{"slug":"mots-c","verification":{"valid":true,"entries":3,"head":"11120febf642572779072ebc16807217339717f0f6397cb4f9f8c6634b94208b"},"count":3,"models":["grok-4.3"],"yield":{"passes":3,"energy_spent_rows":0,"total_cost_usd":0,"waste_cost_usd":0,"total_tokens":0,"material_outputs":0,"usd_per_output":null,"models":[{"model":"grok-4.3","passes":3,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST /api/protocol/collaborate","pricing_ppm":{"grok-4.3":[1.25,2.5],"grok/grok-4.3":[1.25,2.5],"grok-build-0.1":[1,2],"kimi/moonshot-v1-8k":[0.15,0.15],"gemini/gemini-2.5-flash":[0.075,0.3],"gemini/gemini-2.0-flash-lite":[0.075,0.3],"openai/gpt-4o":[2.5,10],"openai/gpt-4o-mini":[0.15,0.6],"system/reflex":[0,0],"ingest:deterministic":[0,0],"fill-slots":[0,0]}}},"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T16:48:53.890Z","model":"grok-4.3","role":"writer","action":"draft","payload":{"title":"mots c","register":"standard","body":"## Overview\nEvidence is being populated by Grok web search.","claims":[],"sources":[]},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"genesis","hash":"43d73a60c7604669baf72f1c5db11b201b6e30d9f7c26713d4630ebb578ff8b3"},{"seq":1,"id":"k2","ts":"2026-06-29T16:49:20.596Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s1","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT07505745","title":"MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity (MOTS-MET)","quote":"This Phase 2a study evaluates whether 12 weeks of treatment with investigational MOTS-c improves insulin sensitivity compared with placebo in adults with prediabetes and overweight/obesity.","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41520850/","title":"MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α/AMPK-dependent manner","quote":"We demonstrate, using two distinct transgenic mouse strains, that administration of MOTS-c augments muscle mitochondrial bioenergetic performance through reliance on both the transcriptional coactivator, Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), and cellular energy-sensing kinase, 5' adenosine monophosphate-activated protein kinase (AMPK).","link_status":"ok","quote_status":"verified"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41551324/","title":"Systemic MOTS-c levels are increased in adults with obesity in association with metabolic dysregulation and remain unchanged after weight loss","quote":"Circulating MOTS-c levels were significantly higher in obese compared to lean individuals (273 ± 56 vs.","link_status":"ok","quote_status":"verified"},{"id":"s4","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12174021/","title":"Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with type 2 diabetes mellitus","quote":"Recent research has identified the mitochondrial open reading frame of the 12S rRNA-c ( MOTS-c ) as a crucial mitochondrial peptide that significantly influences ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"43d73a60c7604669baf72f1c5db11b201b6e30d9f7c26713d4630ebb578ff8b3","hash":"fdc73d154c3dae908e091d5fd8c9335d943ae939f3d00c6a631a6188efe74c88"},{"seq":2,"id":"k3","ts":"2026-06-29T16:49:41.847Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40855115/","title":"Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes","quote":"Our findings suggest that mitochondrial-encoded MOTS-c regulate pancreatic islet cell senescence and that MOTS-c could act as a senotherapeutic agent to prevent pancreatic islet cell senescence and diabetes progression.","link_status":"ok","quote_status":"verified"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39961901/","title":"Exploring the therapeutic potential of MOTS-c in age-related macular degeneration","quote":"The MOTS-c peptide appears to enhance cellular metabolism and regulate gene expression, which could potentially provide therapeutic benefits in AMD.","link_status":"ok","quote_status":"verified"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39706498/","title":"Endurance training enhances skeletal muscle mitochondrial respiration by promoting MOTS-c secretion","quote":"More importantly, we found that endurance training may enhance the mitochondrial respiratory function of skeletal muscle by promoting the secretion of MOTS-c and activating the AMPK/PGC-1α pathway.","link_status":"ok","quote_status":"verified"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40538389/","title":"Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with obstructive sleep apnea","quote":"Recent research has identified the mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) as a crucial mitochondrial peptide that significantly influences metabolic regulation, mimics the effects of exercise, and mitigates oxidative stress.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"fdc73d154c3dae908e091d5fd8c9335d943ae939f3d00c6a631a6188efe74c88","hash":"11120febf642572779072ebc16807217339717f0f6397cb4f9f8c6634b94208b"}]}