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Semaglutide addresses the metabolic load / body weight layer. If a broader profile includes other degeneration layers such as direct muscle catabolism or neural factors, those would require separate targeted approaches. The net effect on muscle depends on the balance between fat loss benefits and any lean mass reduction observed.","status":"active","vx_hash":"0736a08275043fc9bac3234c562b471ddc5aeff854735ce8a7e320c9cf95ecee","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"5088570e8e3c3feda64831c4d5b74145cb736251f3956476331aa36fc601d073","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"6f7d24a877b9a59e0fd2ebc7c40fa38cd39951513bfd8b602baa6ca0800b81dc","detail":{"divided_from":"body","block":7,"kind":"p"},"prev":"genesis","hash":"5088570e8e3c3feda64831c4d5b74145cb736251f3956476331aa36fc601d073"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d7"},{"id":"d8","kind":"h","type":null,"order":8,"text":"## What the evidence actually shows","status":"active","vx_hash":"cc4ebc3460a9c2cbb8449cc93ed6fd5084508f247dbbd0fa81115f8b97b95f53","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"31d140f7008a357314a9db4e2497677452a1b5d5361ae7ef151eddb3e1275ff7","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"a7a051e6a294dc45c15b7d4859b7020d561e719fe73844f03e3a8f9e7fed8de1","detail":{"divided_from":"body","block":8,"kind":"h"},"prev":"genesis","hash":"31d140f7008a357314a9db4e2497677452a1b5d5361ae7ef151eddb3e1275ff7"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d8"},{"id":"d9","kind":"h","type":null,"order":9,"text":"### Human trials (tier: human)","status":"active","vx_hash":"08087e61166e7a6f5461edd49b020827132d7f6b2a2ad5e06ac9ab97e6ff17b3","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"26b34b7414fd5435c988601968d269108f998de658aaa547984f696d4d5a8dee","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"e6715a839803e1f626854d656980facf3161885bb40ecd510c08a13dadfeb97b","detail":{"divided_from":"body","block":9,"kind":"h"},"prev":"genesis","hash":"26b34b7414fd5435c988601968d269108f998de658aaa547984f696d4d5a8dee"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d9"},{"id":"d10","kind":"p","type":null,"order":10,"text":"Multiple randomized controlled trials and substudies using DXA scans document lean mass changes with semaglutide. In the STEP 1 trial (adults with overweight/obesity, no diabetes), semaglutide produced -15.3 kg total weight loss and -6.92 kg lean mass loss (approximately 45% of weight lost as lean mass). Lean mass as a proportion of total body mass still increased slightly in some analyses. In SUSTAIN-8 (type 2 diabetes patients), lean mass fell -2.3 kg with -5.3 kg total weight loss (43% lean fraction), yet the lean-to-total ratio improved by 1.2%. Other trials report lean loss ranging 15-45% of total weight lost, with fat loss typically predominant. One 26-week real-life study of oral semaglutide in type 2 diabetes patients showed preserved or slightly increased skeletal muscle mass and improved skeletal muscle mass to visceral adipose tissue ratio.","status":"active","vx_hash":"9248f1c1f9aba5ad221f28c911190e1d73f98cd164b99ed5103863feaec2960e","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"170ea6cf0edbea4665385fb18fdf688486291577008fa3ee4ed27774416a0f75","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"385076e2936c1830379d0bbcebb8ccdf0f70d36683d12182e8f1f72d03c73e6b","detail":{"divided_from":"body","block":10,"kind":"p"},"prev":"genesis","hash":"170ea6cf0edbea4665385fb18fdf688486291577008fa3ee4ed27774416a0f75"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d10"},{"id":"d11","kind":"p","type":null,"order":11,"text":"A 2024 systematic review noted semaglutide primarily reduces fat mass, with notable but variable lean mass reductions. Recent 2025-2026 analyses confirm heterogeneity; some populations maintain function despite volume loss (e.g., psoas muscle volume down 9.3% at 24 weeks with no significant change in chair rise or gait speed in HIV/MASLD