{"slug":"semaglutide-nsaids","verification":{"valid":true,"entries":5,"head":"44cf01bdd826659b24a423406f06fd56ee7f88c89235743827a2b2d88adf38b6"},"count":5,"sources":[{"id":"s19","type":"pubmed","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa2403664","title":"Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis","quote":"Treatment with once-weekly injectable semaglutide resulted in significantly greater reductions in body weight and pain related to knee osteoarthritis than placebo.","summary":"Randomized controlled human trial, 407 participants, 68 weeks, primary outcomes weight and WOMAC pain.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:23:00.886Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"58d6d308bdb65acdd63158d2c47162e735a72802c78626c442e65d45f5a5c235"},{"id":"s14","type":"medical","url":"https://www.fellahealth.com/guide/can-i-take-ibuprofen-on-semaglutide","title":"Can I Take Ibuprofen on Semaglutide? Safety Guide","quote":"While no direct drug interaction exists between semaglutide and ibuprofen, both medications independently affect the gastrointestinal system.","summary":"Clinical guidance site summarizing interaction data.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:23:00.886Z","link_status":"ok","quote_status":"unverified","prev":"58d6d308bdb65acdd63158d2c47162e735a72802c78626c442e65d45f5a5c235","hash":"1ce0029cda69167b464e3a4d5fe4550c4b08b4a23ac47e0c30fecf7d935364be"},{"id":"s15","type":"medical","url":"https://www.trimbodymd.com/faqs/can-i-take-ibuprofen-while-taking-semaglutide/","title":"Can I Take Ibuprofen While Taking Semaglutide","quote":"Semaglutide slows down how food leaves your stomach, and this delay can keep NSAIDs like ibuprofen in your stomach longer.","summary":"Explains additive GI risk mechanism.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:23:00.886Z","link_status":"ok","quote_status":"unverified","prev":"1ce0029cda69167b464e3a4d5fe4550c4b08b4a23ac47e0c30fecf7d935364be","hash":"da22d2179ead0288c9fba29d6e4f239bde5c7874560f7125570dd1f37e7cdc69"},{"id":"s0","type":"reddit","url":"https://www.reddit.com/r/Semaglutide/comments/1ferdvh/nsaids_wrecking_stomach/","title":"NSAIDs wrecking stomach?","quote":"Started semaglutide in December. In February I took NSAIDS (400mg 2x/day) for two days and it messed me up.","summary":"User anecdote on combined GI effects.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:23:00.886Z","link_status":"ok","quote_status":"unverified","prev":"da22d2179ead0288c9fba29d6e4f239bde5c7874560f7125570dd1f37e7cdc69","hash":"270828b159a361fc1423f023ebafd7dbd9bbdeb4264c8ef109af70888b87c96f"},{"id":"s1","type":"reddit","url":"https://www.reddit.com/r/Semaglutide/comments/1hg5kzo/is_this_the_new_option_for_reducing_inflammation/","title":"Is this the new option for reducing inflammation?","quote":"I went from taking a NSAID multiple times a day to not at all.","summary":"User report of reduced NSAID dependence.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:23:00.886Z","link_status":"ok","quote_status":"unverified","prev":"270828b159a361fc1423f023ebafd7dbd9bbdeb4264c8ef109af70888b87c96f","hash":"44cf01bdd826659b24a423406f06fd56ee7f88c89235743827a2b2d88adf38b6"}]}