{"slug":"semaglutide-cognition","verification":{"valid":true,"entries":5,"head":"f3102ef30053e41d9a800df49613dc3e9ab46456a3d9d085edd9e15ccb1ac641"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14313","title":"Associations of semaglutide with first-time diagnosis of Alzheimer's disease in patients with type 2 diabetes","quote":"Semaglutide was associated with significantly reduced risk for first-time AD diagnosis, most strongly compared with insulin (hazard ratio [HR], 0.33 [95% CI: 0.21 to 0.51])","summary":"Target trial emulation, >1M T2D patients, 3-year follow-up.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:30:06.669Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"b7ccd1ebf1405361eb7e93d76a723100b06730910b7cca08ca6378fc09bbca0c"},{"id":"s2","type":"news","url":"https://www.alzforum.org/news/conference-coverage/semaglutide-does-not-treat-alzheimers-could-it-prevent-dementia","title":"Semaglutide Does Not Treat Alzheimer's. Could It Prevent Dementia?","quote":"Results of two Phase 3 trials evaluating semaglutide in people with AD were flat-out negative.","summary":"EVOKE/EVOKE+ topline results, 2025.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:30:06.669Z","link_status":"http_403","quote_status":"unverified","prev":"b7ccd1ebf1405361eb7e93d76a723100b06730910b7cca08ca6378fc09bbca0c","hash":"3a4f358c3d6f377df6ebc494d2f0c7d0c2170b0939bf1229726c295c87c1393c"},{"id":"s3","type":"pubmed","url":"https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00305-5/fulltext","title":"12-month neurological and psychiatric outcomes of semaglutide use for type 2 diabetes","quote":"semaglutide was associated with reduced risk for several such outcomes, notably cognitive deficit compared to sitagliptin (HR 0.72... ) and dementia compared to sitagliptin (HR 0.52...","summary":"Propensity-matched cohorts, >20k per arm.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:30:06.669Z","link_status":"http_403","quote_status":"unverified","prev":"3a4f358c3d6f377df6ebc494d2f0c7d0c2170b0939bf1229726c295c87c1393c","hash":"c30bea7b6277ef0203eb07dd698c55cbdb44c9c43729f133c570c99472e0cbb0"},{"id":"s4","type":"pubmed","url":"https://www.sciencedirect.com/science/article/pii/S0753332224014264","title":"Semaglutide ameliorates Alzheimer's disease and restores oxytocin in APP/PS1 mice","quote":"Behavioral analyses on APP/PS1 mice demonstrated that Semaglutide improved the cognitive capabilities, particularly in the learning and memory domains.","summary":"Mouse and organoid data.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:30:06.669Z","link_status":"http_403","quote_status":"unverified","prev":"c30bea7b6277ef0203eb07dd698c55cbdb44c9c43729f133c570c99472e0cbb0","hash":"6ca850b170c72f8215798155377cc51f6d344b834b6ad9446fcf5e3c27f4f064"},{"id":"s5","type":"reddit","url":"https://www.reddit.com/r/Semaglutide/comments/1djj4dd/hows_your_brain_doing/","title":"How's your brain doing?","quote":"I really notice a lack of brain fog. It's so quiet in my brain even with super low caloric intake.","summary":"User reports of cognitive changes.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:30:06.669Z","link_status":"ok","quote_status":"unverified","prev":"6ca850b170c72f8215798155377cc51f6d344b834b6ad9446fcf5e3c27f4f064","hash":"f3102ef30053e41d9a800df49613dc3e9ab46456a3d9d085edd9e15ccb1ac641"}]}