{"slug":"pt-141-gabapentin","verification":{"valid":true,"entries":2,"head":"b2eae03d5aee62487314faf424d0c787660653d623e7d4b9e708c2d4b4e471a9"},"energy":{"passes":2,"tokens_in":15249,"tokens_out":2757,"tokens_total":18006,"cost_usd":0,"models":{"grok/grok-4.3":1,"owner":1},"head":"b2eae03d5aee62487314faf424d0c787660653d623e7d4b9e708c2d4b4e471a9"},"provenance":[{"ts":"2026-06-30T01:17:02.233Z","model":"grok/grok-4.3","action":"write","prompt":"","input":"Write a data-first, evidence-graded article: PT 141 for Gabapentin\nSlug: pt-141-gabapentin\nAudience: readers researching peptide evidence for this specific condition or drug cross.\nRules: label every claim tier (human|preclinical|anecdotal|mechanistic|speculative). Separate human trials from rat studies from Reddit/X anecdotes. No medical claims. Repair-vs-suppression framing. register: source_ledger.\n\nENRICHMENT BRIEF (binding section logic — one ## per compound):\n{\"voice\":\"enrichment\",\"article_shape\":\"single_cross\",\"condition\":\"Gabapentin / pregabalin\",\"condition_key\":\"gabapentin-lyrica\",\"primary_peptide\":\"pt-141\",\"peptides_in_scope\":[{\"id\":\"pt-141\",\"name\":\"PT-141\"}],\"drugs_in_scope\":[\"gabapentin-lyrica\"],\"weight_sensitive\":false,\"stimulant_context\":false,\"breaking_down\":{\"section_title\":\"What's breaking down if you have Gabapentin / pregabalin\",\"degenerative_why\":[],\"degenerative_layers\":[],\"note\":\"No condition profile matched — infer degeneration layers from slug/title and ledger claims.\"},\"peptide_chains\":[{\"peptide\":\"pt-141\",\"name\":\"PT-141\",\"section_title\":\"Why PT-141 might help you\",\"layer\":\"sexual / CNS arousal\",\"steps\":[\"You are reading about **Gabapentin / pregabalin** — what breaks down matters before any compound name.\",\"**Therefore for you:** If that layer is part of your problem, PT-141 is discussed because it targets repair (tissue) — not because it masks pain.\"],\"prose\":\"1. You are reading about **Gabapentin / pregabalin** — what breaks down matters before any compound name.\\n2. **Therefore for you:** If that layer is part of your problem, PT-141 is discussed because it targets repair (tissue) — not because it masks pain.\"}],\"drug_chains\":[{\"drug\":\"gabapentin-lyrica\",\"name\":\"Gabapentin / pregabalin\",\"section_title\":\"Why Gabapentin / pregabalin matters for you\",\"steps\":[\"**Drug:** Gabapentin / pregabalin\",\"**What it does:** Masks neuropathic pain signal; does not repair nerve.\",\"**Therefore for you:** state whether this drug **reduces load**, **suppre","response":"{\"slug\":\"pt-141-gabapentin\",\"title\":\"PT-141 and Gabapentin: Evidence-Graded Look at Sexual Arousal Pathways\",\"body\":\"## What's breaking down if you have Gabapentin / pregabalin\\n\\nGabapentin and pregabalin bind voltage-gated calcium channels. This reduces excitatory neurotransmitter release in the central and peripheral nervous system. The primary intended effect is dampening of neuropathic pain signals. A documented side effect profile includes reduced sexual desire, genital numbness, difficulty achieving orgasm, and lowered arousal in some users. These changes occur because the same calcium-channel modulation can blunt sensory and central pathways involved in sexual response. No structural nerve degeneration is proven from the drug itself in standard use, but the functional suppression of signals can persist as long as the medication is taken. This creates a trade-off: pain signal reduction without repair of the underlying nerve issue, and potential added suppression in arousal circuits.\\n\\n## Why PT-141 might help you\\n\\n1. You are reading about Gabapentin / pregabalin — what breaks down matters before any compound name.\\n2. Therefore for you: If reduced sexual desire or arousal forms part of your experience on these medications, PT-141 is discussed because it acts on melanocortin receptors (primarily MC3R and MC4R) in the hypothalamus and other CNS regions to promote sexual motivation and genital arousal responses.\\n3. The mechanism is central nervous system activation of desire pathways rather than peripheral vasodilation alone. If your gabapentin-related numbness or low drive stems from suppressed excitatory signaling, this targeted arousal pathway engagement addresses a different layer than simple signal masking.\\n4. Human data on the approved use show measurable increases in sexual desire scores and reduced distress in premenopausal women with hypoactive sexual desire disorder. No trials test PT-141 specifically against gabapentin-induced changes, so any ben","tokens_in":15249,"tokens_out":2757,"cost":0,"prev":"genesis","hash":"27571ecbefd2de1779c8f1b5811628bb951f963052d59ea50b29cfe885437eab"},{"ts":"2026-07-17T02:41:05.815Z","model":"owner","action":"voxel_divide","prompt":"","input":"pt-141-gabapentin","response":"20 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"27571ecbefd2de1779c8f1b5811628bb951f963052d59ea50b29cfe885437eab","hash":"b2eae03d5aee62487314faf424d0c787660653d623e7d4b9e708c2d4b4e471a9"}]}