{"slug":"pt-141-ssri-sexual-dysfunction","verification":{"valid":true,"entries":27,"head":"41df25d500e6c50088b5f7a13ec6a4395e359bd8d444e43d9274dfa48e7563a7"},"energy":{"passes":27,"tokens_in":3147,"tokens_out":351,"tokens_total":3498,"cost_usd":0,"models":{"grok/grok-4.3":1,"grok-4.3":11,"system/audit-repair":9,"kimi/moonshot-v1-8k":1,"repair":1,"fill-slots":3,"owner":1},"head":"41df25d500e6c50088b5f7a13ec6a4395e359bd8d444e43d9274dfa48e7563a7"},"provenance":[{"ts":"2026-06-29T09:21:13.749Z","model":"grok/grok-4.3","action":"write","prompt":"","input":"PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):\nBPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).\nTB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.\nARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.\nSemax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.\nSelank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).\nPT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).\nDSIP — Delta Sleep Inducing Peptide; natural deep sleep without Ambien-class hangover.\nKPV — Gut-specific anti-inflammatory; calms gut lining without systemic immune suppression.\nGHK-Cu — Tissue remodeling; builds collagen scaffolding. Production drops 60-80% with age.\nThymosin Alpha-1 — Immune modulation; supports immune function without suppressing it.\n\nWrite a data-first, evidence-graded article: PT-141 for SSRI-Induced Sexual Dysfunction\n\nAudience: 37M on SSRIs. The problem: SSRIs cause loss of libido, anorgasmia, ED. Why PT-141 maps: works on brain-level arousal via melanocortin receptors; FDA-approved mechanism under Vyleesi. Novelty: 7/10.\n\nRules: label every claim tier (human|preclinical|anecdotal|mechanistic|speculative). Separate rat studies from human trials from user reports. No medical claims or treatment promises. Use repair-vs-suppression framing where relevant. register: source_ledger.","response":"{\n  \"slug\": \"pt-141-for-ssri-induced-sexual-dysfunction\",\n  \"title\": \"PT-141 for SSRI-Induced Sexual Dysfunction: Evidence-Graded Review\",\n  \"body\": \"## SSRI-Associated Sexual Dysfunction\\nSSRIs are linked to loss of libido, anorgasmia, and erectile dysfunction in clinical observations (human tier). Prevalence estimates range 25-73% depending on specific agent and population (human tier).\\n\\n## PT-141 Mechanism\\nPT-141 (bremelanotide) is a melanocortin receptor agonist that acts at brain-level pathways associated with sexual arousal and desire (mechanistic tier). It selectively activates MC4R in the central nervous system (mechanistic tier).\\n\\nVyleesi (bremelanotide) received FDA approval in 2019 for acquired, generalized HSDD in premenopausal women; the mechanism by which it improves HSDD is unknown but believed to involve melanocortin receptors in the CNS (human tier).\\n\\n## Mapping to SSRI Effects\\nNo approved indication exists for medication-induced sexual dysfunction (human tier). Human trials of bremelanotide focused on primary HSDD, not SSRI-induced cases (human tier).\\n\\nPreclinical (rat) studies showed melanocortin agonists initiate penile erections and enhance sexual behavior (preclinical tier).\\n\\n## Human Trial Data\\nPhase 3 placebo-controlled trials (Studies 301/302) in premenopausal women with HSDD demonstrated statistically significant improvements in sexual desire scores and reductions in distress versus placebo (human tier).\\n\\nEarlier studies explored intranasal PT-141 in men with ED, including sildenafil non-responders, reporting dose-dependent improvements in erectile function scores (human tier).\\n\\n## Novelty and Framing\\nPT-141 represents a centrally acting approach via melanocortin pathways rather than peripheral suppression or hormonal modulation (mechanistic tier). No human data directly address repair versus suppression in SSRI contexts (no human data).