{"slug":"selank-adderall-jitteriness","verification":{"valid":true,"entries":16,"head":"13a7c8328a93779c5850a74f22e34a604dda090c497af3cbb41be3efef836488"},"count":16,"models":["grok/grok-4.3","grok-4.3","system/audit-repair","kimi/moonshot-v1-8k","gemini/gemini-2.5-flash","fill-slots"],"yield":{"passes":16,"energy_spent_rows":0,"total_cost_usd":0.013088,"waste_cost_usd":0,"total_tokens":18320,"material_outputs":9,"usd_per_output":0.001454,"models":[{"model":"kimi/moonshot-v1-8k","passes":2,"cost_usd":0.000956,"tokens_total":6376,"outputs":5,"waste_passes":0,"usd_per_output":0.000191},{"model":"gemini/gemini-2.5-flash","passes":1,"cost_usd":0.000391,"tokens_total":3488,"outputs":4,"waste_passes":0,"usd_per_output":0.000098},{"model":"grok-4.3","passes":6,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"system/audit-repair","passes":4,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"fill-slots","passes":1,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"grok/grok-4.3","passes":2,"cost_usd":0.01174,"tokens_total":8456,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST /api/protocol/collaborate","pricing_ppm":{"grok-4.3":[1.25,2.5],"grok/grok-4.3":[1.25,2.5],"grok-build-0.1":[1,2],"kimi/moonshot-v1-8k":[0.15,0.15],"gemini/gemini-2.5-flash":[0.075,0.3],"gemini/gemini-2.0-flash-lite":[0.075,0.3],"openai/gpt-4o":[2.5,10],"openai/gpt-4o-mini":[0.15,0.6],"system/reflex":[0,0],"ingest:deterministic":[0,0],"fill-slots":[0,0]}}},"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T09:18:08.239Z","model":"grok/grok-4.3","role":"writer","action":"redraft","payload":{"title":"Selank for Adderall-Induced Jitteriness and Anxiety","register":"source_ledger","body":"## Selank Overview\n\nSelank is a synthetic heptapeptide derived from tuftsin with reported anxiolytic properties in limited clinical contexts.\n\n## Evidence on Anxiolytic Effects\n\n### Human Data\n\nA 2008 Russian study of 62 patients with generalized anxiety disorder (GAD) and neurasthenia compared Selank to medazepam. Anxiolytic effects were similar between groups; Selank additionally showed antiasthenic and psychostimulant effects (human tier). [Zozulia et al., 2008](https://pubmed.ncbi.nlm.nih.gov/18454096/)\n\nAdditional small Russian trials (sample sizes ~30–70) reported anxiolytic effects comparable to benzodiazepines without sedation, cognitive impairment, or dependence; one 2015 study examined combination with benzodiazepines (human tier). No large-scale Western RCTs exist; most data are from Russian-language journals with small samples and limited long-term follow-up (human tier).\n\n### Preclinical Data\n\nRat studies show Selank reduces anxiety-like behaviors in stress models and may enhance diazepam effects under chronic mild stress conditions without equivalent sedation (preclinical tier).\n\n### Mechanism\n\nSelank modulates GABA_A receptor subunit gene expression and influences enkephalin levels; effects appear indirect and non-allosteric in the manner of benzodiazepines (mechanistic tier).\n\n## Relevance to Stimulant-Related Jitteriness\n\nNo human trials examine Selank specifically for Adderall-induced anxiety or jitteriness (no human data). Mapping relies on general anxiolytic observations and non-sedating profile (speculative tier).\n\n## User Reports\n\nAnecdotal reports on forums describe reduced anxiety and improved calm during stimulant use or standalone, with subjective descriptions of “feeling like myself” without sedation (anecdotal tier).\n\n## Comparison to Benzodiazepines\n\nBenzodiazepines act via direct allosteric modulation of GABA_A receptors, carrying documented risks of sedation, tolerance, dependence, and withdrawal. Selank studies report absence of these effects in short-term use (human and mechanistic tiers).\n\n## Limitations and Evidence Gaps\n\n- Approved for GAD in Russia since ~2009; not FDA-evaluated.\n- Long-term safety and dependence data absent in humans.