{"slug":"selank-ssri-anxiety","verification":{"valid":true,"entries":18,"head":"ab85f1126e5e05f5a2a07e09d392798d790002fcc3a2e8a825c79ec0266808d7"},"energy":{"passes":18,"tokens_in":3100,"tokens_out":323,"tokens_total":3423,"cost_usd":0,"models":{"grok/grok-4.3":1,"grok-4.3":5,"system/audit-repair":8,"kimi/moonshot-v1-8k":1,"repair":1,"fill-slots":1,"owner":1},"head":"ab85f1126e5e05f5a2a07e09d392798d790002fcc3a2e8a825c79ec0266808d7"},"provenance":[{"ts":"2026-06-29T09:19:04.470Z","model":"grok/grok-4.3","action":"write","prompt":"","input":"PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):\nBPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).\nTB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.\nARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.\nSemax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.\nSelank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).\nPT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).\nDSIP — Delta Sleep Inducing Peptide; natural deep sleep without Ambien-class hangover.\nKPV — Gut-specific anti-inflammatory; calms gut lining without systemic immune suppression.\nGHK-Cu — Tissue remodeling; builds collagen scaffolding. Production drops 60-80% with age.\nThymosin Alpha-1 — Immune modulation; supports immune function without suppressing it.\n\nWrite a data-first, evidence-graded article: Selank for Residual Anxiety on SSRIs\n\nAudience: 37M on SSRIs. The problem: anxiety persists despite SSRIs; doctors add buspirone or benzos. Why Selank maps: anxiolytic through distinct mechanism; no sedation or addiction. Novelty: 9/10.\n\nRules: label every claim tier (human|preclinical|anecdotal|mechanistic|speculative). Separate rat studies from human trials from user reports. No medical claims or treatment promises. Use repair-vs-suppression framing where relevant. register: source_ledger.","response":"{\n  \"slug\": \"selank-residual-anxiety-on-ssris\",\n  \"title\": \"Selank for Residual Anxiety on SSRIs: Evidence Review\",\n  \"body\": \"## Overview\\n\\nSelank is a synthetic heptapeptide derived from tuftsin with reported anxiolytic properties via non-benzodiazepine pathways. Human data are limited to Russian clinical studies in generalized anxiety disorder (GAD) and related conditions.\\n\\n## Human Clinical Evidence\\n\\nTwo randomized studies compared Selank to benzodiazepines in patients with anxiety disorders.\\n\\nIn one trial of 62 patients with GAD or neurasthenia, Selank produced anxiolytic effects comparable to medazepam with additional nootropic benefits and no sedation or dependence noted.\\n\\nA second study of 60 patients with phobic-anxiety and somatoform disorders found Selank had pronounced anxiolytic and mild nootropic effects lasting one week post-treatment, with positive impact on quality of life.\\n\\nNo human trials specifically examine Selank as adjunct to SSRIs for residual anxiety.\\n\\n## Preclinical and Mechanistic Data\\n\\nSelank exhibits concentration-dependent allosteric modulation of GABA receptors, distinct from classical benzodiazepine binding sites.\\n\\nAnimal models demonstrate anxiolytic activity without sedation typical of benzodiazepines; effects include gene expression changes in neurotransmission pathways.\\n\\n## Distinctions from Standard Anxiolytics\\n\\nSelank acts through peptide-mediated pathways (GABA modulation, enkephalin stabilization, cytokine effects) rather than direct receptor agonism or suppression.\\n\\nNo human data address addiction potential, withdrawal, or long-term use in combination regimens.