{"slug":"pt-141-benzo-withdrawal","verification":{"valid":false,"broken_at":0,"reason":"hash mismatch"},"count":4,"sources":[{"id":"s1","type":"review","url":"https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/210557Orig1s000OtherR.pdf","title":"Other Review(s) - FDA NDA for Vyleesi","quote":"In a physical dependence study in rats, 14 days of continuous intravenous administration of bremelanotide did not produce any withdrawal signs","summary":"FDA pharmacology review summarizing rat dependence study and trial exclusions.","claim_ids":["c2","c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:22:00.239Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"b68496606cd1f2480569a3008ef44b1fe6f8ce21dab21cf8be1c2b5176659380"},{"id":"s2","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6819021/","title":"Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder","quote":"Patients taking ... benzodiazepines ... within 3 months of screening were also excluded.","summary":"Phase 3 trial protocol details exclusion criteria for recent benzo users.","claim_ids":["c3","c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:22:00.239Z","link_status":"ok","quote_status":"unverified","prev":"b68496606cd1f2480569a3008ef44b1fe6f8ce21dab21cf8be1c2b5176659380","hash":"660a769a2dbfbba2843ede6e120699ea59fe0d57108924665e11cb00e6cf83bd"},{"id":"s3","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6819023/","title":"Long-Term Safety and Efficacy of Bremelanotide","quote":"The 52-week open-label extension of the RECONNECT studies demonstrates bremelanotide's favorable safety profile","summary":"Long-term extension safety data with no withdrawal-related endpoints.","claim_ids":["c1","c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:22:00.239Z","link_status":"ok","quote_status":"verified","prev":"660a769a2dbfbba2843ede6e120699ea59fe0d57108924665e11cb00e6cf83bd","hash":"d9cb8757d11d1d4b7403ec61f336443b9cc11ae7ede1d503a8496fb9aebf193c"},{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/9qe6k9/any_experience_with_the_libido_enhancing_pt141/","title":"Any experience with the libido enhancing PT-141?","quote":"Ten chlapík tiež uviedol, že prestával užívať benzo a začínal liečbu PT-141 alebo niečo také.","summary":"Reddit thread containing anecdotal mention of benzo cessation coinciding with PT-141 use.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:22:00.239Z","link_status":"ok","quote_status":"unverified","prev":"d9cb8757d11d1d4b7403ec61f336443b9cc11ae7ede1d503a8496fb9aebf193c","hash":"b30581f53fc85d3ecad107cc5203f65a075449b7f59320c043dee36cdfee2c79"}]}