{"slug":"pt-141","verification":{"valid":true,"entries":31,"head":"391f43aa1c293f096dfbe3105b91ee6202fcb511525ac406d9995e9436c60b15"},"count":31,"models":["grok/grok-4.3","grok-4.3","system/audit-repair","kimi/moonshot-v1-8k","fill-slots"],"yield":{"passes":31,"energy_spent_rows":0,"total_cost_usd":0.000533,"waste_cost_usd":0,"total_tokens":3554,"material_outputs":3,"usd_per_output":0.000178,"models":[{"model":"kimi/moonshot-v1-8k","passes":1,"cost_usd":0.000533,"tokens_total":3554,"outputs":3,"waste_passes":0,"usd_per_output":0.000178},{"model":"grok/grok-4.3","passes":1,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"grok-4.3","passes":22,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"system/audit-repair","passes":5,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"fill-slots","passes":2,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST /api/protocol/collaborate","pricing_ppm":{"grok-4.3":[1.25,2.5],"grok/grok-4.3":[1.25,2.5],"grok-build-0.1":[1,2],"kimi/moonshot-v1-8k":[0.15,0.15],"gemini/gemini-2.5-flash":[0.075,0.3],"gemini/gemini-2.0-flash-lite":[0.075,0.3],"openai/gpt-4o":[2.5,10],"openai/gpt-4o-mini":[0.15,0.6],"system/reflex":[0,0],"ingest:deterministic":[0,0],"fill-slots":[0,0]}}},"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T08:32:57.416Z","model":"grok/grok-4.3","role":"writer","action":"redraft","payload":{"title":"PT-141: Brain-Level Arousal","register":"source_ledger","body":"## PT-141 Definition and Mechanism\n\nPT-141 (bremelanotide) is a synthetic melanocortin receptor agonist that activates central nervous system pathways for sexual arousal signaling. [human|mechanistic]\n\n## Human Clinical Data\n\nIn two identical phase 3 randomized double-blind placebo-controlled trials (RECONNECT), subcutaneous bremelanotide 1.75 mg as needed produced statistically significant increases in Female Sexual Function Index-desire domain scores and reductions in Female Sexual Distress Scale scores versus placebo in premenopausal women with hypoactive sexual desire disorder. [human]\n\nBremelanotide received FDA approval in 2019 as Vyleesi for acquired generalized hypoactive sexual desire disorder in premenopausal women. [human]\n\n## Preclinical Context\n\nAnimal studies indicate melanocortin receptor activation in hypothalamic regions linked to sexual behavior. [preclinical]\n\n## Evidence Summary\n\nNo human data on long-term use beyond 52-week open-label extensions in the provided trials. User reports exist outside regulated studies but are not graded here.","claims":[{"id":"c1","text":"PT-141 (bremelanotide) is a synthetic melanocortin receptor agonist that activates central nervous system pathways for sexual arousal signaling.","section":"PT-141 Definition and Mechanism","tier":"mechanistic","source_ids":["s1"],"source_status":"sourced","why_material":"Core mechanism definition matching provided peptide entry.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c2","text":"In two identical phase 3 randomized double-blind placebo-controlled trials (RECONNECT), subcutaneous bremelanotide 1.75 mg as needed produced statistically significant increases in Female Sexual Function Index-desire domain scores and reductions in Female Sexual Distress Scale scores versus placebo in premenopausal women with hypoactive sexual desire disorder.","section":"Human Clinical Data","tier":"human","source_ids":["s2"],"source_status":"sourced","why_material":"Direct evidence from phase 3 human trials separating from preclinical or anecdotal.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c3","text":"Bremelanotide received FDA approval in 2019 as Vyleesi for acquired generalized hypoactive sexual desire disorder in premenopausal women.","section":"Human Clinical Data","tier":"human","source_ids":["s3"],"source_status":"sourced","why_material":"Regulatory human data confirmation.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c4","text":"Animal studies indicate melanocortin receptor activation in hypothalamic regions linked to sexual behavior.","section":"Preclinical Context","tier":"preclinical","source_ids":["s4"],"source_status":"sourced","why_material":"Explicit separation of rat/animal data from human trials.","evidence_basis":"derived_inference","weight":0.5,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}}],"sources":[{"id":"s1","type":"review","url":"https://go.drugbank.com/drugs/DB11653","title":"Bremelanotide: Uses, Interactions, Mechanism of Action","quote":"Bremelanotide is a 7 amino acid peptide used to treat hypoactive sexual desire disorder in premenopausal women.","link_status":"http_403","quote_status":"unverified"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31599840/","title":"Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder","quote":"Both studies demonstrated that bremelanotide significantly improved sexual desire and related distress in premenopausal women with hypoactive sexual desire disorder.","link_status":"ok","quote_status":"verified"},{"id":"s3","type":"medical","url":"https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210557s000lbl.pdf","title":"VYLEESI (bremelanotide injection) Prescribing Information","quote":"VYLEESI (bremelanotide injection), for subcutaneous use. Initial U.S. Approval: 2019.","link_status":"ok","quote_status":"unverified"},{"id":"s4","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2694735/","title":"Melanocortin Receptors, Melanotropic Peptides and Penile Erection","quote":"With its central mechanism of action, PT-141 may act independent or synergistically with PDE-5 inhibitors","link_status":"ok","quote_status":"unverified"}]},"rationale":"","tokens_in":0,"tokens_out":0,"prev_hash":"genesis","hash":"c8552c2bebf744f8eec501a08abe530cefa2def95a13846b0978868a705255c4"},{"seq":1,"id":"k2","ts":"2026-06-29T09:46:05.824Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s5","type":"reddit","url":"https://www.reddit.com/r/erectiledysfunction/comments/1qik4vm/pt141_experience_it_absolutely_works/","title":"PT-141 Experience - it absolutely works","quote":"There is good information about Bremelanotide ( PT-141 ) on the Mayo clinic website. I highly recommend seeing a doctor before using this medicine ...","link_status":"ok","quote_status":"unverified"},{"id":"s6","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1c39lie/pt_141_for_libido/","title":"PT 141 for libido","quote":"Now if you look online , you'll find that almost every scientific report, research paper or search concludes that PT-141 ( bremelanotide ) is the better ( ...","link_status":"ok","quote_status":"unverified"},{"id":"s7","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT02338960","title":"Study to Evaluate the Efficacy/Safety of Bremelanotide in Premenopausal Women