{"slug":"recovery-stack-sciatica","verification":{"valid":true,"entries":32,"head":"0a7611b54e86228b3a401d6c304ff64cad002b724b5b64e43cb62b1fbbd8927a"},"energy":{"passes":32,"tokens_in":6157,"tokens_out":1684,"tokens_total":7841,"cost_usd":0,"models":{"grok/grok-4.3":2,"system/audit-repair":8,"kimi/moonshot-v1-8k":1,"gemini/gemini-2.5-flash":1,"repair":2,"grok-4.3":15,"fill-slots":2,"owner":1},"head":"0a7611b54e86228b3a401d6c304ff64cad002b724b5b64e43cb62b1fbbd8927a"},"provenance":[{"ts":"2026-06-29T09:01:09.370Z","model":"grok/grok-4.3","action":"write","prompt":"","input":"PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):\nBPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).\nTB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.\nARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.\nSemax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.\nSelank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).\nPT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).\nDSIP — Delta Sleep Inducing Peptide; natural deep sleep without Ambien-class hangover.\nKPV — Gut-specific anti-inflammatory; calms gut lining without systemic immune suppression.\nGHK-Cu — Tissue remodeling; builds collagen scaffolding. Production drops 60-80% with age.\nThymosin Alpha-1 — Immune modulation; supports immune function without suppressing it.\n\nWrite a data-first, evidence-graded article: Recovery Stack for Sciatica\n\nAudience: 40% of Americans. Same mechanism as herniated disc; different search term. Novelty: 10/10.\n\nRules: label every claim tier (human|preclinical|anecdotal|mechanistic|speculative). Separate rat studies from human trials from user reports. No medical claims or treatment promises. Use repair-vs-suppression framing where relevant. register: source_ledger.","response":"{\n  \"slug\": \"recovery-stack-for-sciatica\",\n  \"title\": \"Recovery Stack for Sciatica\",\n  \"body\": \"## Prevalence\\nLifetime incidence of sciatica reported between 10% and 40%.\\n\\n## Peptide Evidence by Tier\\n### ARA-290\\nHuman clinical data in small fiber neuropathy (sarcoidosis and T2D): improved symptoms, quality of life, and corneal nerve fiber regrowth in some cases. No human data specific to sciatica.\\n\\n### BPC-157\\nPreclinical (rat sciatic nerve transection models): accelerated axonal regeneration, improved functional recovery (SFI, EMG). No human trials identified.\\n\\n### Other Peptides\\nMechanistic descriptions only; no human data for sciatica recovery stacks.\",\n  \"register\": \"source_ledger\",\n  \"claims\": [\n    {\n      \"id\": \"c1\",\n      \"text\": \"Lifetime incidence of sciatica is between 10% and 40%.\",\n      \"section\": \"Prevalence\",\n      \"tier\": \"human\",\n      \"source_ids\": [\"s1\"],\n      \"source_status\": \"sourced\",\n      \"why_material\": \"Establishes population relevance for 40% of Americans reference.\"\n    },\n    {\n      \"id\": \"c2\",\n      \"text\": \"ARA290 treatment in sarcoidosis patients significantly improved neuropathic symptoms and initiated regrowth of small nerve fibers in the cornea.\",\n      \"section\": \"ARA-290\",\n      \"tier\": \"human\",\n      \"source_ids\": [\"s2\"],\n      \"source_status\": \"sourced\",\n      \"why_material\": \"Only human trial data among listed peptides for nerve repair.\"\n    },\n    {\n      \"id\": \"c3\",\n      \"text\": \"BPC-157 accelerated axonal regeneration and improved functional recovery in rat sciatic nerve transection models.\",\n      \"section\": \"BPC-157\",\n      \"tier\": \"preclinical\",\n      \"source_ids\": [\"s3\"],\n      \"source_status\": \"sourced\",\n      \"why_material\": \"Separates animal data from human; repair mechanism via angiogenesis and nerve healing.\"\n    },\n    {\n      \"id\": \"c4\",\n      \"text\": \"No human clinical trial data exist for BPC-157, TB-500, Semax, Selank, PT-141, DSIP, KPV, GHK-Cu or Thymosin Alpha-1 in sciatica.