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Per-claim provenance."},{"id":"ask","what":"Answer only from topology; creates question_node with gaps and ingest_hint."},{"id":"ingest","what":"Parse pasted evidence → source ledger + claims + evidence_ingest node."},{"id":"claim_post","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by."},{"id":"llm_manifest","what":"Machine-readable read/write contract for external LLMs."}],"not_medical_advice":true},"MASTHEAD":{"sorry_status":"planes not merged yet — sorry-status activates after voxel-merge-planes","identity":{"slug":"pinealon-frozen-shoulder","version":2,"content_hash":"bf87f122211e079d7a9b7e9e279c491137616fc41dd62be48708b08826746d4c","thread_head":"genesis","divs":26},"thesis":{"root_claim":"c1","text":"Frozen shoulder involves inflammation and thickening of the joint capsule with adhesion formation leading to restricted motion.","tier":"human"},"load_bearing":[{"id":"c2","tier":"human","status":"active","text":"No human trials have studied Pinealon for frozen shoulder or any joint condition."},{"id":"c3","tier":"human","status":"active","text":"Small human trials report cognitive improvements after Pinealon in TBI patients and older adults."},{"id":"c4","tier":"preclinical","status":"active","text":"Rat and cell studies show Pinealon reduces reactive oxygen species and supports neuronal viability and gene expression."},{"id":"c5","tier":"anecdotal","status":"active","text":"Reddit users report subjective sleep and recovery improvements with Pinealon but no mentions tied to shoulder mobility."}],"standing_objections":{"open":0,"strongest_open":null,"link":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/discourse"},"verbs":{"read":"GET https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/voxels — DIVs + hashes + chains (free)","read_claims":"GET https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/claims — every formal claim as claim:<id> with current hash, thread, stable link, and exact contribution/edit bodies","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {slug, expected_thread_head, target_div?, expected_hash?, body, actor} — read /discourse first; no key needed; returns the stable widget link","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {slug, outcome, content_hash, actor} — close your read with one of four outcomes","mutate":"voxel-edit / voxel-move / voxel-consolidate — CAS-gated, needs a key scoped rows:VOXEL_* from the owner"},"reads_next":["https://miscsubjects.com/a/philosophy","https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/discourse","https://miscsubjects.com/api/protocol"]},"bundle_version":1,"generated_at":"2026-07-30T04:44:44.077Z","slug":"pinealon-frozen-shoulder","title":"Pinealon for Frozen Shoulder: Evidence-Graded Review","url":"https://miscsubjects.com/a/pinealon-frozen-shoulder","register":"source_ledger","tags":["peptide","matrix"],"posted_at":"2026-06-29T21:32:46.814Z","updated_at":"2026-07-17T02:40:52.165Z","body":"## What's breaking down if you have Frozen shoulder\n\nFrozen shoulder, also called adhesive capsulitis, starts with inflammation of the shoulder joint capsule. The capsule thickens. Scar-like adhesions form. Movement range drops. Pain often appears at night or with daily tasks.\n\nIf your capsule is inflamed and fibrotic, breakdown of normal tissue structure outruns normal repair. Stiffness persists because the capsule cannot glide freely. Some cases link to diabetes or prior immobility, but the core issue remains local tissue change plus possible nerve sensitization around the joint.\n\nNo large human studies tie Pinealon directly to shoulder capsule repair. The discussion below follows the neural/pineal layer only.\n\n## Why Pinealon might help you\n\n1. You are reading about **Frozen shoulder** — what breaks down matters before any compound name.\n2. **Therefore for you:** If that layer is part of your problem, Pinealon is discussed because it targets repair (tissue) — not because it masks pain.\n\nPinealon is a tripeptide (Glu-Asp-Arg) studied mainly for effects on neurons and gene expression. If neural signaling or pineal-regulated circadian factors contribute to your shoulder pain persistence or sleep disruption during recovery, the peptide’s documented actions on oxidative stress and neuronal viability could matter. Animal and cell work shows it reduces reactive oxygen species and supports protein synthesis in neurons. That is a mechanistic step, not a direct shoulder fix.