\\n\\n## Evidence Gaps\\n\\nNo published human data exist on Selank specifically for residual anxiety symptoms in patients already taking SSRIs. All available human trials predate widespread SSRI use for anxiety and do not include SSRI co-administration arms.\",\n  \"register\": \"source_ledger\",\n  \"claims\": [\n    {\n      \"id\": \"c1\",\n      \"text\": \"In a st","tokens_in":0,"tokens_out":0,"cost":0,"prev":"genesis","hash":"2d5d0500558b38219c0a74207aa5533344cd1da13b746287360352846721c044"},{"ts":"2026-06-29T11:16:08.621Z","model":"grok-4.3","action":"sources","prompt":"","input":"selank-ssri-anxiety","response":"6 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"2d5d0500558b38219c0a74207aa5533344cd1da13b746287360352846721c044","hash":"098b6f6843b459a472ff0e544e24b2c509d82220b22ad1d9e8220df2880f3c14"},{"ts":"2026-06-29T11:16:40.698Z","model":"grok-4.3","action":"sources","prompt":"","input":"selank-ssri-anxiety","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"098b6f6843b459a472ff0e544e24b2c509d82220b22ad1d9e8220df2880f3c14","hash":"2b2e6ede855af8da3950b1fedaf17aead18b567d025aa0fa6933cab4ac7ffbfe"},{"ts":"2026-06-29T11:17:11.348Z","model":"grok-4.3","action":"sources","prompt":"","input":"selank-ssri-anxiety","response":"1 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"2b2e6ede855af8da3950b1fedaf17aead18b567d025aa0fa6933cab4ac7ffbfe","hash":"acaf49909d0e9191682411d7ae6d04a9d4aa83e5748b0a7808572b74fd7534b6"},{"ts":"2026-06-29T11:18:10.403Z","model":"grok-4.3","action":"sources","prompt":"","input":"selank-ssri-anxiety","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"acaf49909d0e9191682411d7ae6d04a9d4aa83e5748b0a7808572b74fd7534b6","hash":"cb8e01ee5aa307f3f41b2dda0c8cec9605348535faaffb6b3b7a7dfeac7785c9"},{"ts":"2026-06-29T11:18:37.040Z","model":"grok-4.3","action":"sources","prompt":"","input":"selank-ssri-anxiety","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"cb8e01ee5aa307f3f41b2dda0c8cec9605348535faaffb6b3b7a7dfeac7785c9","hash":"956de42b7ede86ce959e32b0b0319e1b8f86ea9292f584f83ac13134274b6bd4"},{"ts":"2026-06-29T12:49:15.566Z","model":"system/audit-repair","action":"repair","prompt":"","input":"selank-ssri-anxiety","response":"{\"materialized\":0,\"before\":[\"missing constitution slots: what_it_is, what_is_known, limitations, disclaimer\"],\"after\":[\"missing constitution slots: what_it_is, what_is_known, limitations, disclaimer\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"956de42b7ede86ce959e32b0b0319e1b8f86ea9292f584f83ac13134274b6bd4","hash":"8d4af3191d034913dda629afbcbb48510d3818a87ad038c6282974da783a403e"},{"ts":"2026-06-29T12:49:16.160Z","model":"system/audit-repair","action":"claim","prompt":"","input":"selank-ssri-anxiety c25","response":"Selank for Residual Anxiety on SSRIs: Evidence Review is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"8d4af3191d034913dda629afbcbb48510d3818a87ad038c6282974da783a403e","hash":"8258ecad775d61f6d72953512fdfe5aae63a0e66124586b0ac78fcc1ee8f72d3"},{"ts":"2026-06-29T12:49:16.209Z","model":"system/audit-repair","action":"claim","prompt":"","input":"selank-ssri-anxiety c26","response":"Per this ledger on Selank for Residual Anxiety on SSRIs: Evidence Review: 14 scientific and 8 anecdotal sources are catalogued; 6 preclinical claim(s) summarize animal/cell literature in-catalogue.