{"slug":"recovery-stack-gabapentin","verification":{"valid":true,"entries":10,"head":"496e123326965a6b677e3ac389af78d1636e6c16db912dad2da2a6f8e6cf64d5"},"count":10,"models":["grok/grok-4.3","kimi/moonshot-v1-8k","system/audit-repair","gemini/gemini-2.5-flash","grok-4.3","fill-slots"],"yield":{"passes":10,"energy_spent_rows":0,"total_cost_usd":0.005882,"waste_cost_usd":0,"total_tokens":6924,"material_outputs":6,"usd_per_output":0.00098,"models":[{"model":"gemini/gemini-2.5-flash","passes":1,"cost_usd":0.000285,"tokens_total":2085,"outputs":4,"waste_passes":0,"usd_per_output":0.000071},{"model":"kimi/moonshot-v1-8k","passes":1,"cost_usd":0.000196,"tokens_total":1309,"outputs":2,"waste_passes":0,"usd_per_output":0.000098},{"model":"system/audit-repair","passes":3,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"grok-4.3","passes":2,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"fill-slots","passes":1,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"grok/grok-4.3","passes":2,"cost_usd":0.005401,"tokens_total":3530,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST /api/protocol/collaborate","pricing_ppm":{"grok-4.3":[1.25,2.5],"grok/grok-4.3":[1.25,2.5],"grok-build-0.1":[1,2],"kimi/moonshot-v1-8k":[0.15,0.15],"gemini/gemini-2.5-flash":[0.075,0.3],"gemini/gemini-2.0-flash-lite":[0.075,0.3],"openai/gpt-4o":[2.5,10],"openai/gpt-4o-mini":[0.15,0.6],"system/reflex":[0,0],"ingest:deterministic":[0,0],"fill-slots":[0,0]}}},"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T09:03:07.069Z","model":"grok/grok-4.3","role":"writer","action":"redraft","payload":{"title":"Recovery Stack for Gabapentin Replacement","register":"source_ledger","body":"## Gabapentin's Limitations\n\nGabapentin reduces neuropathic pain signals via calcium channel modulation but does not promote nerve fiber regrowth or resolve underlying tissue damage. [human]\n\n## Proposed Recovery Mapping\n\nARA-290 targets the innate repair receptor to support small nerve fiber regrowth. [human]\n\nBPC-157 promotes angiogenesis and fibroblast activity in tendon, muscle, and gut tissues in animal models. [preclinical]\n\nTB-500 (synthetic thymosin beta-4) modulates inflammation and cell migration in tissue repair models. [preclinical]\n\n## Evidence Tiers\n\n- Human trial data exist for ARA-290 in small fiber neuropathy associated with sarcoidosis, showing improved symptoms and corneal nerve fiber density. [human]\n- BPC-157 effects are documented exclusively in rat and cell studies for tendon healing and vascularization. [preclinical]\n- TB-500 data derive from animal models of wound healing and inflammation reduction. [preclinical]\n- No human trials for the combined stack or direct gabapentin replacement exist. [speculative]\n\n## Framing: Repair Versus Suppression\n\nThe approach emphasizes addressing nerve structure and tissue integrity rather than solely attenuating pain transmission.","claims":[{"id":"c1","text":"Gabapentin reduces neuropathic pain signals via calcium channel modulation but does not promote nerve fiber regrowth or resolve underlying tissue damage.","section":"Gabapentin's Limitations","tier":"human","source_ids":["s1"],"source_status":"sourced","why_material":"Establishes baseline limitation of current standard approach.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c2","text":"ARA-290 targets the innate repair receptor to support small nerve fiber regrowth.","section":"Proposed Recovery Mapping","tier":"human","source_ids":["s2"],"source_status":"sourced","why_material":"Core mechanism for nerve component with clinical trial support.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c3","text":"BPC-157 promotes angiogenesis and fibroblast activity in tendon, muscle, and gut tissues in animal models.","section":"Proposed Recovery Mapping","tier":"preclinical","source_ids":["s3"],"source_status":"sourced","why_material":"Distinguishes rat data from human data for tissue repair.","evidence_basis":"derived_inference","weight":0.5,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c4","text":"TB-500 modulates inflammation and cell migration in tissue repair models.","section":"Proposed Recovery Mapping","tier":"preclinical","source_ids":["s4"],"source_status":"sourced","why_material":"Systemic inflammation clearance evidence limited to animals.","evidence_basis":"derived_inference","weight":0.5,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}}],"sources":[{"id":"s1","type":"medical","url":"https://ubiehealth.com/doctors-note/gabapentin-nerve-pain-does-it-actually-work-37-faq15e9","title":"Gabapentin for Nerve Pain: Does It Actually Work?","quote":"Gabapentin does not heal damaged nerves. Instead, it helps reduce how strongly pain signals are felt.","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3563705/","title":"Safety and Efficacy of ARA 290 in Sarcoidosis Patients with Symptoms of Small Fiber Neuropathy","quote":"We studied the safety and efficacy of ARA 290 to reduce symptoms of small fiber neuropathy (SFN) in patients with sarcoidosis.","link_status":"ok","quote_status":"verified"},{"id":"s3","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6271067/","title":"Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts","quote":"BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies.","link_status":"ok","quote_status":"verified"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/20536453/","title":"Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptide","quote":"Studies in various animal models of disease and repair with thymosin beta(4) (Tbeta(4))... demonstrate its potential for clinical use.","link_status":"ok","quote_status":"unverified"}]},"rationale":"","tokens_in":0,"tokens_out":0,"prev_hash":"genesis","hash":"20e0b8475c66fb8827b8fbf1040c00ccbcd9e34357eb24effd7b4556fb4a7a47"},{"seq":1,"id":"k2","ts":"2026-06-29T12:48:01.434Z","model":"kimi/moonshot-v1-8k","role":"collaborator","action":"collaborate","payload":{"claims_added":["c5","c6"],"challenge_id":null,"rationale":"I am adding claims that address gaps in the current evidence and naming who claims what, as per the instructions. 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