{"slug":"pt-141-blood-pressure-meds","verification":{"valid":true,"entries":22,"head":"b9ca11941cab6bd66e3d48661babd776df7e379f058c398bfd1ad4a826234f03"},"energy":{"passes":22,"tokens_in":3161,"tokens_out":397,"tokens_total":3558,"cost_usd":0,"models":{"grok/grok-4.3":1,"grok-4.3":7,"system/audit-repair":9,"kimi/moonshot-v1-8k":1,"repair":1,"fill-slots":2,"owner":1},"head":"b9ca11941cab6bd66e3d48661babd776df7e379f058c398bfd1ad4a826234f03"},"provenance":[{"ts":"2026-06-29T09:22:09.299Z","model":"grok/grok-4.3","action":"write","prompt":"","input":"PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):\nBPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).\nTB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.\nARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.\nSemax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.\nSelank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).\nPT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).\nDSIP — Delta Sleep Inducing Peptide; natural deep sleep without Ambien-class hangover.\nKPV — Gut-specific anti-inflammatory; calms gut lining without systemic immune suppression.\nGHK-Cu — Tissue remodeling; builds collagen scaffolding. Production drops 60-80% with age.\nThymosin Alpha-1 — Immune modulation; supports immune function without suppressing it.\n\nWrite a data-first, evidence-graded article: PT-141 for Sexual Dysfunction on Blood Pressure Medications\n\nAudience: 75M on blood pressure meds. The problem: BP meds cause sexual dysfunction, leading to non-compliance. Why PT-141 maps: restores brain arousal signal regardless of vascular effects. Novelty: 8/10.\n\nRules: label every claim tier (human|preclinical|anecdotal|mechanistic|speculative). Separate rat studies from human trials from user reports. No medical claims or treatment promises. Use repair-vs-suppression framing where relevant. register: source_ledger.","response":"{\n  \"slug\": \"pt-141-sexual-dysfunction-blood-pressure-meds\",\n  \"title\": \"PT-141 (Bremelanotide) and Sexual Dysfunction in the Context of Blood Pressure Medications: Evidence Summary\",\n  \"body\": \"## Overview of PT-141 Mechanism\\nPT-141 (bremelanotide) is a melanocortin receptor agonist that activates MC4R pathways in the central nervous system. Human fMRI data indicate enhanced sexual brain processing following administration.\\n\\n## Approved Use and Human Trial Data\\nBremelanotide (Vyleesi) received FDA approval in 2019 for acquired generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. Clinical trials demonstrated statistically significant but modest improvements on validated questionnaires (human tier). Long-term open-label extension data up to 76 weeks reported sustained safety signals without cumulative blood pressure effects (human tier).\\n\\n## Blood Pressure Effects from Human Studies\\nClinical studies consistently document small, transient increases in blood pressure (peak ~4 hours post-dose, resolving by 8–12 hours) averaging 2–6 mmHg systolic (human tier). The product is contraindicated in uncontrolled hypertension per labeling.\\n\\n## Relation to Antihypertensive-Induced Sexual Dysfunction\\nNo dedicated human clinical trials examine PT-141 specifically for sexual dysfunction induced by blood pressure medications such as beta-blockers. Antihypertensives are associated with sexual side effects in observational data, but PT-141's central mechanism of action is independent of peripheral vascular pathways (mechanistic tier). Preclinical and early male studies explored ED applications but did not isolate antihypertensive co-administration (preclinical tier).\\n\\n## Absence of Specific Evidence\\nNo randomized human data, rat studies, or user reports directly address PT-141 combined with antihypertensives for compliance or dysfunction reversal. Claims of applicability remain speculative.