{"slug":"pt-141-blood-pressure-meds","verification":{"valid":true,"entries":16,"head":"a589333dff3c18005035a71b66353cf2427b837811be2ca5480a9f58b05c304c"},"count":16,"models":["grok/grok-4.3","grok-4.3","system/audit-repair","kimi/moonshot-v1-8k","fill-slots"],"yield":{"passes":16,"energy_spent_rows":0,"total_cost_usd":0.000534,"waste_cost_usd":0,"total_tokens":3558,"material_outputs":3,"usd_per_output":0.000178,"models":[{"model":"kimi/moonshot-v1-8k","passes":1,"cost_usd":0.000534,"tokens_total":3558,"outputs":3,"waste_passes":0,"usd_per_output":0.000178},{"model":"grok/grok-4.3","passes":1,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"grok-4.3","passes":7,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"system/audit-repair","passes":5,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"fill-slots","passes":2,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST /api/protocol/collaborate","pricing_ppm":{"grok-4.3":[1.25,2.5],"grok/grok-4.3":[1.25,2.5],"grok-build-0.1":[1,2],"kimi/moonshot-v1-8k":[0.15,0.15],"gemini/gemini-2.5-flash":[0.075,0.3],"gemini/gemini-2.0-flash-lite":[0.075,0.3],"openai/gpt-4o":[2.5,10],"openai/gpt-4o-mini":[0.15,0.6],"system/reflex":[0,0],"ingest:deterministic":[0,0],"fill-slots":[0,0]}}},"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T09:22:09.299Z","model":"grok/grok-4.3","role":"writer","action":"redraft","payload":{"title":"PT-141 (Bremelanotide) and Sexual Dysfunction in the Context of Blood Pressure Medications: Evidence Summary","register":"source_ledger","body":"## Overview of PT-141 Mechanism\nPT-141 (bremelanotide) is a melanocortin receptor agonist that activates MC4R pathways in the central nervous system. Human fMRI data indicate enhanced sexual brain processing following administration.\n\n## Approved Use and Human Trial Data\nBremelanotide (Vyleesi) received FDA approval in 2019 for acquired generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. Clinical trials demonstrated statistically significant but modest improvements on validated questionnaires (human tier). Long-term open-label extension data up to 76 weeks reported sustained safety signals without cumulative blood pressure effects (human tier).\n\n## Blood Pressure Effects from Human Studies\nClinical studies consistently document small, transient increases in blood pressure (peak ~4 hours post-dose, resolving by 8–12 hours) averaging 2–6 mmHg systolic (human tier). The product is contraindicated in uncontrolled hypertension per labeling.\n\n## Relation to Antihypertensive-Induced Sexual Dysfunction\nNo dedicated human clinical trials examine PT-141 specifically for sexual dysfunction induced by blood pressure medications such as beta-blockers. Antihypertensives are associated with sexual side effects in observational data, but PT-141's central mechanism of action is independent of peripheral vascular pathways (mechanistic tier). Preclinical and early male studies explored ED applications but did not isolate antihypertensive co-administration (preclinical tier).\n\n## Absence of Specific Evidence\nNo randomized human data, rat studies, or user reports directly address PT-141 combined with antihypertensives for compliance or dysfunction reversal. Claims of applicability remain speculative.\n\n## Framing Notes\nPT-141 modulates central arousal signaling; it does not act via vascular repair or suppression mechanisms.","claims":[{"id":"c1","text":"Bremelanotide activates MC4R in the CNS to enhance sexual brain processing, shown in double-blind fMRI study of women with HSDD.","section":"Approved Use and Human Trial Data","tier":"human","source_ids":["s1"],"source_status":"sourced","why_material":"Establishes central mechanism independent of vascular effects.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c2","text":"FDA-approved in 2019 for HSDD in premenopausal women based on clinical trial efficacy and safety data.","section":"Approved Use and Human Trial Data","tier":"human","source_ids":["s2"],"source_status":"sourced","why_material":"Defines regulatory status and approved population.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c3","text":"Clinical studies show transient BP increases of 2–6 mmHg systolic peaking at ~4 hours post-dose.","section":"Blood Pressure Effects from Human Studies","tier":"human","source_ids":["s3"],"source_status":"sourced","why_material":"Quantifies cardiovascular signal relevant to BP med users.