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If selank reaches the affected tissue, it may shift the repair/breakdown balance.\n4. This chain is tested in animal or lab models only.","status":"active","vx_hash":"66808b22f4d57a85df2e88dfe2041a5044cfb79961b4a1f8700c13d867c9a732","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"2ad069a2304936dfeeb7923ebfc53c1be64d42b147f537f2be01c16fc263520b","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:35.052Z","actor":"owner","text_sha":"df1c286ecd84bf251e98c68b3566e716e3a90aff73158444f1ae63073698266a","detail":{"divided_from":"body","block":7,"kind":"list"},"prev":"genesis","hash":"2ad069a2304936dfeeb7923ebfc53c1be64d42b147f537f2be01c16fc263520b"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:35.052Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/selank-benzodiazepines/d7"},{"id":"d8","kind":"h","type":null,"order":8,"text":"## Parent peptide claims relevant here","status":"active","vx_hash":"0a253882ad3bccd709561cf52a4d87ab6e4f46d3a2c18745993eed12520b18fc","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"2f58d9edc59ce137551749cd7845287a6808c92e4cc88e32edd72630f7052dfb","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:35.052Z","actor":"owner","text_sha":"31f07cb7210696cc23da853195a93b5e1d4273330076b2b586a8588e5adda044","detail":{"divided_from":"body","block":8,"kind":"h"},"prev":"genesis","hash":"2f58d9edc59ce137551749cd7845287a6808c92e4cc88e32edd72630f7052dfb"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:35.052Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/selank-benzodiazepines/d8"},{"id":"d9","kind":"list","type":null,"order":9,"text":"- In a 2008 randomized study of 62 patients with GAD and neurasthenia, Selank showed anxiolytic efficacy comparable to medazepam on psychometric scales without reported sedation, cognitive impairment, tolerance or withdrawal.\n- Selank administration in rats alters expression of 45 neurotransmission-related genes at 1 hour and 22 genes at 3 hours, with positive correlation to GABA effects.\n- Commercial vendors and clinics market this compound (7 commercial/clinic sources catalogued) — marketing material, not evidence.\n- 2017 study showing Selank's anxiolytic effects comparable to benzodiazepines in rat stress model.\n- 2019 rat study on Selank protecting against alcohol-related memory issues via BDNF regulation.","status":"active","vx_hash":"83d20ad43d188593b6d1601411bb29f916b6ebccf742495f303bf884976aeeff","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"c798f5f0bf23b54049adadf0a8a02588ba2541362fe5bed47189dab6e82430d6","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:35.052Z","actor":"owner","text_sha":"6b6e56b3a7d609c6ae6250a03bd95881d1f2a9c29b26e6a8f98b0c11fb45f8d9","detail":{"divided_from":"body","block":9,"kind":"list"},"prev":"genesis","hash":"c798f5f0bf23b54049adadf0a8a02588ba2541362fe5bed47189dab6e82430d6"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:35.052Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/selank-benzodiazepines/d9"},{"id":"d10","kind":"h","type":null,"order":10,"text":"## Evidence tier","status":"active","vx_hash":"1527bc25a087abb8a54c5ae6f236a30d9e4cdbb68e230f22750fe5d8fb51ab3e","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"84537bd36783d37a77697d6d9f45243a3a7efaf85c964be640b66bf1dcfeb03a","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:35.052Z","actor":"owner","text_sha":"46cc49f2994c7c079bced82c0ea602796fbaef6304b6684feab577ecaa26d835","detail":{"divided_from":"body","block":10,"kind":"h"},"prev":"genesis","hash":"84537bd36783d37a77697d6d9f45243a3a7efaf85c964be640b66bf1dcfeb03a"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:35.052Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/selank-benzodiazepines/d10"},{"id":"d11","kind":"p","type":null,"order":11,"text":"Preclinical — animal and in vitro studies only. No published human trials for this specific