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This produces effects on arousal pathways. The layer in scope here is sexual / CNS arousal. 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Human data for this specific outcome do not exist. 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Other degeneration layers in frozen shoulder, such as capsule fibrosis or inflammation, remain outside its studied scope.","status":"active","vx_hash":"acc39f0765bbf3a9d02c1fd368bbe10e8f27b090acacf93934fb066ec3cc06fc","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"1112bfea6291a6ae5334ad3f9250d52d3e2f4ca5d51470bc55e6a69c34108d3d","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:05.580Z","actor":"owner","text_sha":"c3a2f09ec26edac4657a403150797a42c89540bcb950777a5237e554c6ae3d91","detail":{"divided_from":"body","block":14,"kind":"p"},"prev":"genesis","hash":"1112bfea6291a6ae5334ad3f9250d52d3e2f4ca5d51470bc55e6a69c34108d3d"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:05.580Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/pt-141-frozen-shoulder/d14"},{"id":"d15","kind":"h","type":null,"order":15,"text":"## What the evidence actually shows","status":"active","vx_hash":"edee4ead0377f126c6fd8a4566cb9ae8c082171e180295235050fd1510787376","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"ab7005eac556aaccfaf6a669e330059b60b79371fd86c2d9c52277f549232a8d","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:05.580Z","actor":"owner","text_sha":"a7a051e6a294dc45c15b7d4859b7020d561e719fe73844f03e3a8f9e7fed8de1","detail":{"divided_from":"body","block":15,"kind":"h"},"prev":"genesis","hash":"ab7005eac556aaccfaf6a669e330059b60b79371fd86c2d9c52277f549232a8d"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:05.580Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/pt-141-frozen-shoulder/d15"},{"id":"d16","kind":"p","type":null,"order":16,"text":"No clinical trials, animal studies, or case reports directly examine PT-141 for adhesive capsulitis. Searches across medical databases and trial registries return zero matching results. (human: none) (preclinical: none)","status":"active","vx_hash":"2ef52d085cf79729bedf5b9ce29c7fa59c81a4b357ec13cd76153714c1e5ccfe","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"23c35f12028b8fb0ae866bf544721e8343bbe407892b1bad2ffeadbf44d516d7","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:05.580Z","actor":"owner","text_sha":"1dbbe7c029b2449542c51f5bafb3afe20572b50ba501223cb577484fbc23325e","detail":{"divided_from":"body","block":16,"kind":"p"},"prev":"genesis","hash":"23c35f12028b8fb0ae866bf544721e8343bbe407892b1bad2ffeadbf44d516d7"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:05.580Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/pt-141-frozen-shoulder/d16"},{"id":"d17","kind":"p","type":null,"order":17,"text":"General frozen shoulder research shows the condition often improves over 1–3 years with conservative management. One randomized trial found watchful waiting produced similar or better value than physical therapy alone at 12 months. (human) (source s17)","status":"active","vx_hash":"e246317a7cbf3645518a59e84f035f8bce27d74e7171186715991c83808f38f8","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"a4b9ba03c047226e8c98f37977a8cff190cf7b48adb3d04ae13c1e3fc60b10a3","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:05.580Z","actor":"owner","text_sha":"f04b923797ba92885e933c05402cc17d4f0211fb1c4cebffb245737bc934eaef","detail":{"divided_from":"body","block":17,"kind":"p"},"prev":"genesis","hash":"a4b9ba03c047226e8c98f37977a8cff190cf7b48adb3d04ae13c1e3fc60b10a3"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:05.580Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/pt-141-frozen-shoulder/d17"},{"id":"d18","kind":"p","type":null,"order":18,"text":"Hormone replacement therapy is under study as an adjunct in perimenopausal women because estrogen may influence capsule biology. That trial is ongoing and unrelated to PT-141. (human, ongoing) (source s3)","status":"active","vx_hash":"34fc18c6822458d06e26f89a94e879801325eaa13b46a3a8a432d357950b90f8","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"f8c3133b9089d45da3d8cf1b91889c9fc533fcda93222b607023aef7ae35114d","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:05.580Z","actor":"owner","text_sha":"19fa4c4d5c4817f7f8130038f37957a0b1df4c619ad0a1b213067ab863947ffd","detail":{"divided_from":"body","block":18,"kind":"p"},"prev":"genesis","hash":"f8c3133b9089d45da3d8cf1b91889c9fc533fcda93222b607023aef7ae35114d"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:05.580Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/pt-141-frozen-shoulder/d18"},{"id":"d19","kind":"h","type":null,"order":19,"text":"## What