{"slug":"retatrutide-carpal-tunnel","verification":{"valid":true,"entries":5,"head":"fe110a80ea8cc6b4d167fc2036f18fe6c0ed52d02e7e06c54f010400c27d0007"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa2301972","title":"Triple–Hormone-Receptor Agonist Retatrutide for Obesity","quote":"At 48 weeks, the least-squares mean percentage change in the retatrutide groups was −8.7% in the 1-mg group, −17.1% in the combined 4-mg group, −22.8% in the combined 8-mg group, and −24.2% in the 12-mg group, as compared with −2.1% in the placebo group.","summary":"Phase 2 trial results showing dose-dependent weight loss in humans.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:04:17.629Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"2b2c199ac1d626ee486fbd092440d8c64a7c3086bed2e91c6156570e24947819"},{"id":"s2","type":"pubmed","url":"https://www.sciencedaily.com/releases/2009/10/091025194759.htm","title":"Weight Loss Can Shed Pounds And Carpal Tunnel","quote":"After weight loss of 50 pounds or more, all but 3 patients reported a resolution of symptoms.","summary":"Human study on bariatric weight loss and CTS symptom resolution.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:04:17.629Z","link_status":"ok","quote_status":"verified","prev":"2b2c199ac1d626ee486fbd092440d8c64a7c3086bed2e91c6156570e24947819","hash":"30fcb4625f067003eb7c9238ce8afab440cf13ceebd38f27faf9b8237407d652"},{"id":"s3","type":"medical","url":"https://meeting.handsurgery.org/program/2025/HS8.cgi","title":"Glucagon-like Peptide-1 Receptor Agonists and Carpal Tunnel","quote":"The GLP-1 cohort was more likely to receive corticosteroid injection (OR 1.17) and operative management (OR 1.15). Subanalysis ... reduced odds of repeat carpal tunnel release (OR 0.91).","summary":"Matched cohort study on GLP-1 and CTS intervention rates.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:04:17.629Z","link_status":"ok","quote_status":"unverified","prev":"30fcb4625f067003eb7c9238ce8afab440cf13ceebd38f27faf9b8237407d652","hash":"ed98c9cad5c8620826e31687e0b6d284d770b75a1b4da42b4026ae519dee538a"},{"id":"s4","type":"news","url":"https://www.prnewswire.com/news-releases/lillys-triple-agonist-retatrutide-drove-substantial-improvements-in-weight-a1c-knee-osteoarthritis-pain-and-obstructive-sleep-apnea-demonstrating-its-remarkable-potential-to-treat-obesity-and-its-complications-302793169.html","title":"Lilly's triple agonist, retatrutide, drove substantial improvements...","quote":"participants on retatrutide 12 mg lost an average of 70.3 lbs (28.3%) over 80 weeks","summary":"Phase 3 topline weight loss data.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:04:17.629Z","link_status":"ok","quote_status":"verified","prev":"ed98c9cad5c8620826e31687e0b6d284d770b75a1b4da42b4026ae519dee538a","hash":"710cb922128b3627361e40f8f711819c22fdb3fa2fee765bb9876323951065c6"},{"id":"s5","type":"medical","url":"https://trytrimi.com/blog/retatrutide-dysesthesia","title":"Retatrutide Dysesthesia","quote":"Dysesthesia — an abnormal sensation of tingling, burning, prickling, or numbness on the skin — is retatrutide's most distinctive side effect. It occurred in approximately 20.9% of patients at the 12mg dose in Phase 2","summary":"Summary of retatrutide side effect profile from trial data.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:04:17.629Z","link_status":"ok","quote_status":"unverified","prev":"710cb922128b3627361e40f8f711819c22fdb3fa2fee765bb9876323951065c6","hash":"fe110a80ea8cc6b4d167fc2036f18fe6c0ed52d02e7e06c54f010400c27d0007"}]}