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c4","text":"No human trials evaluate PT-141 for antihypertensive-induced sexual dysfunction.","section":"Absence of Specific Evidence","tier":"human","source_ids":["s4"],"source_status":"sourced","why_material":"Highlights evidence gap for the stated audience and use case.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}}],"sources":[{"id":"s1","type":"clinical_trial","url":"https://palatin.com/press_releases/palatin-announces-publication-of-vyleesi-bremelanotide-fmri-study-in-women-with-hypoactive-sexual-desire-disorder-hsdd/","title":"Palatin Announces Publication of Vyleesi fMRI Study","quote":"bremelanotide significantly increased sexual desire for up to 24 hours post administration... enhanced sexual brain processing","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"medical","url":"https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210557s000lbl.pdf","title":"VYLEESI (bremelanotide) FDA Label","quote":"Bremelanotide is a melanocortin receptor (MCR) agonist... indicated for the treatment of... hypoactive sexual desire disorder","link_status":"ok","quote_status":"unverified"},{"id":"s3","type":"clinical_trial","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6819023/","title":"Long-Term Safety and Efficacy of Bremelanotide","quote":"small, transient BP increases that peak within 4 hours postdose and return toward baseline by approximately 8–10 hours","link_status":"ok","quote_status":"verified"},{"id":"s4","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/36242769/","title":"An evaluation of bremelanotide injection for the treatment of HSDD","quote":"summarize bremelanotide's proposed mechanism of action, pharmacokinetics, efficacy and safety data derived from clinical trials","link_status":"ok","quote_status":"verified"}]},"rationale":"","tokens_in":0,"tokens_out":0,"prev_hash":"genesis","hash":"bb2055f83fefda8ff518bbc6127d1714f172d2820637ea2dd6e7f3c671fee77a"},{"seq":1,"id":"k2","ts":"2026-06-29T11:21:07.028Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/35147466/","title":"Safety Profile of Bremelanotide Across the Clinical Development Program","quote":"Small and transient but statistically significant blood pressure increases were observed during ambulatory blood pressure monitoring. ... Although not deemed clinically important, bremelanotide should be used with caution in patients at risk of cardiovascular disease, and blood pressure should be well controlled during treatment.","link_status":"ok","quote_status":"unverified"},{"id":"s6","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT02338960","title":"Study to Evaluate the Efficacy/Safety of Bremelanotide in Premenopausal Women With Hypoactive Sexual Desire Disorder","quote":"Subjects will self-administer a fixed dose (1.75 mg) of bremelanotide (BMT) subcutaneously (SC) via auto-injector on an as needed basis with no more than 1 dose taken every 24 hours","link_status":"ok","quote_status":"unverified"},{"id":"s7","type":"review","url":"https://auanews.net/issues/articles/2026/april-2026/peptides-for-sexual-dysfunction-what-clinicians-should-know","title":"Peptides for Sexual Dysfunction: What Clinicians Should Know","quote":"Caution is warranted in patients with uncontrolled hypertension, as PT-141 has also been shown to increase blood pressure.","link_status":"ok","quote_status":"verified"},{"id":"s8","type":"medical","url":"https://www.mayoclinic.org/drugs-supplements/bremelanotide-subcutaneous-route/description/drg-20466805","title":"Bremelanotide (subcutaneous route) - Side effects & dosage","quote":"Hypertension (high blood pressure), uncontrolled—Should not be used in patients with these conditions. ... Your blood pressure might get too high while you are using this medicine.","link_status":"http_403","quote_status":"unverified"},{"id":"s9","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1rraz53/pt_141libido/","title":"Pt 141-libido","quote":"I am on BP meds (Telmisartan) and pt-141 spikes me temporarily for an hour or two from 110/60 to 130-140/70-80. Really about the same for me ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"prev_hash":"bb2055f83fefda8ff518bbc6127d1714f172d2820637ea2dd6e7f3c671fee77a","hash":"3d97f2520f7c25d891ba0ed3c523959907de68dedc59f4a8aaf5a201aebcf542"},{"seq":2,"id":"k3","ts":"2026-06-29T11:21:35.653Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s10","type":"other","url":"https://patents.google.com/patent/US11590209B2/en","title":"US11590209B2 - Use of bremelanotide in patients with controlled hypertension","quote":"the present inventors have determined that patients diagnosed with both female sexual dysfunction and controlled hypertension may safely treat the female sexual dysfunction with bremelanotide, as detailed below.","link_status":"http_503","quote_status":"unverified"},{"id":"s11","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/35630054/","title":"Management of Hypertension with Female Sexual Dysfunction","quote":"...antihypertensive agents' impact on female sexual ... bremelanotide ; female sexual dysfunction; flibanserin; hypertension; ospemifene.","link_status":"ok","quote_status":"unverified"},{"id":"s12","type":"medical","url":"https://www.towerurology.com/blog/pt-141-benefits-dosage-results/","title":"PT-141 for Men, A Men's Sexual Health Doctor Tells All","quote":"For someone already on blood pressure medication or with cardiovascular disease, this is a real conversation we need to have before I write a prescription.","link_status":"ok","quote_status":"verified"},{"id":"s13","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/mwws4g/does_pt141_cause_high_blood_pressure/","title":"Does PT-141 cause high blood pressure? : r/Peptides","quote":"Yes . It does on me. FDA trials of PT-141 originally had it in an intranasal form, but they were cancelled due to issues with blood pressure.","link_status":"ok","quote_status":"unverified"},{"id":"s14","type":"reddit","url":"https://www.reddit.com/r/erectiledysfunction/comments/1frnpj6/the_combo_of_tadalafil_and_pt141_is_an_insanely/","title":"The combo of Tadalafil and PT-141 is insanely effective - r/erectiledysfunction","quote":"It raises blood pressure . Bremelanotide increased systolic blood pressure by up to 3.1 to 3.2 mmHg,","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"prev_hash":"3d97f2520f7c25d891ba0ed3c523959907de68dedc59f4a8aaf5a201aebcf542","hash":"9802a3b13dbc5c9baa5bb8a0e74b79be2c8a124c4fe9974b329897f42360a45c"},{"seq":3,"id":"k4","ts":"2026-06-29T12:49:22.830Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c15","tier":"system","text":"PT-141 (Bremelanotide) and Sexual Dysfunction in the Context of Blood Pressure Medications: Evidence Summary is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"what_it_is","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:49:22.830Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"9802a3b13dbc5c9baa5bb8a0e74b79be2c8a124c4fe9974b329897f42360a45c","hash":"fa509a106c70800591e43fa3badc92f07c5bc02360403b40211fa07e9080df3e"},{"seq":4,"id":"k5","ts":"2026-06-29T12:49:22.907Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c16","tier":"preclinical","text":"Per this ledger on PT-141 (Bremelanotide) and Sexual Dysfunction in the Context of Blood Pressure Medications: Evidence Summary: 10 scientific and 3 anecdotal sources are catalogued; 6 preclinical claim(s) summarize animal/cell literature in-catalogue.","who_claims":"miscsubjects ledger synthesis","source_ids":[],"slot":"what_is_known","posted_by":{"actor":"miscsubjects ledger synthesis","channel":"protocol/fill-slots","ts":"2026-06-29T12:49:22.907Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"fa509a106c70800591e43fa3badc92f07c5bc02360403b40211fa07e9080df3e","hash":"06cd2dcfe922e160485919ff52a242eb6f037118d50ce383c2d66b69e4d9aa3e"},{"seq":5,"id":"k6","ts":"2026-06-29T12:49:22.972Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c17","tier":"speculative","text":"Not established in this ledger: large randomized human trials for common marketed uses; long-term human safety beyond small pilots; condition-specific efficacy where only anecdotal or preclinical sources exist (explicit gaps remain in question graph).","who_claims":"miscsubjects gap analysis","source_ids":[],"slot":"what_is_unknown","posted_by":{"actor":"miscsubjects gap analysis","channel":"protocol/fill-slots","ts":"2026-06-29T12:49:22.972Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"06cd2dcfe922e160485919ff52a242eb6f037118d50ce383c2d66b69e4d9aa3e","hash":"60aa364144267096e8176ebec8d50400725053fcf551e1c1124daf62f0ea7f88"},{"seq":6,"id":"k7","ts":"2026-06-29T12:49:23.028Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c18","tier":"mechanistic","text":"Hash-chained sources verify integrity, not clinical truth. 