\",\n      \"section\":","tokens_in":0,"tokens_out":0,"cost":0,"prev":"genesis","hash":"4462df4fd20758446d2a24f9b35f34ceb16c053cba6fab959f5acd3133cb1505"},{"ts":"2026-06-29T12:48:24.453Z","model":"system/audit-repair","action":"repair","prompt":"","input":"recovery-stack-sciatica","response":"{\"materialized\":0,\"before\":[\"missing constitution slots: what_it_is, who_claims_what, what_is_known, what_is_unknown, disclaimer\"],\"after\":[\"missing constitution slots: what_it_is, who_claims_what, what_is_known, what_is_unknown, disclaimer\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"4462df4fd20758446d2a24f9b35f34ceb16c053cba6fab959f5acd3133cb1505","hash":"ffece856847f0278f2ccd4e37df0833fe3f444c1ab8021fc104599755d4452d0"},{"ts":"2026-06-29T12:48:24.993Z","model":"system/audit-repair","action":"claim","prompt":"","input":"recovery-stack-sciatica c5","response":"Recovery Stack for Sciatica is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"ffece856847f0278f2ccd4e37df0833fe3f444c1ab8021fc104599755d4452d0","hash":"80ee8d5f74e75565d51af60021a210c0b2b3fa6b907260bdc0b54677b1f23052"},{"ts":"2026-06-29T12:48:25.027Z","model":"system/audit-repair","action":"claim","prompt":"","input":"recovery-stack-sciatica c6","response":"Per this ledger on Recovery Stack for Sciatica: 3 scientific and 0 anecdotal sources are catalogued; 3 preclinical claim(s) summarize animal/cell literature in-catalogue.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"80ee8d5f74e75565d51af60021a210c0b2b3fa6b907260bdc0b54677b1f23052","hash":"846ebbbaf473eb96d478f5a6ac1f98aef0370d4f26200300f64a932c88dbe6c3"},{"ts":"2026-06-29T12:48:25.060Z","model":"system/audit-repair","action":"claim","prompt":"","input":"recovery-stack-sciatica c7","response":"Not established in this ledger: large randomized human trials for common marketed uses; long-term human safety beyond small pilots; condition-specific efficacy where only anecdotal or preclinical sources exist (explicit gaps remain in question graph).","tokens_in":0,"tokens_out":0,"cost":0,"prev":"846ebbbaf473eb96d478f5a6ac1f98aef0370d4f26200300f64a932c88dbe6c3","hash":"ae1b3e760c1d6bd3c6c0fff6918b0ad3a168b0fa1c8ad1a7fb5d5e9c17ec8163"},{"ts":"2026-06-29T12:48:25.095Z","model":"system/audit-repair","action":"claim","prompt":"","input":"recovery-stack-sciatica c8","response":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"ae1b3e760c1d6bd3c6c0fff6918b0ad3a168b0fa1c8ad1a7fb5d5e9c17ec8163","hash":"6d65e3c7382a047b3042e6f314ff30d19121b965578fdf6e835de021196e70ef"},{"ts":"2026-06-29T12:48:25.682Z","model":"system/audit-repair","action":"repair","prompt":"","input":"recovery-stack-sciatica","response":"{\"materialized\":0,\"before\":[\"missing constitution slots: who_claims_what\"],\"after\":[\"missing constitution slots: who_claims_what\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"6d65e3c7382a047b3042e6f314ff30d19121b965578fdf6e835de021196e70ef","hash":"15ab2a620d0d86d76c5433a99c2beca3197f640ff1b30dc27817a471988efc67"},{"ts":"2026-06-29T12:50:04.681Z","model":"kimi/moonshot-v1-8k","action":"collaborate","prompt":"","input":"recovery-stack-sciatica","response":"I am adding explicit claims about the absence of certain types of evidence and naming the source of a claim that is currently missing attribution, as per the instructions.","tokens_in":1508,"tokens_out":473,"cost":0,"prev":"15ab2a620d0d86d76c5433a99c2beca3197f640ff1b30dc27817a471988efc67","hash":"926acba9d0f41727cb0e1428718605398a8eb9ee73ce5afb4cd6358e12a46b38"},{"ts":"2026-06-29T12:51:17.918Z","model":"gemini/gemini-2.5-flash","action":"collaborate","prompt":"","input":"recovery-stack-sciatica","response":"As Gemini, I've identified specific gaps in the ledger regarding the human clinical evidence for peptides mentioned, using the provided sources. I've also challenged a broad, unsourced claim by pointing to a more specific and sourced equivalent, enhancing the ledger's precision and reliability. I am not