patients).","status":"active","vx_hash":"a7c531e1c8d53171404088d8ffdf061347bf7cf297c2fc2fd1149a1738a47316","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"69c3cc8325763fbcb2473dc937b3afb8c8ead1a21d48f2bf78ea9ec5f9d09e37","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"ce6c8a6481637833704c524a8221ce315cd05fb7ad605b928aead6e8bbb16d96","detail":{"divided_from":"body","block":11,"kind":"p"},"prev":"genesis","hash":"69c3cc8325763fbcb2473dc937b3afb8c8ead1a21d48f2bf78ea9ec5f9d09e37"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d11"},{"id":"d12","kind":"h","type":null,"order":12,"text":"### Preclinical (tier: preclinical)","status":"active","vx_hash":"b417ed170861466e8c75e21938ff2ba6cb120d22aba44150246932bfe12b2914","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"eb3b70a63c5d3105598a5b6741d1ce7feb8a7cd025c30bedb3e636af701510e9","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"d6d5d9c705c6c3dd2affbdc6aa5116b4b5753f2c74c9fd1a715d3dc31ffe3d8d","detail":{"divided_from":"body","block":12,"kind":"h"},"prev":"genesis","hash":"eb3b70a63c5d3105598a5b6741d1ce7feb8a7cd025c30bedb3e636af701510e9"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d12"},{"id":"d13","kind":"p","type":null,"order":13,"text":"Mouse studies (e.g., 2025 Utah research) found semaglutide reduced skeletal muscle mass less than expected from weight loss alone, but raised questions about strength under stress; muscles weakened in some loaded conditions despite preserved size in others. These do not directly translate to humans due to species differences in weight dynamics.","status":"active","vx_hash":"7be1ff3f7fa2b37266c9e11252887ce0f29ee9b1e81f5c8cff21906efba088d2","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"5c9f618cd2f3f107d740659e6633189d3a1e0fd8a0717e67ea12a6c02bc4f21b","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"0816fd9b92845287023b1b0c837611a8dab120e2ed2f5f4ba5e38e2a7bd8574b","detail":{"divided_from":"body","block":13,"kind":"p"},"prev":"genesis","hash":"5c9f618cd2f3f107d740659e6633189d3a1e0fd8a0717e67ea12a6c02bc4f21b"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d13"},{"id":"d14","kind":"h","type":null,"order":14,"text":"### Anecdotal (tier: anecdotal)","status":"active","vx_hash":"4b7a97a5475131d0fe3d206934d2c6d75e3a235665a712c6a8148461e2a569e1","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"8793a25868c6336c6ebb37ea7febc444381e95b1517a2f74b6a4f71128c71dba","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"e4c3de4c2276dbce825307545841da16142d234405dc9c8e05003c17810c9e5a","detail":{"divided_from":"body","block":14,"kind":"h"},"prev":"genesis","hash":"8793a25868c6336c6ebb37ea7febc444381e95b1517a2f74b6a4f71128c71dba"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d14"},{"id":"d15","kind":"p","type":null,"order":15,"text":"Reddit threads frequently note that any weight loss, including on semaglutide, carries some muscle loss risk, mitigated by resistance training and protein intake. Users report variable experiences: some maintain or build muscle with exercise; others describe noticeable loss confirmed by DEXA or strength declines. Posts emphasize it is not unique to the drug but tied to caloric deficit.","status":"active","vx_hash":"57300fb289c5509ac96d5029d555f1133ae6d73a2a9bae5c30e770f105c60cbf","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"8eedf2bd21c34d4690232a4e3c7a2c16ab4d70056c4c7325ce3e45b69b7a2166","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"44919265b310c712ecb7ca0893f7790c858ba96c8ebc42bc4011237b23faf37a","detail":{"divided_from":"body","block":15,"kind":"p"},"prev":"genesis","hash":"8eedf2bd21c34d4690232a4e3c7a2c16ab4d70056c4c7325ce3e45b69b7a2166"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d15"},{"id":"d16","kind":"h","type":null,"order":16,"text":"## What scientists