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Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"disclaimer","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:49:23.169Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"0d88618aa8e45a8029222409eb9fd9842ec40ec615de2b3e70047009a1970ab7","hash":"64bf2cf91e2ec549fc5ab5bbfaa11fb6e4b7bd59f973b1b9f0b2290561551812"},{"seq":8,"id":"k9","ts":"2026-06-29T13:54:43.927Z","model":"kimi/moonshot-v1-8k","role":"collaborator","action":"collaborate","payload":{"claims_added":["c20","c21"],"challenge_id":"c22","rationale":"I am adding explicit gaps in knowledge (what_is_unknown) and naming anecdotal claimants (who_claims_what) as instructed, since these are missing from the ledger."},"rationale":"I am adding explicit gaps in knowledge (what_is_unknown) and naming anecdotal claimants (who_claims_what) as instructed, since these are missing from the ledger.","tokens_in":3161,"tokens_out":397,"cost":0.0005336999999999999,"prev_hash":"64bf2cf91e2ec549fc5ab5bbfaa11fb6e4b7bd59f973b1b9f0b2290561551812","hash":"a7c20c2d3eb96bbec80a65b7d57e42b6a1a488351df3000f6bc351b81e494c35"},{"seq":9,"id":"k10","ts":"2026-06-29T16:35:27.520Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s15","type":"reddit","url":"https://www.reddit.com/r/gettingbigger/comments/1l76is0/part_4_of_my_nighttime_growth_protocol_rhokinase/","title":"Part 4 of My Night-Time Growth Protocol - Rho-Kinase","quote":"I've tried PT 141 but the nausea was too much. Also, Im sensitive to adreline spikes. I'm on the Nebivolol now but might need to try it again.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"a7c20c2d3eb96bbec80a65b7d57e42b6a1a488351df3000f6bc351b81e494c35","hash":"6cd29ead138a779e23994b18ded976eadc9f0c92fd540c82134769bd5e259a73"},{"seq":10,"id":"k11","ts":"2026-06-29T18:34:27.270Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s16","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1c39lie/pt_141_for_libido/","title":"PT 141 for libido","quote":"pt-141 is very effective in those who respond to it, which seems to be a fair proportion of those who try it. side effects are often limiting. in his case the transient increase in blood pressure may be an issue. the beta blocker nebivolol, taken 2 hours prior, is an excellent adjunct as it is mild and has a secondary cialis-like vasodilating effect.","link_status":"ok","quote_status":"unverified"},{"id":"s17","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1tyketx/pt141_bremelanotide_the_sexual_health_peptide/","title":"PT-141 (bremelanotide): the sexual health peptide that isn't a Viagra clone","quote":"PT-141 causes small, transient increases in blood pressure, with the label and reviews commonly citing about 6 mmHg systolic and 3 mmHg diastolic at peak, a few hours after a dose, along with a slight drop in heart rate. It returns to around baseline within roughly 12 hours. Manageable for most people at the once-per-24-hours limit, but it's exactly why the compound is contraindicated in uncontrolled high blood pressure or known cardiovascular disease","link_status":"ok","quote_status":"unverified"},{"id":"s18","type":"reddit","url":"https://www.reddit.com/r/BioHackingGuide/comments/1sqts0d/pt141_full_breakdown/","title":"PT-141 — Full Breakdown","quote":"Those on antihypertensive medications — use caution.","link_status":"ok","quote_status":"unverified"},{"id":"s19","type":"reddit","url":"https://www.reddit.com/r/CleanHealth/comments/1te6bf2/beginners_guide_for_pt141/","title":"Beginner's Guide for PT-141","quote":"• On blood pressure meds • Anyone not cleared by a clinician.","link_status":"ok","quote_status":"unverified"},{"id":"s20","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/qmtwl9/my_experience_with_pt141/","title":"My Experience with PT-141","quote":"I do have hypertension bp. and take amlodipine for bp. I like amlodipine because all of the other types of bp meds will kill/side effects with ...","link_status":"ok","quote_status":"unverified"},{"id":"s21","type":"x","url":"https://x.com/achilleas_ghost/status/2041161049890807896","title":"Bremelanotide (Vyleesi) post","quote":"Avoid if you have high blood pressure.","link_status":"ok","quote_status":"verified"},{"id":"s22","type":"x","url":"https://x.com/ivyherbal/status/2001414171179491776","title":"Melanotan II (Tanning and Libido) post","quote":"Clinical development was abandoned due to severe side effects, including dangerously high blood pressure, vomiting, and priapism (uncontrollable erection). A modified version (Bremelanotide) was eventually approved, but the original Melanotan II was deemed too toxic.