{"slug":"semaglutide-neuropathy","verification":{"valid":true,"entries":5,"head":"c4e87a7c38fa0f2313223ec50cfd268a3f85c460832c5e7cf2f72a47b502a7d7"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11593193/","title":"Semaglutide Ameliorates Diabetic Neuropathic Pain by Inhibiting Neuroinflammation in the Spinal Cord","quote":"SEMA treatment significantly reduced both allodynia and hyperalgesia in the diabetic group... lowered the activation of microglia and astrocytes in the dorsal horn.","summary":"2024 rat study detailing behavioral and histological outcomes with semaglutide in STZ diabetic model.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:24:14.024Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"4186e147b7d3fd78c1406e0adb9ee194097b9a158ee4f1997b6c696609f7afff"},{"id":"s2","type":"pubmed","url":"https://onlinelibrary.wiley.com/doi/full/10.1111/jnc.16242","title":"Effect of the glucagon‐like peptide‐1 receptor agonists on diabetic peripheral neuropathy: A meta‐analysis","quote":"The GLP-1RA group demonstrated a significant improvement in NCV compared to the control... subgroup analyses revealed no significant effects for... semaglutide or dulaglutide.","summary":"2025 meta-analysis of 6 studies on GLP-1RAs in DPN with NCV outcomes.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:24:14.024Z","link_status":"ok","quote_status":"unverified","prev":"4186e147b7d3fd78c1406e0adb9ee194097b9a158ee4f1997b6c696609f7afff","hash":"6d6c77f37f1aedc456329c8e31bc928ad6a065940bf12e13f5de8540dd08d4d0"},{"id":"s3","type":"pubmed","url":"https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2820255","title":"Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide","quote":"higher risk of NAION for patients prescribed semaglutide (hazard ratio [HR], 4.28; 95% CI, 1.62-11.29)","summary":"Matched cohort study showing elevated NAION risk with semaglutide.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:24:14.024Z","link_status":"http_403","quote_status":"unverified","prev":"6d6c77f37f1aedc456329c8e31bc928ad6a065940bf12e13f5de8540dd08d4d0","hash":"2918822e8d6c0eaadd0128de4db231ddd259a6e0d65dd85182abbb1c1cdacad2"},{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/Semaglutide/comments/17kvjq9/nerve_pain_anyone/","title":"Nerve pain anyone?","quote":"I've been on the 1.7 dose of wegovy... pain on the thigh and lower belly that feels like nerve pain.","summary":"Example Reddit thread with mixed nerve symptom reports.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:24:14.024Z","link_status":"ok","quote_status":"unverified","prev":"2918822e8d6c0eaadd0128de4db231ddd259a6e0d65dd85182abbb1c1cdacad2","hash":"046e8f93040e2ab593f4490b5039f57da5eb5d16475cbcd8e796ea51e00ae368"},{"id":"s5","type":"x","url":"https://x.com/drcyriljosen/status/2070721939279376634","title":"NAION discussion post","quote":"NAION or vision loss is now being studied in USA... Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide","summary":"X post referencing NAION semaglutide studies.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:24:14.024Z","link_status":"ok","quote_status":"unverified","prev":"046e8f93040e2ab593f4490b5039f57da5eb5d16475cbcd8e796ea51e00ae368","hash":"c4e87a7c38fa0f2313223ec50cfd268a3f85c460832c5e7cf2f72a47b502a7d7"}]}