combination.","status":"active","vx_hash":"bc651555a23884488fbbd5d7712926c7a149f6fa03b7c2eeca316acde67f979d","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"c667ba984374782cc075e5d3f39bbc30c496ef2f2a79eafcc24843ac73708437","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:35.052Z","actor":"owner","text_sha":"916881a294f6c5d2b0a647fa0e2e94a6dc933afe9a84d40c97ea5476dee420db","detail":{"divided_from":"body","block":11,"kind":"p"},"prev":"genesis","hash":"c667ba984374782cc075e5d3f39bbc30c496ef2f2a79eafcc24843ac73708437"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:35.052Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/selank-benzodiazepines/d11"},{"id":"d12","kind":"h","type":null,"order":12,"text":"## What we do not know","status":"active","vx_hash":"b246d9c0f2a9dde7901b2b6eddeacc0cc8695e4ce3ea5cbb1f561864c41183bb","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"0a9c3bcadbb5e867d1a5a8211184181cfe8cfcbac28525a584fe864a6e06a616","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:35.052Z","actor":"owner","text_sha":"7d96a49fba77f6a48c0321db2ae4180a902beae62e2aac0d23408fbf8333a177","detail":{"divided_from":"body","block":12,"kind":"h"},"prev":"genesis","hash":"0a9c3bcadbb5e867d1a5a8211184181cfe8cfcbac28525a584fe864a6e06a616"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:35.052Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/selank-benzodiazepines/d12"},{"id":"d13","kind":"list","type":null,"order":13,"text":"- Whether selank reaches benzodiazepines tissue at functional concentrations\n- Optimal dosing, route, and duration for this target\n- Interaction with standard-of-care treatments for benzodiazepines\n- Long-term safety profile in this population","status":"active","vx_hash":"11dba25c06dab6e5a628997a9f2974aea6d880e68b48269a609264d89e6863bd","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"e18136e9137c2fb0d6598a6f331efc7ef7112cb4d3ca7c6370317c186285835d","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:35.052Z","actor":"owner","text_sha":"89a3220d45bd0a0c3401dcb9f39e4e2c47385c9ba0264ed428cb62c41d55d459","detail":{"divided_from":"body","block":13,"kind":"list"},"prev":"genesis","hash":"e18136e9137c2fb0d6598a6f331efc7ef7112cb4d3ca7c6370317c186285835d"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:35.052Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/selank-benzodiazepines/d13"},{"id":"d14","kind":"h","type":null,"order":14,"text":"## Safety note","status":"active","vx_hash":"f0b21e1e371b195f6bdf69c372041c9325d0d5e9e5f29f993ef6ee901400e254","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"67b03969d562328cde128a088d94bcf84644e7bf74c3638052f5a8c81e6f5c9a","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:35.052Z","actor":"owner","text_sha":"e791137ec00c238a3c7c08a992f9f346c2913bba0bdf54937b831a8b4870b043","detail":{"divided_from":"body","block":14,"kind":"h"},"prev":"genesis","hash":"67b03969d562328cde128a088d94bcf84644e7bf74c3638052f5a8c81e6f5c9a"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:35.052Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/selank-benzodiazepines/d14"},{"id":"d15","kind":"p","type":null,"order":15,"text":"All peptide use for benzodiazepines is research-context only. Not medical advice. Consult a physician before any experimental compound.","status":"active","vx_hash":"de9c1abcb164c0f1e1a6fd3cc14b6b293692d74baf2e656b229f5a992f13ec1f","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"ec51ec5f2c56d68e5d17fd5b131fc9ca90d3df9f14cc7e6219cf7eb23e039551","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:35.052Z","actor":"owner","text_sha":"a874aca19f961ebdaa19f317ba5dc99e04df41203a06884d64ff3265e05ddbf7","detail":{"divided_from":"body","block":15,"kind":"p"},"prev":"genesis","hash":"ec51ec5f2c56d68e5d17fd5b131fc9ca90d3df9f14cc7e6219cf7eb23e039551"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:35.052Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/selank-benzodiazepines/d15"}],"voxels":[{"id":"c1","div_id":"claim:c1","kind":"claim","text":"2025/2026 animal study (BALB/c mice) demonstrating that Selank combined with benzodiazepines (diazepam, mezapam) improves anxiolytic efficacy in elevated plus maze while reducing sedative/myorelaxant side effects; also mitigates locomotor decline with diazepam/olanzapine.","tier":"speculative","standing":null,"weight":0.12,"section":"what_is_known","status":"active","source_ids":["s1"],"source_status":"sourced","posted_by":{"actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:54:57.358Z","model":"grok/grok-4.3","rationale":""},"who_claims":"grok-4.3","edges":[{"type":"supported_by","target":"s1","source_type":"medical","hash":"dbea01caa43a3af2"},{"type":"posted_by","actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:54:57.358Z"}],"why_material":"Materialized