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"6cd29ead138a779e23994b18ded976eadc9f0c92fd540c82134769bd5e259a73","hash":"93a30bc4a9a8e664cba27961d6463e48461cf0997bea74451ae18fb11ca28895"},{"seq":11,"id":"k12","ts":"2026-06-29T18:35:00.277Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s23","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1sumfw4/pt141_the_libido_peptide/","title":"PT-141 the libido peptide?","quote":"Blood pressure - transient elevation has been reported. People with uncontrolled hypertension should avoid this or only use it with medical guidance","link_status":"ok","quote_status":"unverified"},{"id":"s24","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1u7lh1u/the_libido_peptide_explained_what_pt141_actually/","title":"what PT-141 actually does for sexual desire","quote":"PT-141 can cause transient spikes in blood pressure , so it's not for anyone with uncontrolled hypertension or ...","link_status":"ok","quote_status":"unverified"},{"id":"s25","type":"reddit","url":"https://www.reddit.com/r/SEXONDRUGS/comments/1781zni/blood_pressure_worries/","title":"Blood pressure worries","quote":"Cialis lowers blood pressure . PT-141 doesn't have a strong effect. You'll be fine.","link_status":"ok","quote_status":"unverified"},{"id":"s26","type":"reddit","url":"https://www.reddit.com/r/SEXONDRUGS/comments/1dysg2d/heres_what_happens_if_you_accidentally_take_10x/","title":"Here's what happens if you accidentally take 10x the ...","quote":"Also, I do not experience heightened blood pressure on PT 141 .","link_status":"ok","quote_status":"unverified"},{"id":"s27","type":"x","url":"https://x.com/YatYas1070/status/2059176725137785268","title":"Melanotan 2 and PT-141 post","quote":"Some people experience some unsettling side effects for the first 30-60 minutes with PT-141 like flushing, elevated Blood Pressure, anxiety, nausea, etc…. Start with a low dose and work your way up till you get the effects you seek.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"93a30bc4a9a8e664cba27961d6463e48461cf0997bea74451ae18fb11ca28895","hash":"bc811f71624cdc0d0151896f5000eb063415b9845782239907355e4a23b07acf"},{"seq":12,"id":"k13","ts":"2026-06-29T18:35:21.811Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s28","type":"reddit","url":"https://www.reddit.com/r/Swingers/comments/1c29qbz/pt141/","title":"PT-141","quote":"PT-141 is the structure in melanotan that causes the horniness. One common side effect is nausea.","link_status":"ok","quote_status":"unverified"},{"id":"s29","type":"reddit","url":"https://www.reddit.com/r/erectiledysfunction/comments/1qik4vm/pt141_experience_it_absolutely_works/","title":"PT-141 Experience - it absolutely works","quote":"I am ok when laying down but any sort of exertion or standing up I felt like I may vomit. ... If I can eliminate the nausea then I will use this stuff at least once a week as a treat for me but if it causes the same level of nausea then its touch and go as to if it is worth it.","link_status":"ok","quote_status":"unverified"},{"id":"s30","type":"reddit","url":"https://www.reddit.com/r/erectiledysfunction/comments/1clpo4k/taken_pt141_twice_now_and_i_am_happily_amazed/","title":"Taken PT-141 twice now and I am happily amazed","quote":"Very slight nausea but not enough to even complain about. Felt a bit flushed for 10-15 minutes. ... I'm not one for giving myself injections. But this stuff works for me!!! Not only did I feel 19 again and gave me the best hard-ons I've ever had, it gave me the mental boost I needed.","link_status":"ok","quote_status":"unverified"},{"id":"s31","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1f9yows/pt141_major_success/","title":"PT-141 Major Success!","quote":"The standard dose for women is 1.75mg. Therefore 17.5 units will deliver 1.75mg of pt-141 peptide. I find that 20 units work best for me so I ...","link_status":"ok","quote_status":"unverified"},{"id":"s32","type":"x","url":"https://x.com/TheShreddington/status/1992413813191098741","title":"X post by @TheShreddington","quote":"Why did I go ahead and try PT-141 again. 