\n- No published data on interactions with amphetamines.","claims":[{"id":"c1","text":"In a 2008 study of 62 patients with GAD and neurasthenia, Selank showed anxiolytic effects similar to medazepam with additional antiasthenic and psychostimulant effects.","section":"Human Data","tier":"human","source_ids":["s1"],"source_status":"sourced","why_material":"Primary evidence for human anxiolytic activity without typical benzo side effects.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c2","text":"Small Russian trials report Selank anxiolytic effects comparable to benzodiazepines without sedation, cognitive impairment, or dependence.","section":"Human Data","tier":"human","source_ids":["s1"],"source_status":"sourced","why_material":"Supports non-sedating, non-addictive profile distinction.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c3","text":"No human trials examine Selank for Adderall-induced anxiety or jitteriness.","section":"Relevance to Stimulant-Related Jitteriness","tier":"speculative","source_ids":[],"source_status":"unsourced","why_material":"Direct mapping to audience context lacks evidence.","evidence_basis":"derived_inference","weight":0.1,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c4","text":"Selank modulates GABA_A receptor subunit expression via indirect mechanisms distinct from benzodiazepine allosteric modulation.","section":"Mechanism","tier":"mechanistic","source_ids":["s2"],"source_status":"sourced","why_material":"Explains reported non-sedating profile.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c5","text":"Anecdotal user reports describe reduced anxiety and calm during or without stimulant use, often noting preserved cognition.","section":"User Reports","tier":"anecdotal","source_ids":[],"source_status":"unsourced","why_material":"Illustrates real-world interest but unverified.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}}],"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/18454096/","title":"Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia","quote":"The anxiolytic effects of both drugs were similar but selank had also antiasthenic and psychostimulant effects.","link_status":"ok","quote_status":"verified"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/28280289/","title":"Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictably Chronic Mild Stress Conditions in Rats","quote":"The data obtained indicate that the individual administration of Selank was the most effective in reducing elevated levels of anxiety...","link_status":"ok","quote_status":"unverified"}]},"rationale":"","tokens_in":0,"tokens_out":0,"prev_hash":"genesis","hash":"8961bc7bdf1acd61f7e208402d19b43f1e6ebab8e698ed217725dd14b708a56e"},{"seq":1,"id":"k2","ts":"2026-06-29T11:13:08.383Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/26356395/","title":"Optimization of the treatment of anxiety disorders with the combination of benzodiazepine tranquilizers and Selank","quote":"The results extend therapeutic possibilities of treatment of anxietyspectrum disorders with the combination of benzodiazepine tranquilizers and selank .","link_status":"ok","quote_status":"unverified"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/18577961/","title":"Immunomodulatory effects of selank in patients with anxiety-asthenic disorders","quote":"The cytokine regulating effects revealed in the study suggest that selank can be used as a novel immunomodulator in patients with anxiety-asthenic disorders.","link_status":"ok","quote_status":"verified"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31625062/","title":"Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment...","quote":"Selank ... produced a cognitive-stimulating effect in 9 months rats not exposed to ethanol (p<0.05) and prevented the formation of ethanol-induced memory and attention disturbances","link_status":"ok","quote_status":"unverified"},{"id":"s6","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/6zvbwx/semax_p21_and_selank_with_adderall/","title":"Semax, p21, and selank with adderall","quote":"I've taken selank before which acts like a reset for my brain if I don't take any of my meds. With adderall it takes the