\\n\\n## Framing Notes\\nPT-141 modulates central arousal sign","tokens_in":0,"tokens_out":0,"cost":0,"prev":"genesis","hash":"e7456d86e4c8b2435ae7ef34b40f5d30c8eb83fa67917e34eebc6dfab4b8b2f2"},{"ts":"2026-06-29T11:21:07.028Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-blood-pressure-meds","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"e7456d86e4c8b2435ae7ef34b40f5d30c8eb83fa67917e34eebc6dfab4b8b2f2","hash":"b691ee5b2a9627e966049792dbf66c2d8d5f810a5dd5f1250613c4854599af9f"},{"ts":"2026-06-29T11:21:35.653Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-blood-pressure-meds","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"b691ee5b2a9627e966049792dbf66c2d8d5f810a5dd5f1250613c4854599af9f","hash":"9137faeb20214b32c8c35abce0bb2b18438687d1ef5d7648ebbedb26cdddec23"},{"ts":"2026-06-29T12:49:22.254Z","model":"system/audit-repair","action":"repair","prompt":"","input":"pt-141-blood-pressure-meds","response":"{\"materialized\":0,\"before\":[\"missing constitution slots: what_it_is, what_is_known, what_is_unknown, limitations, disclaimer\"],\"after\":[\"missing constitution slots: what_it_is, what_is_known, what_is_unknown, limitations, disclaimer\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"9137faeb20214b32c8c35abce0bb2b18438687d1ef5d7648ebbedb26cdddec23","hash":"1ab1e3f75d7034987759a84cddff5e925683395c9dc9a8e1077ce51875f81416"},{"ts":"2026-06-29T12:49:22.830Z","model":"system/audit-repair","action":"claim","prompt":"","input":"pt-141-blood-pressure-meds c15","response":"PT-141 (Bremelanotide) and Sexual Dysfunction in the Context of Blood Pressure Medications: Evidence Summary is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"1ab1e3f75d7034987759a84cddff5e925683395c9dc9a8e1077ce51875f81416","hash":"201e8370ac49fbd03ecf7afc2152364fea9d59ef1352450cc51676c11f3a5e42"},{"ts":"2026-06-29T12:49:22.907Z","model":"system/audit-repair","action":"claim","prompt":"","input":"pt-141-blood-pressure-meds c16","response":"Per this ledger on PT-141 (Bremelanotide) and Sexual Dysfunction in the Context of Blood Pressure Medications: Evidence Summary: 10 scientific and 3 anecdotal sources are catalogued; 6 preclinical claim(s) summarize animal/cell literature in-catalogue.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"201e8370ac49fbd03ecf7afc2152364fea9d59ef1352450cc51676c11f3a5e42","hash":"ad1de1f44efb0f9eff0d9a39e7a425973dadc4afc1b68b774dd982e64879e7d2"},{"ts":"2026-06-29T12:49:22.972Z","model":"system/audit-repair","action":"claim","prompt":"","input":"pt-141-blood-pressure-meds c17","response":"Not established in this ledger: large randomized human trials for common marketed uses; long-term human safety beyond small pilots; condition-specific efficacy where only anecdotal or preclinical sources exist (explicit gaps remain in question graph).","tokens_in":0,"tokens_out":0,"cost":0,"prev":"ad1de1f44efb0f9eff0d9a39e7a425973dadc4afc1b68b774dd982e64879e7d2","hash":"5c6df6dbfc9df0a082acbcafc43391197e5f3db1d5f523a5e215caf235cffc3c"},{"ts":"2026-06-29T12:49:23.028Z","model":"system/audit-repair","action":"claim","prompt":"","input":"pt-141-blood-pressure-meds c18","response":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"5c6df6dbfc9df0a082acbcafc43391197e5f3db1d5f523a5e215caf235cffc3c","hash":"43283067855625171083b2f09b272055df637640ccbb2af9bf4dd7faaea85948"},{"ts":"2026-06-29T12:49:23.169Z","model":"system/audit-repair","action":"claim","prompt":"","input":"pt-141-blood-pressure-meds