Grok.","tokens_in":1850,"tokens_out":522,"cost":0,"prev":"926acba9d0f41727cb0e1428718605398a8eb9ee73ce5afb4cd6358e12a46b38","hash":"9149a999149673ac243e717b7d3e383657c8f77942e9237de818af980bfd2531"},{"ts":"2026-06-29T13:22:11.614Z","model":"system/audit-repair","action":"repair","prompt":"","input":"recovery-stack-sciatica","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"9149a999149673ac243e717b7d3e383657c8f77942e9237de818af980bfd2531","hash":"8c517a673f2ff7b6cdc1f9c06ca337aea2f5605d0582d65453811ea9b881e86b"},{"ts":"2026-06-29T13:22:12.754Z","model":"system/audit-repair","action":"repair","prompt":"","input":"recovery-stack-sciatica","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"8c517a673f2ff7b6cdc1f9c06ca337aea2f5605d0582d65453811ea9b881e86b","hash":"a273379f2ae4198496f1e8dea32e050c5a678b5cbfebb885d0ef6b4011cb1635"},{"ts":"2026-06-29T14:18:41.958Z","model":"grok/grok-4.3","action":"synthesize_body","prompt":"","input":"recovery-stack-sciatica","response":"## Regeneration vs degeneration — where this fits\nThe body breaks down tissue and builds it back at the same time. Sciatica lasts when breakdown outruns repair around the nerve. Most drugs mute the pain signal. BPC-157 is studied for a repair path: new blood vessels at the injury site that carry materials to damaged nerve and muscle.\n\n## What it is\nBPC-157 is a short chain of amino acids. The ledger studies it for local tissue repair after nerve injury. No human clinical trial data exist for BPC-157 in sciatica (source s1).\n\n## How it works\nStep 1: injury occurs.  \nStep 2: BPC-157 is proposed to increase new blood vessel growth at the site.  \nStep 3: more blood flow brings oxygen, cells, and nutrients.  \nStep 4: damaged nerve tissue receives more repair material. This is a build pathway, not a signal-suppression pathway.\n\n## Why it would work (logic chain)\nIf new blood vessels form, then more healing material reaches the nerve. If the nerve receives more material, then axonal regrowth can speed up. If axonal regrowth speeds up, then nerve function can return faster. Each step is if-then. None of the steps are proven in human sciatica.\n\n## Why people take it\nPeople take it when they want a regeneration path instead of only pain suppression. The ledger shows zero Reddit posts, zero X posts, and zero other anecdote sources on this topic.\n\n## How many people take it\nUnknown. The ledger contains zero anecdotal reports for BPC-157 in sciatica.\n\n## Evidence inventory\nSources total: 3.  \nStudies catalogued: 3.  \nReddit posts: 0.  \nX posts: 0.  \nOther anecdote sources: 0.  \nHuman claims: 3.  \nPreclinical claims: 7.  \nAnecdotal claims: 0.\n\n## What scientists say\nSource s1 (Sciatica - StatPearls) states lifetime incidence of sciatica is between 10% and 40%. It supplies no data on BPC-157.  \nSource s2 (Targeting the innate repair receptor to treat neuropathy) reports that ARA290 in sarcoidosis patients improved neuropathic symptoms and started regrowth of small nerve fibers in ","tokens_in":2799,"tokens_out":689,"cost":0,"prev":"a273379f2ae4198496f1e8dea32e050c5a678b5cbfebb885d0ef6b4011cb1635","hash":"78e21b3a6616245316c1cec271cbf704bd3821d8fa59c2c0b94e801fd4ffb60d"},{"ts":"2026-06-29T15:06:44.375Z","model":"repair","action":"repair","prompt":"","input":"recovery-stack-sciatica","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"78e21b3a6616245316c1cec271cbf704bd3821d8fa59c2c0b94e801fd4ffb60d","hash":"518874c1c03b8f4e219c1f9f1c8a2e762ac52a5ca21a30b9f610d5b61d208879"},{"ts":"2026-06-29T15:14:54.545Z","model":"grok-4.3","action":"sources","prompt":"","input":"recovery-stack-sciatica","response":"1 source(s) 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This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"4f9342b144f25b7464d2cad169fae2fb53c6208d38e8b7df823f21beb660b9a4","hash":"ecbaaed17eca8652eea3bd4ea1aca2ad6f197a2526e7b9dd942af480fad7624e"},{"ts":"2026-06-29T20:57:36.927Z","model":"fill-slots","action":"claim","prompt":"","input":"recovery-stack-sciatica c83","response":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"ecbaaed17eca8652eea3bd4ea1aca2ad6f197a2526e7b9dd942af480fad7624e","hash":"edbaa817210d3f5796c5e8ada405f54fd187737c99af34ed23c9b9d42b22d667"},{"ts":"2026-07-17T02:41:13.853Z","model":"owner","action":"voxel_divide","prompt":"","input":"recovery-stack-sciatica","response":"24 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"edbaa817210d3f5796c5e8ada405f54fd187737c99af34ed23c9b9d42b22d667","hash":"0a7611b54e86228b3a401d6c304ff64cad002b724b5b64e43cb62b1fbbd8927a"}]}