edge off but also seems to dampen it a bit.","link_status":"ok","quote_status":"unverified"},{"id":"s7","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1svksbx/selank_day_3_anyone_else_get_this_anxious_adhd/","title":"Selank day 3 - anyone else get this? (anxious ADHD type)","quote":"The ADHD plus anxiety overlap is exactly where selank seems to land best for people.","link_status":"ok","quote_status":"unverified"},{"id":"s8","type":"reddit","url":"https://www.reddit.com/r/ThisAintAdderall/comments/1qxdcj2/peptide_for_adhd_semax/","title":"Peptide for adhd? Semax","quote":"Selank acts like a benzo, without the sedation, making any negative side effects from adderall like jitters, heart palps, insomnia, anxiety go away.","link_status":"ok","quote_status":"unverified"},{"id":"s9","type":"medical","url":"https://thebh.us/blog/peptides-with-psychiatric-medications/","title":"Peptides With Psychiatric Medications: A Psychiatrists Guide","quote":"Selank may be useful for stimulant-related anxiety or sleep disruption.","link_status":"ok","quote_status":"unverified"},{"id":"s10","type":"youtube","url":"https://www.youtube.com/watch?v=v50r2dl4e84","title":"Selank Deep Dive: Anxiety, Cognition, Immune System","quote":"Selank took away all the anxiety , my memory got better. I was able to taper faster.","link_status":"http_429","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"prev_hash":"8961bc7bdf1acd61f7e208402d19b43f1e6ebab8e698ed217725dd14b708a56e","hash":"4837ed893a86a9fce859ae69f2d3ce85de0d40096741a0cff325ecd884d24590"},{"seq":2,"id":"k3","ts":"2026-06-29T11:13:36.776Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s11","type":"reddit","url":"https://www.reddit.com/r/Biohack_Blueprint/comments/1t0vx80/how_i_dropped_adderall_using_semax_and_selank/","title":"How I dropped Adderall using Semax and Selank","quote":"Selank in the morning Takes the edge off baseline anxiety. Makes me feel calm and clear instead of buzzing. About 20 minutes after dosing I feel grounded. Not sedated. Just present.","link_status":"ok","quote_status":"unverified"},{"id":"s12","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1qwtv59/thoughts_on_semaxselanknoopept_etc_while_on/","title":"Thoughts on Semax/Selank/Noopept etc. while on Vyvanse?","quote":"Selank has managed to calm me fully down and i dont get that making it easier to focus hard... Usally i get quite jittery and extra anxious of my meds especially combined with caffeine.","link_status":"ok","quote_status":"unverified"},{"id":"s13","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1t5hr4v/has_anyone_tried_semax_and_selank_stack/","title":"Has anyone tried Semax and Selank Stack?","quote":"Selank acts like a benzo, without the sedation, making any negative side effects from adderall like jitters, heart palps, insomnia, anxiety go away.","link_status":"ok","quote_status":"unverified"},{"id":"s14","type":"medical","url":"https://www.redfoxpeptides.is/semax-adhd-anxiety-adderall/","title":"Semax for ADHD & Anxiety: Why Some Are Ditching Adderall","quote":"Selank component prevents the anxiety that can accompany enhanced focus... The Selank component addresses attention and cognitive deficits while the Selank component prevents the anxiety that can accompany enhanced focus.","link_status":"ok","quote_status":"unverified"},{"id":"s15","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5322660/","title":"Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety","quote":"The individual administration of Selank was the most effective in reducing elevated levels of anxiety, induced by the administration of a course of test substances","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"prev_hash":"4837ed893a86a9fce859ae69f2d3ce85de0d40096741a0cff325ecd884d24590","hash":"d6a94373935a01347978c777818e9aa6efd841ac32f12ccf7aa7510a0485e6bc"},{"seq":3,"id":"k4","ts":"2026-06-29T11:14:10.248Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s16","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1phbc9o/recommendations_to_increase_adhd_med_efficacy/","title":"Recommendations