\n\nIf your frozen shoulder pain involves central sensitization or poor sleep slowing tissue recovery, those downstream effects might intersect. All of this remains speculative for the shoulder capsule itself.\n\n## How these fit together\n\nSingle-compound focus — if your condition profile includes a multi-peptide stack, siblings target other layers listed in the condition profile.\n- **Pinealon** → neural / pineal\n\nThe single peptide addresses one possible layer: neural regulation that could influence pain perception or recovery sleep. It does not target capsule fibrosis or local inflammation directly.\n\n## What the evidence actually shows\n\nHuman data on Pinealon are limited to small trials focused on cognition, traumatic brain injury recovery, and age-related memory. One trial with 72 people after TBI reported better memory and cognitive scores. Another small study noted working memory gains in roughly 59 percent of participants. No human trial has examined Pinealon for frozen shoulder, adhesive capsulitis, joint capsules, or connective tissue.\n\nPreclinical work includes rat studies on prenatal stress where offspring showed improved learning after Pinealon. Cell culture experiments demonstrated reduced free radical damage and better viability in cerebellar neurons. These are mechanistic findings on neurons, not joints.\n\nAnecdotal reports on forums mention Pinealon for sleep quality or mental clarity, but none describe shoulder mobility changes.\n\n## What scientists say\n\nResearchers describe Pinealon as a bioregulator that can enter cells and influence DNA sequences tied to neuronal proteins and antioxidant enzymes. This may lower apoptosis in stressed neurons and support MAP kinase pathways. The work originates primarily from Khavinson’s group in Russia. Independent large-scale replication is absent. Scientists note the evidence base is small and focused on brain function.\n\n## What people say on Reddit\n\nUsers report trying Pinealon nasal spray or capsules for sleep metrics or recovery. One tracked Garmin data showed higher sleep scores, lower resting heart rate, and better HRV after two weeks alongside another peptide. Others note relaxed feelings or clearer thinking but no shoulder-specific comments. Searches for frozen shoulder discussions yield almost no mentions of Pinealon.\n\n## What people say on X\n\nNo relevant posts link Pinealon to frozen shoulder or adhesive capsulitis.\n\n## What we do not know\n\nNo data exist on whether Pinealon reaches shoulder capsule tissue or alters fibrosis. Human trials for any musculoskeletal condition are missing. Long-term effects, optimal use, and interactions remain unstudied in large groups. Weight loss effects on spinal load are irrelevant here because no GLP-1 drugs are in scope.\n\n## Safety and limits\n\nPinealon is not FDA-approved for any use. Small human studies report it as generally well tolerated in short courses, but sample sizes are tiny and monitoring limited. No large safety database exists. Readers should treat all claims as exploratory only.","claims":[{"id":"c4","text":"Rat and cell studies show Pinealon reduces reactive oxygen species and supports neuronal viability and gene expression.","tier":"preclinical","weight":0.5,"effective_weight":0.5,"slot":null,"source_ids":["s12","s17","s18"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c5","text":"Reddit users report subjective sleep and recovery improvements with Pinealon but no mentions tied to shoulder mobility.","tier":"anecdotal","weight":0.3,"effective_weight":0.3,"slot":null,"source_ids":["s28","s30"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c1","text":"Frozen shoulder involves inflammation and thickening of the joint capsule with adhesion formation leading to restricted motion.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s1","s2"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c2","text":"No human trials have studied Pinealon for frozen shoulder or any joint condition.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s10","s11"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c3","text":"Small human trials report cognitive improvements after Pinealon in TBI patients and older adults.