from orphan source s1 by ledger repair","content_hash":null,"stable_url":"https://miscsubjects.com/i/claim/selank-benzodiazepines/c1","machine_url":"https://miscsubjects.com/api/articles/selank-benzodiazepines/claims/c1"},{"id":"c_map_selank-benzodiazepines","div_id":"claim:c_map_selank-benzodiazepines","kind":"claim","text":"Combinatorial mapping (transparent): selank vs benzodiazepines — regen=0.59, degen=0.68, Δ=-0.09. Method: layer_relevance(0.60) × evidence_factor(0.85); catalog.degen_score for Benzodiazepines.","tier":"system","standing":null,"weight":0.35,"section":"what_is_known","status":"active","source_ids":[],"posted_by":null,"who_claims":null,"edges":[],"content_hash":null,"stable_url":"https://miscsubjects.com/i/claim/selank-benzodiazepines/c_map_selank-benzodiazepines","machine_url":"https://miscsubjects.com/api/articles/selank-benzodiazepines/claims/c_map_selank-benzodiazepines"}],"sources":[{"id":"s1","type":"medical","url":"https://link.springer.com/article/10.1134/S1819712425700783","title":"Combined Action of Benzodiazepine Tranquilizers and Peptide Anxiolytic Selank in BALB/с Mice","quote":"Thus, it has been shown in animal experiments that selank enhances the anxiolytic effect and decreases the sedative and myorelaxant action of benzodiazepine tranquilizers.","summary":"2025/2026 animal study (BALB/c mice) demonstrating that Selank combined with benzodiazepines (diazepam, mezapam) improves anxiolytic efficacy in elevated plus maze while reducing sedative/myorelaxant side effects; also mitigates locomotor decline with diazepam/olanzapine.","claim_ids":["c1"],"found_by":"grok-4.3","hash":"dbea01caa43a3af29ea896d8c76df118c060d2e64c5be42bc18dba73037523fb","prev":"genesis"}],"edges":[{"from":"c1","type":"supported_by","target":"s1","source_type":"medical","hash":"dbea01caa43a3af2"},{"from":"c1","type":"posted_by","actor":"grok/grok-4.3","channel":"populate-repair","ts":"2026-06-29T17:54:57.358Z"}],"counts":{"divs":15,"voxels":2,"sources":1,"edges":2},"verification":{"div_mode":true,"divs":15,"all_chains_valid":true,"body_matches_divs":true,"per_div":[{"id":"d1","order":1,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d2","order":2,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d3","order":3,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d4","order":4,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d5","order":5,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d6","order":6,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d7","order":7,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d8","order":8,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d9","order":9,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d10","order":10,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d11","order":11,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d12","order":12,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d13","order":13,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d14","order":14,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d15","order":15,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]}]},"procedure":{"what":"Every article has a human side (/a/selank-benzodiazepines) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"selank-benzodiazepines\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"selank-benzodiazepines\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"selank-benzodiazepines\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"selank-benzodiazepines\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"selank-benzodiazepines\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"selank-benzodiazepines\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/selank-benzodiazepines/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/selank-benzodiazepines/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/selank-benzodiazepines#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."},"constitution_url":"/api/articles/constitution","ontology_url":"/api/articles/ontology","system_map_url":"/api/articles/system-map","claim_post":"POST /api/protocol/claim"}