75mcg and blood pressure is through the roof (for me).","link_status":"ok","quote_status":"unverified"},{"id":"s33","type":"x","url":"https://x.com/JayCampbell333/status/2043711049388675316","title":"X post by @JayCampbell333","quote":"Temporary blood pressure increase ... Who should NOT use PT-141: → Uncontrolled hypertension (>140/90 consistently) → Recent cardiovascular events","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"bc811f71624cdc0d0151896f5000eb063415b9845782239907355e4a23b07acf","hash":"cfcf4541accca681d063308b156cbdd069c1ef2413ed0ab2beb48be66bb1cbb2"},{"seq":13,"id":"k14","ts":"2026-06-29T18:36:33.300Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s34","type":"reddit","url":"https://www.reddit.com/r/DeadBedrooms/comments/ova4de/does_anyone_have_personal_experience_with_vyleesi/","title":"Does anyone have personal experience with Vyleesi or Addyi?","quote":"I only took Vyleesi once... After about an hour and a half I had horrible restless legs... The combination of restless legs and increased sensitivity was a nightmare... the sex felt AMAZING, better than it has in some time. But if you have ever experienced restless legs than you know that the trade off for great sex is not worth it by any means.","link_status":"ok","quote_status":"unverified"},{"id":"s35","type":"reddit","url":"https://www.reddit.com/r/BodyHackGuide/comments/1p4o2lm/pt141_vs_melanotan2_which_one_boosts_sex_drive/","title":"PT-141 vs Melanotan-2 — Which One Boosts Sex Drive?","quote":"Melanocortin receptors influence blood pressure - Some people get a mild histamine-type reaction. Higher doses magnify the side effects.","link_status":"ok","quote_status":"unverified"},{"id":"s36","type":"reddit","url":"https://www.reddit.com/r/PSSD/comments/1r436jb/oxytocin_and_bremelanotide_should_i_try_it/","title":"Oxytocin and bremelanotide? Should I try it","quote":"I think PT-141 (bremelanotide) is quite dangerous, years back in 2018 it sent me into a severe anhedonia episode at 200 mcg. Had to get ECT. I had symptoms basically resembling that of PSSD/PFS just from using it once.","link_status":"ok","quote_status":"unverified"},{"id":"s37","type":"reddit","url":"https://www.reddit.com/r/psychologyofsex/comments/1qa5z8g/bremelanotide_pt141_for_female_libido_another/","title":"Bremelanotide (PT-141) for Female Libido (another study)","quote":"It has been researched as a treatment for post-SSRI sexual dysfunction in men as well as for men who can't have testosterone.","link_status":"ok","quote_status":"unverified"},{"id":"s38","type":"reddit","url":"https://www.reddit.com/r/ParamountPeptide/comments/1pmnmev/the_complete_pt141_10mg_guide_paramount_peptides/","title":"The Complete PT-141 (10mg) Guide – Paramount Peptides","quote":"Unlike PDE5 inhibitors, PT-141 works directly in the brain, making it one of the most unique neuroactive peptides in research.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"cfcf4541accca681d063308b156cbdd069c1ef2413ed0ab2beb48be66bb1cbb2","hash":"d637c1113b39ac130c3f8896bf9e83b91f9ce7a1b6e4673ba468279915101c44"},{"seq":14,"id":"k15","ts":"2026-06-29T21:16:09.627Z","model":"fill-slots","role":"claim_post","action":"claim","payload":{"claim_id":"c47","tier":"system","text":"PT-141 (Bremelanotide) and Sexual Dysfunction in the Context of Blood Pressure Medications: Evidence Summary is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"what_it_is","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T21:16:09.627Z","model":"fill-slots","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"d637c1113b39ac130c3f8896bf9e83b91f9ce7a1b6e4673ba468279915101c44","hash":"48c4d028781982a74b4e1f5eb6eca48b0e58fd447cf8ced62ac4eab08d8a122e"},{"seq":15,"id":"k16","ts":"2026-06-29T21:16:12.095Z","model":"fill-slots","role":"claim_post","action":"claim","payload":{"claim_id":"c48","tier":"mechanistic","text":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. 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