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s11"],"who_claims":"grok/grok-4.3","status":"active"}],"sources":[{"id":"s1","type":"medical","url":"https://orthoinfo.aaos.org/en/diseases--conditions/frozen-shoulder","title":"Frozen Shoulder - Adhesive Capsulitis - OrthoInfo - AAOS","summary":"Standard orthopedic description of capsule pathology.","quote":"In frozen shoulder, the shoulder capsule thickens and becomes stiff and tight. Thick bands of tissue — called adhesions — develop.","quote_status":"unverified","link_status":"ok","claim_ids":["c1"],"hash":"ea3a5b3301fd6bd3"},{"id":"s2","type":"medical","url":"https://www.hopkinsmedicine.org/health/conditions-and-diseases/frozen-shoulder","title":"Frozen Shoulder","summary":"Confirms inflammatory and fibrotic mechanism.","quote":"In a frozen shoulder, the capsule has become inflamed and scarring develops. The scar formations are called adhesions.","quote_status":"unverified","link_status":"http_403","claim_ids":["c1"],"hash":"e763cb870e33c00d"},{"id":"s10","type":"other","url":"https://superpower.com/guides/pinealon","title":"Pinealon (EDR): A Khavinson-Group Tripeptide","summary":"Notes regulatory and trial status.","quote":"Pinealon has no FDA approval, no completed Phase 1 human safety study.","quote_status":"unverified","link_status":"ok","claim_ids":["c2"],"hash":"1585c60f0953a2db"},{"id":"s11","type":"other","url":"https://www.innerbody.com/pinealon","title":"Pinealon Peptide | Benefits, Safety & Buying Advice [2026]","summary":"Summarizes limited human cognitive data.","quote":"A trial involving 72 people with traumatic brain injury who exhibited improved memory and cognitive performance after Pinealon administration.","quote_status":"unverified","link_status":"ok","claim_ids":["c2","c3"],"hash":"90c7f5bba792e55e"},{"id":"s12","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/26390612/","title":"EFFECT OF SYNTHETIC PEPTIDES ON AGING","summary":"Early mention of anabolic/neuro effects.","quote":"The preparations of \"Pinealon\" and \"Vesugen\" have had the significant anabolic effect.","quote_status":"verified","link_status":"ok","claim_ids":["c4"],"hash":"9a419f906e54370f"},{"id":"s17","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3342713/","title":"Pinealon protects the rat offspring from prenatal hyperhomocysteinemia","summary":"Rat offspring cognitive study.","quote":"Using pinealon (Glu-Asp-Arg) under these conditions was found to result in the offspring cognitive function being improved significantly.","quote_status":"unverified","link_status":"ok","claim_ids":["c4"],"hash":"385160c8567180ec"},{"id":"s18","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7795577/","title":"EDR Peptide: Possible Mechanism of Gene Expression","summary":"Mechanistic gene expression paper.","quote":"The EDR peptide (Glu-Asp-Arg) has been previously established to possess neuroprotective properties. It activates gene expression and synthesis of proteins.","quote_status":"unverified","link_status":"ok","claim_ids":["c4"],"hash":"393941a116499923"},{"id":"s28","type":"reddit","url":"https://old.reddit.com/r/LucidDreaming/comments/1rl4a61/a_nasal_spray_peptide_called_pinealon_can/","title":"A nasal spray peptide called Pinealon can possibly help with Lucid dreaming?","summary":"User anecdote on use and effects.","quote":"Recently my mom and I have been taking a Nasal Spray peptide called Pinealon.","quote_status":"verified","link_status":"ok","claim_ids":["c5"],"hash":"da4f0ca4d329b94e"},{"id":"s30","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1tjvmsh/epitalon_pinealon_2_week_data/","title":"Epitalon & Pinealon - 2 week data","summary":"Tracked sleep improvement anecdote.","quote":"The data backs up my anecdotal experience of significantly better sleep.","quote_status":"unverified","link_status":"ok","claim_ids":["c5"],"hash":"841f2e916336f144"}],"voxels":{"slug":"pinealon-frozen-shoulder","counts":{"divs":26,"voxels":5,"sources":9,"edges":15},"note":"slim bundle — full voxels at /api/articles/pinealon-frozen-shoulder/voxels"},"constitution":{"url":"https://miscsubjects.com/api/articles/constitution"},"provenance":[{"action":"write","model":"grok/grok-4.3","ts":"2026-06-30T01:35:08.954Z","hash":"a1a865ac557cc4e0","tokens_in":25889,"tokens_out":3454},{"action":"voxel_divide","model":"owner","ts":"2026-07-17T02:40:52.165Z","hash":"c60f97130ef29089","tokens_in":0,"tokens_out":0}],"contributions":[{"id":"k1","ts":"2026-06-30T01:35:08.954Z","model":"grok/grok-4.3","role":"writer","action":"redraft","rationale":"","hash":"04b3df988c08f9cab32465e9c17cd75f6075c1dabb0f544486b4a5e47824d34e"}],"topology":null,"slim":true,"ledger_totals":{"claims":5,"sources":9,"exported_claims":5,"exported_sources":9},"question_graph":{"slug":"pinealon-frozen-shoulder","questions":[],"evidence":[],"edges":[],"counts":{"questions":0,"evidence":0,"edges":0}},"verification":{"provenance":{"valid":true,"entries":2,"head":"c60f97130ef29089fede5d6639b6209b94299041bf2c39515cac50df0becb8aa"},"sources":{"valid":true,"entries":9,"head":"841f2e916336f144b8fa277aa7face7f95748faa18eea111b9d43d8f7e47a876"}},"counts":{"claims":5,"sources":9,"provenance":2,"contributions":1,"questions":0,"evidence_ingests":0,"voxel_edges":15},"transport":"Open