD improvement","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:20:59.394Z","link_status":"ok","quote_status":"verified","prev":"90308884bb96cbb038bb45885e3bacb3fed8a204439ecd8f0a18b61f271e0c80","hash":"40cfedec51933568441fdd6c40d618c404c40f5b0c8edceaf6f9adb3ca045ac9"},{"id":"s4","type":"news","url":"https://www.medicalnewstoday.com/articles/acid-reflux-drugs-may-increase-risk-of-type-2-diabetes","title":"Acid reflux drugs may increase risk of type 2 diabetes","quote":"people who took PPIs regularly were 24% more likely to develop diabetes than those who did not","summary":"Observational study on long-term PPI risks","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:20:59.394Z","link_status":"ok","quote_status":"verified","prev":"40cfedec51933568441fdd6c40d618c404c40f5b0c8edceaf6f9adb3ca045ac9","hash":"243b8de6337a3acad1633093790959b1960c7acf84f9dc2a630b76b0eb890b74"}]}