{"slug":"pt-141-nerve-damage","verification":{"valid":true,"entries":6,"head":"091fe30de88bbb6159f0b6523dbc11891c593db8b56d947b12fc0dc7be98800f"},"count":6,"sources":[{"id":"s15","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/14963471/","title":"Double-blind, placebo-controlled evaluation of the safety, pharmacokinetics and pharmacodynamics of PT-141","quote":"PT-141 was safely administered and well tolerated in both studies.","summary":"Phase 1/2 safety data for PT-141 in humans; no nerve endpoints.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:13:07.154Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"979ad7a8f971dbf702a7e898e665a0ed00f0cb903fdc77c048c67e47fca2c627"},{"id":"s35","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/12591111/","title":"The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat","quote":"Melanotan-II significantly enhanced the recovery of sensory function following a crush lesion of the sciatic nerve in the rat at a dose of 20 microg kg(-1) per 48 h, s.c.","summary":"Key rat study on MT-II in nerve crush and toxic neuropathy models.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:13:07.154Z","link_status":"ok","quote_status":"verified","prev":"979ad7a8f971dbf702a7e898e665a0ed00f0cb903fdc77c048c67e47fca2c627","hash":"97096ff87faa79af89fc48ce48c11d55d44b5c6351701d65f6ed36205d3cf2c6"},{"id":"s36","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/15249163/","title":"Accelerating sensory recovery after sciatic nerve crush: non-selective versus melanocortin MC4 receptor-selective peptides","quote":"Both peptides did not accelerate sensory recovery in rats with a sciatic nerve crush, whereas the non-selective melanocortin agonist melanotan-II (MTII...) was effective.","summary":"Follow-up rat study comparing selectivity.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:13:07.154Z","link_status":"ok","quote_status":"unverified","prev":"97096ff87faa79af89fc48ce48c11d55d44b5c6351701d65f6ed36205d3cf2c6","hash":"3b589ec2ec8a8bae0dca0cd5fbbb1cadd2449689c31d2142c85f66b66de60d49"},{"id":"s16","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2694735/","title":"Melanocortin Receptors, Melanotropic Peptides and Penile Erection","quote":"PT-141 (Bremelanotide®) is currently the most studied melanocortinergic compound with regard to therapeutic potential for treatment of erectile dysfunction.","summary":"Review of PT-141 mechanism via melanocortin receptors.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:13:07.154Z","link_status":"ok","quote_status":"verified","prev":"3b589ec2ec8a8bae0dca0cd5fbbb1cadd2449689c31d2142c85f66b66de60d49","hash":"69ec7a0c91e644670ee5560f715113dac745c52186b6693883a9d59f169781f8"},{"id":"s20","type":"other","url":"https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/210557Orig1s000OtherR.pdf","title":"Other Review(s) - FDA NDA for Bremelanotide","quote":"Approximately 3500 patients have been treated with Bremelanotide in 43 clinical studies involving indications of erectile dysfunction, and HSDD.","summary":"FDA review confirming approved indications and trial scope.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:13:07.154Z","link_status":"ok","quote_status":"unverified","prev":"69ec7a0c91e644670ee5560f715113dac745c52186b6693883a9d59f169781f8","hash":"8361c9c1eee5066e70c30defcb2c56fb70c06d4196ae808332640a72f3ec1e93"},{"id":"s24","type":"reddit","url":"https://www.reddit.com/r/BodyHackGuide/comments/1p4o2lm/pt141_vs_melanotan2_which_one_boosts_sex_drive/","title":"PT-141 vs Melanotan-2","quote":"MT2 promoted nerve regeneration in sciatic nerve injury","summary":"Community mention of the 2003 rat study in context of related compound.","claim_ids":[],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:13:07.154Z","link_status":"ok","quote_status":"unverified","prev":"8361c9c1eee5066e70c30defcb2c56fb70c06d4196ae808332640a72f3ec1e93","hash":"091fe30de88bbb6159f0b6523dbc11891c593db8b56d947b12fc0dc7be98800f"}]}