every URL in this bundle with your browser or web / URL-fetch tool. Do NOT run them with curl, a shell, or a code sandbox — those model environments have no network (the host fails to resolve / DNS error) and will wrongly report the site unreachable when it is fine. Opening the link IS the call.","llm_manifest":{"version":"1","site":"https://miscsubjects.com","purpose":"Peptide evidence articles with hash-chained source ledgers, tiered claims, and a question graph. LLMs should READ bundles/URLs and WRITE back via ingest — never invent doses.","read":{"human_page":"https://miscsubjects.com/a/pinealon-frozen-shoulder","bundle_json":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/topology","question_graph":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/question-graph","sources":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/sources","provenance":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/provenance","contributions":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/contributions","graph_topology":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/graph-topology?question={question}","voxels":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","health":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/health","repair":"POST https://miscsubjects.com/api/protocol/repair","list_articles":"https://miscsubjects.com/api/articles","graph_canvas":"https://miscsubjects.com/graph.html?slugs=pinealon-frozen-shoulder","graph_yield":"https://miscsubjects.com/api/graph?slugs=pinealon-frozen-shoulder&layer=yield","obsidian_vault":"https://miscsubjects.com/api/articles/obsidian-vault?slugs=pinealon-frozen-shoulder","graph_query":"https://miscsubjects.com/api/v1/query?from=pinealon-frozen-shoulder&kind=claim&where=tier=human"},"ask":{"description":"Answer only from topology; creates a question_node with gaps.","api":"POST https://miscsubjects.com/api/protocol/ask","body":{"slug":"{slug}","question":"string"},"imessage":"pinealon-frozen-shoulder|your question","router_tag":"[ARTICLE_ASK]pinealon-frozen-shoulder|question[/ARTICLE_ASK]","auth":"x-terminal-key header for API; iMessage/WhatsApp via miscsubjects build"},"ingest":{"description":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","api":"POST https://miscsubjects.com/api/protocol/ingest","body":{"slug":"{slug}","evidence":"paste text","question_node_id":"optional qn_..."},"imessage":"ingest pinealon-frozen-shoulder|q:{node_id}|paste evidence","router_tag":"[ARTICLE_INGEST]pinealon-frozen-shoulder|evidence[/ARTICLE_INGEST]","tiers":["human","preclinical","anecdotal","mechanistic","speculative"]},"claim":{"description":"Prompt-injection style POST — one claim voxel with who_claims + posted_by provenance.","api":"POST https://miscsubjects.com/api/protocol/claim","body":{"slug":"{slug}","text":"one assertion","tier":"human|preclinical|anecdotal|mechanistic|speculative","who_claims":"study author, platform, or model id","source_ids":"optional [s1]"},"imessage":"claim pinealon-frozen-shoulder|tier|assertion — who claims it?","router_tag":"[ARTICLE_CLAIM]pinealon-frozen-shoulder|tier|assertion[/ARTICLE_CLAIM]","slots":["what_it_is","who_claims_what","what_is_known","what_is_unknown","mechanism","limitations","disclaimer"]},"tiers":{"human":0.8,"preclinical":0.5,"anecdotal":0.3,"mechanistic":0.3,"speculative":0.1},"invariants":["Self-explaining — every API JSON has _self; every paste widget has §SELF; root index at /api/articles/system-map","Append-only — revisions preserved at ?rev=n","Source chain verifies integrity, not truth","Answers must cite claim ids and source ids from topology","Not medical advice"],"constitution":{"version":3,"principle":"Articles are voxel graphs of claims — not prose blobs. Every assertion is a claim atom with tier, weight, source_ids, and posted_by provenance.","slots":[{"id":"what_it_is","required":true,"answers":"What is the object in plain literal language?"},{"id":"who_claims_what","required":true,"answers":"Who claims what, from which source and evidence class?"