With Hypoactive Sexual Desire Disorder","quote":"Subjects will self-administer a fixed dose (1.75 mg) of bremelanotide (BMT) subcutaneously (SC) via auto-injector on an as needed basis with no more than 1 dose taken every 24 hours for 24 weeks (OLE Study)","link_status":"ok","quote_status":"unverified"},{"id":"s8","type":"news","url":"https://palatin.com/press_releases/palatin-announces-the-initiation-of-a-phase-2-clinical-study-of-bremelanotide-co-administered-with-a-pde5i-for-the-treatment-of-erectile-dysfunction-ed/","title":"Palatin Announces the Initiation of a Phase 2 Clinical Study of Bremelanotide Co-Administered with a PDE5i for the Treatment of Erectile Dysfunction (ED)","quote":"The Phase 2 clinical trial is designed to enroll approximately 50 patients to be treated with BMT co-administered with a PDE5i in an open-label, dose ...","link_status":"ok","quote_status":"unverified"},{"id":"s9","type":"medical","url":"https://www.mayoclinic.org/drugs-supplements/bremelanotide-subcutaneous-route/description/drg-20466805","title":"Bremelanotide (subcutaneous route) - Side effects & dosage","quote":"Bremelanotide injection is used to treat hypoactive sexual desire disorder (HSDD ) in premenopausal women who previously had no problems with sexual desire.","link_status":"http_403","quote_status":"unverified"},{"id":"s10","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/33455598/","title":"The neurobiology of bremelanotide for the treatment of hypoactive sexual desire disorder in premenopausal women","quote":"Bremelanotide may affect female sexual desire by activating presynaptic MC4Rs on neurons in the mPOA of the hypothalamus, leading to increased release of DA.","link_status":"ok","quote_status":"unverified"},{"id":"s11","type":"x","url":"https://x.com/ennulife/status/2071384667882746109","title":"X post on PT-141","quote":"The most underrated peptide for your sex life? PT-141: Works differently than anything else out there — instead of targeting blood flow, it goes straight to your brain's desire and arousal circuitry.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"prev_hash":"c8552c2bebf744f8eec501a08abe530cefa2def95a13846b0978868a705255c4","hash":"3c818f149067d584ef0dc388bb59f32bfe7f6121334fcecb1168d45743ca5780"},{"seq":2,"id":"k3","ts":"2026-06-29T09:46:24.056Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s12","type":"review","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8788464/","title":"Bremelanotide for Treatment of Female Hypoactive Sexual Desire Disorder","quote":"Studies showed improvements in desire, arousal, and orgasm scores when 1.75 mg of bremelanotide was administered before sexual activity compared to a placebo.","link_status":"ok","quote_status":"verified"},{"id":"s13","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/12851303/","title":"PT-141: a melanocortin agonist for the treatment of sexual dysfunction","quote":"Administration of PT-141 to normal men and to patients with erectile dysfunction resulted in a rapid dose-dependent increase in erectile activity.","link_status":"ok","quote_status":"verified"},{"id":"s14","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31599847/","title":"Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder","quote":"Premenopausal women treated with bremelanotide exhibited sustained improvements in hypoactive sexual desire disorder symptoms.","link_status":"ok","quote_status":"verified"},{"id":"s15","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT06565611","title":"A Phase 2 Study Evaluating the Co-Administration of Bremelanotide With a PDE5 Inhibitor for the Treatment of Erectile Dysfunction","quote":"This is a prospective, randomized, double-blind, placebo-controlled study designed to assess the safety and efficacy of bremelanotide (BMT) used in combination...","link_status":"ok","quote_status":"unverified"},{"id":"s16","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT04943068","title":"A Phase 3, Bridging, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Subcutaneously Administered Bremelanotide in Premenopausal Women with Hypoactive Sexual Desire Disorder","quote":"The purpose of this study is to Evaluate the Efficacy and Safety of Subcutaneously Administered Bremelanotide in Premenopausal Women with Hypoactive Sexual...","link_status":"ok","quote_status":"unverified"},{"id":"s17","type":"medical","url":"https://www.towerurology.com/mens-sexual-health/pt-141-for-men/","title":"PT-141 for Men - Los Angeles","quote":"PT-141, also known as Bremelanotide, is a synthetic peptide utilized to treat sexual dysfunction in both men and women.","link_status":"ok","quote_status":"unverified"},{"id":"s18","type":"reddit","url":"https://www.reddit.com/r/erectiledysfunction/comments/1clpo4k/taken_pt141_twice_now_and_i_am_happily_amazed/","title":"Taken PT-141 twice now and I am happily amazed","quote":"I mean I would always get morning wood now and then, but this was completely different. I felt like Ron Jeremy in the bedroom.","link_status":"ok","quote_status":"unverified"},{"id":"s19","type":"youtube","url":"https://www.youtube.com/watch?v=deUV6eDsdTs","title":"PT-141 Myths Busted! The Truth About This Game-Changing Sex Peptide","quote":"Dr Durst & Farideh are breaking down the biggest myths about PT 141, the peptide that’s changing the game for sexual health.","link_status":"http_429","quote_status":"unverified"},{"id":"s20","type":"other","url":"https://en.wikipedia.org/wiki/Bremelanotide","title":"Bremelanotide - Wikipedia","quote":"Bremelanotide, sold under the brand name Vyleesi, is a medication used to treat low sexual desire in women.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"prev_hash":"3c818f149067d584ef0dc388bb59f32bfe7f6121334fcecb1168d45743ca5780","hash":"249d98b0e446641c5a31883592ebe6af2bbfb053aac6d0f5614afe183072b0c4"},{"seq":3,"id":"k4","ts":"2026-06-29T09:46:42.017Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s21","type":"reddit","url":"https://www.reddit.com/r/erectiledysfunction/comments/1frnpj6/the_combo_of_tadalafil_and_pt141_is_insanely/","title":"The combo of Tadalafil and PT-141 is insanely effective","quote":"Yes I've done PT 141 many times by itself and it works wonders if you time it right! A bit of nausea and flushing but not bad. I've also done combo of PT and tadalafil and it's almost too much! After a couple of rounds of sex I could feel a light breeze and get hard again! Kind of cool but also annoying cause you can't turn it off.","link_status":"ok","quote_status":"unverified"},{"id":"s22","type":"reddit","url":"https://www.reddit.com/r/Swingers/comments/1rvyzmc/my_pt141_experience/","title":"My PT-141 experience","quote":"Expect solid/robust erections for up to 48 hours . Nothing painful or