{"slug":"retatrutide-muscle-loss","verification":{"valid":true,"entries":5,"head":"23f55be48f4bb796f6eb24d164e3709bba06269d3c07460a4b910b3fa80c63df"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://www.thelancet.com/journals/landia/article/PIIS2213-8587(25)00092-0/abstract","title":"Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2 trial","quote":"The proportion of lean mass loss to weight loss was similar to other obesity treatments. These findings could provide reassurance that a greater proportion of lean mass is not lost with retatrutide despite the overall increased weight loss.","summary":"Phase 2 substudy results on fat and lean mass changes with retatrutide vs comparators in T2D patients.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:57:28.314Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"7f8a4eb453aadfcea08fca045b517dfa4a510db828b156ae2dbd5832dbcba7df"},{"id":"s2","type":"pubmed","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa2301972","title":"Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial","quote":"At 48 weeks, the least-squares mean percentage change in the retatrutide groups was −24.2% in the 12-mg group, as compared with −2.1% in the placebo group.","summary":"Primary weight loss efficacy data from the phase 2 obesity trial.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:57:28.314Z","link_status":"http_403","quote_status":"unverified","prev":"7f8a4eb453aadfcea08fca045b517dfa4a510db828b156ae2dbd5832dbcba7df","hash":"e0812fdfe2c98254a3e3780514ee4b61ee5e4774a4c7be7d71327fb98b5338b0"},{"id":"s3","type":"pubmed","url":"https://www.nature.com/articles/s41366-026-02025-2","title":"Efficacy of GLP-1 analog peptides, semaglutide, tirzepatide, and retatrutide, in MC4R knockout obese mice","quote":"Retatrutide significantly reduced the soleus muscle weight.","summary":"Preclinical animal data on body composition effects including lean mass.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:57:28.314Z","link_status":"ok","quote_status":"unverified","prev":"e0812fdfe2c98254a3e3780514ee4b61ee5e4774a4c7be7d71327fb98b5338b0","hash":"8c3240f9e3739deca6b3ddb5688b143e27d3192ec71cef2aaf3c2e4863dfa1b0"},{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/Retatrutide/comments/1qctov9/terrible_muscle_loss_any_suggestions/","title":"Terrible muscle loss - any suggestions?","quote":"It can be hard on GLP-1's, but that's likely why you lost so much muscle during your weight loss. As everyone says, aiming for 1g per pound...","summary":"User discussion on muscle loss experiences and mitigation strategies.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:57:28.314Z","link_status":"ok","quote_status":"unverified","prev":"8c3240f9e3739deca6b3ddb5688b143e27d3192ec71cef2aaf3c2e4863dfa1b0","hash":"bd5b45fd5a1af062f6d6d33820be659485eec9597bce5ed64fb6b50553ef2c09"},{"id":"s5","type":"x","url":"https://x.com/TheOldTone/status/2067348343152579055","title":"X post on retatrutide lean mass data","quote":"Don't be mislead. Retatrutide is amazing but...it does NOT preserve muscle. Lily's own trials say 35% lean mass lost which is more than Tirzepatide per trial data.","summary":"Example of X discussion citing trial lean mass percentages.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:57:28.314Z","link_status":"ok","quote_status":"verified","prev":"bd5b45fd5a1af062f6d6d33820be659485eec9597bce5ed64fb6b50553ef2c09","hash":"23f55be48f4bb796f6eb24d164e3709bba06269d3c07460a4b910b3fa80c63df"}]}