c19","response":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"43283067855625171083b2f09b272055df637640ccbb2af9bf4dd7faaea85948","hash":"bcf3f90653b1ac2dbab43a6f44192b92114bbeb51cb9d157987b6bec67ab36ae"},{"ts":"2026-06-29T12:49:23.841Z","model":"system/audit-repair","action":"repair","prompt":"","input":"pt-141-blood-pressure-meds","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"bcf3f90653b1ac2dbab43a6f44192b92114bbeb51cb9d157987b6bec67ab36ae","hash":"221ff9105421cac4d03d1f1036e2b8685016abeef68d7debc043e6c5a03e9760"},{"ts":"2026-06-29T13:23:06.719Z","model":"system/audit-repair","action":"repair","prompt":"","input":"pt-141-blood-pressure-meds","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"221ff9105421cac4d03d1f1036e2b8685016abeef68d7debc043e6c5a03e9760","hash":"3b7a66589a6a6c3d551b0c5f0f8b90f647c5c7511f0e6a4c6608802e636b92da"},{"ts":"2026-06-29T13:23:07.913Z","model":"system/audit-repair","action":"repair","prompt":"","input":"pt-141-blood-pressure-meds","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"3b7a66589a6a6c3d551b0c5f0f8b90f647c5c7511f0e6a4c6608802e636b92da","hash":"c7b6e64b33ce6e5ad78572090b9759741c146c0b33678dde0e83fc722b1d6d9a"},{"ts":"2026-06-29T13:54:43.927Z","model":"kimi/moonshot-v1-8k","action":"collaborate","prompt":"","input":"pt-141-blood-pressure-meds","response":"I am adding explicit gaps in knowledge (what_is_unknown) and naming anecdotal claimants (who_claims_what) as instructed, since these are missing from the ledger.","tokens_in":3161,"tokens_out":397,"cost":0,"prev":"c7b6e64b33ce6e5ad78572090b9759741c146c0b33678dde0e83fc722b1d6d9a","hash":"402949fc51f71400c26032fe37a3930b30ae60e41986e0433c598ce418f14f43"},{"ts":"2026-06-29T16:35:27.520Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-blood-pressure-meds","response":"1 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"402949fc51f71400c26032fe37a3930b30ae60e41986e0433c598ce418f14f43","hash":"3f88ae40dec4cdbd3d71342d23ce148cf2d91350b6625a8559ad6eefb9a9d0f1"},{"ts":"2026-06-29T18:34:27.270Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-blood-pressure-meds","response":"7 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"3f88ae40dec4cdbd3d71342d23ce148cf2d91350b6625a8559ad6eefb9a9d0f1","hash":"69819ab4d4ab08fd18375223f524bb370c1a4b10bc0b74cec53c7a0430fd9db8"},{"ts":"2026-06-29T18:35:00.277Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-blood-pressure-meds","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"69819ab4d4ab08fd18375223f524bb370c1a4b10bc0b74cec53c7a0430fd9db8","hash":"6c206050edb2f1ba9cff0e87c6c6de180f16f78a1c13d91b6b30446044124b93"},{"ts":"2026-06-29T18:35:21.811Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-blood-pressure-meds","response":"6 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"6c206050edb2f1ba9cff0e87c6c6de180f16f78a1c13d91b6b30446044124b93","hash":"2f09f86f50a2e4c0223769ebb58818e9d9951935a15b0f7588398cabd9aa7fb0"},{"ts":"2026-06-29T18:36:33.300Z","model":"grok-4.3","action":"sources","prompt":"","input":"pt-141-blood-pressure-meds","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"2f09f86f50a2e4c0223769ebb58818e9d9951935a15b0f7588398cabd9aa7fb0","hash":"1970214f96754d3d4c32c91544ea6606e17289e279a1218024f9369011b0ea07"},{"ts":"2026-06-29T20:05:05.429Z","model":"repair","action":"repair","prompt":"","input":"pt-141-blood-pressure-meds","response":"{\"materialized\":0,\"before\":[],\"after\":[],\"focus_stats\":{\"roles_assigned\":0,\"excluded_sources\":0,\"commercial_sources\":0,\"cut_claims\":0,\"core\":0,\"cycle\":0,\"adjacent\":29}}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"1970214f96754d3d4c32c91544ea6606e17289e279a1218024f9369011b0ea07","hash":"84cdfcad6052f2ff891fa9bc6a14de8b3d293425e365d09a08052107dd72b836"},{"ts":"2026-06-29T21:16:09.627Z","model":"fill-slots","action":"claim","prompt":"","input":"pt-141-blood-pressure-meds c47","response":"PT-141 (Bremelanotide) and Sexual Dysfunction in the Context of Blood Pressure Medications: Evidence Summary is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). 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