{"slug":"nad-plus-stimulants","verification":{"valid":true,"entries":7,"head":"720177cd5370423ceab31b020bb4234735183b4dde2ea8cb3fd426b0a7a8263c"},"count":7,"sources":[{"id":"s0","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/16996699/","title":"Semax, an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome","quote":"It has been found to stimulate memory and attention in rodents and humans after intranasal application.","summary":"Reviews Semax effects including BDNF in animals.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:41:10.256Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"51dd87e0e113556ec5d9779e7cf59758164f7e2f06e94cbfc0f537cfd6b9bf2a"},{"id":"s1","type":"review","url":"https://www.sciencedirect.com/science/article/abs/pii/S0306987706005391","title":"Semax, an analogue of adrenocorticotropin (4–10), is a potential agent for the treatment of attention-deficit hyperactivity disorder","quote":"Evidence from animal studies revealed that Semax can augment the effects of psychostimulants on central dopamine release and also stimulates central brain-derived neurotrophic factor (BDNF) synthesis.","summary":"Proposes Semax for ADHD based on dopamine and BDNF data.","claim_ids":[],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:41:10.256Z","link_status":"http_403","quote_status":"unverified","prev":"51dd87e0e113556ec5d9779e7cf59758164f7e2f06e94cbfc0f537cfd6b9bf2a","hash":"a3e825323e254a5b9692ae6b022a172b3ba3290c08aef75c1083e192be2a1c0c"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/16635254/","title":"Semax, an analogue of adrenocorticotropin (4-10), binds specifically to the rat basal forebrain","quote":"Sandwich immunoenzymatic analysis revealed that Semax applied intranasally at 50 and 250 microg/kg bodyweight resulted in a rapid increase in BDNF levels after 3 h in the basal forebrain","summary":"Direct rat BDNF measurement after Semax.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:41:10.256Z","link_status":"ok","quote_status":"verified","prev":"a3e825323e254a5b9692ae6b022a172b3ba3290c08aef75c1083e192be2a1c0c","hash":"103bb95be0ebdba5074bbe9eb1f3e459dd77f0354a6812445e4ad3b90613fabd"},{"id":"s12","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/18454096/","title":"Efficacy and possible mechanisms of action of a new peptide anxiolytic Selank","quote":"Sixty-two patients with generalized anxiety disorder (GAD) and neurasthenia were studied. The effect of selank (30 patients) was compared to that of medazepam","summary":"Human GAD trial results.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:41:10.256Z","link_status":"ok","quote_status":"verified","prev":"103bb95be0ebdba5074bbe9eb1f3e459dd77f0354a6812445e4ad3b90613fabd","hash":"eb4e7d0f36c83146ac29868122a0152f698abd2bd2ff40c39437ad6f5ef5e333"},{"id":"s15","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/6548818/","title":"DSIP reduces amphetamine-induced hyperthermia in mice","quote":"It was reported that DSIP reversed the increase in temperature of rats injected at room temperature with 15 mg d-amphetamine per kg body weight.","summary":"Animal thermoregulation data with amphetamine.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:41:10.256Z","link_status":"ok","quote_status":"verified","prev":"eb4e7d0f36c83146ac29868122a0152f698abd2bd2ff40c39437ad6f5ef5e333","hash":"d86e27e1fa46e458b88d8f6b3839ca9f6d08d3ffc9e7e0ec465ab0c1563b446f"},{"id":"s19","type":"other","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7278809/","title":"Sobriety and Satiety: Is NAD+ the Answer?","quote":"These studies implicate raising intracellular NAD+ levels as a potential target for managing and treating addictive behaviour and reducing cravings","summary":"Reviews NAD+ in addiction models.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:41:10.256Z","link_status":"ok","quote_status":"verified","prev":"d86e27e1fa46e458b88d8f6b3839ca9f6d08d3ffc9e7e0ec465ab0c1563b446f","hash":"e33cbdf4c0839443ff3ef6f51ae5a232578dc850a4885d6c4530c48558f08aac"},{"id":"s21","type":"medical","url":"https://www.webmd.com/mental-health/addiction/nad-therapy-addiction","title":"NAD Therapy for Addiction: What to Know","quote":"The first study testing NAD for substance use disorders came out many decades ago. The doctor who did the study gave NAD in an IV to more than 100 people with alcohol use disorder, opioid use disorder, or other substance use disorders.","summary":"Summarizes historical NAD observations in substance issues.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-30T01:41:10.256Z","link_status":"ok","quote_status":"verified","prev":"e33cbdf4c0839443ff3ef6f51ae5a232578dc850a4885d6c4530c48558f08aac","hash":"720177cd5370423ceab31b020bb4234735183b4dde2ea8cb3fd426b0a7a8263c"}]}