scientists say","status":"active","vx_hash":"29f837cd3107736e3dbcae8a7345cc76ff0868dc2eef135709b39e93adf96f9c","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"243c3fd277521f46b02b8be004a79b1acb30093f8fb27d7ed39bb61f2bea159b","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:05.580Z","actor":"owner","text_sha":"2f1dd55083de1fa734f2f06a8337a050d5a0b3f635bfc8bb709abab75705a1ef","detail":{"divided_from":"body","block":19,"kind":"h"},"prev":"genesis","hash":"243c3fd277521f46b02b8be004a79b1acb30093f8fb27d7ed39bb61f2bea159b"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:05.580Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/pt-141-frozen-shoulder/d19"},{"id":"d20","kind":"p","type":null,"order":20,"text":"Researchers describe frozen shoulder as an inflammatory and fibrotic process without a single identified cause. Treatments target symptoms and mechanical restoration rather than a specific peptide pathway. Melanocortin agonists like PT-141 have documented roles in sexual function and limited exploration in other CNS-mediated processes. No peer-reviewed commentary links them to shoulder capsule remodeling. (mechanistic)","status":"active","vx_hash":"4e3a622d702939459d0d09e02ad922d58896d1702e24df376b608fcfd3dee8f5","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"3e90b1e202f2bcc46307bb056234d67c0b55c1a7f21778e1736861f3dd1bc2d6","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:05.580Z","actor":"owner","text_sha":"167a80da14b92a08d93f1a0d9a995240f3ce3b7b4c6039fc70444a88f0f4058a","detail":{"divided_from":"body","block":20,"kind":"p"},"prev":"genesis","hash":"3e90b1e202f2bcc46307bb056234d67c0b55c1a7f21778e1736861f3dd1bc2d6"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:05.580Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/pt-141-frozen-shoulder/d20"},{"id":"d21","kind":"h","type":null,"order":21,"text":"## What people say on Reddit","status":"active","vx_hash":"01da2ba99b9d77f1d5c6b6b5df38a0a233edf5b1f52e18a6cee49df2ad5ee265","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"7776c6c73a3dabc618af1f3dbb1e95406763aba65385f3f4278aa7e1c79a34ab","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:05.580Z","actor":"owner","text_sha":"feb303756a303788527cf602bf2c3c6b00ab8c384fb9fff4baa9ffc53e0049c3","detail":{"divided_from":"body","block":21,"kind":"h"},"prev":"genesis","hash":"7776c6c73a3dabc618af1f3dbb1e95406763aba65385f3f4278aa7e1c79a34ab"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:05.580Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/pt-141-frozen-shoulder/d21"},{"id":"d22","kind":"p","type":null,"order":22,"text":"Anecdotal reports are sparse and indirect. One user mentioned injecting PT-141 into the shoulder for general use and reported good results, but the post concerned administration method, not frozen shoulder treatment. (anecdotal) (source s11)","status":"active","vx_hash":"6e5633edc2b7a0880cb6d3ffa84c633155489574d023b642e4e15191a6d4dac4","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"80d5d9e73966b49dc6e9e6cc2a2a15e754ea1b9977d6b3c87730224eaa57e9ae","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:05.580Z","actor":"owner","text_sha":"d3b1ce861cd46b06bc000765170182fa87e54cdca323471548f622561cbe4184","detail":{"divided_from":"body","block":22,"kind":"p"},"prev":"genesis","hash":"80d5d9e73966b49dc6e9e6cc2a2a15e754ea1b9977d6b3c87730224eaa57e9ae"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:05.580Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/pt-141-frozen-shoulder/d22"},{"id":"d23","kind":"p","type":null,"order":23,"text":"Another user in a peptide report noted attempting to repair a shoulder injury and feeling improvement after PT-141, yet no details confirmed a frozen shoulder diagnosis or ruled out other factors. (anecdotal) (source s13)","status":"active","vx_hash":"fe04bc5aec9c160ea478c4ac0e9fbc6d321879be35a2dd327211632b8d57050f","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"f4687bb4521e8f071bb37ecacfa52bd4e65843a0bf92b1baaf58f2208a7eec69","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:05.580Z","actor":"owner","text_sha":"c0c6c497b3452f5da2634ef109fac0e3b4d89f1174e2ae7bbcd2ce43a9d8cd33","detail":{"divided_from":"body","block":23,"kind":"p"},"prev":"genesis","hash":"f4687bb4521e8f071bb37ecacfa52bd4e65843a0bf92b1baaf58f2208a7eec69"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:05.580Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/pt-141-frozen-shoulder/d23"},{"id":"d24","kind":"h","type":null,"order":24,"text":"## What people say on