unwanted. Just robust - HardAF. Try it and let us know your experience.","link_status":"ok","quote_status":"unverified"},{"id":"s23","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1iypi6c/pt141_gamechanger_or_overrated_need_real/","title":"PT-141: Game-Changer or Overrated? Need Real ...","quote":"The side effects aren't worth it, imo. Nausea, itchy throat, weird 'full' feeling in my penis for 24 hours , super red face and skin feeling hot.","link_status":"ok","quote_status":"unverified"},{"id":"s24","type":"x","url":"https://x.com/choi_sun_k/status/2071114945425526870","title":"X post about PT-141 bunk experience","quote":"I had the same experience with pt-141, should feel something at 1mg or 2mg, but I went to 3mg and felt absolutely nothing, not even nausea. Probably bunk","link_status":"ok","quote_status":"verified"},{"id":"s25","type":"x","url":"https://x.com/BjjJoshD/status/2071232843049513342","title":"X post on peptide experiences including PT-141","quote":"PT-141 was fun but I don’t have libido or ED issues. For me it’s just not cost effective to inject things that I can’t see or feel results with.","link_status":"ok","quote_status":"verified"},{"id":"s26","type":"reddit","url":"https://www.reddit.com/r/Swingers/comments/1c29qbz/pt141/","title":"PT-141","quote":"One common side effect is nausea . There was a story from some dude that waaayyyyyy overdosed it and had a raging hard on to the point of ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"prev_hash":"249d98b0e446641c5a31883592ebe6af2bbfb053aac6d0f5614afe183072b0c4","hash":"31ef48f92aec7b5ed4f1ea8a59a1cba3d697e669f1185ed8cc4f34059e3d5f91"},{"seq":4,"id":"k5","ts":"2026-06-29T09:46:59.840Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s27","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/36809187/","title":"Bremelanotide for Hypoactive Sexual Desire Disorder","quote":"Bremelanotide's benefits are statistically modest and limited to outcomes for which scant evidence of validity among women with HSDD exists.","link_status":"ok","quote_status":"verified"},{"id":"s28","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1tyketx/pt141_bremelanotide_the_sexual_health_peptide/","title":"PT-141 (bremelanotide): the sexual health peptide that isn't talked about enough","quote":"What it is PT-141, or bremelanotide , is a synthetic cyclic heptapeptide and a melanocortin receptor agonist.","link_status":"ok","quote_status":"unverified"},{"id":"s29","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1u7lh1u/the_libido_peptide_explained_what_pt141_actually/","title":"what PT-141 actually does for sexual desire","quote":"PT-141 activates melanocortin receptors (mainly MC4R) in the brain's reward and arousal centers , which bumps up dopamine in the areas tied to sexual motivation ...","link_status":"ok","quote_status":"unverified"},{"id":"s30","type":"medical","url":"https://riteaid.com/peptides/pt-141","title":"PT 141 Peptide (Bremelanotide): Benefits, Dosage & Nasal Spray","quote":"PT-141 , known generically as bremelanotide , is studied and used for low sexual desire and arousal.","link_status":"http_403","quote_status":"unverified"},{"id":"s31","type":"medical","url":"https://www.joinmidi.com/post/pt-141","title":"PT-141 Peptide: What It Is, How It Works, and Safety Info","quote":"Published phase 3 trials found that premenopausal women with HSDD who took bremelanotide had increased sexual desire and decreased distress about low sexual desire after 24 weeks, compared with those in placebo groups.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 4","tokens_in":0,"tokens_out":0,"prev_hash":"31ef48f92aec7b5ed4f1ea8a59a1cba3d697e669f1185ed8cc4f34059e3d5f91","hash":"b0d7b263730067fd4b8fd433bdbb82cdbe1fb88e395a7a3081f28f7ab49d6534"},{"seq":5,"id":"k6","ts":"2026-06-29T09:48:07.341Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s32","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39793696/","title":"Female Syrian hamster analyses of bremelanotide, a US FDA approved drug for the treatment of female hypoactive sexual desire disorder","quote":"Bremelanotide, trade name Vyleesi, has been approved by the United States Food and Drug Administration to treat HSDD. However, despite approval, very little is known about its neurobiological mechanism of action.","link_status":"ok","quote_status":"verified"},{"id":"s33","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40069591/","title":"Intravenous peptides and amino acids for erectile dysfunction: a narrative review of current applications and future directions","quote":"This narrative review examines recent developments in peptide and amino acid therapies for ED, focusing on PT-141, PnPP-19, L-arginine, and L-citrulline.","link_status":"ok","quote_status":"verified"},{"id":"s34","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39197897/","title":"Melanocortin Receptor Agonist Bremelanotide Induces Cell Death and Growth Inhibition in Glioblastoma Cells via Suppression of Survivin Expression","quote":"Bremelanotide reduced survivin expression and induced cell death in glioblastoma cells at concentrations that were not toxic to normal human cells, and both of these effects were canceled in the presence of an antagonist of melanocortin receptors 3 and 4.","link_status":"ok","quote_status":"verified"},{"id":"s35","type":"x","url":"https://x.com/formulaterx/status/1854151329087987828","title":"Bremelanotide (PT-141) post on X","quote":"In the world of sexual health, Bremelanotide (PT-141) has emerged as an innovative option for enhancing libido and supporting sexual ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"prev_hash":"b0d7b263730067fd4b8fd433bdbb82cdbe1fb88e395a7a3081f28f7ab49d6534","hash":"a0733778e8e34e92c62f5e01778a7b55f590947953da8c8aba6939f2e0311683"},{"seq":6,"id":"k7","ts":"2026-06-29T09:48:23.788Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s36","type":"medical","url":"https://www.ncbi.nlm.nih.gov/books/NBK573221/","title":"Bremelanotide - LiverTox® - NCBI Bookshelf","quote":"Bremelanotide is a parenterally administered melanocortin receptor agonist that is used to treat female hypoactive sexual desire disorder.","link_status":"ok","quote_status":"verified"},{"id":"s37","type":"medical","url":"https://auanews.net/issues/articles/2026/april-2026/peptides-for-sexual-dysfunction-what-clinicians-should-know","title":"Peptides for Sexual Dysfunction: What Clinicians Should Know","quote":"A new addition to the arsenal of peptide drugs available to the urologist is bremelanotide (PT-141; Vyleesi). PT-141 was approved by the Food and Drug Administration (FDA) in 2019 for the treatment of hypoactive sexual desire disorder in premenopausal women following several randomized, placebo-controlled