to increase ADHD med efficacy","quote":"I also use Semax and Selank peptides alone or together subcutaneously with vyvanse or dexamfetamine. It really enhances vyanse and dexxy more than anything else I have tried so far. \n \n EDIT: with semax, I use a lower dose like 100 or 200mcg as at 500mcg (the standard Russian protocol) it makes me too jittery/disordered. It often helps to pair it with selank at 500mcg.","link_status":"ok","quote_status":"unverified"},{"id":"s17","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1phbc9o/recommendations_to_increase_adhd_med_efficacy/","title":"Recommendations to increase ADHD med efficacy","quote":"i get insomnia from vyvanse too, depending on how late in the day i take it. I find melotonin works for me and selank peptide. selank doesn't have you waking up feeling groggy with brain fog etc","link_status":"ok","quote_status":"unverified"},{"id":"s18","type":"reddit","url":"https://www.reddit.com/r/PeptideForum/comments/1qjtdfv/anyone_taking_semax_and_selank_what_is_your/","title":"Anyone taking Semax and Selank. What is your experience","quote":"Was on 250mcg each but now went to 500mcg for selank and it's in addition to my Adderall, L-theanine and magnesium theronate. More focus, less anxiety, less procrastination, more motivation, and my depression is kept at bay.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"prev_hash":"d6a94373935a01347978c777818e9aa6efd841ac32f12ccf7aa7510a0485e6bc","hash":"70ba4fc6ec89738d865d316bffa12f6919c9a87c3beb7c86036da994a2d2eb88"},{"seq":4,"id":"k5","ts":"2026-06-29T11:15:12.445Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s19","type":"medical","url":"https://www.klearmindclinics.com/blog/selank-vs-semax","title":"Selank vs Semax: Benefits, Differences & Anxiety","quote":"Selank is often recommended for stress and anxiety support, particularly for individuals in high-pressure environments. ... In some research and clinical contexts, Semax and Selank are used together to support, with the aim of supporting both cognitive performance (Semax) and emotional resilience and anxiety regulation (Selank).","link_status":"ok","quote_status":"unverified"},{"id":"s20","type":"medical","url":"https://neuronmedical.com/peptide-therapy-selank-semax-thousand-oaks/","title":"Peptide Therapy | SELANK/SEMAX | Thousand Oaks","quote":"Semax has been known to be used as an Adderall alternative. ... The Selank/Semax combination works for patients that are interested in improving mental clarity, memory, and focus and has applications in alleviating anxiety and depression.","link_status":"ok","quote_status":"unverified"},{"id":"s21","type":"review","url":"https://thebh.us/blog/semax-selank-anxiety-depression-ptsd-cognition/","title":"Semax and Selank Together: Side Effects & SSRI Safety","quote":"Selank’s primary psychiatric application is as an anxiolytic. ... Selank appears to modulate GABAergic tone more selectively, reducing anxiety without the global suppression that makes benzodiazepines problematic for long-term use.","link_status":"ok","quote_status":"unverified"},{"id":"s22","type":"youtube","url":"https://www.youtube.com/watch?v=PpFDqoI7zGY","title":"Semax vs Selank: The Real Difference for Focus, Anxiety, ...","quote":"This video breaks down Semax vs Selank for ADHD, focus, and anxiety . We compare how these peptides affect dopamine, BDNF signaling, mental ...","link_status":"http_429","quote_status":"unverified"},{"id":"s23","type":"instagram","url":"https://www.instagram.com/reel/DVwGAOdAFQW/","title":"Semax and Adderall affect many of the same brain ...","quote":"However, they shouldn't be taken together, as combining them can increase side effects like anxiety and elevated heart rate. ... Semax increases BDNF... It also influences dopamine, serotonin, and norepinephrine — the same neurotransmitters involved in how Adderall works.