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Statistical physics of adaptation. Phys Rev X. 2016;6:021036. Preprint arXiv:1412.1875.","status":"active","vx_hash":"cc8d9a85c487dc2a2c2a633b2905d4f45aae651544629662bb0fddb438efe2f0","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"843a6d84d9810a9b6e71fbe887b49c392ef0efac62ba7a4af02aa4033f2e3e72","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"587201c1630c50af627eb780e8a62acee9f1b448e33d41c2ab878131113d85bd","detail":{"divided_from":"body","block":6,"kind":"p"},"prev":"genesis","hash":"843a6d84d9810a9b6e71fbe887b49c392ef0efac62ba7a4af02aa4033f2e3e72"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d6"},{"id":"d7","kind":"p","type":null,"order":7,"text":"Key passage from the abstract: \"Building on past fundamental results in far-from-equilibrium statistical mechanics, we demonstrate a generalization of the Helmholtz free energy for the finite-time stochastic evolution of driven Newtonian matter. By analyzing this expression term by term, we are able to argue for a general tendency in driven many-particle systems towards self-organization into states formed through exceptionally reliable absorption and dissipation of work energy from the surrounding environment.\"","status":"active","vx_hash":"91b2a3357bae0343d6ddc261508e2ab43a6d916a22e4f46225830fed24cb92e6","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"3f921606bc7fec22a07f10cd08ec5f6063b55995652a030e9fbad877ed643464","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"2f66609f61e973b4c615783ac29ffffd3e20c923dc9269cd4d1bf3237bcd9a13","detail":{"divided_from":"body","block":7,"kind":"p"},"prev":"genesis","hash":"3f921606bc7fec22a07f10cd08ec5f6063b55995652a030e9fbad877ed643464"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d7"},{"id":"d8","kind":"p","type":null,"order":8,"text":"From the introduction: \"we will derive and analyze a generalization of the Helmholtz free energy for out-of-equilibrium macroscopic systems, arguing that driven stochastic evolution can favor the discovery of organized states that form through increased dissipation and the suppression of fluctuations.\"","status":"active","vx_hash":"b3c6625d9bc228f25ee98b67147d62aa8888264cfcbb97714c56e516d5e7b63f","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"c9f176eb9100cab0025b9848bfa40fbf2e82dd03688d1791805b17186ab2ab0a","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"bfff7423d02f55932448bfd25d96c21964def678d458ab44d135c18fa1e159a2","detail":{"divided_from":"body","block":8,"kind":"p"},"prev":"genesis","hash":"c9f176eb9100cab0025b9848bfa40fbf2e82dd03688d1791805b17186ab2ab0a"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d8"},{"id":"d9","kind":"p","type":null,"order":9,"text":"The derivation rests on Crooks' microscopic reversibility relation and prior nonequilibrium results linking entropy production to transition probabilities.","status":"active","vx_hash":"1a7e36d63e38b63860ac7691810ba6873c9aee843c8230b0443b46b5612ff348","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"6396c9c216b20acfee3208caa525060e426147ca8bbff7acdeba41859210ad6a","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"951159ac0ec0f0103adae49706414e968574b853172ee82eb0952ac15a3e58b8","detail":{"divided_from":"body","block":9,"kind":"p"},"prev":"genesis","hash":"6396c9c216b20acfee3208caa525060e426147ca8bbff7acdeba41859210ad6a"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d9"},{"id":"d10","kind":"h","type":null,"order":10,"text":"## Convergence patterns touched","status":"active","vx_hash":"d17ff408bfc2e79eaec8f4d2498c599d14662bd96e39f74d2433b1087d78df66","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"369ddde67652c66b37fa62a84f3b49f115e188598c723a2066d1b6f4576c99e0","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"bf39d3a2f856f5bc17fb18e05415848b80831879f908e0cfa9e92d7220d64063","detail":{"divided_from":"body","block":10,"kind":"h"},"prev":"genesis","hash":"369ddde67652c66b37fa62a84f3b49f115e188598c723a2066d1b6f4576c99e0"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d10"},{"id":"d11","kind":"p","type":null,"order":11,"text":"The work touches branching and flow networks (self-organization under drives), memory (accumulated information about external drives in hysteretic systems), and bounded chaos (stochastic trajectories in driven landscapes). It addresses the step from structure to memory in the Ladder by showing how reliable dissipation creates persistent organized states.","status":"active","vx_hash":"88190a7d411baeaa01cfc9e43283d848226d379562be1b4b957224aae810b7c5","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"221ecfa03c02dd98d56dea835fa5b206053eaff95a45c55e9cb5554c39efcd36","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"ba7404e83adbdd81e7d3e8752fbbba2776cd7d3dd9f828eba1c7b679a3dfa6dc","detail":{"divided_from":"body","block":11,"kind":"p"},"prev":"genesis","hash":"221ecfa03c02dd98d56dea835fa5b206053eaff95a45c55e9cb5554c39efcd36"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d11"},{"id":"d12","kind":"p","type":null,"order":12,"text":"It