clinical trials demonstrating improved sexual desire and arousal in this population.","link_status":"ok","quote_status":"verified"},{"id":"s38","type":"reddit","url":"https://www.reddit.com/r/BodyHackGuide/comments/1p4o2lm/pt141_vs_melanotan2_which_one_boosts_sex_drive/","title":"PT-141 vs Melanotan-2 — Which One Boosts Sex Drive?","quote":"Built specifically for sexual arousal. Hits the exact brain receptors tied to desire. Used “on demand”. FDA-approved as Vyleesi for low desire in women.","link_status":"ok","quote_status":"unverified"},{"id":"s39","type":"reddit","url":"https://www.reddit.com/r/USPeptides/comments/1sz6al5/pt141_oxytocin_nasal_spray_research_guide/","title":"PT-141 / Oxytocin Nasal Spray: Research Guide","quote":"PT-141 / Oxytocin is a dual-compound nasal spray combining two of the most targeted compounds available for sexual desire, arousal, and intimacy enhancement.","link_status":"ok","quote_status":"unverified"},{"id":"s40","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT00425256","title":"Evaluate the Safety and Efficacy of Bremelanotide in Women With Female Sexual Arousal Disorder","quote":"This 8 week at home study is designed to explore efficacy endpoints and evaluate the safety of intranasal Bremelanotide in women with Female Sexual Arousal Disorder.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"prev_hash":"a0733778e8e34e92c62f5e01778a7b55f590947953da8c8aba6939f2e0311683","hash":"829bf32876158b7a0fd6476a5050c66cebd84e275462c9e9c0dff1cc44854987"},{"seq":7,"id":"k8","ts":"2026-06-29T09:48:42.342Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s41","type":"reddit","url":"https://www.reddit.com/r/SEXONDRUGS/comments/1h1v6ds/our_first_experience_with_pt141/","title":"Our first experience with PT-141","quote":"Took a long time to kick in, 6-8 hours or so. No real increase in libido but we decided to fool around out of boredom and sick of waiting to ...","link_status":"ok","quote_status":"unverified"},{"id":"s42","type":"reddit","url":"https://www.reddit.com/r/SEXONDRUGS/comments/1h49qtr/pt141_risks_and_dangers/","title":"PT141: risks and dangers","quote":"Queasy and bloated and pressure in abdomen. Felt horrible. Zero increase in libido . Quite the opposite effect. I think I'd steer clear of this ...","link_status":"ok","quote_status":"unverified"},{"id":"s43","type":"reddit","url":"https://www.reddit.com/r/Swingers/comments/1rwa4zo/how_many_have_tried_pt141_does_it_work/","title":"How many have tried PT 141? Does it work ?","quote":"It works great. I use it regularly. Better erections stronger libido . I find that 1.5mg works best for me. 2mg gives me a headache.","link_status":"ok","quote_status":"unverified"},{"id":"s44","type":"reddit","url":"https://www.reddit.com/r/SEXONDRUGS/comments/1fdx18h/first_experience_with_pt141_bremelanotide/","title":"First experience with PT-141 (Bremelanotide)","quote":"Some muscle soreness in my back and minor face/neck flushing were the only side effects that I noted and both were very minor. I had no \"flu- ...","link_status":"ok","quote_status":"unverified"},{"id":"s45","type":"x","url":"https://x.com/itsjoshkade/status/2071233606815764547","title":"Peptide note: PT-141 (Bremelanotide)","quote":"Peptide note: PT-141 (Bremelanotide) 1. boosts libido and sexual desire 2. human RCTs in premenopausal HSDD; effect is modest 3. nausea: 40% in trials; BP can rise; daily use is wrong","link_status":"ok","quote_status":"verified"},{"id":"s46","type":"youtube","url":"https://www.youtube.com/watch?v=mpcioV-Q5J0","title":"Can a simple PT-141 Nasal Spray make you a ROCKSTAR in ...","quote":"Im 71 and have used injectable pt141 occasionally for a year, The nasal spray hasnt been affective. The only down side for me is that it lasts up to 12 hours, and when Im tired and want to sleep , spontaneous erections and drive continues. My wife also uses it and is happy with the 12 hour duration, but she is 59 . The up side is that its like being 18 again.","link_status":"http_429","quote_status":"unverified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"prev_hash":"829bf32876158b7a0fd6476a5050c66cebd84e275462c9e9c0dff1cc44854987","hash":"afe0d632aa3a0ea2cf130fb9ea498a83b125b515eeac5c742122326005088134"},{"seq":8,"id":"k9","ts":"2026-06-29T09:48:56.066Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s47","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41960633/","title":"Should Bremelanotide Be Considered for the Treatment of Sexual Arousal and Desire Disorders in Men?","quote":"Should Bremelanotide Be Considered for the Treatment of Sexual Arousal and Desire Disorders in Men? J Clin Psychopharmacol. 2026 May-Jun;46(3):245-248. doi: 10.1097/JCP.0000000000002179.","link_status":"ok","quote_status":"unverified"},{"id":"s48","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42021992/","title":"Therapeutic peptides in gerontology: mechanisms and applications for healthy aging","quote":"Nine peptides were identified spanning diverse aging interventions: ... and sexual function (bremelanotide).","link_status":"ok","quote_status":"unverified"},{"id":"s49","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39846877/","title":"Novel Pharmacologic Treatments of Female Sexual Dysfunction","quote":"This review evaluates pharmacologic treatments for female sexual dysfunction (FSD), focusing on hypoactive sexual desire disorder (HSDD). ... FDA-approved medications (flibanserin and bremelanotide)","link_status":"ok","quote_status":"unverified"},{"id":"s50","type":"review","url":"https://palatin.com/press_releases/palatin-provides-update-on-clinical-programs-strategic-priorities-and-anticipated-milestones/","title":"Palatin Provides Update on Clinical Programs, Strategic Priorities and Anticipated Milestones","quote":"Our clinical program evaluating bremelanotide co-formulated with a PDE5i for the treatment of ED in patients who do not respond to PDE5i monotherapy is expected to begin in the first half of calendar year 2025.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 4","tokens_in":0,"tokens_out":0,"prev_hash":"afe0d632aa3a0ea2cf130fb9ea498a83b125b515eeac5c742122326005088134","hash":"2fd1d926eb0f3def3cacebf6b485e677be3daae2a38a44be4f008bc87aca0798"},{"seq":9,"id":"k10","ts":"2026-06-29T09:50:08.514Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s51","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT06867835","title":"Single Dose of Vyleesi in Lactating Female Subjects to Evaluate Drug Secretion in Breast Milk","quote":"The primary objectives of this clinical trial performed with Vyleesi (Bremelanotide Injection) are: to evaluate if Bremelanotide (BMT) is secreted in breast milk","link_status":"ok","quote_status":"unverified"},{"id":"s52","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/36242769/","title":"An evaluation of bremelanotide injection for the treatment of hypoactive sexual desire disorder","quote":"Bremelanotide appears to be moderately safe and well-tolerated ; the most common adverse reaction is nausea (40%).","link_status":"ok","quote_status":"unverified"},{"id":"s53","type":"medical","url":"https://www.ncbi.nlm.nih.gov/books/NBK603746/","title":"Female Sexual Interest and Arousal Disorder - StatPearls","quote":"Bremelanotide: In June 2019, the FDA approved bremelanotide for treating FSIAD in premenopausal women.