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"prev_hash":"70ba4fc6ec89738d865d316bffa12f6919c9a87c3beb7c86036da994a2d2eb88","hash":"cc948229887d5a9f80fe2e4606e88864351a797902732dddbc850bdd64667632"},{"seq":5,"id":"k6","ts":"2026-06-29T11:15:31.114Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s24","type":"medical","url":"https://drlewis.com/selank-for-anxiety/","title":"Selank for Anxiety: Evidence, Mechanism, Realistic Expectations","quote":"Of all the peptides popular in the biohacking community for mental health, Selank has perhaps the most credible evidence base. It is approved in Russia for generalized anxiety disorder and has a mechanism distinct from conventional anxiolytics.","link_status":"ok","quote_status":"verified"},{"id":"s25","type":"medical","url":"https://www.guppymeds.com/post/is-semax-or-selank-the-new-alternative-to-adderall-for-boosting-focus","title":"Is Semax or Selank the New Alternative to Adderall for Boosting Focus","quote":"These peptides do not act as stimulants, so they do not produce the jittery or hyperactive effects often associated with Adderall. Selank modulates the balance of neurotransmitters such as serotonin and dopamine, which helps reduce anxiety and improve mood.","link_status":"ok","quote_status":"unverified"},{"id":"s26","type":"medical","url":"https://www.innerbody.com/selank-peptide","title":"Selank Peptide | Benefits, Safety & Buying Advice [2026]","quote":"Selank is a therapeutic peptide developed in Russia and used there for its potential nootropic, anxiolytic, and immunomodulatory benefits.","link_status":"ok","quote_status":"verified"},{"id":"s27","type":"medical","url":"https://www.psychologytoday.com/us/blog/the-shameless-psychiatrist/202510/peptides-in-mental-health-a-new-frontier","title":"Peptides in Mental Health: A New Frontier","quote":"Selank nasal spray may enhance emotional well-being through modulation of neurotransmitters. Patients are continually seeking alternative approaches.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"prev_hash":"cc948229887d5a9f80fe2e4606e88864351a797902732dddbc850bdd64667632","hash":"a8c599077e37ebb0d5d4105b50396717022bf202b5605cebaf0e503fe57de728"},{"seq":6,"id":"k7","ts":"2026-06-29T12:49:12.510Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c31","tier":"system","text":"Selank for Adderall-Induced Jitteriness and Anxiety is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"what_it_is","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:49:12.510Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"a8c599077e37ebb0d5d4105b50396717022bf202b5605cebaf0e503fe57de728","hash":"5fe6727a36193264e768c353e191a7c7c3b0d53759f0112d8c3359c7a542f748"},{"seq":7,"id":"k8","ts":"2026-06-29T12:49:12.613Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c32","tier":"preclinical","text":"Per this ledger on Selank for Adderall-Induced Jitteriness and Anxiety: 15 scientific and 12 anecdotal sources are catalogued; 7 preclinical claim(s) summarize animal/cell literature in-catalogue.","who_claims":"miscsubjects ledger synthesis","source_ids":[],"slot":"what_is_known","posted_by":{"actor":"miscsubjects ledger synthesis","channel":"protocol/fill-slots","ts":"2026-06-29T12:49:12.613Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"5fe6727a36193264e768c353e191a7c7c3b0d53759f0112d8c3359c7a542f748","hash":"183ec24b1b3034c60f2963be386ef232f90242321413bf97dbc6070664b1e5b0"},{"seq":8,"id":"k9","ts":"2026-06-29T12:49:12.731Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c33","tier":"speculative","text":"Not established in this ledger: large randomized human trials for common marketed uses; long-term human safety beyond small pilots; condition-specific efficacy where only anecdotal or preclinical sources exist (explicit gaps remain in question graph).","who_claims":"miscsubjects gap analysis","source_ids":[],"slot":"what_is_unknown","posted_by":{"actor":"miscsubjects gap