supports the GRAIN claim that energy flows produce narrow families of structural patterns across scales. The Mirror Layer appears indirectly: the reader (physicist) models the system from inside the driven universe.","status":"active","vx_hash":"e8b05e89103ab348f83df49e528d09297064675b1b745424b8777f2355e4865e","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"e53dc01e3767b312b259b380ce753811dd158c569d8ae71e712450df127b0380","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"b5e0a02c4f4acbdcaa492f57ff75c45af04a0810a0145885f68f8a46cfea1361","detail":{"divided_from":"body","block":12,"kind":"p"},"prev":"genesis","hash":"e53dc01e3767b312b259b380ce753811dd158c569d8ae71e712450df127b0380"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d12"},{"id":"d13","kind":"h","type":null,"order":13,"text":"## Distance from the full OIP/GRAIN synthesis","status":"active","vx_hash":"49389d5eb4296514cce06c88691d9b044303b968dcb840447f057a6b6efac02f","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"142f12269eb45e724475cad5928dee2254773821c09ef4687d75353c5f01f403","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"78b248fc09f46aa233e0ee4e7ccd8141328a45bdb7ef545daf36dd82e28468ad","detail":{"divided_from":"body","block":13,"kind":"h"},"prev":"genesis","hash":"142f12269eb45e724475cad5928dee2254773821c09ef4687d75353c5f01f403"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d13"},{"id":"d14","kind":"p","type":null,"order":14,"text":"The paper stays at the mechanistic level of dissipative adaptation. It supplies a free-energy principle for self-organization but does not address the full Ladder to life or mind, nor does it formalize object invocation or ledger receipts. It provides physical grounding for the \"grain\" without claiming universality across all scales or addressing the reader-inside-system explicitly.","status":"active","vx_hash":"56e55fc54eccb91a96857c805c95523f3735b14edd4ca85e3bf8349c043c7773","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"f34e7f3454044fa12ff54fd77eee41df6fc8043b57250b1d5e1be47484be95d3","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"b8ea671b8971f4d5de97c49ae345e8f0053d7ca18b7338b1f1951a5ea7ff475c","detail":{"divided_from":"body","block":14,"kind":"p"},"prev":"genesis","hash":"f34e7f3454044fa12ff54fd77eee41df6fc8043b57250b1d5e1be47484be95d3"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d14"},{"id":"d15","kind":"h","type":null,"order":15,"text":"## Honest limits and disconfirming edges","status":"active","vx_hash":"827088ddd7099723528a201a7db77b233f52eee09eb3eee4361598c03ff45512","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"e42aabd765e907f5ec8aee1940a8c1accce6b69c220f2bbe9f0f24dab71befd2","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"a4ff4542a1095d01f9181ea0192500270e1b6d9e89daf971127e5a818cfedd26","detail":{"divided_from":"body","block":15,"kind":"h"},"prev":"genesis","hash":"e42aabd765e907f5ec8aee1940a8c1accce6b69c220f2bbe9f0f24dab71befd2"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d15"},{"id":"d16","kind":"p","type":null,"order":16,"text":"The analysis assumes classical Newtonian particles, a heat bath, and time-dependent driving fields. It does not treat quantum effects or closed systems. The tendency is statistical and holds in the ensemble; individual trajectories can deviate. No empirical data on living systems appear; the claims remain theoretical. Reductionist objections note that the generalized free energy describes correlations already implicit in the dynamics rather than introducing new causation.","status":"active","vx_hash":"ac2fecb5fa6aa8f69e80ae65be2927cd2db28ddca7995486a0bffbdb8e5fe12a","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"428aa5d940fa2188c0d259e0e4e81acc936a43e303b7ebe83eff0dbd93fe3dfe","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"f5d322dc810caad0a23dd30124e7d067c838f54c0516d95aa6917d14e84a43fc","detail":{"divided_from":"body","block":16,"kind":"p"},"prev":"genesis","hash":"428aa5d940fa2188c0d259e0e4e81acc936a43e303b7ebe83eff0dbd93fe3dfe"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d16"},{"id":"d17","kind":"h","type":null,"order":17,"text":"## Atomic claims","status":"active","vx_hash":"b9ff4dba098094ccee9f5d1973d88adee6f5987dc14252d43e842feafa43e64e","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"d40eb8b4b88703b6fa9362e7805a72946573cc6914e5c8a3cb1bd841cec227b8","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"9a382a5a107db7309f221934370fa79485a1e2535e9f0d737b737a80828eb515","detail":{"divided_from":"body","block":17,"kind":"h"},"prev":"genesis","hash":"d40eb8b4b88703b6fa9362e7805a72946573cc6914e5c8a3cb1bd841cec227b8"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d17"},{"id":"d18","kind":"list","type":null,"order":18,"text":"- Claim c1: The paper derives a generalized Helmholtz free energy for finite-time driven stochastic evolution. Tier: mechanistic. Source: arXiv:1412.1875 abstract and section on entropy production.