[25][45] Bremelanotide, a melanocortin agonist, is administered at a dose of 1.75 mg subcutaneously as needed once daily, approximately 45 minutes before the commencement of sexual activity.","link_status":"ok","quote_status":"unverified"},{"id":"s54","type":"medical","url":"https://mensreproductivehealth.com/pt-141-for-men-a-new-drug-to-treat-erectile-dysfunction-and-low-libido/","title":"PT-141 FOR MEN: A NEW DRUG TO TREAT ERECTILE DYSFUNCTION AND LOW LIBIDO","quote":"In 2024, Goldstein and Goldstein published results from an observational study of 21 men with various sexual dysfunctions (low libido, ED, trouble with orgasm, etc.)","link_status":"ok","quote_status":"verified"},{"id":"s55","type":"reddit","url":"https://www.reddit.com/r/BiohackingU/comments/1pwho0k/your_full_pt141_mini_guide_in_2026_benefits_side/","title":"Your Full PT-141 Mini Guide in 2026 (Benefits, Side Effects ...)","quote":"PT-141 is a melanocortin receptor agonist that acts specifically on the MC3R and MC4R receptors to help raise sex drive for both men and women","link_status":"ok","quote_status":"unverified"},{"id":"s56","type":"youtube","url":"https://www.youtube.com/watch?v=7eMDpfKKmD0","title":"PT-141 (Bremelanotide): A Comprehensive Guide to Treating Sexual Dysfunction","quote":"00:00 Introduction to PT 141 ; 00:30 Mechanism of Action ; 02:05 Clinical Applications ; 02:59 Benefits and Risks ; 04:30 Dosage and Administration","link_status":"http_429","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"prev_hash":"2fd1d926eb0f3def3cacebf6b485e677be3daae2a38a44be4f008bc87aca0798","hash":"75756c3a73548aee36dda63b97a54ccd1a6b5243650667086ff245e878cb76a7"},{"seq":10,"id":"k11","ts":"2026-06-29T09:50:28.395Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s57","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT01382719","title":"Study Details | NCT01382719 | Bremelanotide in ...","quote":"PT-141 . Participant Group/Arm, Experimental : bremelanotide arm 2. Middle dose: Investigational product: Bremelanotide aqueous solution for subcutaneous (SC) ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"prev_hash":"75756c3a73548aee36dda63b97a54ccd1a6b5243650667086ff245e878cb76a7","hash":"e0ac296f52677628a1fbc8a769bbc028d54b1faa00756eeed8c2c3b40e3cb9a3"},{"seq":11,"id":"k12","ts":"2026-06-29T09:50:45.656Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s58","type":"reddit","url":"https://www.reddit.com/r/ParamountPeptide/comments/1py8p7x/pt141_realworld_benefits_side_effects_and_how/","title":"PT-141 Real-World Benefits, Side Effects, and How People ...","quote":"Men use PT-141 for a mix of libido and erectile support; women ... PT-141 side effects and what happens if you overdo it. The trade-off ...","link_status":"ok","quote_status":"unverified"},{"id":"s59","type":"reddit","url":"https://www.reddit.com/r/pt141info/comments/1tei9ca/pt141_experience/","title":"PT-141 experience","quote":"Taking PT-141 for low libido /Psychological ED. Has anyone weaned off it? I ordered PT-141 because of low libido and psychological ED.","link_status":"ok","quote_status":"unverified"},{"id":"s60","type":"reddit","url":"https://www.reddit.com/r/Swingers/comments/1lwfcpq/pt141_questions/","title":"PT-141 Questions","quote":"Scientists then discovered that it was the bremelanotide that had the libido effects and synthesized it by itself. ... My PT-141 experience . 67.","link_status":"ok","quote_status":"unverified"},{"id":"s61","type":"reddit","url":"https://www.reddit.com/r/SEXONDRUGS/comments/quttun/anyone_tried_pt_141/","title":"Anyone tried PT 141?","quote":"I've tried PT-141 about 6 times. (3 times at the preferred dosage) It didn't do anything obvious for the libido but I did have an on again/off again erection ...","link_status":"ok","quote_status":"unverified"},{"id":"s62","type":"x","url":"https://x.com/innerbalanc8l3e/status/2071009790571303160","title":"X post by Inner Balance","quote":"Have better sex 👏 Libida™ is the first women-first libido solution combining bremelanotide + oxytocin — two powerful, complementary pathways that activate both the neurochemical spark of desire and the bonding, intimacy, connection pathways that sha...","link_status":"ok","quote_status":"verified"},{"id":"s63","type":"x","url":"https://x.com/AntiDoc/status/2070206787538542625","title":"X post by AntiDoc","quote":"New from Elite Research: Pt-141 + Oxytocin…spray. This is superhuman libido + pair bonding in a bottle. Pt-141 yields not only naturally unachievable erections, but also the mental arousal. Both your body and your mind are ready to go…very ready to go.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"prev_hash":"e0ac296f52677628a1fbc8a769bbc028d54b1faa00756eeed8c2c3b40e3cb9a3","hash":"973f04f135197a2a514b50e404c329ef85935ef3072a24de5eec28709c6c8f45"},{"seq":12,"id":"k13","ts":"2026-06-29T12:47:30.362Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c5","tier":"system","text":"PT-141: Brain-Level Arousal is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"what_it_is","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:47:30.362Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"973f04f135197a2a514b50e404c329ef85935ef3072a24de5eec28709c6c8f45","hash":"b27f7ad57ea81d8d9b675b405a1b5bcd6f7b8066642fd61f3368450b325078f3"},{"seq":13,"id":"k14","ts":"2026-06-29T12:47:30.431Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c6","tier":"preclinical","text":"Per this ledger on PT-141: Brain-Level Arousal: 31 scientific and 30 anecdotal sources are catalogued; 2 preclinical claim(s) summarize animal/cell literature in-catalogue.","who_claims":"miscsubjects ledger synthesis","source_ids":[],"slot":"what_is_known","posted_by":{"actor":"miscsubjects ledger synthesis","channel":"protocol/fill-slots","ts":"2026-06-29T12:47:30.431Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"b27f7ad57ea81d8d9b675b405a1b5bcd6f7b8066642fd61f3368450b325078f3","hash":"9acc4703e52b688ad5d35d4734a6c96b4c686982318afd18feabf0b2ac06a7ae"},{"seq":14,"id":"k15","ts":"2026-06-29T12:47:30.633Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c7","tier":"speculative","text":"Not established in this ledger: large randomized