\\n\\nUser reports on forums remain anecdotal and unverified for this specific applicatio","tokens_in":0,"tokens_out":0,"cost":0,"prev":"genesis","hash":"009fdc74e2ba1c3ab2c1e595420df98c8f4db2c4bc8e1feea8b0a83eddc0ca9e"},{"ts":"2026-06-29T11:20:14.788Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"009fdc74e2ba1c3ab2c1e595420df98c8f4db2c4bc8e1feea8b0a83eddc0ca9e","hash":"f7b44c68cba2abebb6056dd8d7d72244423be44084e9dbf05095833fdddfdd99"},{"ts":"2026-06-29T11:20:42.010Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"f7b44c68cba2abebb6056dd8d7d72244423be44084e9dbf05095833fdddfdd99","hash":"017f75b3a899e8b6efb154db8acf8c7e2155ae1bbd18080d44d9c6c12079805d"},{"ts":"2026-06-29T12:49:18.801Z","model":"system/audit-repair","action":"repair","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"{\"materialized\":0,\"before\":[\"missing constitution slots: what_it_is, what_is_known, what_is_unknown, limitations, disclaimer\"],\"after\":[\"missing constitution slots: what_it_is, what_is_known, what_is_unknown, limitations, disclaimer\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"017f75b3a899e8b6efb154db8acf8c7e2155ae1bbd18080d44d9c6c12079805d","hash":"efe6f9131a39104ecd5db7dc598da7d38f2eb4964a98d888b8d0f3ce2ed5b62d"},{"ts":"2026-06-29T12:49:19.361Z","model":"system/audit-repair","action":"claim","prompt":"","input":"pt-141-ssri-sexual-dysfunction c14","response":"PT-141 for SSRI-Induced Sexual Dysfunction: Evidence-Graded Review is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"efe6f9131a39104ecd5db7dc598da7d38f2eb4964a98d888b8d0f3ce2ed5b62d","hash":"f91dd17713a416434c732590da3298dd33ab90a5387077ebdc010e2875a15cf1"},{"ts":"2026-06-29T12:49:19.419Z","model":"system/audit-repair","action":"claim","prompt":"","input":"pt-141-ssri-sexual-dysfunction c15","response":"Per this ledger on PT-141 for SSRI-Induced Sexual Dysfunction: Evidence-Graded Review: 7 scientific and 4 anecdotal sources are catalogued; 3 preclinical claim(s) summarize animal/cell literature in-catalogue.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"f91dd17713a416434c732590da3298dd33ab90a5387077ebdc010e2875a15cf1","hash":"ccdd999d80b3af1c5f305265986f4391319fdc35d5979da7a5e5fb7e1e0d6f37"},{"ts":"2026-06-29T12:49:19.482Z","model":"system/audit-repair","action":"claim","prompt":"","input":"pt-141-ssri-sexual-dysfunction c16","response":"Not established in this ledger: large randomized human trials for common marketed uses; long-term human safety beyond small pilots; condition-specific efficacy where only anecdotal or preclinical sources exist (explicit gaps remain in question graph).","tokens_in":0,"tokens_out":0,"cost":0,"prev":"ccdd999d80b3af1c5f305265986f4391319fdc35d5979da7a5e5fb7e1e0d6f37","hash":"6cea4a14d357774791ef3dc9606e5206549bc8f97c995e3196c7e05a0a18d5c0"},{"ts":"2026-06-29T12:49:19.521Z","model":"system/audit-repair","action":"claim","prompt":"","input":"pt-141-ssri-sexual-dysfunction c17","response":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"6cea4a14d357774791ef3dc9606e5206549bc8f97c995e3196c7e05a0a18d5c0","hash":"7a2dbe197d54eed55a1fa9be5df51a21d0cfa2e5101bc39340c67d163a5261ab"},{"ts":"2026-06-29T12:49:19.568Z","model":"system/audit-repair","action":"claim","prompt":"","input":"pt-141-ssri-sexual-dysfunction c18","response":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"7a2dbe197d54eed55a1fa9be5df51a21d0cfa2e5101bc39340c67d163a5261ab","hash":"0df211fb17a81929368aed63473e3bf98dba9a8e5a494b583b8345a8406f7998"},{"ts":"2026-06-29T12:49:20.472Z","model":"system/audit-repair","action":"repair","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"0df211fb17a81929368aed63473e3bf98dba9a8e5a494b583b8345a8406f7998","hash":"dcf2309f1a84f6e53ee7a5d2700e5bc02306657fe48c7e52e41461340ea8fc45"},{"ts":"2026-06-29T13:23:10.953Z","model":"system/audit-repair","action":"repair","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"dcf2309f1a84f6e53ee7a5d2700e5bc02306657fe48c7e52e41461340ea8fc45","hash":"72d4ed890c090ce60fd801e3d97478335be53f396d0e20fac53f7a849e8b981c"},{"ts":"2026-06-29T13:23:12.095Z","model":"system/audit-repair","action":"repair","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"72d4ed890c090ce60fd801e3d97478335be53f396d0e20fac53f7a849e8b981c","hash":"541363a10167894e5f1e837d982b2c00b1485fda0e82ca7fc644bb7b796b8e08"},{"ts":"2026-06-29T13:56:44.625Z","model":"kimi/moonshot-v1-8k","action":"collaborate","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"I am adding claims to fulfill the explicit gaps in the ledger as instructed. I am not Grok because I am adding new claims that were not previously present in the ledger, and I am not challenging existing claims but rather filling in the gaps.","tokens_in":3147,"tokens_out":351,"cost":0,"prev":"541363a10167894e5f1e837d982b2c00b1485fda0e82ca7fc644bb7b796b8e08","hash":"4c49d48424813efe7efa8e780e88caab3991fe667307d4a557850d932c71cf86"},{"ts":"2026-06-29T16:30:27.234Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"3 