analysis","channel":"protocol/fill-slots","ts":"2026-06-29T12:49:12.731Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"183ec24b1b3034c60f2963be386ef232f90242321413bf97dbc6070664b1e5b0","hash":"9bafdbadd9cd21344c948654249708f2d5f98530ec7245c2290d2dc82f92f11c"},{"seq":9,"id":"k10","ts":"2026-06-29T12:49:12.858Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c34","tier":"human","text":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"disclaimer","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:49:12.858Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"9bafdbadd9cd21344c948654249708f2d5f98530ec7245c2290d2dc82f92f11c","hash":"d2b52a539460e4d196501dbde67478ca4aadbc1b14506389c93ca68dfcfa4aaf"},{"seq":10,"id":"k11","ts":"2026-06-29T13:11:19.231Z","model":"kimi/moonshot-v1-8k","role":"collaborator","action":"collaborate","payload":{"claims_added":["c35","c36"],"challenge_id":"c37","rationale":"I am adding explicit gaps in knowledge and naming anecdotal claimants as instructed. I am not Grok because I am providing additional context and claims that are not present in the existing topology, which is my role as collaborator #1 on the miscsubjects peptide evidence ledger."},"rationale":"I am adding explicit gaps in knowledge and naming anecdotal claimants as instructed. I am not Grok because I am providing additional context and claims that are not present in the existing topology, which is my role as collaborator #1 on the miscsubjects peptide evidence ledger.","tokens_in":2774,"tokens_out":527,"cost":0.00049515,"prev_hash":"d2b52a539460e4d196501dbde67478ca4aadbc1b14506389c93ca68dfcfa4aaf","hash":"0dc9398a05bbe46aa11dc6f09a22f02a4aa03a3c2693a9623f5a468948395f5c"},{"seq":11,"id":"k12","ts":"2026-06-29T13:12:10.621Z","model":"kimi/moonshot-v1-8k","role":"collaborator","action":"collaborate","payload":{"claims_added":["c38","c39"],"challenge_id":null,"rationale":"I am adding explicit gaps in knowledge and naming sources for anecdotal claims as instructed, which are missing from the current ledger. I am not Grok because I am focusing on filling in the gaps and sourcing anecdotes, rather than challenging existing claims."},"rationale":"I am adding explicit gaps in knowledge and naming sources for anecdotal claims as instructed, which are missing from the current ledger. I am not Grok because I am focusing on filling in the gaps and sourcing anecdotes, rather than challenging existing claims.","tokens_in":2776,"tokens_out":299,"cost":0.00046125,"prev_hash":"0dc9398a05bbe46aa11dc6f09a22f02a4aa03a3c2693a9623f5a468948395f5c","hash":"0c57ff4095c440551f277b394a69651705aaaeb347d47ca52bf4dff5bf497ba7"},{"seq":12,"id":"k13","ts":"2026-06-29T14:38:57.729Z","model":"gemini/gemini-2.5-flash","role":"collaborator","action":"collaborate","payload":{"claims_added":["c40","c41","c42"],"challenge_id":"c43","rationale":"I am Gemini, not Grok. I have added three claims to the ledger, focusing on the 'who_claims_what' slot to materialize orphan sources from the topology and provide a more complete picture of discussions and professional perspectives surrounding Selank. I also challenged a broad, unsourced anecdotal claim with more specific, sourced anecdotal evidence to improve the ledger's precision."},"rationale":"I am Gemini, not Grok. I have added three claims to the ledger, focusing on the 'who_claims_what' slot to materialize orphan sources from the topology and provide a more complete picture of discussions and professional perspectives surrounding Selank. I also challenged a broad, unsourced anecdotal claim with more specific, sourced anecdotal evidence to improve the ledger's precision.","tokens_in":2911,"tokens_out":577,"cost":0.00039142499999999993,"prev_hash":"0c57ff4095c440551f277b394a69651705aaaeb347d47ca52bf4dff5bf497ba7","hash":"f76d90c839e3bd54ca5f8a6b77160dcf2d3b6c165956973508373b247ab8b425"},{"seq":13,"id":"k14","ts":"2026-06-29T14:39:50.469Z","model":"grok/grok-4.3","role":"editor","action":"synthesize_body","payload":{"chars":4502,"claims_used":30,"legibility":{"pass":true,"reasons":[]}},"rationale":"Reader body rewritten from ranked ledger topology — plain English","tokens_in":7520,"tokens_out":936,"cost":0.01174,"prev_hash":"f76d90c839e3bd54ca5f8a6b77160dcf2d3b6c165956973508373b247ab8b425","hash":"725ede4fd3048d5146457ec612cc1764a57fdb2a91256e2b5186b407c33e6948"},{"seq":14,"id":"k15","ts":"2026-06-29T18:30:24.303Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s28","type":"reddit","url":"https://www.reddit.com/r/peptideforums/comments/1sq9kqz/any_known_peptides_to_help_with_anxiety/","title":"Any