say","status":"active","vx_hash":"f11b5ac76ca27647a41b6639792f971264e25aa8ad443760b3431930fa1d34b5","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"17b9013a6dfacaaa1eb80ab27ccfe634aaf50a92e7295f44584b2e6c468d5b78","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"2f1dd55083de1fa734f2f06a8337a050d5a0b3f635bfc8bb709abab75705a1ef","detail":{"divided_from":"body","block":16,"kind":"h"},"prev":"genesis","hash":"17b9013a6dfacaaa1eb80ab27ccfe634aaf50a92e7295f44584b2e6c468d5b78"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d16"},{"id":"d17","kind":"p","type":null,"order":17,"text":"Researchers highlight that lean loss is common in any substantial weight reduction but can exceed the typical “one-quarter fat-free mass” benchmark in GLP-1 trials. Proportionate body composition often improves (higher lean percentage). Calls for more human data on muscle strength, quality, and long-term function persist, especially in older adults or those with sarcopenic obesity. Combination strategies (resistance exercise, higher protein, or adjunct agents like bimagrumab) are explored to shift weight loss toward nearly 100% fat mass.","status":"active","vx_hash":"42df866ce9e444ad036910bfb6b6752d60fe3957275a4b16cfcce7744b53a976","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"e64e97e16cbfc64bb290ad0a08d80185ff5ef3622d0e7e66d3e54f5adb7918ba","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"8ee4c3778220150d3ed75ee3295b7108955289028db055d7db865511f5b31707","detail":{"divided_from":"body","block":17,"kind":"p"},"prev":"genesis","hash":"e64e97e16cbfc64bb290ad0a08d80185ff5ef3622d0e7e66d3e54f5adb7918ba"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d17"},{"id":"d18","kind":"h","type":null,"order":18,"text":"## What people say on Reddit","status":"active","vx_hash":"06b7d47028be1a40985f19ba23fc39c8e714e989d78340355151463bfc3c5ddf","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"11ca0dee2b4d1806f5063bf71cfc8451c7f1e7c44c8ae439bdd27f30d9cff854","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"feb303756a303788527cf602bf2c3c6b00ab8c384fb9fff4baa9ffc53e0049c3","detail":{"divided_from":"body","block":18,"kind":"h"},"prev":"genesis","hash":"11ca0dee2b4d1806f5063bf71cfc8451c7f1e7c44c8ae439bdd27f30d9cff854"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d18"},{"id":"d19","kind":"p","type":null,"order":19,"text":"Discussions center on mitigation: resistance training is repeatedly cited as key to minimizing loss. Some users share DEXA results showing 30-40% lean contribution to weight drop; others report preserved strength and muscle with consistent lifting and protein. Concerns focus on rapid loss versus gradual approaches. Threads stress individual factors like baseline muscle, age, and adherence to exercise.","status":"active","vx_hash":"0551df237d6bc0d3a6da2862577bf39c938e266406029ae9bf45f1a7ea26e85e","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"da69d1790ddf6c543250dc0d288d0c63abb112e7d3f4a8be5ed1c8561840c57b","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"dfe14332249ed4ff70fa076f4a2fe8ad5fbe47542af391c4b849c031a07da670","detail":{"divided_from":"body","block":19,"kind":"p"},"prev":"genesis","hash":"da69d1790ddf6c543250dc0d288d0c63abb112e7d3f4a8be5ed1c8561840c57b"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d19"},{"id":"d20","kind":"h","type":null,"order":20,"text":"## What people say on X","status":"active","vx_hash":"7cd35ee759918860ff88643bb62f375c2354a7e57375bc8d6e5250e1a724ec36","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"775dccf2f33c88f66f799791457303c44d964fc2dcce3f42470cbb8ea978e8da","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"4dd8bbfdb0452cc6235c2300209b5132daba3913b8f54ab179b1a73109c298dd","detail":{"divided_from":"body","block":20,"kind":"h"},"prev":"genesis","hash":"775dccf2f33c88f66f799791457303c44d964fc2dcce3f42470cbb8ea978e8da"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d20"},{"id":"d21","kind":"p","type":null,"order":21,"text":"Similar themes appear: rapid weight loss amplifies muscle concerns, countered by calls for protein targets and lifting. Anecdotes range from “lost some but function improved” to warnings about sarcopenia risk without lifestyle support. Posts often link back to trial percentages (e.g., ~40% lean loss in STEP 