{"slug":"retatrutide-nsaids","verification":{"valid":true,"entries":4,"head":"265735ed0da2dd750c12f1f8a30f13ca8f3b51c926eda3511cdffecb797a14dc"},"count":4,"sources":[{"id":"s1","type":"clinical_trial","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa2301972","title":"Triple–Hormone-Receptor Agonist Retatrutide for Obesity","quote":"At 48 weeks, the least-squares mean percentage change in body weight ... −24.2% in the 12-mg group","summary":"Phase 2 RCT results showing dose-dependent weight loss up to 24% at 48 weeks.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:54:53.212Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"7284f879205fcbf9ee33d19b6efbffd98425d9f16f459d2f8d5a9532355cf0ec"},{"id":"s2","type":"news","url":"https://www.rsna.org/media/press/i/2379","title":"NSAIDs May Worsen Arthritis Inflammation","quote":"Joint inflammation and cartilage quality were worse at baseline in the participants taking NSAIDs ... and worsened at four-year follow-up.","summary":"RSNA presentation on observational human data for long-term NSAID use in OA.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:54:53.212Z","link_status":"ok","quote_status":"unverified","prev":"7284f879205fcbf9ee33d19b6efbffd98425d9f16f459d2f8d5a9532355cf0ec","hash":"fedd9d6c4b7a699a12a7c67808bd74dc18b507b87d623da95f264265d62d867a"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31851037/","title":"Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Their Effect on Wound Healing","quote":"The majority of in vitro studies demonstrated that NSAIDs have a harmful effect on biological processes involved in tendon-healing and regeneration","summary":"Review concluding negative effects in most in-vitro and many animal tendon studies.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:54:53.212Z","link_status":"ok","quote_status":"verified","prev":"fedd9d6c4b7a699a12a7c67808bd74dc18b507b87d623da95f264265d62d867a","hash":"ce4e2d786b7b2ba8d2f78f10dc495e5c4a9dbc2709c3bdc9f285379334ab912b"},{"id":"s4","type":"news","url":"https://www.pharmacytimes.com/view/once-weekly-retatrutide-reduces-weight-and-knee-pain-in-patients-with-obesity-and-osteoarthritis","title":"Once-Weekly Retatrutide Reduces Weight and Knee Pain...","quote":"Retatrutide also lowered weight by an average of 28.7% and reduced pain by an average of 4.5 points based on the WOMAC pain score.","summary":"Report on post-hoc analysis from retatrutide trial in OA patients.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:54:53.212Z","link_status":"ok","quote_status":"verified","prev":"ce4e2d786b7b2ba8d2f78f10dc495e5c4a9dbc2709c3bdc9f285379334ab912b","hash":"265735ed0da2dd750c12f1f8a30f13ca8f3b51c926eda3511cdffecb797a14dc"}]}