X","status":"active","vx_hash":"b03f0322f7ce3d8e412e49d87b78ba47cfc4944d14c85037fba9a41c5fac7b78","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"6941b3bfb0f0b40a75a8d460e2fdfab84fd6e0c76bdb6624e712c2cba5070380","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:05.580Z","actor":"owner","text_sha":"4dd8bbfdb0452cc6235c2300209b5132daba3913b8f54ab179b1a73109c298dd","detail":{"divided_from":"body","block":24,"kind":"h"},"prev":"genesis","hash":"6941b3bfb0f0b40a75a8d460e2fdfab84fd6e0c76bdb6624e712c2cba5070380"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:05.580Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/pt-141-frozen-shoulder/d24"},{"id":"d25","kind":"p","type":null,"order":25,"text":"No relevant posts appear in targeted searches linking PT-141 to frozen shoulder symptoms or recovery. (anecdotal: none found)","status":"active","vx_hash":"4e091579897d416793f01561398b8ef67f4e8629257d27ac144b2d89ec42846f","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"a295472479ac00d8912d3c1bd83ac84566be3fe3c30e5178351c51de1ea322cd","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:05.580Z","actor":"owner","text_sha":"d84f4a1baf7622f78f13cb67aaf1c5d8048051c5f3491fa619d02dae012d3392","detail":{"divided_from":"body","block":25,"kind":"p"},"prev":"genesis","hash":"a295472479ac00d8912d3c1bd83ac84566be3fe3c30e5178351c51de1ea322cd"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:05.580Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/pt-141-frozen-shoulder/d25"},{"id":"d26","kind":"h","type":null,"order":26,"text":"## What we do not know","status":"active","vx_hash":"68d4131d48a2bf3384f08ff3f8eed3b8317713643414a5202aa1fc19945fbf75","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"abffb8939e11195711f6d785198a0999ab9ae1c5256d4cce0afb885a655562b5","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:05.580Z","actor":"owner","text_sha":"7d96a49fba77f6a48c0321db2ae4180a902beae62e2aac0d23408fbf8333a177","detail":{"divided_from":"body","block":26,"kind":"h"},"prev":"genesis","hash":"abffb8939e11195711f6d785198a0999ab9ae1c5256d4cce0afb885a655562b5"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:05.580Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/pt-141-frozen-shoulder/d26"},{"id":"d27","kind":"p","type":null,"order":27,"text":"Whether PT-141 alters capsule fibrosis, inflammation, or range of motion in humans remains unknown. No dose, duration, or outcome data exist for this condition. Long-term effects on shoulder tissue are unstudied. Interactions with physical therapy or standard injections are unexamined. 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Any off-label consideration carries the same unknowns that apply to all untested applications. Readers should consult qualified clinicians and review primary sources before any decision. This article presents available data only; it does not recommend use.","status":"active","vx_hash":"ca94afb9b91ce71387c9d6ae60bbe40806ba22a70269464b65fbeb5261ec583f","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"4fc7da91671dbf89f4840bc822815a4a8952ce0a80eea8ab7a7b6d8edb90d11f","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:41:05.580Z","actor":"owner","text_sha":"a0caea5af413b46fb18b7f1965086bb543c6deb7f7b18ee39a62c21180d854a2","detail":{"divided_from":"body","block":29,"kind":"p"},"prev":"genesis","hash":"4fc7da91671dbf89f4840bc822815a4a8952ce0a80eea8ab7a7b6d8edb90d11f"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:41:05.580Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/pt-141-frozen-shoulder/d29"}],"voxels":[{"id":"c1","div_id":"claim:c1","kind":"claim","text":"Frozen shoulder involves thickening and tightening 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clinical trials or animal studies test PT-141 for adhesive capsulitis.","tier":"human","standing":null,"weight":0.8,"section":"What the evidence actually shows","status":"active","source_ids":[],"source_status":"unsourced","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-30T01:18:06.392Z","model":"grok/grok-4.3","rationale":""},"who_claims":"grok/grok-4.3","edges":[{"type":"posted_by","actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-30T01:18:06.392Z"}],"why_material":"Highlights absence of direct evidence.","content_hash":null,"stable_url":"https://miscsubjects.com/i/claim/pt-141-frozen-shoulder/c2","machine_url":"https://miscsubjects.com/api/articles/pt-141-frozen-shoulder/claims/c2"},{"id":"c3","div_id":"claim:c3","kind":"claim","text":"One Reddit user reported shoulder improvement after PT-141 while attempting to repair an injury.","tier":"anecdotal","standing":null,"weight":0.3,"section":"What people say on 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