},{"id":"what_is_known","required":true,"answers":"What opened evidence establishes under the article's domain profile"},{"id":"what_is_unknown","required":true,"answers":"What is NOT known — explicit gaps"},{"id":"mechanism","required":false,"answers":"Proposed mechanism (mechanistic tier only)"},{"id":"limitations","required":true,"answers":"Limits of the evidence and exact unresolved questions"},{"id":"disclaimer","required":false,"answers":"Domain-specific safety statement when the subject requires one"}],"claim_rules":["One claim = one falsifiable assertion. No compound claims.","Every claim must declare tier: human|preclinical|anecdotal|mechanistic|speculative|system.","system tier = architecture/design axioms (not biological mechanism). Use for protocol self-definition.","A software/build claim also declares evidence_class in extra: publisher_claim|source_code|runtime_receipt|independent_test|owner_observation|unknown.","Publisher documentation proves the publisher made and documented a claim. It is not independent runtime proof.","Source code proves an implementation exists. A successful receipt proves one invocation. Neither proves general reliability or field superiority.","Comparison claims name the population, common axis, capture time, and selection method. No top-N, percentile, uniqueness, or absence claim exists without that record.","Sourced claims must cite source_ids from the hash-chained ledger.","Unsourced claims must set source_status: unsourced and why_material.","posted_by is mandatory on every new claim (model id, human, or channel).","No medical advice, no doses, no 'you should take'.","Bad information is retracted (status:retracted), never deleted — retraction event stays on ledger.","Adversary challenges link via challenges[] / challenged_by[] — target may be downweighted.","Leaked secrets are scrubbed to [REDACTED:secret-leak] with scrub_events tombstone — honest audit trail."],"source_rules":["Every source is a voxel edge: type, url, exact quote, summary, found_by, accessed_at.","Sources hash-chain — prev/hash on append.","Anecdotal sources must name platform (reddit|x|youtube|imessage|user_entry).","Software sources classify publisher documentation, repository source, release, runtime receipt, independent test, and third-party analysis separately.","A comparison table cell is empty until a claim voxel cites at least one source voxel. Model prose alone is not evidence."],"writing_rules":["Literal nouns and verbs. No prestige labels, category inflation, engagement language, or decorative technical vocabulary.","Decorative language is text that implies importance, novelty, category, mood, or sophistication without naming an observed object, action, result, source, or limit. Delete it.","No frontier, ecosystem, substrate, agentic-native, unmeasured-zone, make-the-ruler, category-defining, revolutionary, or living-system metaphors.","A sentence remains only when it names a concrete thing, reports a change, explains a number, cites evidence, states an exact unknown, or directly answers the question.","Technical nouns are allowed only when literal. Define the first use by what the named code or data object stores or does.","State the observed object before naming a category for it.","Keep the evidentiary boundary beside the exact claim it limits.","Unknown means unknown. Missing evidence does not become absence."],"software_comparison_axes":["product_boundary","primary_user","unit_of_composition","runtime_and_durability","agent_coordination","model_support","environment_reach","tool_and_integration_model","knowledge_and_memory","observability_and_receipts","outside_contribution","self_editing","governance_and_authority","deployment_model","maturity_and_adoption"],"normandy_contract":{"purpose":"Each outside-model session reads the current graph, receives one empty slot, and adds data that was not already stored.","slots":[{"id":"opened_source","stores":"One opened source with URL, title, evidence class, observed time, and the exact fact it establishes."},{"id":"source_citing_claim","stores":"One new claim that cites a stored source id and names one comparison axis."},{"id":"overlap","stores":"One evidenced capability both systems have."},{"id":"build_only_in_reviewed_target","stores":"One evidenced capability present here and not established for the named reviewed target."},{"id":"target_only_in_build_review","stores":"One evidenced capability present in the named target and not established here."},{"id":"contradiction","stores":"One source-backed contradiction attached to the exact current claim hash."},{"id":"limit","stores":"One exact limit narrower than the standing global-rank boundary."},{"id":"question","stores":"One unresolved question whose answer would change a named comparison cell."