known peptides to help with anxiety?","quote":"Just for context, I'm a 21-year-old male in college that recently got prescribed Adderall and it makes me super anxious and to an extent ... Selank is supposed to help calm anxiety. ... I agree, Selank and Semax as a stack with Selank being used more heavily and Semax for the focus and confidence benefits is a good starting point. ... Selank - Gaba modulation, more relaxing ... Semax - A calm focus, lacks the intense physical stimulation (or, for some, the calming effect) which Adderall has.","link_status":"ok","quote_status":"unverified"},{"id":"s29","type":"reddit","url":"https://www.reddit.com/r/Anxiety/comments/1nf7y8w/experiences_with_selank/","title":"Experiences with Selank","quote":"took Selank for the first time this afternoon, and my experience wasn’t the greatest to say the least. I vomited half hour after, followed by cold/hot flashes, and randomly elevated heart rate at times. After sitting down and taking a long shower, those symptoms went away and i felt extremely calm. ... Im on day 4 of selank and yes, the pounding(with some discomfort), racing heart thing is throwing me way off. I thought it was supposed to be the opposite.","link_status":"ok","quote_status":"unverified"},{"id":"s30","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1klzoj7/selank_life_changing_so_far/","title":"Selank. Life changing so far.","quote":"One week into using Selank to manage GAD and panic disorder. I don't think my brain has ever been this stable. ... The following day I went to work and had absolutely zero anxiety. It’s usually pretty bad especially in the morning but not this day or any day since starting Selank. ... Panicky thoughts were either stopped entirely or would just wash over me with no effect.","link_status":"ok","quote_status":"unverified"},{"id":"s31","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1ua8doj/paradoxical_insomniaanxiety_reaction_to_selank/","title":"Paradoxical insomnia/anxiety reaction to Selank?","quote":"I know it could be coincidence, but has anyone else had a paradoxical reaction to Selank , especially insomnia, feeling wired, or even increased anxiety ? ... The highest I went was three sprays/day for a couple days, but I never really felt calmer or less anxious from it. ... Around the same time, my sleep got much worse. I couldn’t fall asleep until 4–5 a.m. and only slept a few hours. My anxiety also got worse... - dyl_h (Score: 3): I have that reaction. Selank is like jet fuel for my brain, and it lasts too long for it to be usable for me","link_status":"ok","quote_status":"unverified"},{"id":"s32","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1srylgg/semax_adhd_severe_anxiety_depression_long_term/","title":"Semax, ADHD, Severe Anxiety & Depression - Long Term?","quote":"If I had a 5 day / 2 day off, is taking selank to help in the 2 days off a good idea? ... Selank is helpful on its own, but not as effective. ... Selank definitely helps, but not as much. If I need to cycle the two, I'll do 5 or 6 days on semax and the other(s) on selank.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"725ede4fd3048d5146457ec612cc1764a57fdb2a91256e2b5186b407c33e6948","hash":"aeaef01465c8f679f203f685a9a24b4f315b00eefbded297a227aa670a478af3"},{"seq":15,"id":"k16","ts":"2026-06-29T21:12:01.443Z","model":"fill-slots","role":"claim_post","action":"claim","payload":{"claim_id":"c49","tier":"system","text":"Selank for Adderall-Induced Jitteriness and Anxiety is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"what_it_is","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T21:12:01.443Z","model":"fill-slots","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"aeaef01465c8f679f203f685a9a24b4f315b00eefbded297a227aa670a478af3","hash":"13a7c8328a93779c5850a74f22e34a604dda090c497af3cbb41be3efef836488"}]}