{"slug":"pt-141-cognition","verification":{"valid":true,"entries":4,"head":"cadfae1aef2e6e5bee3467d30fdbe993c4f356d7f18d478dd74b2c993de97327"},"count":4,"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31599840/","title":"Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder","quote":"Both studies demonstrated that bremelanotide significantly improved sexual desire and related distress in premenopausal women with hypoactive sexual desire disorder.","summary":"Phase 3 RCT results showing desire and distress improvements; no cognitive measures.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:18:54.082Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"2e68dd963d3bb9dbc811249c2ee9030d338819fd534e65c496d38645db60f7ed"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/12851303/","title":"PT-141: a melanocortin agonist for the treatment of sexual dysfunction","quote":"PT-141, a synthetic peptide analogue of alpha-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R, which are expressed primarily in the central nervous system.","summary":"Mechanism paper confirming receptor targets and CNS expression.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:18:54.082Z","link_status":"ok","quote_status":"verified","prev":"2e68dd963d3bb9dbc811249c2ee9030d338819fd534e65c496d38645db60f7ed","hash":"79f4cee5b28928ac0cb6b51a93bddf771f2dc889e751308b2cc7e5566b16ee36"},{"id":"s3","type":"other","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8788464/","title":"Bremelanotide for Treatment of Female Hypoactive Sexual Desire Disorder","quote":"The most common side effects of bremelanotide are nausea, vomiting, and flushing.","summary":"Review confirming trial focus remains sexual; no cognition data referenced.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:18:54.082Z","link_status":"ok","quote_status":"unverified","prev":"79f4cee5b28928ac0cb6b51a93bddf771f2dc889e751308b2cc7e5566b16ee36","hash":"f9b242c4b338f755dbcb6e284b5f6d2dcbd4143c8874c86a87d788036a5d2774"},{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1c39lie/pt_141_for_libido/","title":"PT 141 for libido","quote":"I have an increased sense of well-being, almost zero depression... increased pleasure (hedonic) beyond its effects used for ED.","summary":"User anecdote linking PT-141 to well-being but not to tested cognitive outcomes.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:18:54.082Z","link_status":"ok","quote_status":"unverified","prev":"f9b242c4b338f755dbcb6e284b5f6d2dcbd4143c8874c86a87d788036a5d2774","hash":"cadfae1aef2e6e5bee3467d30fdbe993c4f356d7f18d478dd74b2c993de97327"}]}