{"slug":"retatrutide-ibd","verification":{"valid":true,"entries":6,"head":"fa4eec819108b622ddca30941d07f39e7025fbcafbb6b1135fb29258f8b7f446"},"count":6,"sources":[{"id":"s1","type":"pubmed","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa2301972","title":"Triple–Hormone-Receptor Agonist Retatrutide for Obesity","quote":"At 48 weeks, a weight reduction of 5% or more, 10% or more, and 15% or more had occurred in 92%, 75%, and 60%, respectively, of the participants who received 4 mg of retatrutide... the 12-mg group... −24.2%","summary":"Phase 2 trial results showing dose-dependent weight loss with retatrutide.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:58:10.557Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"a278d79912605fda4a8b1833d791a752f07a55cd49adb341da3f2aafdbd3b959"},{"id":"s2","type":"news","url":"https://pharmaceutical-journal.com/article/news/phase-iii-retatrutide-study-demonstrates-30-weight-loss","title":"Phase III retatrutide study demonstrates 30% weight loss","quote":"participants with severe obesity who took retatrutide 9mg or 12mg achieved up to 30% weight loss... at 104 weeks","summary":"Topline phase 3 weight loss outcomes for retatrutide.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:58:10.557Z","link_status":"ok","quote_status":"unverified","prev":"a278d79912605fda4a8b1833d791a752f07a55cd49adb341da3f2aafdbd3b959","hash":"969ea15592ef8437d2eeb4490435da8256925e98b367e754eb48c821ebd7bace"},{"id":"s3","type":"pubmed","url":"https://academic.oup.com/ecco-jcc/article/19/10/jjaf181/8280408","title":"Glucagon-like peptide 1 receptor agonists and the clinical course of IBD","quote":"Weight loss was achieved using semaglutide (−9.6 kg... tirzepatide (−11.8 kg... GLP1-RAs were associated with lower risk of surgery... and reduced risk of hospitalization in the subset of obese patients","summary":"Meta-analysis of GLP-1 RAs in IBD showing weight and outcome associations.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:58:10.557Z","link_status":"http_403","quote_status":"unverified","prev":"969ea15592ef8437d2eeb4490435da8256925e98b367e754eb48c821ebd7bace","hash":"5dfe4d4b3d50561d1fabb13528147a5f27348c1929023d00bd7300286ab88dc7"},{"id":"s4","type":"medical","url":"https://resources.healthgrades.com/pro/the-potential-for-glp-1s-in-the-treatment-of-crohns-disease","title":"The Potential for GLP-1s in the Treatment of Crohn's Disease","quote":"these patients successfully lost more than 6% of their body weight, but the treatment had no effect on IBD activity... nausea was very common and one patient withdrew due to diarrhea","summary":"Cohort study noting weight loss without IBD activity change and GI side effects.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:58:10.557Z","link_status":"ok","quote_status":"unverified","prev":"5dfe4d4b3d50561d1fabb13528147a5f27348c1929023d00bd7300286ab88dc7","hash":"fcc1f8e2d5592f810cd6818261e17a3d985c03bf387cde530f81d20b8ae452c9"},{"id":"s5","type":"review","url":"https://www.mdpi.com/2227-9059/13/5/1128","title":"GLP-1R Agonists and Their Therapeutic Potential in Inflammatory Bowel Disease","quote":"there is a wealth of pre-clinical animal data suggesting that GLP-1RAs can ameliorate experimental colitis... lack of prospective clinical studies","summary":"Systematic review contrasting preclinical colitis signals with clinical evidence gaps.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:58:10.557Z","link_status":"http_403","quote_status":"unverified","prev":"fcc1f8e2d5592f810cd6818261e17a3d985c03bf387cde530f81d20b8ae452c9","hash":"1849c741dafdfb9c2b59b02901baedb908ec76cec11fe5df6ce78d482e1ac86d"},{"id":"s6","type":"reddit","url":"https://www.reddit.com/r/Retatrutide/comments/1q37uvg/reta_with_crohns/","title":"reta with crohns","quote":"i was wondering if anyone knew about any complications for if i take reta while having crohn's disease or any other IBD","summary":"User inquiry on retatrutide compatibility with Crohn's, no outcome data.","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T00:58:10.557Z","link_status":"ok","quote_status":"unverified","prev":"1849c741dafdfb9c2b59b02901baedb908ec76cec11fe5df6ce78d482e1ac86d","hash":"fa4eec819108b622ddca30941d07f39e7025fbcafbb6b1135fb29258f8b7f446"}]}