{"slug":"pt-141-trigeminal","verification":{"valid":true,"entries":3,"head":"32e645dc3950a0fe817a8e785d4baa27953a23cf12e2c27c7fb71248d34f1da3"},"count":3,"sources":[{"id":"s1","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2694735/","title":"Melanocortin Receptors, Melanotropic Peptides and Penile Erection","quote":"With its central mechanism of action, PT-141 may act independent or synergistically with PDE-5 inhibitors","summary":"Describes PT-141 central melanocortin action for sexual response.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:05:57.869Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"38a341bdef183a029fa322f24898518fb03557981be3c7b90fa610175215a474"},{"id":"s2","type":"review","url":"https://www.mayoclinic.org/drugs-supplements/bremelanotide-subcutaneous-route/description/drg-20466805","title":"Bremelanotide (subcutaneous route)","quote":"Bremelanotide injection is used to treat hypoactive sexual desire disorder (HSDD)","summary":"Approved use limited to HSDD; no trigeminal mention.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:05:57.869Z","link_status":"http_403","quote_status":"unverified","prev":"38a341bdef183a029fa322f24898518fb03557981be3c7b90fa610175215a474","hash":"c1b7a3cf80b240d3a1fa90007cf108d908349100c899c086129c04c1e4d9e972"},{"id":"s3","type":"other","url":"https://palmettopeptides.com/blogs/news/pt-141-vs-mt-2-melanocortin-research-comparison","title":"PT-141 vs MT-2 Melanocortin Research Comparison","quote":"The intranasal route is particularly relevant for CNS-targeted research with these compounds, as it facilitates delivery via the olfactory and trigeminal nerve pathways to the CNS","summary":"Mechanistic note on trigeminal involvement in delivery only.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:05:57.869Z","link_status":"http_526","quote_status":"unverified","prev":"c1b7a3cf80b240d3a1fa90007cf108d908349100c899c086129c04c1e4d9e972","hash":"32e645dc3950a0fe817a8e785d4baa27953a23cf12e2c27c7fb71248d34f1da3"}]}