\n- Claim c2: Driven many-particle systems exhibit a statistical tendency toward states with reliable work absorption and dissipation. Tier: mechanistic. Source: same, term-by-term analysis.\n- Claim c3: The result extends dissipative adaptation ideas to a broader free-energy framework. Tier: mechanistic. Source: introduction and conclusion.\n- Claim c4: Random hopping in driven landscapes illustrates the self-organization mechanism. Tier: mechanistic. Source: analytical examples section.","status":"active","vx_hash":"be9f4a17ff0fca2a5cf838b985aeb60f99ea73a79d1d5d410dccdee3a2d717b1","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"c3f95f127256ee3607a8b31265945c17046d8890a422c551dba7c91a88bcbd3f","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"4722b89447f71ac355d73726f8e1273b3c3d49148f08387a3b57493d67fd18b4","detail":{"divided_from":"body","block":18,"kind":"list"},"prev":"genesis","hash":"c3f95f127256ee3607a8b31265945c17046d8890a422c551dba7c91a88bcbd3f"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d18"},{"id":"d19","kind":"h","type":null,"order":19,"text":"## What the evidence actually shows","status":"active","vx_hash":"9998a892a735f684b90826e18423bbde065b5bc4f2d5014ed590080cb814be06","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"44b177751c32a3b3221e9c9e69e54dcdf5479ca2946eb65ccae706117cde1af7","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"a7a051e6a294dc45c15b7d4859b7020d561e719fe73844f03e3a8f9e7fed8de1","detail":{"divided_from":"body","block":19,"kind":"h"},"prev":"genesis","hash":"44b177751c32a3b3221e9c9e69e54dcdf5479ca2946eb65ccae706117cde1af7"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d19"},{"id":"d20","kind":"p","type":null,"order":20,"text":"The derivations are formal proofs from stochastic thermodynamics. They predict organized states emerge preferentially when dissipation is favored. No simulation or experiment is presented in the 2016 paper itself.","status":"active","vx_hash":"385468c0d6e6685ae9899b2d9ebf6da73f8dadca21f5f28ca3b94a5a45d3d163","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"fd401e4df77d807caf83f506b9713f5438028bf5fbda9b62ea4663fa04051ea1","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"5e7b6d233e53fc905fcd13520d05cd89ad114346667e84b034b7ebee9fd00b48","detail":{"divided_from":"body","block":20,"kind":"p"},"prev":"genesis","hash":"fd401e4df77d807caf83f506b9713f5438028bf5fbda9b62ea4663fa04051ea1"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d20"},{"id":"d21","kind":"h","type":null,"order":21,"text":"## What scientists say","status":"active","vx_hash":"55a36639e370738630f1df8012ea4f165f2e59f50cc9eecc3126f6e7023af6fd","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"9f911c415c877051550a5c2f53271c97497598e77b934f2da7796c40ae4242cc","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"2f1dd55083de1fa734f2f06a8337a050d5a0b3f635bfc8bb709abab75705a1ef","detail":{"divided_from":"body","block":21,"kind":"h"},"prev":"genesis","hash":"9f911c415c877051550a5c2f53271c97497598e77b934f2da7796c40ae4242cc"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d21"},{"id":"d22","kind":"p","type":null,"order":22,"text":"Subsequent citations link the result to self-replication and origins-of-life models. The paper is treated as a rigorous extension of England's earlier dissipative adaptation work.","status":"active","vx_hash":"e813be1a296208e0d55425bc1b9d8c24cd2c52b748955fbb49cead1fefdd8011","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"f2d9aaca9586288f2560f0eab027fcb9afd809a1d8d632a13460aa81db9383f2","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"3f7240ef00cd9e1ac36fe620e28a48fe2724bacc3f032c937d2f939979542ef1","detail":{"divided_from":"body","block":22,"kind":"p"},"prev":"genesis","hash":"f2d9aaca9586288f2560f0eab027fcb9afd809a1d8d632a13460aa81db9383f2"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d22"},{"id":"d23","kind":"h","type":null,"order":23,"text":"## What we do not know","status":"active","vx_hash":"a1dd9b21354073dc40ba55ad5e98317ba158257269b09705e81cb7f2e8338696","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"991dd3a721abdad00bd3b8c3030de68307a5b81ab5c19bc0c59c042cd5ac9379","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:37:30.224Z","actor":"owner","text_sha":"7d96a49fba77f6a48c0321db2ae4180a902beae62e2aac0d23408fbf8333a177","detail":{"divided_from":"body","block":23,"kind":"h"},"prev":"genesis","hash":"991dd3a721abdad00bd3b8c3030de68307a5b81ab5c19bc0c59c042cd5ac9379"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:37:30.224Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/paper-perunov-n-marsland-r-a-and-england-j-l-2016-statistical-physics-of-adaptation/d23"},{"id":"d24","kind":"p","type":null,"order":24,"text":"Whether the generalized free energy applies quantitatively to real molecular or biological systems at observable scales remains open. 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