{"slug":"mots-c","verification":{"valid":true,"entries":8,"head":"6a0c29ea20ba0fe50ffacb45be11a612eee56e478fd174bc1f65617993d5c8de"},"count":8,"sources":[{"id":"s1","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT07505745","title":"MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity (MOTS-MET)","quote":"This Phase 2a study evaluates whether 12 weeks of treatment with investigational MOTS-c improves insulin sensitivity compared with placebo in adults with prediabetes and overweight/obesity.","summary":"Ongoing Phase 2a randomized double-blind placebo-controlled trial started in 2026 testing MOTS-c for insulin sensitivity in prediabetes and obesity.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:49:18.130Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"a73220426455a8c344baf23ca9400d8122ca7602c083e80af60d517526b84cf4"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41520850/","title":"MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α/AMPK-dependent manner","quote":"We demonstrate, using two distinct transgenic mouse strains, that administration of MOTS-c augments muscle mitochondrial bioenergetic performance through reliance on both the transcriptional coactivator, Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), and cellular energy-sensing kinase, 5' adenosine monophosphate-activated protein kinase (AMPK).","summary":"2026 study showing MOTS-c improves skeletal muscle mitochondrial function via PGC-1α/AMPK in mice, reduces ROS, without changing respiratory protein content.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:49:18.130Z","link_status":"ok","quote_status":"verified","prev":"a73220426455a8c344baf23ca9400d8122ca7602c083e80af60d517526b84cf4","hash":"8d6ab9b172068b7280ae1aebe13c77ea1e16e09cf71ba48b8c6e45afe4f95e1d"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41551324/","title":"Systemic MOTS-c levels are increased in adults with obesity in association with metabolic dysregulation and remain unchanged after weight loss","quote":"Circulating MOTS-c levels were significantly higher in obese compared to lean individuals (273 ± 56 vs.","summary":"2025 study finding elevated circulating MOTS-c in obesity linked to metabolic issues, unchanged post-weight loss, suggesting compensatory response.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:49:18.130Z","link_status":"ok","quote_status":"verified","prev":"8d6ab9b172068b7280ae1aebe13c77ea1e16e09cf71ba48b8c6e45afe4f95e1d","hash":"139987cf6c26d253f3df5c0ad60fb7233511c30024f16f655d6e7909e852f91c"},{"id":"s4","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12174021/","title":"Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with type 2 diabetes mellitus","quote":"Recent research has identified the mitochondrial open reading frame of the 12S rRNA-c ( MOTS-c ) as a crucial mitochondrial peptide that significantly influences ...","summary":"2025 paper on reduced serum MOTS-c levels in T2DM patients.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:49:18.130Z","link_status":"ok","quote_status":"unverified","prev":"139987cf6c26d253f3df5c0ad60fb7233511c30024f16f655d6e7909e852f91c","hash":"80bd0a417370176a2fe4c518c261bec3dc9a61d48880a67017b32ab342353c6e"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40855115/","title":"Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes","quote":"Our findings suggest that mitochondrial-encoded MOTS-c regulate pancreatic islet cell senescence and that MOTS-c could act as a senotherapeutic agent to prevent pancreatic islet cell senescence and diabetes progression.","summary":"2025 review/paper on MOTS-c reducing pancreatic islet senescence in mouse models and potential as senotherapeutic for diabetes.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:49:41.153Z","link_status":"ok","quote_status":"verified","prev":"80bd0a417370176a2fe4c518c261bec3dc9a61d48880a67017b32ab342353c6e","hash":"cf911b91ee6bc788020337fefa280711c410948764b359c0fb9b70e47a5b4cea"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39961901/","title":"Exploring the therapeutic potential of MOTS-c in age-related macular degeneration","quote":"The MOTS-c peptide appears to enhance cellular metabolism and regulate gene expression, which could potentially provide therapeutic benefits in AMD.","summary":"2025 PubMed article on MOTS-c therapeutic potential in age-related macular degeneration (AMD).","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:49:41.153Z","link_status":"ok","quote_status":"verified","prev":"cf911b91ee6bc788020337fefa280711c410948764b359c0fb9b70e47a5b4cea","hash":"8e63ab875e8ce6ab27b01c7d8c23a817ba9cda2e2560bc7e3421a526e9fd84ff"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39706498/","title":"Endurance training enhances skeletal muscle mitochondrial respiration by promoting MOTS-c secretion","quote":"More importantly, we found that endurance training may enhance the mitochondrial respiratory function of skeletal muscle by promoting the secretion of MOTS-c and activating the AMPK/PGC-1α pathway.","summary":"2025 study linking endurance training, MOTS-c secretion, and improved muscle mitochondrial function via AMPK/PGC-1α.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:49:41.153Z","link_status":"ok","quote_status":"verified","prev":"8e63ab875e8ce6ab27b01c7d8c23a817ba9cda2e2560bc7e3421a526e9fd84ff","hash":"c644857acaf3d4e17df8a29d36544ea258eef4bb6c4804dae7d4e356745bf379"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40538389/","title":"Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with obstructive sleep apnea","quote":"Recent research has identified the mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) as a crucial mitochondrial peptide that significantly influences metabolic regulation, mimics the effects of exercise, and mitigates oxidative stress.","summary":"2025 study on reduced serum MOTS-c levels in OSA patients.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:49:41.153Z","link_status":"ok","quote_status":"verified","prev":"c644857acaf3d4e17df8a29d36544ea258eef4bb6c4804dae7d4e356745bf379","hash":"6a0c29ea20ba0fe50ffacb45be11a612eee56e478fd174bc1f65617993d5c8de"}]}