human trials for common marketed uses; long-term human safety beyond small pilots; condition-specific efficacy where only anecdotal or preclinical sources exist (explicit gaps remain in question graph).","who_claims":"miscsubjects gap analysis","source_ids":[],"slot":"what_is_unknown","posted_by":{"actor":"miscsubjects gap analysis","channel":"protocol/fill-slots","ts":"2026-06-29T12:47:30.633Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"9acc4703e52b688ad5d35d4734a6c96b4c686982318afd18feabf0b2ac06a7ae","hash":"d99329ec290bc65246b6cd8c8b98e18c96dba0ab32f586623ee84f740bc848b2"},{"seq":15,"id":"k16","ts":"2026-06-29T12:47:30.706Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c8","tier":"mechanistic","text":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"limitations","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:47:30.706Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"d99329ec290bc65246b6cd8c8b98e18c96dba0ab32f586623ee84f740bc848b2","hash":"3aaafbd41ef3a1ba6f92d9ce28163399b1d2d4ea625042949d9e79b89e4a6af0"},{"seq":16,"id":"k17","ts":"2026-06-29T12:47:30.809Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c9","tier":"human","text":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"disclaimer","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:47:30.809Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"3aaafbd41ef3a1ba6f92d9ce28163399b1d2d4ea625042949d9e79b89e4a6af0","hash":"678d151592fed2af362e935e933d586e5d6cd24be0bf5603f0152ed29e1afeb7"},{"seq":17,"id":"k18","ts":"2026-06-29T13:53:44.331Z","model":"kimi/moonshot-v1-8k","role":"collaborator","action":"collaborate","payload":{"claims_added":["c69","c70"],"challenge_id":"c71","rationale":"I am adding explicit gaps regarding what is unknown and naming who claims what from anecdotes that are missing, as per the instructions."},"rationale":"I am adding explicit gaps regarding what is unknown and naming who claims what from anecdotes that are missing, as per the instructions.","tokens_in":3159,"tokens_out":395,"cost":0.0005330999999999999,"prev_hash":"678d151592fed2af362e935e933d586e5d6cd24be0bf5603f0152ed29e1afeb7","hash":"471978391a6183d6e28d4c07a1b93850367ea65218de40718acd90633121ba65"},{"seq":18,"id":"k19","ts":"2026-06-29T15:32:20.112Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s64","type":"x","url":"https://x.com/DavidWitti9510/status/2071576219745669209","title":"X post about PT-141 nausea ramp up","quote":"My wife started with MT2 at 400mcg, waves of nausea for about 30 minutes that stopped completely over a few nights. When going to the isolated PT-141 we went with a ramp up schedule in hopes of a similar result with the nausea. MUCH more pronounced on 141. 200mcg to 1mg ramp.","link_status":"ok","quote_status":"verified"},{"id":"s65","type":"x","url":"https://x.com/hyde2171/status/2070324941782683732","title":"X post oral PT-141","quote":"Oh and it’s supposedly 2.5mg of pt141 I was scared bc 1mg makes me nausea without Zofran.. but this oral version did squat..","link_status":"ok","quote_status":"verified"},{"id":"s66","type":"reddit","url":"https://www.reddit.com/r/SEXONDRUGS/comments/1bvae0n/trying_pt141_this_weekend_anything_else_i_should/","title":"Trying PT-141 this weekend","quote":"So the simple answer for me is, yes, I can combine PT141 and Cialis without a problem. My wife never experienced any enhanced libido from it.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"471978391a6183d6e28d4c07a1b93850367ea65218de40718acd90633121ba65","hash":"e98ab06968001ec37378bf5188ad2854f96fa280b50d52cd02f9aaff02c4c433"},{"seq":19,"id":"k20","ts":"2026-06-29T15:32:59.010Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s67","type":"reddit","url":"https://www.reddit.com/r/erectiledysfunction/comments/1ox9cmp/pt141_actually_works/","title":"Pt141 actually works","quote":"So I haven’t been able to get erections for years. Even with Viagra and lots of it. But I tried pt141 this week to test it. 1mg in the morning every other day. It takes 8 hours for me to see anything but after that I get erections from thinking This hasn’t happened since I was a teenager and I am 46.","link_status":"ok","quote_status":"unverified"},{"id":"s68","type":"reddit","url":"https://www.reddit.com/r/erectiledysfunction/comments/1ox9cmp/pt141_actually_works/","title":"Pt141 actually works","quote":"I start to see the effects after about 5 or 6 hours but if I wait 11 to 12 hours for sex the results are great. The effects last another 12 hours so the window is broad... I am dosing 1mg","link_status":"ok","quote_status":"unverified"},{"id":"s69","type":"reddit","url":"https://www.reddit.com/r/pt141info/comments/1ppfi6h/strategies_to_prevent_nausea_from_pt141/","title":"Strategies to Prevent Nausea from PT-141","quote":"When it comes to PT-141 (bremelanotide), one of the most talked-about side effects is nausea. ... People have also suggested simple things like starting with a lower amount and easing up gradually, eating a light snack beforehand, staying well-hydrated, and avoiding heavy or greasy foods right before.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"e98ab06968001ec37378bf5188ad2854f96fa280b50d52cd02f9aaff02c4c433","hash":"64c1358dd3a267092b2b7668e127c38eca542c1736b62a4b8053aa7cc6d43230"},{"seq":20,"id":"k21","ts":"2026-06-29T15:33:26.253Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s70","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1pzuued/pt_141_side_effects/","title":"PT 141 Side Effects","quote":"My wife (53) has tried PT141 to help with libido. The few times it didn't give her nausea/headache we had amazing, multiple times a night sex...which...","link_status":"ok","quote_status":"unverified"},{"id":"s71","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1jdk15l/to_those_who_have_tried_the_sexpeptide_pt141_have/","title":"To Those Who Have Tried The \"Sex-Peptide\" PT-141","quote":"My brain became permanently sensitized from taking PT141 once. Very similar to those who get PSSD PFS. Years later i crashed due to covid and a hangover and got ... Over a year later i still have moderate anhedonia.","link_status":"ok","quote_status":"unverified"},{"id":"s72","type":"reddit","url":"https://www.reddit.com/r/SEXONDRUGS/comments/1tbv1sb/men_that_have_tried_pt141_what_was_your_experience/","title":"Men that have tried PT-141. What was your experience?","quote":"The other quite noticeable effect is facial flushing for the first half hour or so. I also get a slight headache that lasts for 3-4 hours, but faded by the time ...","link_status":"ok","quote_status":"unverified"},{"id":"s73","type":"reddit","url":"https://www.reddit.com/r/BodyHackGuide/comments/1qzd7hi/pt141_experience/","title":"PT141 experience","quote":"PT141 experience . Been out of the dating scene for some time. Post Covid ED ... Side effects : Mild nausea for a brief period of time after injection ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"64c1358dd3a267092b2b7668e127c38eca542c1736b62a4b8053aa7cc6d43230","hash":"26b9f4c80035ad1621e43a35b0cffa509a9c7bfe37e829254ebc99d1c6bc3c79"},{"seq":21,"id":"k22","ts":"2026-06-29T15:34:19.763Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s74","type":"reddit","url":"https://www.reddit.com/r/erectiledysfunction/comments/1tfpdh9/tried_pt_141_loved_1st_experience_2nd_experience/","title":"Tried pt 141 loved 1st experience, 2nd experience was a dud help!","quote":"Tried pt 141 loved 1st experience, 2nd experience was a dud help! Supplements ... Ahh, twice a week maximum frequency, from my experience.","link_status":"ok","quote_status":"unverified"},{"id":"s75","type":"reddit","url":"https://www.reddit.com/r/ResearchCompounds/comments/1rv9nov/any_girls_in_here_that_have_done_pt141/","title":"Any girls in here that have done pt-141?","quote":"I'm not a girl, but I am a woman, and I have tried it 3-4 times. It made me nauseous and gave me a headache. Didn't do anything for me.","link_status":"ok","quote_status":"unverified"},{"id":"s76","type":"reddit","url":"https://www.reddit.com/r/Biohacking/comments/1tjx91d/ok_so_pt141_is_insane_lol/","title":"Ok so PT141 is insane lol","quote":"I'm 61 and it's a game changer for both! Works amazing for both my bride & I.","link_status":"ok","quote_status":"unverified"},{"id":"s77","type":"reddit","url":"https://www.reddit.com/r/PeptideForum/comments/1n16uk0/time_machine_the_pt141_experience/","title":"Time Machine - The PT141 Experience","quote":"Holy shit. We both agreed afterwards - this stuff literally brings you back to being a teenager. The intensity, the sensitivity, the whole experience. It was like someone hit a reset button on my dick and dialed it back 20 years. Side effects were pretty minimal - random erections like I’m 16 again and my face got a bit flushed.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"26b9f4c80035ad1621e43a35b0cffa509a9c7bfe37e829254ebc99d1c6bc3c79","hash":"c16f4cd8d7caa0cc1fecf07ba790057059096c935c919219fb28b122d7c02a3e"},{"seq":22,"id":"k23","ts":"2026-06-29T15:34:57.725Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s78","type":"reddit","url":"https://www.reddit.com/r/Peptides_for_Women/comments/1jm2axz/experience_with_pt141/","title":"Experience with PT-141?","quote":"I love it and do does my husband. I get a little flush and nausea for maybe 5 minutes and then wow. I'm 53 and it's like a waterfall and my netherss are buzzing.","link_status":"ok","quote_status":"unverified"},{"id":"s79","type":"reddit","url":"https://www.reddit.com/r/Peptides_for_Women/comments/1jm2axz/experience_with_pt141/","title":"Experience with PT-141?","quote":"It helps a little, but the face flushing and the dark skin it threw me off. I did for darker, taking 2mg of PT141 2 rimes per week, and it did help me with the dryness.","link_status":"ok","quote_status":"unverified"},{"id":"s80","type":"reddit","url":"https://www.reddit.com/r/Peptides_for_Women/comments/1jm2axz/experience_with_pt141/","title":"Experience with PT-141?","quote":"For me it took about an hour to kick in. I felt a few minutes of body discomfort and then whole body buzzing, like I had been sexually stimulated. I think it’s best described as being close to orgasm continuously, and for me the effects seem to last almost a whole day","link_status":"ok","quote_status":"unverified"},{"id":"s81","type":"reddit","url":"https://www.reddit.com/r/Peptides_for_Women/comments/1jm2axz/experience_with_pt141/","title":"Experience with PT-141?","quote":"I tried it once and became very congested with dry mouth! Needless to say it didn't happen help the current situation. I had no increase in libido","link_status":"ok","quote_status":"unverified"},{"id":"s82","type":"x","url":"https://x.com/BowTiedHRT/status/2070197193924034976","title":"PT-141 and oxytocin combination experience","quote":"For me and for the clients who respond well to it, that presents as genuinely improved erectile quality and a noticeable lift in arousal. ... Combined with PT-141, it tips the whole experience over the edge.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"c16f4cd8d7caa0cc1fecf07ba790057059096c935c919219fb28b122d7c02a3e","hash":"ba26bb0802d91e6356c8f624b319b60e32edb1a91254ce9a92fdf836c81ab037"},{"seq":23,"id":"k24","ts":"2026-06-29T17:34:22.942Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s83","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1sumfw4/pt141_the_libido_peptide/","title":"PT-141 the libido peptide?","quote":"PT-141 / Bremelanotide what it does, how to dose it, and what to expect. PT-141 is one of the more talked about peptides for libido and arousal","link_status":"ok","quote_status":"unverified"},{"id":"s84","type":"reddit","url":"https://www.reddit.com/r/PSSD/comments/1r436jb/oxytocin_and_bremelanotide_should_i_try_it/","title":"Oxytocin and bremelanotide? Should I try it","quote":"I think PT-141 (bremelanotide) is quite dangerous, years back in 2018 it sent me into a severe anhedonia episode at 200 mcg.","link_status":"ok","quote_status":"unverified"},{"id":"s85","type":"x","url":"https://x.com/felixbe54584201/status/2071612779648135596","title":"PT-141 dosing anecdote","quote":"I took 500 mcg at first and then added another 250mcg She took 1.5mg in 1 go. Man… when I tell you I felt euphoric. Like if I was on drugs lol. Only down side is now I can’t really leave the house. Getting erect every 30 min without even trying 🤣🤣🤣 Definitely recommend Pt-141 9 out of 10","link_status":"ok","quote_status":"verified"},{"id":"s86","type":"x","url":"https://x.com/HateTcells/status/2071633517805555941","title":"PT-141/Vyleesi for HSDD","quote":"We got several meds approved for female hypo-sexual desire disorder (HSDD) Vyleesi (bremelanotide) - Melanocortin agonist","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"ba26bb0802d91e6356c8f624b319b60e32edb1a91254ce9a92fdf836c81ab037","hash":"f661a59c794fd047cb2e36cd58f9f661e995309c959e44c396bd42f36efbea0c"},{"seq":24,"id":"k25","ts":"2026-06-29T17:34:47.904Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s87","type":"x","url":"https://x.com/FowardAssist/status/2071620968238170494","title":"PT-141 effect mention","quote":"PT-141 hits me like that.","link_status":"ok","quote_status":"verified"},{"id":"s88","type":"x","url":"https://x.com/texturedprotein/status/2071614676975161626","title":"PT-141 prescription mention","quote":"my dr just sent in for vyleesi/pt-141 and also wants to come see my new bar/restaurant 🤠","link_status":"ok","quote_status":"unverified"},{"id":"s89","type":"x","url":"https://x.com/TinkerTailor534/status/2071648478841761998","title":"PT-141 