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Per-claim provenance."}],"not_medical_advice":true},"slug":"mk-677","title":"mk 677","register":"standard","tags":[],"updated_at":"2026-07-17T02:40:22.723Z","body_excerpt":"## Overview\nEvidence is being populated by Grok web search.","ranking":"safety-first (interaction_risk/limitations), then quote-gated effective_weight","claims":[{"id":"c1","text":"2025 BMJ Case Reports case study documenting reversible hepatotoxicity (transaminitis) in a healthy man after 2 months of MK-677 use.","tier":"preclinical","weight":0.5,"section":"what_is_known","slot":"what_is_known","interaction_risk":false,"status":"active","source_ids":["s1"],"source_status":"sourced","why_material":"Materialized from orphan source s1 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.5,"quote_gated":false},{"id":"c3","text":"2025 Drug Testing and Analysis GEON network study of 324 seized illegal products; ibutamoren (MK-677) was the most frequently reported GHS in performance-enhancing medicines/supplements.","tier":"preclinical","weight":0.5,"section":"what_is_known","slot":"what_is_known","interaction_risk":false,"status":"active","source_ids":["s3"],"source_status":"sourced","why_material":"Materialized from orphan source s3 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.5,"quote_gated":false},{"id":"c2","text":"2026 Clinica Chimica Acta study establishing hair incorporation levels of ibutamoren/MK-677 after single 10mg dose (1.3 pg/mg) and chronic use (224 pg/mg), relevant for doping detection.","tier":"human","weight":0.8,"section":"what_is_known","slot":"what_is_known","interaction_risk":false,"status":"active","source_ids":["s2"],"source_status":"sourced","why_material":"Materialized from orphan source s2 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true}],"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40675653/","title":"Hepatotoxicity induced by MK-677","quote":"MK-677, a growth hormone secretagogue, is gaining popularity among performance-enhancing supplements. 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After consumption of 60 capsules at 10 mg (whole vial), the 0 to 4 cm hair segment of a user for enhancement of athletic performances tested positive at 224 pg/mg, highlighting for the first time the incorporation in hair of this molecule.","summary":"2026 Clinica Chimica Acta study establishing hair incorporation levels of ibutamoren/MK-677 after single 10mg dose (1.3 pg/mg) and chronic use (224 pg/mg), relevant for doping detection.","claim_ids":["c2"],"link_status":"ok","quote_status":"unverified","hash":"6f08722d8748ade4b5750c8a18d18775d5d6ddf410bd77b1ecb3391928188bd2"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40551438/","title":"SARMs, Metabolic Modulators and Growth Hormone Secretagogues in Suspected Illegal Medicines, Bought as Sport Performance Enhancers: A Retro- and Prospective Study Within the GEON","quote":"Eighteen different molecules, within the scope of the study, were reported with as top 5: ibutamoren, ligandrol, ostarine, cardarine and andarine. 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