{"slug":"semaglutide-muscle-loss","verification":{"valid":true,"entries":5,"head":"0f0df43d3bb6ae649329fcc943783d0a94f90e473c1af6363f24d59edbe20bd7"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38629387/","title":"A systematic review of the effect of semaglutide on lean mass","quote":"Semaglutide displays potential for weight loss primarily through fat mass reduction. However, concerns arise from notable reductions ...","summary":"Systematic review summarizing lean mass effects across semaglutide trials.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:25:25.415Z","link_status":"timeout","quote_status":"unverified","prev":"genesis","hash":"592615ccd3c4475663f309753de70ae125bc5833a23501bc1e5ff13929a7309a"},{"id":"s2","type":"news","url":"https://healthcare.utah.edu/newsroom/news/2025/08/new-study-raises-questions-about-how-ozempic-affects-muscle-size-and-strength","title":"New Study Raises Questions About How Ozempic Affects Muscle Size and Strength","quote":"A study in mice on Ozempic found less muscle mass loss than expected.","summary":"Reports mouse findings on semaglutide and muscle.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:25:25.415Z","link_status":"ok","quote_status":"verified","prev":"592615ccd3c4475663f309753de70ae125bc5833a23501bc1e5ff13929a7309a","hash":"68ca34c863d6c57fc0ea99b61729d5be66352562d8679a4ffed43809a59edfb4"},{"id":"s3","type":"review","url":"https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.15728","title":"Changes in lean body mass with glucagon‐like peptide‐1 receptor agonists","quote":"In the STEP-1 trial of semaglutide, lean mass was reduced by −6.92 kg ... yielding a fraction of weight lost from lean mass of 45.2%.","summary":"Details STEP 1 and SUSTAIN-8 lean mass data.","claim_ids":["c1","c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:25:25.415Z","link_status":"timeout","quote_status":"unverified","prev":"68ca34c863d6c57fc0ea99b61729d5be66352562d8679a4ffed43809a59edfb4","hash":"00ae1eba14ad30861a8b16462296ff53c067070b3fb7c3da501e998e45b4e325"},{"id":"s15","type":"reddit","url":"https://www.reddit.com/r/Semaglutide/comments/1iqpty6/thinking_of_starting_semaglutide_but_concerned/","title":"Thinking of Starting Semaglutide, But Concerned About Muscle Loss","quote":"Sema doesn't lead to muscle loss , except in the sense that any weight loss may lead to muscle loss. I personally keep up my exercise routine.","summary":"User discussion on mitigation strategies.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:25:25.415Z","link_status":"ok","quote_status":"unverified","prev":"00ae1eba14ad30861a8b16462296ff53c067070b3fb7c3da501e998e45b4e325","hash":"2c910278c192b14d29371bd9c3c73f9b149fed3229db1933595764dd349fb0c1"},{"id":"s19","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10416191/","title":"Oral Semaglutide Induces Loss of Body Fat Mass Without Affecting Muscle Mass","quote":"Thus, although we did not directly measure muscle strength, it is likely that oral semaglutide does not induce loss of muscle strength.","summary":"Real-life study showing muscle preservation with oral semaglutide.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:25:25.415Z","link_status":"ok","quote_status":"verified","prev":"2c910278c192b14d29371bd9c3c73f9b149fed3229db1933595764dd349fb0c1","hash":"0f0df43d3bb6ae649329fcc943783d0a94f90e473c1af6363f24d59edbe20bd7"}]}