suggestion","quote":"Maybe PT-141 or using prp in your genitalia would help? Both are supposedly helpful against such a condition","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"f661a59c794fd047cb2e36cd58f9f661e995309c959e44c396bd42f36efbea0c","hash":"a8e661badf775c07f6738de8fcf083d8bc11fce92aad5028b814b9a56d154acf"},{"seq":25,"id":"k26","ts":"2026-06-29T17:35:27.587Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s90","type":"reddit","url":"https://www.reddit.com/r/ParamountPeptide/comments/1pmnmev/the_complete_pt141_10mg_guide_paramount_peptides/","title":"The Complete PT-141 (10mg) Guide – Paramount Peptides","quote":"PT-141 is a synthetic cyclic heptapeptide derived from α-MSH (alpha-melanocyte-stimulating hormone). ... Unlike PDE5 inhibitors, PT-141 works directly in the brain","link_status":"ok","quote_status":"unverified"},{"id":"s91","type":"reddit","url":"https://www.reddit.com/r/gettingbigger/comments/1eb5tzg/i_tried_a_pt141_nasal_spray_heres_what_happened/","title":"I tried a PT-141 nasal spray, here's what happened","quote":"I bought a 10 mg nasal spray from an online store ... It's labeled as a research chemical and not for human use","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"a8e661badf775c07f6738de8fcf083d8bc11fce92aad5028b814b9a56d154acf","hash":"34f4457cd1fd1c9e29f6abf4409872c52b4b977ec012716d374f2153b1a3b636"},{"seq":26,"id":"k27","ts":"2026-06-29T17:36:24.611Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s92","type":"reddit","url":"https://www.reddit.com/r/PrematureEjaculation/comments/1t6x6hm/any_of_you_guys_with_recent_experience_using/","title":"Any of you guys with recent experience using PT-141 / Bremelanotide?","quote":"PT-141 is a peptide also called bremelanotide . It was just approved for hypoactive sexual desire disorder in women under the brand name ...","link_status":"ok","quote_status":"unverified"},{"id":"s93","type":"x","url":"https://x.com/felixbe54584201/status/2071361679766544413","title":"pt-141 part 2 dosing update","quote":"Alright fam… here goes pt-141 part 2 I’m taking 500mcg and the wife is taking 1.5mg. She didn’t feel much last time at 1mg. Let’s see what happens now. Gonna be fun night 😝 #biohacking #pt141 #Peptides","link_status":"ok","quote_status":"verified"},{"id":"s94","type":"reddit","url":"https://www.reddit.com/r/BodyHackGuide/comments/1iyozhb/pt141_the_ultimate_guide_to_the_libidoboosting/","title":"PT-141: The Ultimate Guide to the Libido-Boosting Peptide","quote":"PT-141 ( Bremelanotide ) is a peptide that directly stimulates the brain to enhance sexual desire and arousal.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"34f4457cd1fd1c9e29f6abf4409872c52b4b977ec012716d374f2153b1a3b636","hash":"efbe49ad0c00a254ab2b2447b196e9a971be74b6c4b1606897be85e6789e4024"},{"seq":27,"id":"k28","ts":"2026-06-29T17:36:52.690Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s95","type":"reddit","url":"https://www.reddit.com/r/SEXONDRUGS/comments/1h68l77/pt141_dose_timing/","title":"Pt-141 dose timing","quote":"Most users report using 1-3mg (0.1-0.3ml) per injection. Personally, I dose 2mg (0.2ml) with excellent results and minimal side effects.","link_status":"ok","quote_status":"unverified"},{"id":"s96","type":"x","url":"https://x.com/y3tz3rh4r4tr4p/status/2071378259321696646","title":"X post about first PT-141 experience","quote":"tried PT-141 for the first time today and phewww","link_status":"ok","quote_status":"verified"},{"id":"s97","type":"x","url":"https://x.com/endpointarena/status/2071614676975161626","title":"X post mentioning PT-141 in peptide stack","quote":"my NYC taxi driver is on 4 peptides > \"peptide, coffee, garlic, and lemon. that's all you need.\" > grey-market Chinese semaglutide, BPC-157, PT-141, melanotan stored in amazon cooler","link_status":"ok","quote_status":"unverified"},{"id":"s98","type":"reddit","url":"https://www.reddit.com/r/psychologyofsex/comments/1qa5z8g/bremelanotide_pt141_for_female_libido_another/","title":"Bremelanotide (PT-141) for Female Libido (another study ...","quote":"Conclusions: Bremelanotide , dosed as needed approximately 45 minutes before sexual activity, facilitated sexual arousal and orgasm in ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"efbe49ad0c00a254ab2b2447b196e9a971be74b6c4b1606897be85e6789e4024","hash":"fb3a6e6264970256da15e92159943c1a54bef88d49fba261d44518c283c15de5"},{"seq":28,"id":"k29","ts":"2026-06-29T17:37:20.374Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s99","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1tzra4p/pt141_dose_recommendations/","title":"Pt-141 dose recommendations?","quote":"Me and my girl both want to try pt141 but dont know what dose we should start with im afraid she won't want to try it again if she gets real bad nausea","link_status":"ok","quote_status":"unverified"},{"id":"s100","type":"reddit","url":"https://www.reddit.com/r/SEXONDRUGS/comments/1soznxb/to_any_of_you_who_have_taken_pt_141_would_you/","title":"To any of you who have taken pt 141, would you recommend, yes, no and why?","quote":"Pt141 stands on its own ... ive used it since July last year & I think its ...","link_status":"ok","quote_status":"unverified"},{"id":"s101","type":"x","url":"https://x.com/texturedprotein/status/2071618508086038756","title":"X post by @texturedprotein","quote":"my dr just sent in for vyleesi/pt-141 and also wants to come see my new bar/restaurant 🤠","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"fb3a6e6264970256da15e92159943c1a54bef88d49fba261d44518c283c15de5","hash":"c4d9d404c2a25c7f62a36b07a59a93929138baff2c191b342d6d28b9d277aaed"},{"seq":29,"id":"k30","ts":"2026-06-29T20:40:03.367Z","model":"fill-slots","role":"claim_post","action":"claim","payload":{"claim_id":"c110","tier":"system","text":"PT-141: Brain-Level Arousal is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"what_it_is","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T20:40:03.367Z","model":"fill-slots","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"c4d9d404c2a25c7f62a36b07a59a93929138baff2c191b342d6d28b9d277aaed","hash":"35215532989d337bfba606e16bb5110b15dd47ac5bd6b3723a128996b8dcdbe9"},{"seq":30,"id":"k31","ts":"2026-06-29T20:40:05.817Z","model":"fill-slots","role":"claim_post","action":"claim","payload":{"claim_id":"c111","tier":"mechanistic","text":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"limitations","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T20:40:05.817Z","model":"fill-slots","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"35215532989d337bfba606e16bb5110b15dd47ac5bd6b3723a128996b8dcdbe9","hash":"391f43aa1c293f096dfbe3105b91ee6202fcb511525ac406d9995e9436c60b15"}]}