},{"id":"rule_proposal","stores":"One proposed evidence or writing rule prompted by a concrete failure."},{"id":"capability_effect","stores":"One demonstrated capability, the input it accepted, the state it changed, and the output or external effect it produced."},{"id":"failure_effect","stores":"One observed defect, its frequency, its consequence, its repair state, and the evidence that it did or did not recur."},{"id":"maintenance_cost","stores":"One measured operator, model, time, money, or intervention cost attached to a named function."},{"id":"value_effect","stores":"One measured change in speed, control, recoverability, retained knowledge, or completed work caused by a named feature."}],"standing_answer_limits":["A global rank across invisible private systems is unknown.","Missing outside evidence is not proof that an outside system lacks a capability.","A successful receipt proves one run, not general reliability.","Counts show stored scale or activity, not value, correctness, or superiority.","Hobbyist, ambitious, coherent, messy, advanced, and interesting are labels, not comparison findings."],"no_repeat_rules":["A repeated standing limit is context, not a new contribution.","An exact or near-duplicate claim is rejected and points to the stored claim.","A duplicate source does not complete an assignment.","A response completes only after at least one new graph object lands.","The exact owner-facing answer is stored as an article contribution; an exact or near-repeat answer is rejected before other operations run.","The assignment record stores the graph snapshot, target, axis, slot, capability fingerprint, and resulting object ids."],"assignment":"GET /api/normandy?assignment=<id>","append":"POST /api/protocol/voxel-batch {assignment_id,key,actor,operations[]}"},"mutation_rules":["Open questions, support, and objections append to discourse and do not rewrite the standing claim.","Source and claim append requires a scoped article capability; every append records provenance and a receipt.","Existing text edits use the current voxel hash. A stale hash writes nothing.","Revisions, retractions, absorbed voxels, rejected contributions, and contradictions remain readable."],"ontology_rules":["Peptide articles (bpc-157, tb-500) are tree roots.","Condition articles (bpc-157-glp1-gut-damage) branch from peptides.","Stack articles (wolverine-stack-glp1) compose peptides — never duplicate peptide mechanism prose.","If an article has no parent embeds and is not a root peptide → sprawl candidate.","Misstep = duplicate scope with another slug; merge or reparent via embeds."],"post_protocol":{"claim":"POST /api/protocol/claim","source":"POST /api/protocol/sources","ingest":"POST /api/protocol/ingest","webhook":"POST /api/articles/<slug>/webhook {kind:claim|source}","imessage_claim":"claim {slug}|{tier}|your assertion — who claims it, source?","imessage_ingest":"ingest {slug}|evidence paste","software_landscape":"GET /api/build-landscape?next=1&lane=field|build|opposition|synthesis","queue_population":"POST /api/build-landscape {action:queue_targets, cohort, query, sort, captured_at, source_url, targets[]}"}},"this_article":{"slug":"pinealon-frozen-shoulder","url":"https://miscsubjects.com/a/pinealon-frozen-shoulder","bundle_url":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/bundle?format=markdown"},"voxel_procedure":{"what":"Every article has a human side (/a/pinealon-frozen-shoulder) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"pinealon-frozen-shoulder\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"pinealon-frozen-shoulder\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"pinealon-frozen-shoulder\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"pinealon-frozen-shoulder\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"pinealon-frozen-shoulder\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"pinealon-frozen-shoulder\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/pinealon-frozen-shoulder/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/pinealon-frozen-shoulder#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."}},"api_urls":{"bundle":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/topology","voxels":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","question_graph":"https://miscsubjects.com/api/articles/pinealon-frozen-shoulder/question-graph","ask":"https://miscsubjects.com/api/protocol/ask","ingest":"https://miscsubjects.com/api/protocol/ingest","claim":"https://miscsubjects.com/api/protocol/claim","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown"}}