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"4c49d48424813efe7efa8e780e88caab3991fe667307d4a557850d932c71cf86","hash":"28ce73b872fa131639d1a66b2bca2faca6e5d24cad213bebd2c12614f45f0c68"},{"ts":"2026-06-29T16:31:04.436Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"6 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"28ce73b872fa131639d1a66b2bca2faca6e5d24cad213bebd2c12614f45f0c68","hash":"c5371f045462b608292e00b725a2140255fb894c34d821c14388f9d5ee159b7e"},{"ts":"2026-06-29T16:31:44.844Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"c5371f045462b608292e00b725a2140255fb894c34d821c14388f9d5ee159b7e","hash":"82482c6d9cb625130edede2d78f50d698fe2248156ee9758cf26527013608620"},{"ts":"2026-06-29T16:32:40.681Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"7 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"82482c6d9cb625130edede2d78f50d698fe2248156ee9758cf26527013608620","hash":"037b4743d10be8510123819d170cb051c73dde1ac37fe8bc9ea827fed2538c3c"},{"ts":"2026-06-29T16:33:21.524Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"037b4743d10be8510123819d170cb051c73dde1ac37fe8bc9ea827fed2538c3c","hash":"8a5a46c5f1218e2728f0b7f5a6cbce3253d1f0609b774dbecbe36215c97232cd"},{"ts":"2026-06-29T16:34:28.275Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"8a5a46c5f1218e2728f0b7f5a6cbce3253d1f0609b774dbecbe36215c97232cd","hash":"73e4cf11880018ba2249ed772a0bd041a6609f9609a8af5e60da9ed9c24af411"},{"ts":"2026-06-29T18:33:30.225Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"73e4cf11880018ba2249ed772a0bd041a6609f9609a8af5e60da9ed9c24af411","hash":"bc24b52e04c860ea684c8ee1f5b50b82d9a750876d7440928123f8f40651396b"},{"ts":"2026-06-29T18:34:09.592Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"6 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"bc24b52e04c860ea684c8ee1f5b50b82d9a750876d7440928123f8f40651396b","hash":"1b1bcb4ef4560bf34a786ac057046b501fe6dc0aebf0f85e6c73bb92021edfd0"},{"ts":"2026-06-29T18:34:40.401Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"6 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"1b1bcb4ef4560bf34a786ac057046b501fe6dc0aebf0f85e6c73bb92021edfd0","hash":"65de548c023f20f3461a1258d99c48bd92c7f02ece58b4b02e401e47dc8cead7"},{"ts":"2026-06-29T20:04:03.654Z","model":"repair","action":"repair","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"{\"materialized\":0,\"before\":[],\"after\":[],\"focus_stats\":{\"roles_assigned\":0,\"excluded_sources\":0,\"commercial_sources\":0,\"cut_claims\":0,\"core\":0,\"cycle\":8,\"adjacent\":46}}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"65de548c023f20f3461a1258d99c48bd92c7f02ece58b4b02e401e47dc8cead7","hash":"5bee25d83c0e7b4bebe3fa6dcb648e031212e393c42c1bd00ba731a58de166ab"},{"ts":"2026-06-29T21:15:03.135Z","model":"fill-slots","action":"claim","prompt":"","input":"pt-141-ssri-sexual-dysfunction c67","response":"PT-141 for SSRI-Induced Sexual Dysfunction: Evidence-Graded Review is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"5bee25d83c0e7b4bebe3fa6dcb648e031212e393c42c1bd00ba731a58de166ab","hash":"655a598505c21a1bea72e85095101df51d554d13374f2c3c8567ddf9e355cc0a"},{"ts":"2026-06-29T21:15:05.540Z","model":"fill-slots","action":"claim","prompt":"","input":"pt-141-ssri-sexual-dysfunction c68","response":"Not established in this ledger: large randomized human trials for common marketed uses; long-term human safety beyond small pilots; condition-specific efficacy where only anecdotal or preclinical sources exist (explicit gaps remain in question graph).","tokens_in":0,"tokens_out":0,"cost":0,"prev":"655a598505c21a1bea72e85095101df51d554d13374f2c3c8567ddf9e355cc0a","hash":"e75ad7814020d4659245fc8cad924f5ebd9911501f07814f84ee473848e59b50"},{"ts":"2026-06-29T21:15:06.836Z","model":"fill-slots","action":"claim","prompt":"","input":"pt-141-ssri-sexual-dysfunction c69","response":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"e75ad7814020d4659245fc8cad924f5ebd9911501f07814f84ee473848e59b50","hash":"c73fd1434a7eaecab87e14bbf2fab6fcb9838b74133105db4382513e84811187"},{"ts":"2026-07-17T02:41:11.017Z","model":"owner","action":"voxel_divide","prompt":"","input":"pt-141-ssri-sexual-dysfunction","response":"17 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"c73fd1434a7eaecab87e14bbf2fab6fcb9838b74133105db4382513e84811187","hash":"41df25d500e6c50088b5f7a13ec6a4395e359bd8d444e43d9274dfa48e7563a7"}]}