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"8258ecad775d61f6d72953512fdfe5aae63a0e66124586b0ac78fcc1ee8f72d3","hash":"a5c8810ec62f565648f695f4c0c9e785cf151eb07abc61e1d77ffae94a04ba28"},{"ts":"2026-06-29T12:49:16.309Z","model":"system/audit-repair","action":"claim","prompt":"","input":"selank-ssri-anxiety c27","response":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"a5c8810ec62f565648f695f4c0c9e785cf151eb07abc61e1d77ffae94a04ba28","hash":"d7584e4dd1bff8147c420969b5d2370613e6871f14a70853e281d4a3d51a82eb"},{"ts":"2026-06-29T12:49:16.417Z","model":"system/audit-repair","action":"claim","prompt":"","input":"selank-ssri-anxiety c28","response":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"d7584e4dd1bff8147c420969b5d2370613e6871f14a70853e281d4a3d51a82eb","hash":"54312b9c707b392a3d55e4dc152e54d31b0232a6318f850a84fcfdb37c6aece3"},{"ts":"2026-06-29T12:49:17.139Z","model":"system/audit-repair","action":"repair","prompt":"","input":"selank-ssri-anxiety","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"54312b9c707b392a3d55e4dc152e54d31b0232a6318f850a84fcfdb37c6aece3","hash":"d93bf4266d506f37cb6427e5bd6f00b718860a45a2feae6c10c6be597c003179"},{"ts":"2026-06-29T13:23:14.883Z","model":"system/audit-repair","action":"repair","prompt":"","input":"selank-ssri-anxiety","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"d93bf4266d506f37cb6427e5bd6f00b718860a45a2feae6c10c6be597c003179","hash":"8d1dcf72578a5fd079b27c7d62b9818bd2b86193a5ece6a9040c0bf1b63aec50"},{"ts":"2026-06-29T13:23:16.171Z","model":"system/audit-repair","action":"repair","prompt":"","input":"selank-ssri-anxiety","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"8d1dcf72578a5fd079b27c7d62b9818bd2b86193a5ece6a9040c0bf1b63aec50","hash":"35134e65e0761ca654b2176e17919fb4ef19514bee29cd866a8aec2a4d790165"},{"ts":"2026-06-29T14:02:47.596Z","model":"kimi/moonshot-v1-8k","action":"collaborate","prompt":"","input":"selank-ssri-anxiety","response":"I added explicit gaps in knowledge regarding the combination of Selank with SSRIs for residual anxiety, as well as named who claims what from anecdotes which were missing from the ledger. I am not Grok because I am adding claims that are tier-honest and filling in gaps as per the instructions, rather than inventing new claims or sources.","tokens_in":3100,"tokens_out":323,"cost":0,"prev":"35134e65e0761ca654b2176e17919fb4ef19514bee29cd866a8aec2a4d790165","hash":"80ef7d1000f14a2583310fc5d59667303b6eaf565a1dab904506fd3eb9463bc7"},{"ts":"2026-06-29T20:02:05.608Z","model":"repair","action":"repair","prompt":"","input":"selank-ssri-anxiety","response":"{\"materialized\":0,\"before\":[],\"after\":[],\"focus_stats\":{\"roles_assigned\":0,\"excluded_sources\":0,\"commercial_sources\":0,\"cut_claims\":0,\"core\":14,\"cycle\":0,\"adjacent\":0}}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"80ef7d1000f14a2583310fc5d59667303b6eaf565a1dab904506fd3eb9463bc7","hash":"8e6973bbdaa4cb2d268ece625b569ff1276614f95ae8aa55bb401b119f0eeef7"},{"ts":"2026-06-29T21:13:04.382Z","model":"fill-slots","action":"claim","prompt":"","input":"selank-ssri-anxiety c30","response":"Selank for Residual Anxiety on SSRIs: Evidence Review is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"8e6973bbdaa4cb2d268ece625b569ff1276614f95ae8aa55bb401b119f0eeef7","hash":"f4224d42d975559416c32abf44b466e29f2b2f4412dfc00b9473a6cfaff90988"},{"ts":"2026-07-17T02:41:41.405Z","model":"owner","action":"voxel_divide","prompt":"","input":"selank-ssri-anxiety","response":"18 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"f4224d42d975559416c32abf44b466e29f2b2f4412dfc00b9473a6cfaff90988","hash":"ab85f1126e5e05f5a2a07e09d392798d790002fcc3a2e8a825c79ec0266808d7"}]}