1).","status":"active","vx_hash":"f0802087177ad702ac04d42a182de243fa2ac804633d40a85abc88d35425334f","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"34ea4d031e47b30f8b2cc1833592b22e4715f5f9ef20e3c87380a42a9c419e77","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"020ff0989cb717d6b18f2e6c1b0a64d141d38b9786b07b3dfab6889aee105a60","detail":{"divided_from":"body","block":21,"kind":"p"},"prev":"genesis","hash":"34ea4d031e47b30f8b2cc1833592b22e4715f5f9ef20e3c87380a42a9c419e77"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d21"},{"id":"d22","kind":"h","type":null,"order":22,"text":"## What we do not know","status":"active","vx_hash":"16db44365c3d714d55673ccb5248225c478ba485d6675c2f43548c292b29e21c","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"399734004eb6ce4267879f5dc042d30b28779bd2dffa6a9e3ccfc001afe434b0","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"7d96a49fba77f6a48c0321db2ae4180a902beae62e2aac0d23408fbf8333a177","detail":{"divided_from":"body","block":22,"kind":"h"},"prev":"genesis","hash":"399734004eb6ce4267879f5dc042d30b28779bd2dffa6a9e3ccfc001afe434b0"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d22"},{"id":"d23","kind":"p","type":null,"order":23,"text":"Long-term effects (>1 year) on muscle strength, quality, and sarcopenia progression in diverse populations remain understudied. Optimal protein/exercise protocols specifically for semaglutide users lack large dedicated RCTs. Direct causation versus caloric deficit effect is not fully isolated. Impacts on muscle repair pathways versus simple mass reduction need further mechanistic human data.","status":"active","vx_hash":"f1a4ecd1feda0f3b185bc1bb6c7ea73092cbdf18722722f7dd84266cc47afff9","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"58c2f6801eb3d87810902681da05f99eb398ccaee8488b8b420d58a62097c74c","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"080e018233404bef53f0bf86f7e22844919877c66e20de884b7dbab828ef0c32","detail":{"divided_from":"body","block":23,"kind":"p"},"prev":"genesis","hash":"58c2f6801eb3d87810902681da05f99eb398ccaee8488b8b420d58a62097c74c"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d23"},{"id":"d24","kind":"h","type":null,"order":24,"text":"## Safety and limits","status":"active","vx_hash":"335e4c0d839ab2af1ee2c18f471be5bf8eb233afad72341fe210953675522171","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"62c254ba35b3423ef8d41d332893d67379d373caf1cb6ef6a908396c98ac7e28","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:47.065Z","actor":"owner","text_sha":"404f7427c043c6ec7a5cb4416bbec9ec336e19f8757fb217be5c5c2161ff8cb6","detail":{"divided_from":"body","block":24,"kind":"h"},"prev":"genesis","hash":"62c254ba35b3423ef8d41d332893d67379d373caf1cb6ef6a908396c98ac7e28"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:47.065Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/semaglutide-muscle-loss/d24"},{"id":"d25","kind":"p","type":null,"order":25,"text":"Semaglutide is associated with gastrointestinal side effects and requires medical supervision. Lean mass reductions occur alongside fat loss; monitoring body composition and function is discussed in literature when relevant. No claims are made regarding treatment of any condition. Evidence grades reflect available publications as of mid-2026; ongoing trials may refine ratios and mitigation 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article has a human side (/a/semaglutide-muscle-loss) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"semaglutide-muscle-loss\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"semaglutide-muscle-loss\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"semaglutide-muscle-loss\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"semaglutide-muscle-loss\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"semaglutide-muscle-loss\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. 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Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. 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